Articles:
| J-Stage: | Antioxidative Properties of Vanillic Acid Esters in Multiple Antioxidant Assays |
4-hydroxy-3-methoxybenzoic acid
Notes:
a flavoring agent. it is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (j biotechnol 1996;50(2-3):107-13). Vanillic acid is a phenolic acid found in some forms of vanilla and many other plant extracts. It is a flavoring and scent agent that produces a pleasant, creamy odor. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13). Vanillic acid, which is a chlorogenic acid, is an oxidized form of vanillin. It is also an intermediate in the production of vanillin from ferulic acid. Vanillic acid is a metabolic byproduct of caffeic acid and is often found in the urine of humans who have consumed coffee, chocolate, tea and vanilla-flavored confectionary. Vanillic acid selectively and specifically inhibits 5'nucleotidase activity. (PMID: 16899266)
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Beijing Lys Chemicals Co, LTD. From Grams to Tons Fine chemical high-tech company which contains R&D, production, and sales. BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services. Email: Mr. Jia Email: Mr. Guo Voice: 86-10-68418738 Fax: 86-10-68418739 Mr. Guo 86-10-68483445 Mr. Guo 86-10-68418739 News Product(s): 10449 Vanillic acid
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 121-34-6 p-Vanillic Acid >98%
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Lluch Essence S.L. A family company dedicated to sales and distribution Flexibility, availability, price and quality. Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world. Email: Info Voice: 34 93 379 38 49 Fax: 34 93 370 65 04 Linkedin Product(s): VANILLIC ACID
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M&U International LLC Steady supply & demand Meeting customers increasing demands at home as well as abroad. M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. Email: Sales US Email: Sales Voice: +86-21-32515501 60762991 60762992 Fax: +86-21-32515502 64204960 US Voice: 908-359-9000 US Fax: 908-359-9002 News Product(s): A0571 Vanillic Acid
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 22-25000 VANILLIC ACID 22-25001 VANILLIC ACID TECH. GRADE
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Prodasynth PRODUCTEUR PAR ESSENCE Chemical specialist in manufacturing, distributing and sourcing of tailor-made ingredients for the Flavour & Fragrance industry. Today we are also proud to say, we have created an important range of Natural Molecules which can be found in our Raw Material Compendium. The versatility of our small but efficient structure is one of our main strengths when trying to fulfill our clients' requirements. Email: Info: Email: Sales Team Prodasynth Voice: (33) 4 93 09 00 11 Fax: (33) 4 22 13 07 38 New Catalog Products List: View Product(s): VANILLIC ACID (> 95%)
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Sigma-Aldrich Complete Supply Chain The perfect blend of products and services that bring your creativity to life. Sigma-Aldrich is a leading Life Science and High Technology company dedicated to providing high-quality, safe and certified flavor ingredients with transparent and easily accessible documentation to customers around the globe. Sigma-Aldrich also provides a suite of analytical tools that allow food analysts to simplify sample preparation, cleanup and analysis steps, while increasing sensitivity to trace ingredients and harmful substances to meet regulations and quality standards. Email: Information US Email: Sales US Voice: 800-244-1173 US Fax: 800-368-4661 Facebook Twitter Instagram Linkedin Flavors and Fragrances Analysis FandF Newsletter Subscription Flavors and Fragrances Learning Center Certified Food Grade Products Product(s): W398802 Vanillic acid, ≥97%, FG SDS
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Synerzine, Inc. Innovation. Customization. Aroma Ingredients. Synerzine is a leading supplier of flavor and fragrance ingredients. Synerzine expresses what we have grown to embody as an organization - the synergy and connection between raw ingredients, science, technology, and the final product. Our experienced team is passionate about bringing our customers high-quality innovative ingredients that they can trust. Building upon our 44 year history, the Synerzine team provides customers around the globe with convenient access to over 1200 high-quality aroma ingredients. We actively engage with customers to add a wide array of new products and services on a regular basis. Our aim is to delight every customer with our exceptional services, large product selection, customization and the highest quality and safety standards. We provide our customers with true value designed to help them bring their products to market faster. US Email: Customer Service US Email: Sales US Voice: (404) 524-6744 US Fax: (404) 577-1651 Inquiry Products List: View Product(s): W2121 Vanillic Acid
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TCI AMERICA Moving Your Chemistry Forward We continuously strive to advance our technology. With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping! Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis. US Email: Sales Email: Technical Support Voice: 1-800-423-8616 Fax: 1- 888-520-1075 Facebook Twitter Instagram Linkedin Product(s): V0017 Vanillic Acid >98.0%(GC)(T)
