3,5-cocoa pyrazine
2-ethyl-3,5-dimethylpyrazine
 
Notes:
Isol. from coffee aroma. Also present in raw asparagus, wheat bread, other breads, smoked fatty fish, roast chicken, roast beef, lamb and mutton liver, black tea, hydrolyzed soy protein and other foods. Organoleptic agent. Flavouring agent
  • Augustus Oils
    • Augustus Oils Ltd
      The Premier Supplier
      Augustus Oils Ltd, in harmony with nature - to present it at its best...
      A wealth of experience, expertise and knowledge has allowed Augustus to bridge the gulf in expectation and trust between growers and users of natural ingredients. The Company works in partnership with customers on the one hand, and growers, farmers and distillers on the other. Both users and producers can then focus on exactly what they do best, while skilled Augustus technicians closely monitor and control the delivered product. This ensures users can have the confidence that they will receive the best raw materials suited to their requirements.
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      Fax: +44 (0)1420 592420
      Services
      Product(s):
      2 Ethyl 3,5-6 Dimethyl Pyrazine
       
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
      Email: Mr. Jia
      Email: Mr. Guo
      Voice: 86-10-68418738
      Fax: 86-10-68418739
      Mr. Guo86-10-68483445
      Mr. Guo86-10-68418739
      News
      Product(s):
      10078 2-Ethyl-3(5or6)-dimethyl pyrazine
       
  • BOC Sciences
    • BOC Sciences
      Best of Chemicals Supplier
      Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
      BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services.
      BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
      Email: Marketing
      US Email: Marketing
      Email: Sales
      US Email: Sales
      Voice: 1-631-504-6093
      Fax: 1-631-614-7828
      US Voice: 1-631-504-6093
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      Product(s):
      13925-07-0 2-Ethyl-3,5-dimethylpyrazine
       
  • Excellentia International
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers.
      Email: Sales
      US Email: Sales
      Voice: +86-21-32515501 60762991 60762992
      Fax: +86-21-32515502 64204960
      US Voice: 908-359-9000
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      News
      Product(s):
      H0209 3,5 Cocoa Pyrazine
       
Synonyms   Articles   Notes   Search
    Flavor Demo Formulas
CAS Number: 13925-07-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 237-694-1
FDA UNII: R182EY5L8C
Nikkaji Web: J113.400K
Beilstein Number: 0636984
CoE Number: 727
XlogP3: 1.50 (est)
Molecular Weight: 136.19764000
Formula: C8 H12 N2
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
JECFA Food Flavoring: 776  2-ethyl-3,5-dimethylpyrazine
DG SANTE Food Flavourings: 14.024  2-ethyl-3,5-dimethylpyrazine
FEMA Number: 3150 2-ethyl-3,5-dimethylpyrazine
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):13925-07-0 ; 3-ETHYL-2,6-DIMETHYLPYRAZINE
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00 % sum of isomers
Food Chemicals Codex Listed: No
Boiling Point: 180.00 to  182.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.814000 mmHg @ 25.00 °C. (est)
Flash Point: 156.00 °F. TCC ( 68.89 °C. )
logP (o/w): 1.457 (est)
Soluble in:
 alcohol
 water
 water, 1473 mg/L @ 25 °C (est)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
 
Odor Type: nutty
 
Odor Strength: high ,
recommend smelling in a 0.10 % solution or less
 
 burnt  almond  roasted  nutty  coffee  
Odor Description:
at 0.10 % in dipropylene glycol. 
burnt almonds roasted nuts coffee
 
 peanut  nutty  caramellic  coffee  musty  cocoa  roasted  
Odor Description:
Peanut, nutty, caramel, coffee, musty, cocoa, pyrazine and roasted
Mosciano, Gerard P&F 22, No. 5, 67, (1997)
 
