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Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystals (est) |
| Assay: | 98.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 77.00 to 79.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 287.00 to 288.00 °C. @ 760.00 mm Hg
|
| Acid Value: | 1.00 max. KOH/g
|
| Vapor Pressure: | 0.002000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 256.00 °F. TCC ( 124.44 °C. )
|
| logP (o/w): | 1.576 (est) |
| Soluble in: |
| | alcohol | | | ethyl ether | | | water, slightly | | | water, 3057 mg/L @ 25 °C (est) |
Organoleptic Properties:
| |
| Odor Type: vanilla |
| |
| | sweet creamy vanilla powdery heliotrope |
Odor Description: at 100.00 %. | sweet creamy vanilla powdery heliotropin |
| |
| | sweet creamy vanilla powdery heliotrope |
Odor Description:
| Sweet, creamy, vanilla-like with a powdery heliotropine nuance Mosciano, Gerard P&F 19, No. 2, 55, (1994) |
| |
| |
| Flavor Type: vanilla |
| |
| | sweet vanilla creamy powdery balsamic beany |
Taste Description: at 40.00 ppm. | Sweet, vanilla, creamy, powdery with a balsamic beany nuance Mosciano, Gerard P&F 19, No. 2, 55, (1994) |
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| Alfrebro |
| VANILLIN ACETATE |
| Odor Description: | Vanilla, Floral, Balsamic |
| |
| Indukern F&F |
| VANILLIN ACETATE |
| Odor Description: | SWEET, CREAMY, POWDERY, VANILLA |
| |
| |
Cosmetic Information:
Suppliers:
| Advanced Biotech |
| VANILLIN ACETATE NATURAL
Odor: Milky, Vanilla |
| Alfrebro |
| VANILLIN ACETATE NATURAL
Odor: Floral, Vanilla, Sweet |
| Alfrebro |
| VANILLIN ACETATE
Odor: Vanilla, Floral, Balsamic |
| Anhui Haibei |
| Vanillin acetate
Odor: Sweet creamy vanilla powdery heliotropin |
| Apple Flavor & Fragrance |
| Vanillin acetate
|
| Aromiens International |
| Vanillin Acetate, Natural
|
| Beijing Lys Chemicals |
| Vanillin acetate
|
| BOC Sciences |
| For experimental / research use only. |
| acetyl vanillin 98%
|
| Indukern F&F |
| VANILLIN ACETATE
Odor: SWEET, CREAMY, POWDERY, VANILLA |
| Inoue Perfumery |
| ACETYL VANILLIN
|
| Jiangyin Healthway |
| Vanillin acetate
|
| New functional food ingredients |
| Kingchem Laboratories |
| O-ACETYLVANILLIN
|
| Lluch Essence |
| VANILLIN ACETATE NATURAL
|
| M&U International |
| VANILLYL ACETATE
|
| Matrix Scientific |
| For experimental / research use only. |
| 4-Formyl-2-methoxyphenyl acetate
|
| Penta International |
| VANILLIN ACETATE NATURAL
|
| Penta International |
| VANILLIN ACETATE
|
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Vanillyl Acetate
|
| Shanghai Vigen Fine Chemical |
| Vanillin Acetate
|
| Shijiazhuang Donglian Nankai Aroma Chemicals |
| Vanillin Acetate
Odor: Milk and vanillia |
| Sigma-Aldrich |
| Vanillin acetate, ≥98%, FG
Odor: balsam; floral |
| Certified Food Grade Products |
| Synerzine |
| Vanillin Acetate
|
| TCI AMERICA |
| For experimental / research use only. |
| Vanillin Acetate >98.0%(GC)
|
| Tianjin Danjun International |
| Vanillin acetate
|
| United International |
| Vanillin acetate
|
| WholeChem |
| Vanillin acetate
|
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xi - Irritant |
R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing.
