gamma-hexalactone
hexano-1,4-lactone
 
Notes:
4-hydroxy-Hexanoic acid gamma-lactone is occasionally found as a volatile component of human urine. 4-hydroxy-Hexanoic acid gamma-lactone has been found in the polar fraction of human blood. Biological fluids such as blood and urine have been shown to contain a large number of components, some of them volatiles (low boiling point) apparently present in all individuals, while others such are much more variable. In some cases differences up to an order of magnitude are observed. Although some of these changes may have dietary origins, others seem to be characteristic of the individual. (PMID: 5556886, 6480763, 15835926)
  • ACS International
    • ACS International GmbH
      Creativity Beyond Chemistry
      Production • Distribution • Sourcing • Logistics • Consulting
      Our hybrid business model, combining manufacturing with sourcing and exclusive distribution agreements, results in a superior level of purchasing power that when added to our global warehouse network with locations near all major flavor and fragrance industry compounding centers around the globe, make A.C.S. International your one-stop sourcing partner.
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      Product(s):
      20967 Hexalactone gamma
       
  • Advanced Biotech
    • Advanced Biotech. Inc.
      Inspired by Nature
      A diverse range of products, all meeting our stringent commitment to quality.
      Advanced Biotech is a leading manufacturer and supplier of high-quality Natural flavoring ingredients & botanical extracts for the food/beverage, cosmetic and personal care industries. With over 25 years of experience working with Fermentation processing & botanical extracts, we can help develop new innovative and functional products for today’s competitive marketplace. Our company prides itself in the ability to cater to our customer’s specific needs while maintaining our focus on integrity, honesty and the commitment to high quality product standards. We proudly offer our quality Natural ingredients to companies around the world.
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      1599 GAMMA HEXALACTONE NATURAL
      SDS
       
  • Alfrebro
    • Alfrebro LLC/ Archer Daniels Midland Company
      Let's get reacquainted
      Building great taste with aroma chemicals, extracts, and distillates
      The Alfrebro brand was established in the early 1900s by Alex Fries & Brothers, a Cincinnati Flavor Company. In 1980, the brand was re-launched as an aroma chemical manufacturer. Since its inception, Alfrebro’s primary focus has been to provide quality natural and high value synthetic chemicals.
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  • Augustus Oils
    • Augustus Oils Ltd
      The Premier Supplier
      Augustus Oils Ltd, in harmony with nature - to present it at its best...
      A wealth of experience, expertise and knowledge has allowed Augustus to bridge the gulf in expectation and trust between growers and users of natural ingredients. The Company works in partnership with customers on the one hand, and growers, farmers and distillers on the other. Both users and producers can then focus on exactly what they do best, while skilled Augustus technicians closely monitor and control the delivered product. This ensures users can have the confidence that they will receive the best raw materials suited to their requirements.
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  • Axxence Aromatic
    • Axxence Aromatic GmbH
      We bring nature to your flavour
      Dedicated to provide the best possible quality and supply service of natural aroma ingredients.
      Axxence Aromatic is entirely dedicated to provide the best possible quality and supply service of natural aroma ingredients to the Flavour & Fragrance Industry worldwide.
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      255600 gamma-HEXALACTONE Natural Kosher
       
  • Bedoukian Research
    • Bedoukian Research, Inc.
      Constantly Improving
      Working closely with our customers to meet their requirements.
      Paul Bedoukian founded the company to fill a niche as a supplier of high quality specialty aroma and flavor ingredients. In 1975 the company began manufacturing insect pheromones which are chemically similar to flavor and fragrance ingredients. Today, Bedoukian Research offers more than 450 Aroma Chemicals and 50 Insect Pheromones, while also providing custom manufacturing services to the pharmaceutical, agrochemical, and specialty chemical industries.
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      449 gamma-HEXALACTONE ≥98.0%, FCC, Kosher
      Smooth, coumarin-like note lends itself to creamy, vanilla compositions.
      Used mostly in beverages, ice cream, candy and tobacco; also an enhancer for maple, almond, cognac, whiskey and coconut flavors.
       
       
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
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      Product(s):
      10334 gamma-Hexalactone
       
  • Berjé
    • Berje Inc.
      Where the world comes to its senses
      Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.
      Berjé is a family-owned business that has been in operation for six decades. The company's origins and strength lie in a profound understanding of the supply and the quality of the diverse raw materials consumed by the flavor and fragrance industries. This base was expanded upon more than two decades ago to include fragrance production. The company's unparalleled raw material expertise is focused on the supply of essential oils and aromatic chemicals. This is supported by our long-standing relationships with a worldwide fabric of producers ensuring the greatest prospects for uninterrupted supply in markets that are often volatile and unpredictable.
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      gamma-Hexalactone
       
  • BOC Sciences
    • BOC Sciences
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      Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
      BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services.
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      Product(s):
      695-06-7 gamma-HEXALACTONE FCC 98.0%
       