 
Flavor Type: nutty
 
 sweet  nutty  caramellic  coffee  corn  cocoa  potato  
Taste Description:
at 2.00 ppm.  
Sweet, nutty, caramellic, coffee, corn, cocoa and potato
Mosciano, Gerard P&F 22, No. 5, 67, (1997)
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
Synonyms   Articles   Notes   Search   Top
Suppliers:
Anhui Haibei
2-Ethyl-3(5/6)-dimethyl pyrazine
Odor: Pungent Nutty Roasted
Augustus Oils
2 Ethyl 3,5-6 Dimethyl Pyrazine
Services
Beijing Lys Chemicals
2-Ethyl-3(5or6)-dimethyl pyrazine
BOC Sciences
For experimental / research use only.
2-Ethyl-3,5-dimethylpyrazine
Excellentia International
2-Ethyl-3,6-Dimethyl Pyrazine (Pyrazine Mix. # 10, 14, 24) Natural
Jinan Enlighten Chemical Technology(Wutong Aroma )
2-Ethyl-3,(5or6)-dimethyl pyrazine, Kosherk
M&U International
3,5 Cocoa Pyrazine
Moellhausen
3,5 COCOA PIRAZINA
Parchem
3,5-cocoa pyrazine
Penta International
2-ETHYL-3,5,6-DIMETHYLPYRAZINE NATURAL
Penta International
3-ETHYL-2,6-DIMETHYL PYRAZINE NATURAL
Penta International
3-ETHYL-2,6-DIMETHYL PYRAZINE
Robinson Brothers
2-Ethyl-3,5(6)-dimethylpyrazine F&F
https://www.robinsonbrothers.uk/chemistry-competences
Santa Cruz Biotechnology
For experimental / research use only.
3,5-Dimethyl-2-ethylpyrazine
Tianjin Danjun International
2-Ethyl-3(5or6)-dimethyl pyrazine
WholeChem
2-Ethyl-3(5or6)-dimethyl pyrazine
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
gavage-rat LD50  [sex: M,F] 504 mg/kg
(Posternak et al., 1975)

oral-rat LD50  456 mg/kg
Drug and Chemical Toxicology. Vol. 3, Pg. 249, 1980.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: flavor and fragrance agents
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for 3,5-cocoa pyrazine usage levels up to:
  0.1000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 1.20 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.30 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 4
Click here to view publication 4
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): -5.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -5.00000
fruit ices: -5.00000
gelatins / puddings: -5.00000
granulated sugar: --
gravies: --
hard candy: -5.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. View pdf
European Food Safety Athority(EFSA): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf
Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species
View page or View pdf
EPI System: View
EPA Substance Registry Services (TSCA): 13925-07-0
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 26334
National Institute of Allergy and Infectious Diseases: Data
 2-ethyl-3,5-dimethylpyrazine
Chemidplus: 0013925070
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References:
 2-ethyl-3,5-dimethylpyrazine
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 13925-07-0
Pubchem (cid): 26334
Pubchem (sid): 134990417
Flavornet: 13925-07-0
Pherobase: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
CHEMBL: View
HMDB (The Human Metabolome Database): HMDB40299
FooDB: FDB020021
YMDB (Yeast Metabolome Database): YMDB01441
Typical G.C.
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
For Odor
alliaceous
alliaceous
 methyl furfuryl disulfideFL/FR
balsamic
2-acetyl furanFL/FR
bready
 furfuralFL/FR
buttery
3,4-hexane dioneFL/FR
 coffee dioneFL/FR
 cycloteneFL/FR
 fenugreek absoluteFL/FR
 malt fragranceFR
 rosefuranFL/FR
2,6-dimethyl pyrazineFL/FR
2,5-dimethyl pyrazineFL/FR
2-methoxy-3-methyl pyrazineFL/FR
2,4,5-trimethyl thiazoleFL/FR
coumarinic
 tonka bean resinoidFR
 tonka bean resinoid replacerFR
creamy
gamma-butyrolactoneFL/FR
fruity
 tetrahydrofurfuryl acetateFL/FR
herbal
 butyl levulinateFL/FR
musty
 hazelnut pyrazineFL/FR
2-methyl pyrazineFL/FR
 nutty cyclohexenoneFL/FR
2,3,5-trimethyl pyrazineFL/FR
phenolic
4-methyl-2,6-dimethoxyphenolFL/FR
popcorn
2-acetyl pyrazineFL/FR
2-acetyl thiazoleFL/FR
 furfuryl thioacetateFL/FR
S-furfuryl thioformateFL/FR
tonka
 tonka bean absoluteFR
waxy
 butyl laurateFL/FR
 