|
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| Recommendation for vanillyl acetate usage levels up to: | | | 5.0000 % in the fragrance concentrate.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 1.80 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 1.00 (μg/capita/day) |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 3 |
| Click here to view publication 3 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 28.00000 |
| beverages(nonalcoholic): | - | 11.00000 |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | 11.00000 |
| fruit ices: | - | 11.00000 |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | 28.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
| Flavor & Extract Manufacturers Association (FEMA) reference(s): |
| The FEMA GRAS assessment of hydroxyl- and alkoxy-substituted benzyl derivatives used as flavor ingredients. View pdf |
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf |
Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 881-68-5 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 61229 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | (4-formyl-2-methoxyphenyl) acetate |
| Chemidplus: | 0000881685 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | acethyl vanillin | | | acetovanillin | | 4- | acetoxy-3-methoxybenzaldehyde | | 4-( | acetyl oxy)-3-methoxybenzaldehyde | | | acetyl vanillin | | 4-( | acetyloxy)-3-methoxybenzaldehyde | | | acetylvanillin | | 4-O- | acetylvanillin | | O- | acetylvanillin | | | benzaldehyde, 4-(acetyloxy)-3-methoxy- | | 4- | formyl-2-methoxyphenol acetate | | 4- | formyl-2-methoxyphenyl acetate | | (4- | formyl-2-methoxyphenyl) acetate | | 3- | methoxy-4-acetoxybenzaldehyde | | 3- | methoxy-4-acetoxybenzaldehyde natural | | | vanillin acetate | | | vanillin acetate natural | | | vanillin, acetate |
Articles:
| PubMed: | [Chemical constituents from tubers of Cremastra appendiculata]. |
| PubMed: | Synthesis, crystal structure, fluorescence and electrochemical studies of a new tridentate Schiff base ligand and its nickel(II) and palladium(II) complexes. |
| PubMed: | Identifying inhibitory compounds in lignocellulosic biomass hydrolysates using an exometabolomics approach. |
| PubMed: | [Chemical constituents of Cudrania cochinchinensis]. |
| PubMed: | Inhibition of arachidonic acid metabolism by the Andean crude drug Parastrephia lucida (Meyen) Cabrera. |
| PubMed: | Sensitive and selective determination of phenolic compounds from aromatic plants using an electrochemical detection coupled with HPLC method. |
| PubMed: | Inhibitory activity of carbonyl compounds on alcoholic fermentation by Saccharomyces cerevisiae. |
| PubMed: | A new taraxerol derivative from the roots of Microcos tomentosa. |
| PubMed: | A study on anticancer activity of Caulis Spatholobi extract on human osteosarcoma Saos-2 cells. |
| PubMed: | Distribution of withaferin A, an anticancer potential agent, in different parts of two varieties of Withania somnifera (L.) Dunal. grown in Sri Lanka. |
| PubMed: | The volatile profiles of a rare apple (Malus domestica Borkh.) honey: shikimic acid-pathway derivatives, terpenes, and others. |
| PubMed: | Orchid bee (Hymenoptera: Apidae) community from a gallery forest in the Brazilian Cerrado. |
| PubMed: | Ferrocene-based compartmental ligand for the assembly of neutral Zn(II)/Ln(III) heterometallic complexes. |
| PubMed: | Inhibition of growth of Zymomonas mobilis by model compounds found in lignocellulosic hydrolysates. |
| PubMed: | [Study on chemical composition of ethylacetate fraction from Polygonum amplexicaule var. sinense]. |
| PubMed: | Rapid and sensitive high performance liquid chromatographic determination of zonisamide in human serum application to a pharmacokinetic study. |
| PubMed: | Biological activities and chemical composition of the stems and roots of Helichrysum oligocephalum DC grown in Iran. |