  • DeLong Chemicals America
    • DeLong Chemicals America
      Custom Manufacturing
      Supplier of aroma chemicals, pharmaceutical and specialty chemical intermediates.
      DeLong Chemicals America, LLC is an extension of Shijiazhuang Lida Chemical Co, Ltd to North America, a leading supplier and manufacturer of aroma chemicals, serving the industries of food, tobacco and perfume, while also providing intermediates, custom synthesis and custom manufacturing for pharmaceutical and specialty chemical industries.
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      Product(s):
      9886 gamma-Hexalactone
       
  • Excellentia International
    • Excellentia International
      Ingredients by Nature
      Exceptional quality and excellence in meeting our customers requirements.
      Excellentia International was founded in 2010 through the merger of Excellentia Flavors LLC and Polarome International. Collectively, these companies account for more than one hundred years of industry experience, and are recognized for exceptional quality and excellence in meeting our customers’ requirements.
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      Voice: 732.749.9840
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      Product(s):
      gamma-Hexalactone Natural
      gamma-Hexalactone
       
  • Indukern F&F
  • Lluch Essence
    • Lluch Essence S.L.
      A family company dedicated to sales and distribution
      Flexibility, availability, price and quality.
      Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world.
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      Fax: 34 93 370 65 04
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      Product(s):
      gamma-HEXALACTONE
      gamma-HEXALACTONE NATURAL
       
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers.
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      Voice: +86-21-32515501 60762991 60762992
      Fax: +86-21-32515502 64204960
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      Product(s):
      A0074 gamma-Hexalactone, Kosher
      N0167 NAT. gamma-HEXALACTONE
       
  • Moellhausen
  • Odowell Co.,ltd
    • Odowell Co.,ltd
      Fulfilling Demand
      Product quality and consistency.
      Odowell is specialized in producing and distributing aroma chemicals for Flavors &Fragrances industry since 2012. Product ranges are ketones, esters,alcohols, aldehydes , ethers and lactones. We have the most comprehensive range of C3-C15 aliphatic ketones, aromatic ketones and high purity electronic chemicals, providing to many industries related to our daily life.
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      Phone, Kunshan Odowell+86-512-55380008
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      Product(s):
      10-81-031 Gamma hexalactone PURITY: 99%MIN.
       
  • OQEMA
    • OQEMA
      With a focus on providing the highest level of service
      OQEMA has established itself at the forefront of the global chemical industry.
      The guiding principles of OQEMA have always been to establish long term relationships with customers and suppliers alike to build sustainable and profitable business for all parties. Through OQEMA’s business divisions the company tailors products and services to better support and service our customers requirements. This structure also allows the company to focus its marketing campaigns more effectively to certain industries. Over the last decade OQEMA has achieved strong growth as a result of the expansion of our business model. Going forward, the company will be expanding this business model into existing and new strategic territories.
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      US Email: Dean Matienzo
      Email: Sales
      US Email: Dean Matienzo - Sales Manager
      Voice: +44 1993 843081
      Fax: +44 1993 841261
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      Product(s):
      Hexalactone Gamma
       
  • Penta International
  • Prodasynth
    • Prodasynth
      PRODUCTEUR PAR ESSENCE
      Chemical specialist in manufacturing, distributing and sourcing of tailor-made ingredients for the Flavour & Fragrance industry.
      Today we are also proud to say, we have created an important range of Natural Molecules which can be found in our Raw Material Compendium. The versatility of our small but efficient structure is one of our main strengths when trying to fulfill our clients' requirements.
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      Email: Karine Cohen
      Voice: (33) 4 93 09 00 11
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      Product(s):
      GAMMA HEXALACTONE (> 98%)
       
  • Riverside Aromatics
    • Riverside Aromatics Ltd.
      Speciality Aroma Chemicals, Naturals and Synthetics
      A specialist supplier of raw materials to the flavour industry.
      Peter Cannon & David Rowe established Riverside Aromatics in 2006 in Poole, UK, to offer a new type of specialist raw material supplier to the Flavour & Fragrance Industry. We bring together over 40 years of commercial & technical experience in the F&F industry which allows us to understand the needs of the Global F&F business and especially that of the West European Market.
      Email: Info
      Email: Peter Cannon (sales)
      Voice: +44 (0) 1202 679532
      Fax: +44 (0) 1202 679532
      Products List: View
      Product(s):
      HL1060 gamma-HEXALACTONE
       
  • Robertet
    • Robertet, Inc.
      HOME OF NATURE, SEED TO SCENT
      HOME OF NATURE – natural ingredients from the source.
      Robertet is a leader in the production of natural ingredients with facilities in France, Bulgaria, Turkey, South Africa, India, China, New Caledonia,… Founded in 1850, Robertet remains a family owned business (5th Generation) and one of the largest producers of aromatic extracts. Brand acquisitions include: Charabot, Sapad, Hitex.
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      US Email: Arnaud Adrian
      Email: Flavor:
      Email: Fragrance:
      Voice: 33 4 93 40 33 66
      Fax: 33 4 93 70 68 09
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      +1 212 710 4600Robertet New York Creative Center
      +1 212 245 4092Robertet New York Creative Center
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      Product(s):
      100638 gamma-Hexalactone nat.
       
