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Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
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| EU Patents: | Search |
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| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 952 5,6,7,8-tetrahydroquinoxaline |
| DG SANTE Food Flavourings: | 14.015 5,6,7,8-tetrahydroquinoxaline |
| FEMA Number: | 3321 5,6,7,8-tetrahydroquinoxaline |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 34413-35-9 ; 5,6,7,8-TETRAHYDROQUINOXALINE |
Physical Properties:
| Appearance: | colorless to amber clear solid (est) |
| Assay: | 98.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.07700 to 1.08700 @ 25.00 °C.
|
| Pounds per Gallon - (est).: | 8.962 to 9.045
|
| Refractive Index: | 1.53800 to 1.54800 @ 20.00 °C.
|
| Melting Point: | 29.00 to 30.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 108.00 to 111.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 85.00 °C. @ 3.00 mm Hg
|
| Vapor Pressure: | 0.055000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 4.6 ( Air = 1 ) |
| Flash Point: | 195.00 °F. TCC ( 90.56 °C. )
|
| logP (o/w): | 1.158 (est) |
| Shelf Life: | 12.00 month(s) or longer if stored properly. |
| Storage: | refrigerate in tightly sealed containers. |
| Soluble in: |
| | alcohol | | | water, slightly | | | water, 2091 mg/L @ 25 °C (est) |
Organoleptic Properties:
| |
| Odor Type: nutty |
| |
| | musty nutty roasted beany cereal corn chip cheesy |
Odor Description: at 0.10 % in dipropylene glycol. | musty nut roasted bean cereal corn chip cheese |
| |
| | musty nutty roasted beany cereal |
Odor Description:
| Musty, nutty, roasted, beany, cereal cracker-like, with corn nuances Mosciano, Gerard P&F 19, No. 2, 55, (1994) |
| |
| |
| Flavor Type: nutty |
| |
| | nutty musty corn taco popcorn |
Taste Description: at 10.00 ppm. | Nutty, musty, corn taco and popcorn-like Mosciano, Gerard P&F 19, No. 2, 55, (1994) |
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| R C Treatt & Co Ltd |
| 5,6,7,8-Tetrahydroquinoxaline Halal, Kosher |
| Odor Description: | Fatty/cheesy |
| Taste Description: | nutty, roasted, cereal |
| |
| OQEMA |
| 5,6,7,8-Tetrahydro Quinoxaline |
| Odor Description: | Fatty/cheesy |
| Taste Description: | nutty, roasted, cereal |
| |
| |
Cosmetic Information:
Suppliers:
| Advanced Biotech |
| 5,6,7,8 TETRAHYDROQUINOXALINE
|
| Ambles Nature et Chimie |
| 5.6.7.8-TETRAHYDROQUINOXALINE
|
| Anhui Haibei |
| 5,6,7,8-Tetrahydroquinoxaline
Odor: Musty nut roasted bean cereal cracker corn cheese |
| Anhui Suzhou Jinli Aromatic Chemicals |
| 5,6,7,8-Tetrahydro quinoxaline
Odor: baked hazel nut, baked peanut |
| Beijing Lys Chemicals |
| 5,6,7,8-Tetrahydroquinoxaline
|
| BOC Sciences |
| For experimental / research use only. |
| 5.6.7.8-Tetrahydroquinoxaline
|
| Charkit Chemical |
| TETRAHYDROQUINOXALINE,5,6,7,8- FEMA 3321
|
| De Monchy Aromatics |
| 5,6,7,8-Tetrahydroquinoxaline
|
| DeLong Chemicals America |
| 5,6,7,8-Tetrahydroquinoxaline, Kosher
|
| Endeavour Specialty Chemicals |
| 5,6,7,8-Tetrahydroquinoxaline
|
| Speciality Chemical Product Groups |
| FCI SAS |
| TETRAHYDROQUINOXALINE
Odor: Roasted peanut |
| Fleurchem |
| 5,6,7,8-tetrahydroquinoxaline
|
| Frutarom |
| 5-6-7-8-TETRAHYDROQUINOXALINE
KOSHER Flavor: Bean, Musty, Nutty, Roasted |
| CBD Offering |
| IFF |
| 5-6-7-8-TETRAHYDROQUINOXALINE
KOSHER Flavor: Bean, Musty, Nutty, Roasted |
| Indukern F&F |
| TETRAHYDROQUINOXALINE
Odor: CHEESE, NUTTY, CEREAL |
| Jiangyin Healthway |