| PubMed: | High performance thin layer chromatography-densitometry: a step further for quality control of cranberry extracts. |
| PubMed: | Polynuclear lanthanide (Ln) complexes of a tri-functional hydrazone ligand--mononuclear (Dy), dinuclear (Yb, Tm), tetranuclear (Gd), and hexanuclear (Gd, Dy, Tb) examples. |
| PubMed: | Anti-biofouling property of vanillin on Aeromonas hydrophila initial biofilm on various membrane surfaces. |
| PubMed: | Identification of the key odorants in Tahitian cured vanilla beans (Vanilla tahitensis) by GC-MS and an aroma extract dilution analysis. |
| PubMed: | Fungi benefit from two decades of increased nutrient availability in tundra heath soil. |
| PubMed: | Diastereoselective synthesis of 5-hydroxy-8-methoxy-1-oxaspiro[5,5]undeca-7,10-diene-9-one. |
| PubMed: | In vitro degradation of lysine by ruminal fluid-based fermentations and by Fusobacterium necrophorum. |
| PubMed: | Synthesis, antioxidant and antimicrobial activity of novel vanillin derived piperidin-4-one oxime esters: preponderant role of the phenyl ester substituents on the piperidin-4-one oxime core. |
| PubMed: | Estimation of inhibitory effects of hemicellulosic wood hydrolysate inhibitors on PHA production by Burkholderia cepacia ATCC 17759 using response surface methodology. |
| PubMed: | Correlation between slow magnetic relaxation and the coordination structures of a family of linear trinuclear Zn(II)-Ln(III)-Zn(II) complexes (Ln = Tb, Dy, Ho, Er, Tm and Yb). |
| PubMed: | Antitumor and antimicrobial activities of some hetero aromatic benzofurans derived from naturally occurring visnagin. |
| PubMed: | Validated determination of primulasaponins in primula root by a high-performance-thin-layer-chromatography densitometric approach. |
| PubMed: | Comparative study of organosolv lignin extracted from prairie cordgrass, switchgrass and corn stover. |
| PubMed: | Global regulator engineering significantly improved Escherichia coli tolerances toward inhibitors of lignocellulosic hydrolysates. |
| PubMed: | Simultaneous determination of five active compounds in chimonanthus nitens by double-development HPTLC and scanning densitometry. |
| PubMed: | Purification of vetiver alcohols and esters for quantitative high-performance thin-layer chromatography determination in Haitian vetiver essential oils and vetiver acetates. |
| PubMed: | [Liposoluble constituents from Iodes cirrhosa and their neuroprotective and potassium channel-blocking activity]. |
| PubMed: | Bioproduction of vanillin using an organic solvent-tolerant Brevibacillus agri 13. |
| PubMed: | [Study on chemical constituents from ethyl acetate extract of Myricaria bracteata]. |
| PubMed: | Evaluation of dual flow counter-current chromatography and intermittent counter-current extraction. |
| PubMed: | Enhanced repellency of binary mixtures of Zanthoxylum armatum seed oil, vanillin, and their aerosols to mosquitoes under laboratory and field conditions. |
| PubMed: | The Zymomonas mobilis regulator hfq contributes to tolerance against multiple lignocellulosic pretreatment inhibitors. |
| PubMed: | Spectral study on the inclusion complex of cryptophane-E and CHCl3. |
| PubMed: | Fast and green microwave-assisted conversion of essential oil allylbenzenes into the corresponding aldehydes via alkene isomerization and subsequent potassium permanganate promoted oxidative alkene group cleavage. |
| PubMed: | Prediction of solubility of drugs and other compounds in organic solvents. |
| PubMed: | Fate of key odorants in Sauternes wines through aging. |
| PubMed: | [Olfactory functional magnetic resonance imaging with modified OEP-98C olfactometer and event-related design]. |
| PubMed: | Effects of biomass hydrolysis by-products on oleaginous yeast Rhodosporidium toruloides. |
| PubMed: | Scale-up of counter-current chromatography: demonstration of predictable isocratic and quasi-continuous operating modes from the test tube to pilot/process scale. |
