4-methoxysalicylaldehyde
2-hydroxy-4-methoxybenzaldehyde
 
Notes:
From African medicinal plants: Mondia whitei (Asclepiadaceae), Rhus vulagaris (Anacardiaceae), Sclerocarya caffra (Anacardiaceae). from african medicinal plants: mondia whitei (asclepiadaceae), rhus vulagaris (anacardiaceae), sclerocarya caffra (anacardiaceae).
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      Product(s):
      673-22-3 4-Methoxysalicylaldehyde >98%
       
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      Product(s):
      08-64822 2-HYDROXY-4-METHOXYBENZALDEHYDE
       
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      Product(s):
      H0699 2-Hydroxy-4-methoxybenzaldehyde >97.0%(T)
       
Synonyms   Articles   Notes   Search
CAS Number: 673-22-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 211-604-0
FDA UNII: 2N395P88LW
Nikkaji Web: J155.609F
Beilstein Number: 1072443
MDL: MFCD00003327
XlogP3: 1.50 (est)
Molecular Weight: 152.14936000
Formula: C8 H8 O3
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
FEMA Number: 4435 2-hydroxy-4-methoxybenzaldehyde
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):673-22-3 ; 2-HYDROXY-4-METHOXYBENZALDEHYDE
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Physical Properties:
Appearance: colorless to pale yellow clear solid (est)
Assay: 97.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 41.00 to  43.00 °C. @ 760.00 mm Hg
Boiling Point: 269.00 to  270.00 °C. @ 760.00 mm Hg
Boiling Point: 124.00 °C. @ 12.00 mm Hg
Vapor Pressure: 0.004000 mmHg @ 25.00 °C. (est)
Flash Point: 235.00 °F. TCC ( 112.78 °C. )
logP (o/w): 2.057 (est)
Soluble in:
 alcohol
 water, 4651 mg/L @ 25 °C (est)
Insoluble in:
 water
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Organoleptic Properties:
 