  • Sigma-Aldrich
  • Soda Aromatic
    • Soda Aromatic Co., Ltd.
      Depth of Experience
      We guarantees product safety and quality.
      Our international sales department is happy to design the most suitable flavor & fragrance for specific uses of processed food, cosmetics, and fragrance manufactures all over the world, specializing in Asia.Let us help you with your flavor & fragrance needs.
      Email: Info
      Email: Sales
      Voice: +81-3-5645-7347
      Fax: +81-3-3664-5204
      Product(s):
      111146045 gamma-Hexalactone
       
  • Sunaux International
    • Sunaux International
      Buy With Confidence
      We have industry leading processes and procedures to ensure nothing but the most reliable product.
      Sunaux International was founded in 2012 by the owner Mr.John Felton after spending 18 years involved in developing global business in the aromatic chemicals, fragrance and flavour compounds business.
      Email: John Felton
      Email: Stephen Zhou (Sales)
      Voice: 0512-57995626
      Fax: 0512-57570299
      Sales0512-57995626
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      Product(s):
      A0077 gamma-Hexalactone
       
  • TCI AMERICA
    • TCI AMERICA
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 28,000 Reagents available today in benchtop to bulk quantities. Sign up for a TCI account today for fast and free shipping!
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 60 years of synthesis experience and multi-purpose plants enable TCI to offer more than 28,000 products as well as custom synthesis. TCI has established overseas facilities in North America, Europe, China and India to serve customers worldwide.
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      Product(s):
      H0514 gamma-Hexalactone >98.0%(GC)
       
  • WholeChem
    • WholeChem, LLC
      Connecting Innovators To the Building Blocks Of the Universe
      Custom manufacturer and distributor of specialty ingredients. We make global local.
      We owe our success to our integrity, our dedication to the industry, and our commitment to our clients. We invite your inquiries regarding our current product list and any other products you may be having trouble sourcing.
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      Product(s):
      Gamma-hexalactone
       
Synonyms   Articles   Notes   Search
Fragrance Demo Formulas    Flavor Demo Formulas
CAS Number: 695-06-7Picture of molecule3D/inchi
Other(deleted CASRN): 57129-70-1
ECHA EINECS - REACH Pre-Reg: 211-778-8
FDA UNII: J16NAT1G41
Nikkaji Web: J45.665I
Beilstein Number: 0107260
MDL: MFCD00005401
CoE Number: 2254
XlogP3: 0.70 (est)
Molecular Weight: 114.14410000
Formula: C6 H10 O2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
EFSA/JECFA Comments: JECFA evaluted gamma-hexalactone (CASrn as in Register). Register CASrn refers to the racemate.
Category: flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 223  gamma-hexalactone
DG SANTE Food Flavourings: 10.021  hexano-1,4-lactone
FEMA Number: 2556 gamma-hexalactone
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):695-06-7 ; GAMMA-HEXALACTONE
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.515 Synthetic flavoring substances and adjuvants.
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: colorless to pale yellow clear liquid (est)
Assay: 98.00 to 100.00 % 
Food Chemicals Codex Listed: Yes
Specific Gravity: 1.02000 to 1.02500 @  25.00 °C.
Pounds per Gallon - (est).: 8.487 to  8.529
Refractive Index: 1.43700 to 1.44200 @  20.00 °C.
Melting Point: -18.00 °C. @ 760.00 mm Hg
Boiling Point: 100.00 to  102.00 °C. @ 18.00 mm Hg
Boiling Point: 215.50 °C. @ 760.00 mm Hg
Acid Value: 1.00 max. KOH/g
Vapor Pressure: 0.152000 mmHg @ 25.00 °C. (est)
Vapor Density: >1 ( Air = 1 )
Flash Point: 209.00 °F. TCC ( 98.33 °C. )
logP (o/w): 0.413 (est)
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage: store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
 alcohol
 dipropylene glycol
 propylene glycol
 water, slightly
 water, 3.219e+004 mg/L @ 25 °C (est)
Insoluble in:
 water
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
 
Odor Type: tonka
 
Odor Strength: medium ,
recommend smelling in a 10.00 % solution or less
 
Substantivity: 128 hour(s) at 100.00 %
 
 herbal  coconut  sweet  coumarinic  tobacco  
Odor Description:
at 10.00 % in dipropylene glycol. 
herbal coconut sweet coumarin tobacco
Luebke, William tgsc, (2004)
 
 sweet  creamy  lactonic  tobacco  coumarinic  green  coconut  
Odor Description:
Sweet, creamy, lactonic, tobacco and coumarin-like with green coconut nuances
Mosciano, Gerard P&F 17, No. 3, 57, (1992)
 
 
Flavor Type: creamy
 
 sweet  creamy  vanilla  green  lactonic  powdery  
Taste Description:
at 75.00 ppm.  
Sweet, creamy, vanilla-Iike with green lactonic powdery nuances
Mosciano, Gerard P&F 17, No. 3, 57, (1992)
 
Odor and/or flavor descriptions from others (if found).
 