For Flavor
 
No flavor group found for these
2-acetyl-3,4,5,6-tetrahydropyridineFL
 benzyl disulfideFL
2(4)-isobutyl-4(2),6-dimethyl dihydro-4H-1,3,5-dithiazineFL
 furfuryl acetoneFL
 peanut dithiazineFL
 rosefuranFL/FR
brown
 furfuralFL/FR
 tetrahydrofurfuryl acetateFL/FR
buttery
3,4-hexane dioneFL/FR
caramellic
 butterscotch praline flavorFL
 caramel furanoneFL
 caramel nut cream flavorFL
 caramel nut fudge flavorFL
 cycloteneFL/FR
 fenugreek absoluteFL/FR
 fenugreek distillatesFL
 maple nut flavorFL
chocolate
 chocolate caramel nut flavorFL
cocoa
 butyraldehydeFL
2-methyl furanFL
coffee
 coffee dioneFL/FR
 coffee enhancersFL
 methyl furfuryl disulfideFL/FR
2-isopropyl pyrazineFL
2-thiophene thiolFL
corn chip
2-acetyl thiazoleFL/FR
dairy
 creme brulle coffee flavorFL
herbal
 butyl levulinateFL/FR
5-hydroxymethyl furfuralFL
malty
 malt flavorFL
milky
gamma-butyrolactoneFL/FR
mustard
 furfuryl methyl etherFL
musty
2,5-dimethyl pyrazineFL/FR
 hazelnut pyrazineFL/FR
2,3,5-trimethyl pyrazineFL/FR
nutty
2-acetyl furanFL/FR
3,5(6)-cocoa pyrazineFL
2,6-dimethyl pyrazineFL/FR
2-methoxy-3-methyl pyrazineFL/FR
2-methyl pyrazineFL/FR
 nutty cyclohexenoneFL/FR
 peanut brittle flavorFL
 peanut oxazoleFL
2,4,5-trimethyl thiazoleFL/FR
phenolic
4-methyl-2,6-dimethoxyphenolFL/FR
roasted
2-acetyl pyrazineFL/FR
 furfuryl thioacetateFL/FR
sulfurous
 butyl mercaptanFL
S-ethyl thioacetateFL
S-furfuryl thioformateFL/FR
2-thienyl mercaptanFL
waxy
 butyl laurateFL/FR
 
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Potential Uses:
 almondFR
 breadFL
 burntFL
 chicory rootFL
 chocolate cocoaFL
 coffeeFR
 meatFL
 nutFL
 peanutFR
 potatoFL
 saffronFR
 tobaccoFR
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 barley roasted barley
Search Trop  Picture
 chicory root
Search Trop  Picture
 coffee
Search  PMC Picture
 lavender oil spike spain @ 0.019%
Data  GC  Search Trop  Picture
 peanut roasted peanut
Search Trop  Picture
 potato
Search Trop  Picture
 rice cakes
PbMd  Search  PMC Picture
 rum
Search  PMC Picture
 tea leaf
Search Trop  Picture
 whiskey
Search  Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
3,5-cocoa pyrazine
3,5-dimethyl-2-ethylpyrazine
2,6-dimethyl-3-ethyl pyrazine
2,6-dimethyl-3-ethylpyrazine
3-ethyl-2,6-dimethyl pyrazine
3-ethyl-2,6-dimethylpyrazine
2-ethyl-3,5-dimethyl pyrazine
2-ethyl-3,5-dimethyl-pyrazine
2-ethyl-3,5-dimethylpyrazine
 pyrazine, 2-ethyl-3,5-dimethyl-
 pyrazine, 2,6-dimethyl-3-ethyl-
 pyrazine, 3,5-dimethyl-2-ethyl-
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