| 5,6,7,8-Tetrahydroquinoxaline
|
| New functional food ingredients |
| Jinan Enlighten Chemical Technology(Wutong Aroma ) |
| 5,6,7,8-Tetrahydro quinoxaline, Kosherk
|
| Lluch Essence |
| 5,6,7,8-TETRAHYDROQUINOXALINE
|
| M&U International |
| 5,6,7,8-TETRAHYDROQUINOXALINE, Kosher
|
| OQEMA |
| 5,6,7,8-Tetrahydro Quinoxaline
|
| Penta International |
| 5,6,7,8-TETRAHYDROQUINOXALINE
|
| R C Treatt & Co Ltd |
| 5,6,7,8-Tetrahydroquinoxaline
Halal, Kosher Odor: Fatty/cheesy Flavor: nutty, roasted, cereal |
| Robinson Brothers |
| 5,6,7,8-Tetrahydroquinoxaline F&F
|
| https://www.robinsonbrothers.uk/chemistry-competences |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 5,6,7,8-Tetrahydroquinoxaline
|
| Sigma-Aldrich |
| 5,6,7,8-Tetrahydroquinoxaline, ≥97%, FG
Odor: cheese |
| Certified Food Grade Products |
| Sunaux International |
| 5,6,7,8-Tetrahydroquinoxaline
|
| Synerzine |
| 5,6,7,8-Tetrahydroquinoxaline
also named Cyclohexapyrazine |
| Taytonn ASCC |
| 5,6,7,8-Tetrahydroquinoxaline
Odor: Bean, Musty, Nutty, Roast |
| TCI AMERICA |
| For experimental / research use only. |
| 5,6,7,8-Tetrahydroquinoxaline >98.0%(GC)(T)
|
| Tengzhou Jitian Aroma Chemiclal |
| 5,6,7,8-Tetrahydroquinoxaline
|
| Tengzhou Xiang Yuan Aroma Chemicals |
| 5.6.7.8-Tetrohydro quinoxaline
|
| Tianjin Danjun International |
| 5,6,7,8-Tetrahydroquinoxaline
|
| United International |
| 5,6,7,8-Tetrahydroquinoxaline
|
| Vigon International |
| Tetrahydroquinoxaline-5,6,7,8
|
| WholeChem |
| 5.6.7.8-Tetrahydroquinoxaline
|
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xi - Irritant |
R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection.
|
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| Recommendation for nutty quinoxaline usage levels up to: | | | 0.1000 % in the fragrance concentrate.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 8.00 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | ND (μg/capita/day) |
| Structure Class: | III |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 5 |
| Click here to view publication 5 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 5.00000 |
| beverages(nonalcoholic): | - | 5.00000 |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | 2.00000 |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | 2.00000 |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | - |
| fruit ices: | - | - |
| gelatins / puddings: | - | 2.00000 |
| granulated sugar: | - | - |
| gravies: | - | 2.00000 |
| hard candy: | - | 5.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | 2.00000 |
| milk products: | - | 1.00000 |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | 2.00000 |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
| Flavor & Extract Manufacturers Association (FEMA) reference(s): |
| The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. View pdf |
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1] View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010) View page or View pdf |
Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species View page or View pdf |
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 34413-35-9 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 36822 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | 5,6,7,8-tetrahydroquinoxaline |
| Chemidplus: | 0034413359 |
References:
Other Information:
Potential Blenders and core components note
| |
| For Odor |
| No odor group found for these |
| | sulfuryl octanoate | FL/FR |
|
| | sulfuryl butyrate | FL/FR |
| | sulfuryl decanoate | FL/FR |