Bedoukian Research
gamma-HEXALACTONE ≥98.0%, FCC, Kosher
Odor Description: An herbaceous, waxy, creamy note
Smooth, coumarin-like note lends itself to creamy, vanilla compositions.
Taste Description: sweet creamy
Used mostly in beverages, ice cream, candy and tobacco; also an enhancer for maple, almond, cognac, whiskey and coconut flavors.
 
Moellhausen
Gamma-HEXALACTONE
Odor Description: herbaceous, tobacco-like, creamy
Taste Description: sweet, creamy, vanilla-like with green lactonic powdery nuances
 
Alfrebro
gamma-Hexalactone, Natural
Odor Description: Herbal Coconut Sweet
 
 
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: masking agents
perfuming agents
Synonyms   Articles   Notes   Search   Top
Suppliers:
ACS International
Hexalactone gamma
Operational Capabilities
Advanced Biotech
GAMMA HEXALACTONE NATURAL
Alfrebro
gamma-Hexalactone, Natural
Odor: Herbal Coconut Sweet
Ambles Nature et Chimie
GAMMA HEXALACTONE NAT
Anhui Haibei
gamma-Hexalactone
Odor: caramel,nutty,malty,herb
Apple Flavor & Fragrance
gamma-Hexalactone
Artiste
gamma-Hexalactone
Augustus Oils
Gamma Hexalactone
Services
Aurochemicals
gamma-HEXALACTONE Natural
Axxence Aromatic
gamma-HEXALACTONE Natural
Kosher
Sustainability
Bedoukian Research
gamma-HEXALACTONE
≥98.0%, FCC, Kosher
Odor: An herbaceous, waxy, creamy note
Use: Smooth, coumarin-like note lends itself to creamy, vanilla compositions.
Flavor: sweet creamy
Used mostly in beverages, ice cream, candy and tobacco; also an enhancer for maple, almond, cognac, whiskey and coconut flavors.
Beijing Lys Chemicals
gamma-Hexalactone
Berjé
gamma-Hexalactone
Happening at Berje
BeYonde
Gamma-Hexalactone
BOC Sciences
For experimental / research use only.
gamma-HEXALACTONE FCC 98.0%
Citrus and Allied Essences
gamma-Hexalactone FCC
Market Report
DeLong Chemicals America
gamma-Hexalactone
Diffusions Aromatiques
gamma-HEXALACTONE NATURELLE
Diffusions Aromatiques
gamma-HEXALACTONE
EMD Millipore
For experimental / research use only.
gamma-Caprolactone
Ernesto Ventós
HEXALACTONE GAMMA
Excellentia International
gamma-Hexalactone Natural
Excellentia International
gamma-Hexalactone
Indenta Group
gamma-Hexalactone
Indukern F&F
GAMMA-HEXALACTONE
Odor: HERBAL, CREAMY, TOBACCO
Inoue Perfumery
gamma-HEXALACTONE
K.L. Koh Enterprise
GAMMA-HEXALACTONE
Kingchem Laboratories
GAMMA HEXALACTONE
Kun Shan P&A
gamma-Hexalactone
Kunshan Sainty
gamma-Hexalactone, Kosher
Lluch Essence
gamma-HEXALACTONE NATURAL
Lluch Essence
gamma-HEXALACTONE
Odor: CREAMY, HERBACEOUS, TOBACCO
M&U International
gamma-Hexalactone, Kosher
M&U International
NAT. gamma-HEXALACTONE
Mane
Gamma Hexalactone (S)
Odor: Sweet Creamy Vanilla
Moellhausen
Gamma-HEXALACTONE
Odor: herbaceous, tobacco-like, creamy
Flavor: sweet, creamy, vanilla-like with green lactonic powdery nuances
Odowell Co.,ltd
Gamma hexalactone
PURITY: 99%MIN.
Omega Ingredients
gamma Hexalactone Natural >97%
OQEMA
Hexalactone Gamma
Penta International
GAMMA-HEXALACTONE FCC
Penta International
GAMMA-HEXALACTONE NATURAL FCC GRADE
Penta International
GAMMA-HEXALACTONE NATURAL
Penta International
GAMMA-HEXALACTONE
Prodasynth
GAMMA HEXALACTONE
(> 98%)
Odor: SWEET, BALSAMIC
R C Treatt & Co Ltd
gamma-Hexalactone
Reincke & Fichtner
gamma-Hexalactone
Riverside Aromatics
gamma-HEXALACTONE
Robertet
gamma-Hexalactone nat.
Santa Cruz Biotechnology
For experimental / research use only.
gamma-Caprolactone 98%
Shanghai Vigen Fine Chemical
gamma-Hexalactone
Sigma-Aldrich
g-Hexalactone, ≥98%, FCC, FG
Odor: herbaceous; sweet
Certified Food Grade Products
Sigma-Aldrich
g-Hexalactone, natural, 97%, FG
Odor: herbaceous
Soda Aromatic
gamma-Hexalactone
Sunaux International
gamma-Hexalactone
TCI AMERICA
For experimental / research use only.
gamma-Hexalactone >98.0%(GC)
Tengzhou Xiang Yuan Aroma Chemicals
gamma-Hexalactone
The Good Scents Company
gamma-hexalactone
Odor: herbal coconut sweet coumarin tobacco
United International
Gamma Hexalactone
Vigon International
HEXALACTONE GAMMA NATURAL
Vigon International
Hexalactone Gamma
WholeChem
Gamma-hexalactone
Wujiang CIYUN Flavor & Fragrance
gamma-Hexalactone ≥ 99.0%,Natural
Wujiang CIYUN Flavor & Fragrance
gamma-Hexalactone ≥ 99.0%
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Eye irritation (Category 2A), H319
GHS Label elements, including precautionary statements
 