| PubMed: | Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols. |
| PubMed: | New 18-l process-scale counter-current chromatography centrifuge. |
| PubMed: | Synthesis and characterization of a novel cross-linking complex of beta-cyclodextrin-o-vanillin furfuralhydrazone and highly selective spectrofluorimetric determination of trace gallium. |
| PubMed: | Chemical constituents of Antrodia camphorata submerged whole broth. |
| PubMed: | Vanillin inhibits matrix metalloproteinase-9 expression through down-regulation of nuclear factor-kappaB signaling pathway in human hepatocellular carcinoma cells. |
| PubMed: | Qualitative and quantitative analysis of four species of Curcuma rhizomes using twice development thin layer chromatography. |
| PubMed: | [Composition and seasonality of Euglossina Species (Hymenoptera: Apidae) in forest and dune in the Environmental Protection Area of the Mamanguape River Bar, PB]. |
| PubMed: | Spectral study on the interaction of cryptophane-A and neutral molecules CHnCl4-n (n=0, 1, 2). |
| PubMed: | Chemical profile of rums as a function of their origin. The use of chemometric techniques for their identification. |
| PubMed: | [Activity time of male Euglossina and preference for artificial fragrances in forest and dunes in the Environmental Protection Area of the Mamanguape River Bar, Rio Tinto, ParaĆba, Brazil]. |
| PubMed: | Effects of phenolic monomers on the enzymes activities and volatile fatty acids production of Neocallimastix frontalis B9. |
| PubMed: | [Chemical constituents from root barks of Periploca sepium]. |
| PubMed: | Effects of Chamaecyparis formosensis Matasumura extractives on lipopolysaccharide-induced release of nitric oxide. |
| PubMed: | Quantitative determination of phyllanthin and hypophyllanthin in Phyllanthus species by high-performance thin layer chromatography. |
| PubMed: | Aroma extraction dilution analysis of Sauternes wines. Key role of polyfunctional thiols. |
| PubMed: | Effect of essential oil active compounds on rumen microbial fermentation and nutrient flow in in vitro systems. |
| PubMed: | Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis. |
| PubMed: | Aroma composition of red wines by different extraction methods and Gas Chromatography-SIM/MASS spectrometry analysis. |
| PubMed: | Cholesterol-dependent hemolytic activity of Passiflora quadrangularis leaves. |
| PubMed: | HPLC determination of salinomycin and related compounds in fermentation media of Streptomyces albus and premixes. |
| PubMed: | Cytotoxic chromenes from Myriactis humilis. |
| PubMed: | Synthesis of a novel host molecule of cross-linking-polymeric-beta-cyclodextrin-o-vanillin furfuralhydrazone and spectrofluorimetric analysis of its identifying cadmium. |
| PubMed: | Comparison between cachaƧa and rum using pattern recognition methods. |
| PubMed: | Crystal structure and magnetic interactions in nickel(II) dibridged complexes formed by two azide groups or by both phenolate oxygen-azide, -thiocyanate, -carboxylate, or -cyanate groups. |
| PubMed: | Gas chromatography-olfactometry and chemical quantitative study of the aroma of six premium quality spanish aged red wines. |
| PubMed: | Characterization of odor-active compounds in Californian chardonnay wines using GC-olfactometry and GC-mass spectrometry. |
| PubMed: | Synthesis and characterization of a novel cross-linking complex of beta-cyclodextrin-o-vanillin benzoylhydrazone and its selective spectrofluorimetric determination of trace amounts of zinc. |
| PubMed: | Nitrite as an energy-conserving electron sink for the acetogenic bacterium Moorella thermoacetica. |
| PubMed: | Optimum methamphetamine profiling with sample preparation by solid-phase microextraction. |
| PubMed: | New chemical constituents of Euphorbia quinquecostata and absolute configuration assignment by a convenient Mosher ester procedure carried out in NMR tubes. |