Odor Type: vanilla
 
Odor Strength: medium
 
 vanilla  
Odor Description:
at 100.00 %. 
vanillin like
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Axsyn
For experimental / research use only.
Benzaldehyde,2-hydroxy-4-methoxy-
BOC Sciences
For experimental / research use only.
4-Methoxysalicylaldehyde >98%
EMD Millipore
For experimental / research use only.
2-Hydroxy-4-methoxybenzaldehyde
Glentham Life Sciences
2-Hydroxy-4-methoxybenzaldehyde
Parchem
4-methoxysalicylaldehyde
Penta International
2-HYDROXY-4-METHOXYBENZALDEHYDE
Santa Cruz Biotechnology
For experimental / research use only.
4-Hydroxy-4-methoxybenzaldehyde
Sigma-Aldrich: Aldrich
For experimental / research use only.
2-Hydroxy-4-methoxybenzaldehyde 98%
TCI AMERICA
For experimental / research use only.
2-Hydroxy-4-methoxybenzaldehyde >97.0%(T)
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Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavoring agents
Recommendation for 4-methoxysalicylaldehyde usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 24
Click here to view publication 24
 average usual ppmaverage maximum ppm
baked goods: 10.00000100.00000
beverages(nonalcoholic): 5.0000050.00000
beverages(alcoholic): 20.0000050.00000
breakfast cereal: 10.00000100.00000
cheese: --
chewing gum: 20.00000100.00000
condiments / relishes: --
confectionery froastings: 10.0000050.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: 10.0000050.00000
fruit ices: --
gelatins / puddings: 10.0000050.00000
granulated sugar: --
gravies: --
hard candy: 20.00000100.00000
imitation dairy: --
instant coffee / tea: 10.0000025.00000
jams / jellies: --
meat products: --
milk products: 10.0000050.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: 100.000001000.00000
snack foods: --
soft candy: 10.0000050.00000
soups: --
sugar substitutes: --
sweet sauces: 10.0000050.00000
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Safety References:
EPI System: View
Cancer Citations: Search
EPA Substance Registry Services (TSCA): 673-22-3
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 69600
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 2-hydroxy-4-methoxybenzaldehyde
Chemidplus: 0000673223
RTECS: BZ2810000 for cas# 673-22-3
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References:
 2-hydroxy-4-methoxybenzaldehyde
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 69600
Pubchem (sid): 135028287
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
CHEBI: View
CHEMBL: View
HMDB (The Human Metabolome Database): Search
FooDB: FDB005824
Export Tariff Code: 2912.49.2600
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
For Odor
anisic
anisic
para-acetanisoleFL/FR
para-anisaldehydeFL/FR
ortho-anisaldehydeFL/FR
 methyl para-anisateFL/FR
balsamic
siam benzoin absoluteFL/FR
 benzoin absolute replacerFL/FR
sumatra benzoin gumFL/FR
sumatra benzoin resinFL/FR
siam benzoin resinFL/FR
sumatra benzoin resinoidFL/FR
siam benzoin resinoidFL/FR
1-benzoyl acetoneFL/FR
 peru balsam absoluteFL/FR
 peru balsam oilFL/FR
 peru balsam resinoidFL/FR
berry
 raspberry ketone methyl etherFL/FR
caramellic
 levulinic acidFL/FR
chocolate
 vanillyl ethyl etherFL/FR
coconut
alpha-angelica lactoneFL/FR
coumarinic
 coumaneFL/FR
creamy
 butyl lactateFL/FR
para-vanillic acidFL/FR
para-vanillyl alcoholFL/FR
 veratraldehydeFL/FR
floral
 acetophenoneFL/FR
para-cresyl laurateFL/FR
 heliotropinFL/FR
para-methyl acetophenoneFL/FR
fruity
para-anisyl propionateFL/FR
 ethyl methyl-para-tolyl glycidateFL/FR
 guaiacyl propionateFL/FR
 tolualdehydes (mixed o,m,p)FL/FR
musk
omega-pentadecalactoneFL/FR
naphthyl
2,4-dimethyl benzaldehydeFL/FR
nutty
 nutty cyclohexenoneFL/FR
2,3,5,6-tetramethyl pyrazineFL/FR
phenolic
ortho-guaiacolFL/FR
powdery
para-anisyl acetateFL/FR
smoky
alpha-ethoxy-ortho-cresolFL/FR
spicy
para-anisyl formateFL/FR
4-ethyl guaiacolFL/FR
3-(2-furyl) acroleinFL/FR
(E)-para-methoxycinnamaldehydeFL/FR
para-methoxycinnamaldehydeFL/FR
4-methyl guaiacolFL/FR
 spicy acetoacetateFL/FR
 zingeroneFL/FR
sweet
 vanilla bean absolute (vanilla spp.)FL/FR
 vanilla oleoresin baliFL/FR
 vanilla resinoidFL/FR
 vanilla tahitensis fruit extractFL/FR
tonka
 mint lactoneFL/FR
 octahydrocoumarinFL/FR
tropical
 curcuma amada roxb. rhizome oil CO2 extractFL/FR
vanilla
 acetovanilloneFL/FR
ortho-dimethyl hydroquinoneFL/FR
 ethyl vanillinFL/FR
 ethyl vanillin isobutyrateFL/FR
 ethyl vanillin propylene glycol acetalFL/FR
 heliotropyl alcoholFL/FR
 methyl vanillateFL/FR
 propenyl guaetholFL/FR
 vanilla aromatica fruit extractFL/FR
 vanilla bean absolute (vanilla planifolia)FL/FR
 vanilla bean absolute CO2 extract (vanilla planifolia)FL/FR
 vanilla bean oil (vanilla tahitensis)FL/FR
 vanilla bean oil CO2 extractFL/FR
 vanilla extractFL/FR
 vanilla oleoresin bourbonFL/FR
 vanilla planifolia fruit extractFL/FR
 vanilla planifolia fruit waterFL/FR
 vanillinFL/FR
 vanillin 2,3-butylene glycol acetalFL/FR
 vanillin propylene glycol acetalFL/FR
 vanillyl acetateFL/FR
 vanillyl isobutyrateFL/FR
 vanillylidene acetoneFL/FR
woody
4-hydroxybenzaldehydeFL/FR
 