Pictogramexclamation-mark.jpg
 
Signal word Warning
Hazard statement(s)
H319 - Causes serious eye irritation
Precautionary statement(s)
P264 - Wash skin thouroughly after handling.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337 + P313 - IF eye irritation persists: Get medical advice/attention.
Human Experience:
12 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50  > 5000 mg/kg
(Moreno, 1977f)

oral-rat LD50  > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 17, Pg. 794, 1979.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 17, Pg. 794, 1979.

Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: flavor and fragrance agents
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for gamma-hexalactone usage levels up to:
  12.0000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 160.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -21.00000
beverages(nonalcoholic): -7.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 0.0700084.00000
fruit ices: -84.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -21.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of lactones used as flavor ingredients. View pdf
European Food Safety Athority(EFSA): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf
EPI System: View
EPA Substance Registry Services (TSCA): 695-06-7
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 12756
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
 5-ethyloxolan-2-one
Chemidplus: 0000695067
RTECS: LU4220000 for cas# 695-06-7
Synonyms   Articles   Notes   Search   Top
References:
Leffingwell: Chirality or Article
 5-ethyloxolan-2-one
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 695-06-7
Pubchem (cid): 12756
Pubchem (sid): 134976441
Flavornet: 695-06-7
Pherobase: View
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
CHEBI: View
CHEMBL: View
HMDB (The Human Metabolome Database): HMDB03843
FooDB: FDB008075
Export Tariff Code: 2932.20.5050
Typical G.C.
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
EFSA Update of results on the monitoring of furan levels in food: Read Report
EFSA Previous report: Results on the monitoring of furan levels in food: Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food: Read Report
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
For Odor
amber
amber
 ambrette seed absoluteFL/FR
 angelica root oilFL/FR
 cistus ladaniferus resinoidFL/FR
animal
 civet absoluteFL/FR
 costus valerolactoneFR
6-methyl quinolineFL/FR
anisic
para-anisaldehydeFL/FR
balsamic
 amyl phenyl acetateFL/FR
 amyris wood oilFL/FR
siam benzoin resinoidFL/FR
 benzyl cinnamateFL/FR
 benzyl salicylateFL/FR
isobutyl cinnamateFL/FR
 copaiba balsam oilFL/FR
 ethyl cinnamateFL/FR
 fir balsam absoluteFR
 methyl cinnamateFL/FR
 peru balsam oilFL/FR
 tolu balsamFL/FR
berry
 raspberry ketoneFL/FR
buttery
 acetoinFL/FR
 ethyl maltolFL/FR
 immortelle absoluteFL/FR
cereal
 bran absoluteFR
cheesy
2-heptanoneFL/FR
coconut
alpha-angelica lactoneFL/FR
 coconut decanone methylFR
 coconut naphthalenoneFL/FR
delta-decalactoneFL/FR
delta-2-dodecenolactoneFL/FR
gamma-heptalactoneFL/FR
delta-heptalactoneFL/FR
 hexahydrocoumarinCS
delta-nonalactoneFL/FR
gamma-nonalactone (aldehyde C-18 (so-called))FL/FR
delta-octalactoneFL/FR
gamma-octalactoneFL/FR
 propyl octanoateFL/FR
 tetrahydrojasmoneFR
delta-undecalactoneFL/FR
 wine lactoneFL/FR
coumarinic
 phthalideFL/FR
creamy
 creamy lactoneFL/FR