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Tianjin Danjun International Trade Co., LTD. Quality Products We know the Chinese chemical market well. Tianjin danjun international trade co., LTD. is an organic chemicals trading company approved by the relevant state authorities to register. We have about 300 kinds of products (natural aroma chemicals, synthetic aroma chemicals and pharmaceutical intermediates). Most of the products are used in flavor and fragrance industry. We know the Chinese chemical market well and we have close relationship with many of the main manufacturers, and to provide our customers with quality goods together with comprehensive service. Email: Info Email: Sales Voice: +86-15822601686 Products List: View Product(s): G-062 vanillic acid
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Qingdao Free Trade Zone United International Co Ltd Quality Products A partner in your supply chain solution. Qingdao Free Trade Zone United International Trade Co., Ltd.was founded in 1996, specializing in the production and import and export of food additives,flavor raw materials and pharmaceutical and chemical raw materials. The company has experienced R&D and business personnel,product quality, low price, efficient service and fast insight and grasp the latest market information. Email: Info Email: Sales Voice: +86-532-83893699 Fax: +86-532-83893695 Product(s): 7262 Vanillic Acid
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WholeChem, LLC Connecting Innovators To the Building Blocks Of the Universe Custom manufacturer and distributor of specialty ingredients. We make global local. SQF-Certified Supplier We owe our success to our integrity, our dedication to the industry, and our commitment to our clients. We invite your inquiries regarding our current product list and any other products you may be having trouble sourcing. Email: Info Email: Orders Voice: +1 (262) 995.8668 Certification Our Services Products List: View Product(s): Vanillic acid
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| CAS Number: | 121-34-6 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 204-466-8 | |
| FDA UNII: | GM8Q3JM2Y8 | |
| Nikkaji Web: | J5.337F | |
| Beilstein Number: | 2208364 | |
| MDL: | MFCD00002551 | |
| CoE Number: | 697 | |
| XlogP3: | 1.40 (est) | |
| Molecular Weight: | 168.14856000 | |
| Formula: | C8 H8 O4 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 959 4-hydroxy-3-methoxy benzoic acid |
| DG SANTE Food Flavourings: | 08.043 vanillic acid |
| FEMA Number: | 3988 4-hydroxy-3-methoxybenzoic acid |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 121-34-6 ; VANILLIC ACID |
Physical Properties:
| Appearance: | white to beige powder (est) |
| Assay: | 98.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 210.00 to 213.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 353.43 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure: | 0.000020 mmHg @ 25.00 °C. |
| Flash Point: | > 212.00 °F. TCC ( > 100.00 °C. ) |
| logP (o/w): | 1.430 |
| Soluble in: | |
| alcohol, 5% slightly hazy | |
| dipropylene glycol | |
| water, 1500 mg/L @ 14C (exp) | |
| Insoluble in: | |
| water | |
Organoleptic Properties:
| Odor Type: creamy | |
| dairy milky sweet creamy powdery vanilla beany | |
| Odor Description: at 100.00 %. | dairy milky sweet creamy powdery vanilla bean Luebke, William tgsc, (2007) |
| sweet creamy phenolic brown powdery vanilla beany | |
| Odor Description: | Sweet creamy, phenolic, brown and powdery with vanilla beany nuances Mosciano, Gerard P&F 18, No. 4, 51, (1993) |
| Flavor Type: creamy | |
| creamy milky sweet vanilla powdery | |
| Taste Description: at 30.00 ppm. | Creamy, milky, sweet and vanilla with cardboard-like nuances Mosciano, Gerard P&F 18, No. 4, 51, (1993) |
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
Safety Information:
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| None - None found. | |
|
S 02 - Keep out of the reach of children. S 22 - Do not breath dust. S 24/25 - Avoid contact with skin and eyes. S 36 - Wear suitable protective clothing. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intraperitoneal-rat LD50 5020 mg/kg Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 243, Pg. 609, 1956. intraperitoneal-mouse LD50 > 2691 mg/kg Yakugaku Zasshi. Journal of Pharmacy. Vol. 104, Pg. 793, 1984. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavor and fragrance agents | ||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| Recommendation for para-vanillic acid usage levels up to: | |||
| 0.5000 % in the fragrance concentrate. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 24.00 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 26.00 (μg/capita/day) | ||
| Structure Class: | I | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 20 | |||
| Click here to view publication 20 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | - | |
| beverages(nonalcoholic): | - | - | |