For Flavor
 
No flavor group found for these
para-anisyl propionateFL/FR
1-benzoyl acetoneFL/FR
 coumaneFL/FR
ortho-dimethyl hydroquinoneFL/FR
alpha-ethoxy-ortho-cresolFL/FR
3-(2-furyl) acroleinFL/FR
 glucoethyl vanillinFL
 glucovanillinFL
 guaiacyl propionateFL/FR
 heliotropyl alcoholFL/FR
(E)-para-methoxycinnamaldehydeFL/FR
 methyl para-anisateFL/FR
 methyl vanillateFL/FR
 vanilmandelic acidFL
acidic
 levulinic acidFL/FR
anisic
para-acetanisoleFL/FR
ortho-anisaldehydeFL/FR
balsamic
 benzoin absolute replacerFL/FR
sumatra benzoin gumFL/FR
siam benzoin resinFL/FR
sumatra benzoin resinFL/FR
siam benzoin resinoidFL/FR
sumatra benzoin resinoidFL/FR
 peru balsamFL
 peru balsam absoluteFL/FR
 peru balsam oilFL/FR
 peru balsam resinoidFL/FR
 vanillylidene acetoneFL/FR
berry
 raspberry ketone methyl etherFL/FR
bready
2-propionyl thiazoleFL
cherry
 heliotropinFL/FR
para-methoxycinnamaldehydeFL/FR
coconut
6-methyl coumarinFL
 octahydrocoumarinFL/FR
creamy
alpha-angelica lactoneFL/FR
para-anisaldehydeFL/FR
 divanillinFL
4-hydroxybenzaldehydeFL/FR
para-methyl acetophenoneFL/FR
 mint lactoneFL/FR
para-vanillic acidFL/FR
para-vanillyl alcoholFL/FR
 veratraldehydeFL/FR
dairy
 butyl lactateFL/FR
fruity
para-anisyl acetateFL/FR
 ethyl methyl-para-tolyl glycidateFL/FR
 tolualdehydes (mixed o,m,p)FL/FR
meaty
4-allyl-2,6-dimethoxyphenolFL
naphthyl
2,4-dimethyl benzaldehydeFL/FR
nutty
 furfural acetoneFL
 nutty cyclohexenoneFL/FR
2,3,5,6-tetramethyl pyrazineFL/FR
powdery
 acetophenoneFL/FR
 powdery ketoneFL
rummy
 vanillyl ethyl etherFL/FR
spicy
para-anisyl formateFL/FR
siam benzoin absoluteFL/FR
 spicy acetoacetateFL/FR
 zingeroneFL/FR
sweet
 vanilla bean absolute (vanilla spp.)FL/FR
 vanilla oleoresin baliFL/FR
 vanilla resinoidFL/FR
 vanilla tahitensis fruit extractFL/FR
tropical
 curcuma amada roxb. rhizome oil CO2 extractFL/FR
vanilla
 acetovanilloneFL/FR
 ethyl vanillinFL/FR
 ethyl vanillin isobutyrateFL/FR
 ethyl vanillin propylene glycol acetalFL/FR
4-methyl guaiacolFL/FR
omega-pentadecalactoneFL/FR
 propenyl guaetholFL/FR
 vanilla aromatica fruit extractFL/FR
 vanilla bean absolute (vanilla planifolia)FL/FR
 vanilla bean absolute CO2 extract (vanilla planifolia)FL/FR
 vanilla bean oil (vanilla tahitensis)FL/FR
 vanilla bean oil CO2 extractFL/FR
 vanilla extractFL/FR
 vanilla oleoresin bourbonFL/FR
 vanilla planifolia fruit extractFL/FR
 vanilla planifolia fruit waterFL/FR
 vanillinFL/FR
 vanillin 2,3-butylene glycol acetalFL/FR
 vanillin propylene glycol acetalFL/FR
 vanillyl acetateFL/FR
 vanillyl isobutyrateFL/FR
waxy
para-cresyl laurateFL/FR
woody
4-ethyl guaiacolFL/FR
ortho-guaiacolFL/FR
 