fatty
 lauric acidFL/FR
floral
 acetophenoneFL/FR
isoamyl salicylateFL/FR
 boronia butenalFR
isobutyl salicylateFL/FR
 cananga oilFL/FR
delta-damasconeFL/FR
 dihydrojasmoneFL/FR
 dihydrojasmone lactoneFL/FR
 floral pyranolFR
 heliotropinFL/FR
 heliotropyl acetoneFL/FR
 heliotropyl diethyl acetalFR
 hexenyl cyclopentanoneFR
alpha-hexyl cinnamaldehydeFL/FR
 hydroxycitronellalFL/FR
 ilex paraguariensis oleoresinFL/FR
 jasmin lactone (IFF)FL/FR
 lavender oilFL/FR
para-methyl acetophenoneFL/FR
 nerolidolFL/FR
 ocean propanalFL/FR
 orris rhizome absolute (iris pallida)FL/FR
 palmarosa oilFL/FR
2-pentyl cyclopentanoneFR
 phenethyl phenyl acetateFL/FR
 tobacco flower absoluteFR
fruity
alpha-amyl cinnamyl isovalerateFL/FR
 amyl heptanoateFL/FR
isoamyl octanoateFL/FR
 cyclohexanone diethyl acetalFL/FR
(E)-beta-damasconeFL/FR
(Z)-beta-damasconeFL/FR
beta-damasconeFL/FR
gamma-decalactoneFL/FR
 ethyl 3-hydroxyhexanoateFL/FR
4-hydroxybenzyl alcoholFL/FR
 methyl (Z)-5-octenoateFL/FR
isopropyl octanoateFL/FR
gamma-undecalactone (aldehyde C-14 (so-called))FL/FR
fungal
 methyl 2-furoateFL/FR
green
alpha-decalactoneFL/FR
 diphenyl methaneFL/FR
 galbanum oilFL/FR
 heptyl heptanoateFL/FR
3-phenyl propionaldehydeFL/FR
hay
 beeswax absoluteFL/FR
 hay absoluteFR
 tobacco leaf absoluteFL/FR
 woodruff absoluteFR
herbal
 apium graveolens seed oil indiaFL/FR
abrialis lavandin oilFL/FR
 linalyl acetateFL/FR
 matricaria chamomilla flower oilFL/FR
 methyl nicotinateFL/FR
 origanum oil greeceFL/FR
 saffron indenoneFL/FR
 safranalFL/FR
 theaspiraneFL/FR
gamma-valerolactoneFL/FR
 yerba mate absoluteFL/FR
honey
 phenyl acetic acidFL/FR
mossy
 oakmoss absoluteFL/FR
 treemoss absoluteFR
 veramoss (IFF)FR
musty
ketoisophoroneFL/FR
naphthyl
beta-naphthyl ethyl etherFL/FR
beta-naphthyl methyl etherFL/FR
nutty
 resorcinolFR
phenolic
2'-hydroxyacetophenoneFL/FR
popcorn
2-acetyl pyridineFL/FR
powdery
para-anisyl alcoholFL/FR
soapy
 ethyl undecanoateFL/FR
spicy
 benzyl isoeugenolFL/FR
 croton eluteria bark oilFL/FR
 cubeb oilFL/FR
N,N-diethyl octanamideFR
isoeugenyl acetateFL/FR
 ginger root oil chinaFL/FR
 levisticum officinale root oilFL/FR
 methyl heptadienoneFL/FR
 nutmeg oilFL/FR
thujonic
 armoise oilFR
tobacco
para-cresyl isovalerateFL/FR
3-ethyl pyridineFL/FR
 methyl benzoxoleFL/FR
 tobacco concreteFR
(E,E/E,Z)-tobacco cyclohexenoneFL/FR
2,6,6-trimethyl-2-hydroxycyclohexanoneFL/FR
 veltonal (Bedoukian)FR
tonka
6-amyl-alpha-pyroneFL/FR
 deertongue absoluteFR
(±)-dihydromint lactoneFL/FR
7-methyl coumarinCS
 mint lactoneFL/FR
 octahydrocoumarinFL/FR
 saffron resinoidFL/FR
 tonka bean absoluteFR
 tonka undecanoneFR
 whiskey lactoneFL/FR
tropical
delta-dodecalactoneFL/FR
 genet absoluteFL/FR
 glyceryl 5-hydroxydecanoateFL/FR
 glyceryl 5-hydroxydodecanoateFL/FR
vanilla
 ethyl vanillinFL/FR
 propenyl guaetholFL/FR
 vanilla bean absolute (vanilla planifolia)FL/FR
 vanillyl acetateFL/FR
waxy
1-dodecanolFL/FR
 methyl laurateFL/FR
 myristyl alcoholFL/FR
2-tridecanoneFL/FR
 undecanoic acidFL/FR
woody
 amber decatrieneFR
alpha-cedrene epoxideFR
 guaiacwood oilFL/FR
isolongifolene ketoneFR
 methyl cedryl ketoneFL/FR
 patchouli ethanoneFR
 patchouli oilFL/FR
 sandalwood oilFL/FR
 santallFR
 spruce needle oil canadaFL/FR
 tobacarol (IFF)FR
 tobacco noneneFR
 vetiver oil haitiFL/FR
 vetiverolFL/FR
 woody acetateFR
 woody cyclohexanoneFR
 woody dioxolaneFR
 woody etherFR
 woody propanolFR
 