| PubMed: | Amperometric biosensors for detection of phenol using chemically modified electrodes containing immobilized bacteria. |
| PubMed: | [TLC analysis of harpagoside in devil claw extract and its tablets]. |
| PubMed: | A novel strategy for the synthesis of benzofuran skeleton neolignans: application to ailanthoidol, XH-14, and obovaten. |
| PubMed: | Identification of impurities and statistical classification of methamphetamine tablets (Ya-Ba) seized in Thailand. |
| PubMed: | Purification and characterization of a microbial dehydrogenase: a vanillin:NAD(P)+ oxidoreductase. |
| PubMed: | Volatile components of Loureira, Dona Branca, and Treixadura wines. |
| PubMed: | Bioactive aromatic compounds from leaves and stems of Vanilla fragrans. |
| PubMed: | Functional consequences following infection of the olfactory system by intranasal infusion of the olfactory bulb line variant (OBLV) of mouse hepatitis strain JHM. |
| PubMed: | Measurement of urinary methoxyphenols and their use for biological monitoring of wood smoke exposure. |
| PubMed: | Characterization of Volatiles in Rambutan Fruit (Nephelium lappaceum L.). |
| PubMed: | Neurophysiological and behavioral responses to olfactory stimuli in the snail Helix pomatia L. |
| PubMed: | Sensitivity of the olfactory sense declines with the aging in senescence-accelerated mouse (SAM-P1). |
| PubMed: | Effects of the sniffing port air makeup in gas chromatography-olfactometry. |
| PubMed: | Endothelial cell oxidant production: effect of NADPH oxidase inhibitors. |
| PubMed: | [Color reactions for identification of nalidixic acid]. |
| PubMed: | Similarities in the aroma chemistry of Gewürztraminer variety wines and lychee (Litchi chinesis sonn.) fruit. |
| PubMed: | Veratryl alcohol-mediated oxidation of isoeugenyl acetate by lignin peroxidase. |
| PubMed: | Trace-level determination of polar flavour compounds in butter by solid-phase extraction and gas chromatography-mass spectrometry. |
| PubMed: | Odor response properties of rat olfactory receptor neurons. |
| PubMed: | Antiosteoporotic activity of the stems of Sambucus sieboldiana. |
| PubMed: | Hyposmia for butanol and vanillin in mutant staggerer male mice. |
| PubMed: | Determination of ionophores in the tissues of food animals by liquid chromatography. |
| PubMed: | [Substituted methoxyphenol with antioxidative activity: correlation between physicochemical and biological results]. |
| PubMed: | Nitrate as a preferred electron sink for the acetogen Clostridium thermoaceticum. |
| PubMed: | Generation of mutagenicity by ozonation of humic substances' components. |
| PubMed: | The role of sucrose-sensitive neurons in ingestion of sweet stimuli by hamsters. |
| PubMed: | Xylose uptake by the ruminal bacterium Selenomonas ruminantium. |
| PubMed: | Isolation, characterization and biological activities of a toxin from Bacillus megaterium (B-23). |
| PubMed: | High-speed liquid chromatographic determination of monensin, narasin, and salinomycin in feeds, using post-column derivatization. |
| PubMed: | Reverse phase liquid chromatographic determination of some food additives. |
| PubMed: | Effects of ammoniation of tall fescue on phenolic composition, feed intake, site and extent of nutrient digestion and ruminal dilution rates of steers. |
| PubMed: | Mechanism of the desmutagenic effect of humic acid. |
| PubMed: | Measurement of plasma vanillylmandelic acid by liquid chromatography with electrochemical detection. |
| PubMed: | Iron Deficiency Decreases Suberization in Bean Roots through a Decrease in Suberin-Specific Peroxidase Activity. |
| PubMed: | Evaluation of immunomodulatory chemicals: alteration of macrophage function in vitro. |
| PubMed: | Neuroblastoma cell as model for olfactory cell: mechanism of depolarization in response to various odorants. |
| PubMed: | Biosynthesis, deposition, and partial characterization of potato suberin phenolics. |
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