| | sulfuryl hexanoate | FL/FR |
| | sulfuryl isobutyrate | FL/FR |
| | sulfuryl propionate | FL/FR |
| anisic |
| para- | anisaldehyde | FL/FR |
| balsamic |
| 2- | acetyl furan | FL/FR |
| iso | butyl cinnamate | FL/FR |
| | ethyl cinnamate | FL/FR |
| | methyl cinnamate | FL/FR |
| 3- | phenyl propyl alcohol | FL/FR |
| bready |
| | coffee furanone | FL/FR |
| | cyclotene | FL/FR |
| | immortelle absolute | FL/FR |
| | maltol | FL/FR |
| iso | propenyl pyrazine | FL/FR |
| | strawberry furanone | FL/FR |
| cereal |
| | bran absolute | FR |
| chocolate |
| iso | amyl phenyl acetate | FL/FR |
| 2,5- | dimethyl pyrazine | FL/FR |
| coconut |
| gamma- | nonalactone (aldehyde C-18 (so-called)) | FL/FR |
| gamma- | octalactone | FL/FR |
| coffee |
| | cichorium intybus root solid extract | FL/FR |
| | popcorn pyrimidine | FL/FR |
| earthy |
| | nutty pyrazine | FL/FR |
| floral |
| | bois de rose oil brazil | FL/FR |
| | ethyl phenyl acetate | FL/FR |
| green |
| 2- | heptyl furan | FL/FR |
| hay |
| | beeswax absolute | FL/FR |
| honey |
| | phenyl acetic acid | FL/FR |
| medicinal |
| | quinoline | CS |
| musty |
| 2- | acetyl pyrrole | FL/FR |
| 3- | acetyl-2,5-dimethyl furan | FL/FR |
| | hazelnut pyrazine | FL/FR |
| | menthofuran | FL/FR |
| 2- | acetyl-3-ethyl pyrazine | FL/FR |
| 2- | acetyl-3-methyl pyrazine | FL/FR |
| 2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
| 2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
| 5- | acetyl-4-methyl thiazole | |
| 2- | acetyl-5-methyl furan | FL/FR |
| roasted | chestnut fragrance | FR |
| 3,6- | cocoa pyrazine | FL/FR |
| 4,5- | dimethyl-2-ethyl-3-thiazoline | FL/FR |
| 2,4- | dimethyl-5-ethyl thiazole | |
| 2- | ethyl pyrazine | FL/FR |
| | filbert heptenone | FL/FR |
| | filbert heptenone B | FL/FR |
| | filbert pyrazine | FL/FR |
| 2,6- | lutidine | FL/FR |
| | methoxymethyl pyrazine | FL/FR |
| 5- | methyl quinoxaline | FL/FR |
| | nutty cyclohexenone | FL/FR |
| | sesame absolute | FL/FR |
| 2,3,5,6- | tetramethyl pyrazine | FL/FR |
| 2,3,5- | trimethyl pyrazine | FL/FR |
| | vinyl sulfurol | FL/FR |
| popcorn |
| 2- | acetyl pyrazine | FL/FR |
| 2- | acetyl thiazole | FL/FR |
| powdery |
| para- | anisyl alcohol | FL/FR |
| roasted |
| 2- | acetyl-2-pyrroline | |
| spicy |
| | cassia bark oil china | FL/FR |
| | clove bud oil | FL/FR |
| alpha- | methyl cinnamaldehyde | FL/FR |
| sulfurous |
| | dimethyl sulfide | FL/FR |
| | furfuryl thioacetate | FL/FR |
| tonka |
| | tonka bean absolute | FR |
| vanilla |
| | ethyl vanillin | FL/FR |
| | vanilla bean absolute (vanilla planifolia) | FL/FR |
| | vanillyl acetate | FL/FR |
| woody |
| 4- | hydroxybenzaldehyde | FL/FR |
| |
| For Flavor |
| |
| No flavor group found for these |
| | acetyl acetaldehyde dimethyl acetal | FL |
| 2- | acetyl-2-pyrroline | |
| 5- | acetyl-4-methyl thiazole | |
| (E)- | aconitic acid | FL |
| | cyclohexyl methyl pyrazine | FL |
| 2,5- | diethyl thiazole | FL |
| 6,7- | dihydro-2,3-dimethyl-5H-cyclopentapyrazine | FL |
| | dimethyl dihydrocyclopentapyrazine | FL |
| 6,7- | dimethyl dihydrocyclopentapyrazine | FL |
| 2,5- | dimethyl pyrazine and 2,6-dimethyl pyrazine mixture | FL |
| 2,5- | dimethyl thiazole | FL |
| 2,4- | dimethyl-5-ethyl thiazole | |
| | methyl 2-(methyl thio) acetate | FL |
| | pyrazines mixture | FL |
| | sulfuryl butyrate | FL/FR |
| | sulfuryl decanoate | FL/FR |
| | sulfuryl hexanoate | FL/FR |
| | sulfuryl isobutyrate | FL/FR |
|
| 5- | acetyl-2,3-dihydro-1,4-thiazine | FL |
| | sulfuryl formate | FL |