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Potential Uses:
 antioxidants 
 heliotropeFR
 vanillaFL
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Occurrence (nature, food, other): note
 decalepis hamiltonii
Search Trop  Picture
 periploca sepium
Search Trop  Picture
 walnut black walnut oil
Search Trop  Picture
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Synonyms:
p-anisaldehyde, 2-hydroxy-
 benzaldehyde, 2-hydroxy-4-methoxy-
 benzaldehyde,2-hydroxy-4-methoxy-
2-formyl-5-methoxyphenol
2-hydroxy-4-methoxybenzaldehyde
4-hydroxy-4-methoxybenzaldehyde
2-hydroxy-p-anisaldehyde
o-hydroxy-p-methoxybenzaldehyde
2-hydroxy-para-anisaldehyde
ortho-hydroxy-para-methoxybenzaldehyde
 salicylaldehyde, 4-methoxy-
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Chemical composition of root aroma of Decalepis arayalpathra (J. Joseph and V. Chandras.) Venter, an endemic and endangered ethnomedicinal plant from Western Ghats, India.
PubMed: 7-Substituted-sulfocoumarins are isoform-selective, potent carbonic anhydrase II inhibitors.
PubMed: Flavoring extracts of Hemidesmus indicus roots and Vanilla planifolia pods exhibit in vitro acetylcholinesterase inhibitory activities.
PubMed: Shikimate pathway modulates the elicitor-stimulated accumulation of fragrant 2-hydroxy-4-methoxybenzaldehyde in Hemidesmus indicus roots.
PubMed: Essential oils composition of Periploca laevigata Aiton subsp. angustifolia (Labill.) Markgraf (Apocynaceae-Periplocoideae).
PubMed: Food protective effects of Periploca sepium oil and its active component against stored food mites.
PubMed: Modification of gold nanoparticle loaded on activated carbon with bis(4-methoxysalicylaldehyde)-1,2-phenylenediamine as new sorbent for enrichment of some metal ions.
PubMed: Spectral studies of copper(II) complexes of tridentate acylhydrazone ligands with heterocyclic compounds as coligands: X-ray crystal structure of one acylhydrazone copper(II) complex.
PubMed: Synthesis and characterization of Mo(VI) complexes derived from ONO donor acylhydrazones.
PubMed: Inhibition of Helicobacter pylori growth and its cytotoxicity by 2-hydroxy 4-methoxy benzaldehyde of Decalepis hamiltonii (Wight & Arn); a new functional attribute.
PubMed: Antimicrobial and antioxidant activities of the root bark essential oil of Periploca sepium and its main component 2-hydroxy-4-methoxybenzaldehyde.
PubMed: A manganese single-chain magnet exhibits a large magnetic coercivity.
PubMed: Two thiosemicarbazones derived from salicylaldehyde: very specific hydrogen-bonding interactions of the N-H...S=C type.
PubMed: Synthesis, spectral characterization and crystal structure of N-2-hydroxy-4-methoxybenzaldehyde-N'-4-nitrobenzoyl hydrazone and its square planar Cu(II) complex.
PubMed: Repellent from traditional Chinese medicine, Periploca sepium Bunge.
PubMed: Phenylalanine ammonia-lyase-mediated biosynthesis of 2-hydroxy-4-methoxybenzaldehyde in roots of Hemidesmus indicus.
PubMed: Antioxidant property of Decalepis hamiltonii Wight & Arn.
PubMed: Isolation of antioxidant compounds from the methanolic extract of the roots of Decalepis hamiltonii (Wight and Arn.).
PubMed: Production of 2-hydroxy-4-methoxybenzaldehyde in roots of tissue culture raised and acclimatized plants of Decalepis hamiltonii Wight & Arn., an endangered shrub endemic to Southern India and evaluation of its performance vis-a-vis plants from natural habitat.
PubMed: 2-hydroxy-4-isopropylbenzaldehyde, a potent partial tyrosinase inhibitor.
PubMed: Determination of 2-hydroxy-4-methoxybenzaldehyde in roots of Decalepis hamiltonii (Wight & Arn.) and Hemidesmus indicus R.Br.
PubMed: Essential oil constituents and in vitro antimicrobial activity of Decalepis hamiltonii roots against foodborne pathogens.
PubMed: 2-Hydroxy-4-methoxybenzaldehyde: a potent tyrosinase inhibitor from African medicinal plants.
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