For Flavor
 
No flavor group found for these
 amyl phenyl acetateFL/FR
 capsicum oleoresinFL
 cistus ladaniferus resinoidFL/FR
 coconut naphthalenoneFL/FR
 cyclohexanone diethyl acetalFL/FR
alpha-decalactoneFL/FR
 dimethyl benzofuranoneFL
delta-2-dodecenolactoneFL/FR
 fig leaf absoluteFL
 ilex paraguariensis oleoresinFL/FR
 jasmin lactone (IFF)FL/FR
 lauric acidFL/FR
 massoia bark oilFL
 methyl nicotinateFL/FR
 myristyl alcoholFL/FR
4-octen-3-oneFL
 propyl octanoateFL/FR
2-propyl pyridineFL
(R)-tonka furanoneFL
2,6,6-trimethyl-2-hydroxycyclohexanoneFL/FR
 wine lactoneFL/FR
beta-damasconeFL/FR
animal
 civet absoluteFL/FR
6-methyl quinolineFL/FR
balsamic
siam benzoin resinoidFL/FR
 benzyl salicylateFL/FR
isobutyl cinnamateFL/FR
 copaiba balsam oilFL/FR
 ethyl cinnamateFL/FR
 peru balsam oilFL/FR
 tolu balsamFL/FR
berry
 heliotropyl acetoneFL/FR
 raspberry ketoneFL/FR
brown
 beeswax absoluteFL/FR
buttery
 butter cream frosting flavorFL
caramellic
 caramel furanoneFL
 ethyl maltolFL/FR
3-ethyl pyridineFL/FR
 methyl 2-furoateFL/FR
cheesy
2-heptanoneFL/FR
cherry
 heliotropinFL/FR
citrus
ketoisophoroneFL/FR
coconut
delta-decalactoneFL/FR
(R)-massoia lactoneFL
6-methyl coumarinFL
gamma-nonalactone (aldehyde C-18 (so-called))FL/FR
 octahydrocoumarinFL/FR
delta-octalactoneFL/FR
cooling
isobutyl salicylateFL/FR
 theaspiraneFL/FR
corn
2-acetyl pyridineFL/FR
coumarinic
 phthalideFL/FR
creamy
 acetoinFL/FR
6-amyl-alpha-pyroneFL/FR
alpha-angelica lactoneFL/FR
para-anisaldehydeFL/FR
 creamy lactoneFL/FR
5,5-dibutyl dihydrofuran-2(3H)-oneFL
 dihydrocoumarinFL
delta-dodecalactoneFL/FR
 glyceryl 5-hydroxydecanoateFL/FR
 glyceryl 5-hydroxydodecanoateFL/FR
para-methyl acetophenoneFL/FR
 mint lactoneFL/FR
delta-nonalactoneFL/FR
delta-undecalactoneFL/FR
gamma-undecalactone (aldehyde C-14 (so-called))FL/FR
dairy
 methyl (Z)-5-octenoateFL/FR
fatty
2-tridecanoneFL/FR
floral
 cananga oilFL/FR
 dihydrojasmoneFL/FR
 linalyl acetateFL/FR
 ocean propanalFL/FR
 phenyl acetic acidFL/FR
fruity
alpha-amyl cinnamyl isovalerateFL/FR
 amyl heptanoateFL/FR
isoamyl octanoateFL/FR
para-anisyl alcoholFL/FR
(Z)-beta-damasconeFL/FR
(E)-beta-damasconeFL/FR
gamma-decalactoneFL/FR
 ethyl 3-hydroxyhexanoateFL/FR
4-hydroxybenzyl alcoholFL/FR
isopropyl octanoateFL/FR
grassy
 palmarosa oilFL/FR
 tobacco leaf absoluteFL/FR
green
isoamyl salicylateFL/FR
 angelica root oilFL/FR
 diphenyl methaneFL/FR
 galbanum oilFL/FR
 heptyl heptanoateFL/FR
 immortelle absoluteFL/FR
 methyl heptadienoneFL/FR
 nerolidolFL/FR
 oakmoss absoluteFL/FR
3-phenyl propionaldehydeFL/FR
hay
 genet absoluteFL/FR
herbal
 apium graveolens seed oil indiaFL/FR
abrialis lavandin oilFL/FR
 lavender oilFL/FR
 matricaria chamomilla flower oilFL/FR
 origanum oil greeceFL/FR
 saffron indenoneFL/FR
 yerba mate absoluteFL/FR
honey
 phenethyl phenyl acetateFL/FR
lactonic
(±)-dihydromint lactoneFL/FR
gamma-heptalactoneFL/FR
delta-heptalactoneFL/FR
gamma-octalactoneFL/FR
meaty
4-allyl-2,6-dimethoxyphenolFL
naphthyl
2'-hydroxyacetophenoneFL/FR
beta-naphthyl methyl etherFL/FR
nutty
 methyl benzoxoleFL/FR
(E,E/E,Z)-tobacco cyclohexenoneFL/FR
phenolic
para-cresyl isovalerateFL/FR
powdery
 acetophenoneFL/FR