| | sulfuryl octanoate | FL/FR |
| | sulfuryl propionate | FL/FR |
| ammoniacal |
| 2- | methyl piperidine | FL |
| balsamic |
| iso | butyl cinnamate | FL/FR |
| | ethyl cinnamate | FL/FR |
| bready |
| 2- | propionyl thiazole | FL |
| brown |
| | beeswax absolute | FL/FR |
| burnt |
| iso | propenyl pyrazine | FL/FR |
| buttery |
| | diacetyl | FL |
| caramellic |
| | caramel furanone | FL |
| | cyclotene | FL/FR |
| | maltol | FL/FR |
| | strawberry furanone | FL/FR |
| coconut |
| gamma- | nonalactone (aldehyde C-18 (so-called)) | FL/FR |
| coffee |
| | cichorium intybus root solid extract | FL/FR |
| corn chip |
| 2- | acetyl thiazole | FL/FR |
| 2- | acetyl-2-thiazoline | FL |
| | popcorn pyrimidine | FL/FR |
| creamy |
| para- | anisaldehyde | FL/FR |
| 4- | hydroxybenzaldehyde | FL/FR |
| fatty |
| 2- | heptyl furan | FL/FR |
| fishy |
| 4,5- | dimethyl thiazole | FL |
| floral |
| iso | amyl phenyl acetate | FL/FR |
| | bois de rose oil brazil | FL/FR |
| | phenyl acetic acid | FL/FR |
| fruity |
| para- | anisyl alcohol | FL/FR |
| 2- | ethyl-2,5-dihydro-4-methyl thiazole | FL |
| green |
| | immortelle absolute | FL/FR |
| honey |
| | ethyl phenyl acetate | FL/FR |
| lactonic |
| gamma- | octalactone | FL/FR |
| malty |
| | yeast thiazoline | FL |
| musty |
| 2,5- | dimethyl pyrazine | FL/FR |
| 2- | ethoxythiazole | FL |
| | hazelnut pyrazine | FL/FR |
| | menthofuran | FL/FR |
| 2,3,5- | trimethyl pyrazine | FL/FR |
| nutty |
| 2- | acetyl furan | FL/FR |
| 2- | acetyl pyrrole | FL/FR |
| 3- | acetyl-2,5-dimethyl furan | FL/FR |
| 3- | acetyl-2,5-dimethyl thiophene | FL |
| 2- | acetyl-3-ethyl pyrazine | FL/FR |
| 2- | acetyl-3-methyl pyrazine | FL/FR |
| 2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
| 2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
| 2- | acetyl-5-methyl furan | FL/FR |
| | arachis hypogaea fruit extract | FL |
| 3,6- | cocoa pyrazine | FL/FR |
| | coffee furanone | FL/FR |
| 4,5- | dimethyl-2-ethyl-3-thiazoline | FL/FR |
| 2- | ethyl pyrazine | FL/FR |
| 1- | ethyl-2-acetyl pyrrole | FL |
| | filbert heptenone | FL/FR |
| | filbert heptenone B | FL/FR |
| | filbert pyrazine | FL/FR |
| 2,6- | lutidine | FL/FR |
| | methoxymethyl pyrazine | FL/FR |
| 5- | methyl quinoxaline | FL/FR |
| | nutty cyclohexenone | FL/FR |
| | nutty pyrazine | FL/FR |
| | nutty thiazole | FL |
| | peanut oxazole | FL |
| | sesame absolute | FL/FR |
| 2,3,5,6- | tetramethyl pyrazine | FL/FR |
| | vinyl sulfurol | FL/FR |
| popcorn |
| 2- | propionyl-2-thiazoline | FL |
| roasted |
| 2- | acetyl pyrazine | FL/FR |
| 3,5- | diisobutyl-1,2,4-trithiolane | FL |
| | furfuryl thioacetate | FL/FR |
| spicy |
| | cassia bark oil china | FL/FR |
| | clove bud oil | FL/FR |
| alpha- | methyl cinnamaldehyde | FL/FR |
| | methyl cinnamate | FL/FR |
| 3- | phenyl propyl alcohol | FL/FR |
| sulfurous |
| | dimethyl sulfide | FL/FR |
| vanilla |
| | ethyl vanillin | FL/FR |
| | vanilla bean absolute (vanilla planifolia) | FL/FR |
| | vanillyl acetate | FL/FR |
| |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | cyclohexapyrazine | | | quinoxaline, 5,6,7,8-tetrahydro- | | 5,6,7,8- | tetrahydro quinoxaline | | | tetrahydro terrazine-014 (IFF) | | | tetrahydroquinoxaline | | 5,6,7,8- | tetrahydroquinoxaline | | 5,6,7,8- | tetrahydroquinoxaline natural | | 5,6,7,8- | tetrahydroquinoxaline natural 1% in ethyl alcohol | | 5,6,7,8- | tetrahydroquinoxaline natural 5% in ethyl alcohol | | | tetrahydroterrazine (IFF) |
Articles:
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