Odor: characteristic

Use: Dehydrocostus lactone exhibited strong larvicidal activity against A. albopictus with LC50 values of 2.34 µg/ml Nitric oxide (NO) and tumor necrosis factor a (TNF-a) are the major mediators produced in activated macrophages which contribute to the circulatory failure associated with septic shock. A sesquiterpene lactone compound (dehydrocostus lactone) inhibited the production of NO in lipopolysaccharide (LPS)-activated RAW 264.7 cells by suppressing inducible nitric oxide synthase enzyme expression. This compound also decreased the TNF-a level in LPS-activated systems in vitro and in vivo. Thus, dehydrocostus lactone may be a possible candidate for the development of new drugs to treat endotoxemia accompanied by the overproduction of NO and TNF-aostus lactone. In radiorespirometric bioassays against Mycobacterium tuberculosis and Mycobacterium avium, dehydrocostus lactone exhibited minimum inhibitory concentrations of 2 and 16 µg/Ml.