| beverages(alcoholic): | 5.00000 | 25.00000 | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | 5.00000 | 25.00000 | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | 5.00000 | 25.00000 | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | - | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | 3.00000 | 15.00000 | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| Flavor & Extract Manufacturers Association (FEMA) reference(s): | |
| The FEMA GRAS assessment of hydroxyl- and alkoxy-substituted benzyl derivatives used as flavor ingredients. View pdf | |
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): | |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf | |
| Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf | |
| Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf | |
| Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf | |
| Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009) View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf | |
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 121-34-6 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 8468 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 1 |
| 4-hydroxy-3-methoxybenzoic acid | |
| Chemidplus: | 0000121346 |
| RTECS: | YM5300000 for cas# 121-34-6 |
References:
| 4-hydroxy-3-methoxybenzoic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 121-34-6 |
| Pubchem (cid): | 8468 |
| Pubchem (sid): | 134975711 |
| Pherobase: | View |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| Metabolomics Database: | Search |
| UM BBD: | Search |
| KEGG (GenomeNet): | C06672 |
| HMDB (The Human Metabolome Database): | HMDB00484 |
| FooDB: | FDB000846 |
| YMDB (Yeast Metabolome Database): | YMDB01802 |
| Export Tariff Code: | 2918.99.4700 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
Potential Uses:
| chocolate cocoa | FL | |
| coconut | FR | |
| cream | FR | |
| milk | FL | |
| nut | FL | |
| vanilla | FR | |
| whiskey | FL |
Occurrence (nature, food, other): note
| apricot fruit Search Trop Picture | |
| arrowroot leaf Search Trop Picture | |
| banana plant Search Trop Picture | |
| barley fruit Search Trop Picture | |
| barley seed Search Trop Picture | |
| beer Search PMC Picture | |
| beet leaf Search Trop Picture | |
| bilberry fruit Search Trop Picture | |
| bilberry fruit juice Search Trop Picture | |
| bilberry leaf Search Trop Picture | |
| blueberry plant Search Trop Picture | |
| brandy Search PMC Picture | |
| broccoli asparagus broccoli plant Search Trop Picture | |
| buckwheat testa Search Trop Picture | |
| cacao bean Search Trop Picture | |
| cardamom leaf Search Trop Picture | |
| carrot tissue culture Search Trop Picture | |
| chamomile sweet false chamomile plant Search Trop Picture | |
| cherry sour cherry plant Search Trop Picture | |
| chicory Search Trop Picture | |
| chicory leaf Search Trop Picture | |
| coconut leaf Search Trop Picture | |
| coriander fruit Search Trop Picture | |
| coriander plant Search Trop Picture | |
| coriander seed Search Trop Picture | |
| corn Search Trop Picture | |
| corn sprout Search Trop Picture | |
| corn tissue culture Search Trop Picture | |
| dandelion flower Search Trop Picture | |
| fennel seed Search Trop Picture | |
| fig wood Search Trop Picture | |
| garlic bulb Search Trop Picture | |
| ginger Search Trop Picture | |
| ginger plant Search Trop Picture | |
| ginkgo biloba leaf Search Trop Picture | |
| ginkgo biloba plant Search Trop Picture | |
| goosefoot fruit Search Trop Picture | |
| grape Search Trop Picture | |
| grape hull husk Search Trop Picture | |
| grape leaf Search Trop Picture | |
| guava fruit Search Trop Picture | |
| horseradish root Search Trop Picture | |
| oat seed Search Trop Picture | |
| olive fruit Search Trop Picture | |
| onion bulb Search Trop Picture | |
| oregano plant Search Trop Picture | |
| pea root Search Trop Picture | |
| pea seed Search Trop Picture | |
| peanut seed Search Trop Picture | |
| poppy opium poppy pericarp Search Trop Picture | |
| raspberry red raspberry plant Search Trop Picture | |
| rhubarb plant Search Trop Picture | |
| rice Search Trop Picture | |
| rice plant Search Trop Picture | |
| rubus spectabilis leaf Search Trop Picture | |
| rum Search PMC Picture | |
| saffron Search Trop Picture | |
| sage Search Trop Picture | |
| sage plant Search Trop Picture | |
| salmonberry leaf Search Trop Picture | |
| sesame leaf Search Trop Picture | |
| sherry Search PMC Picture | |
| soybean root Search Trop Picture | |
| soybean seed Search Trop Picture | |
| tarragon leaf Search Trop Picture | |
| thyme plant Search Trop Picture | |
| turmeric leaf Search Trop Picture | |
| vanilla Search Picture | |
| walnut black walnut nut Search Trop Picture | |
| wheat seed Search Trop Picture | |
| whiskey scotch whiskey Search Picture | |
| wine red wine Search Picture | |
| wine white wine Search Picture |
Synonyms:
| acid, p-hydroxy-m-methoxy-benzoic | |
| m- | anisic acid, 4-hydroxy- |
| benzoic acid, 4-hydroxy-3-methoxy- | |
| 4- | hydroxy-3-methoxy benzoic acid |
| 4- | hydroxy-3-methoxy-benzoic acid |
| 4- | hydroxy-3-methoxybenzoate |
| 4- | hydroxy-3-methoxybenzoic acid |
| 4- | hydroxy-m-anisic acid |
| p- | hydroxy-m-methoxy-benzoic acid |
| p- | hydroxy-m-methoxy-benzonic acid |
| 4- | hydroxy-meta-anisic acid |
| 3- | methoxy-4-hydroxybenzoic acid |
| protocatechuic acid 3-methyl ester | |
| vanillic acid | |
| p- | vanillic acid |
| vanillic acid, tech. grade | |
| vanillicacid |