beta-naphthyl ethyl etherFL/FR
soapy
1-dodecanolFL/FR
spicy
 benzyl cinnamateFL/FR
 benzyl isoeugenolFL/FR
 benzylidene acetoneFL
 croton eluteria bark oilFL/FR
 cubeb oilFL/FR
isoeugenyl acetateFL/FR
 ginger root oil chinaFL/FR
 levisticum officinale root oilFL/FR
 methyl cinnamateFL/FR
 nutmeg oilFL/FR
 paprika oleoresinFL
 root beer float flavorFL
sweet
 ethyl 3-(2-hydroxyphenyl) propionateFL
 orange vanilla cream flavorFL
 orris rhizome absolute (iris pallida)FL/FR
 saffron resinoidFL/FR
tonka
gamma-valerolactoneFL/FR
vanilla
 ethyl vanillinFL/FR
vanilla ice cream flavorFL
 propenyl guaetholFL/FR
 vanilla bean absolute (vanilla planifolia)FL/FR
 vanillyl acetateFL/FR
waxy
 dihydrojasmone lactoneFL/FR
 ethyl undecanoateFL/FR
alpha-hexyl cinnamaldehydeFL/FR
 hydroxycitronellalFL/FR
 methyl laurateFL/FR
 undecanoic acidFL/FR
woody
 ambrette seed absoluteFL/FR
 amyris wood oilFL/FR
delta-damasconeFL/FR
 guaiacwood oilFL/FR
 methyl cedryl ketoneFL/FR
 patchouli oilFL/FR
 safranalFL/FR
 sandalwood oilFL/FR
 spruce needle oil canadaFL/FR
 vetiver oil haitiFL/FR
 vetiverolFL/FR
 whiskey lactoneFL/FR
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 almond toasted almondFL
 apricotFR
 beef roasted beefFL
 bread white breadFL
 caramelFL
 chocolate cocoaFL
 cloudberry bakeappleFL
 coconutFR
 creamFR
 grapeFR
 hay new mown hayFR
 herbalFR
 mapleFR
 passion fruitFR
 peachFR
 pineappleFR
 plumFR
 raspberryFR
 strawberryFR
 tea green teaFR
 tobaccoFR
 tomatoFL
 tonka beanFR
 vanillaFR
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 apricot fruit
Search Trop  Picture
 bread
Search  PMC Picture
 cloudberry fruit
Search Trop  Picture
 cocoa
Search Trop  Picture
 filbert roasted filbert
Search Trop  Picture
 grape dried grape
Search  PMC Picture
 malpighia glabra l. fruit oil @ 0.60%
Data  GC  Search Trop  Picture
 milk
Search  PMC Picture
 passion fruit
Search Trop  Picture
 peach fruit
Search Trop  Picture
 pineapple fruit
Search Trop  Picture
 plum fruit
Search Trop  Picture
 raspberry red raspberry fruit
Search Trop  Picture
 strawberry wild strawberry fruit
Search Trop  Picture
 tea green tea with jasmin
PbMd  Search  Picture
 tomato
Search Trop  Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
g-caprolactone
gamma-caprolactone
 dehydrotonkalide
4-ethyl butan-4-olide
 ethyl butyrolactone
gamma-ethyl butyrolactone
5-ethyl dihydro-2(3H)-furanone
5-ethyl tetrahydro-2-furanone
4-ethyl-4-butanolide
4-ethyl-4-hydroxybutanoic acid lactone
5-ethyl-dihydro-furan-2-one
gamma-ethyl-gamma-butyrolactone
gamma-ethyl-N-butyrolactone
4-ethylbutan-4-olide
5-ethyldihydro-2(3H)-furanone
5-ethyloxolan-2-one
5-ethyltetrahydro-2-furanone
 furan-2(3H)-one, 5-ethyldihydro-
 furan-2(5H)-one, 3,4-dihydro-5-ethyl-
2(3H)-furanone, 5-ethyldihydro-
gamma-hexalactone
gamma hexalactone
gamma-hexalactone FCC
 hexalactone gamma
gamma-hexalactone natural
 hexan-4-olide
 hexano-1,4-lactone
gamma-hexanolactone
4-hexanolide
 hexanolide-1,4
4-hydroxyhexanoic acid gamma-lactone
4-hydroxyhexanoic acid lactone
 tonkalide
Synonyms   Articles   Notes   Search   Top
Synonyms   Articles   Notes   Search   Top
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