Articles:
| J-Stage: | Cellulase Applied to the Leaves of Sweet Pepper (Capsicum annuum L. var. grossum) Upregulates the Production of Salicylic and Azelaic Acids |
4-hydroxybenzoic acid
Notes:
Isol. from many plants, free and combined. Alkyl esters of 4-hydroxybenzoic acid (see below) are used as food and cosmetic preservatives, mainly in their Na salt form, which makes them more water soluble. They are active at low concentrations and more pH-independent than the commonly used Benzoic acid DVN38-Z and 2,4-Hexadienoic acid GMZ10-P . The taste is more detectable than for those preservatives. Effectiveness increases with chain length of the alcohol, but for some microorganisms this reduces cell permeability and thus counteracts the increased efficiency
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Beijing Lys Chemicals Co, LTD. From Grams to Tons Fine chemical high-tech company which contains R&D, production, and sales. BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services. Email: Mr. Jia Email: Mr. Guo Voice: 86-10-68418738 Fax: 86-10-68418739 Mr. Guo 86-10-68483445 Mr. Guo 86-10-68418739 News Product(s): 10792 4-Hydroxybenzoic acid
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 99-96-7 4-Hydroxybenzoic acid 98%
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Charkit Chemical Corporation The Specialty Chemical Specialists Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you. about: Since 1982, Charkit has been committed to expanding the markets we serve as our roster of products and services continues to grow with us. Our substantial portfolio of personal care ingredients now include a wide array of luxury and exotic components to compliment the key products we have always offered. We have expanded our offerings to the nutraceutical, industrial, and resin markets with a growing roster of versatile and unique ingredients. We continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions. Please contact us to learn how we can help you reach your goals. Email: Sales Voice: 203-299-3220 Fax: 203-299-1355 Facebook Twitter Linkedin Latest News Events Blog Products List: View Product(s): HYDROXYBENZOIC ACID,4- PURIFIED CLEAN ROOM HYDROXYBENZOIC ACID, P- POLYMER GRADE
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 08-57000 p-HYDROXYBENZOIC ACID
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Prodasynth PRODUCTEUR PAR ESSENCE Chemical specialist in manufacturing, distributing and sourcing of tailor-made ingredients for the Flavour & Fragrance industry. Today we are also proud to say, we have created an important range of Natural Molecules which can be found in our Raw Material Compendium. The versatility of our small but efficient structure is one of our main strengths when trying to fulfill our clients' requirements. Email: Info: Email: Sales Team Prodasynth Voice: (33) 4 93 09 00 11 Fax: (33) 4 22 13 07 38 New Catalog Products List: View Product(s): PARA-HYDROXYBENZOIC ACID (> 99%)
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Sigma-Aldrich Complete Supply Chain The perfect blend of products and services that bring your creativity to life. Sigma-Aldrich is a leading Life Science and High Technology company dedicated to providing high-quality, safe and certified flavor ingredients with transparent and easily accessible documentation to customers around the globe. Sigma-Aldrich also provides a suite of analytical tools that allow food analysts to simplify sample preparation, cleanup and analysis steps, while increasing sensitivity to trace ingredients and harmful substances to meet regulations and quality standards. Email: Information US Email: Sales US Voice: 800-244-1173 US Fax: 800-368-4661 Facebook Twitter Instagram Linkedin Flavors and Fragrances Analysis FandF Newsletter Subscription Flavors and Fragrances Learning Center Certified Food Grade Products Product(s): W398608 4-Hydroxybenzoic acid, ≥99%, FG SDS
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TCI AMERICA Moving Your Chemistry Forward We continuously strive to advance our technology. With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping! Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis. US Email: Sales Email: Technical Support Voice: 1-800-423-8616 Fax: 1- 888-520-1075 Facebook Twitter Instagram Linkedin Product(s): H0207 4-Hydroxybenzoic Acid >99.0%(GC)(T)
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| CAS Number: | 99-96-7 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 202-804-9 | |
| FDA UNII: | JG8Z55Y12H | |
| Nikkaji Web: | J43.201F | |
| Beilstein Number: | 0970950 | |
| MDL: | MFCD00002547 | |
| CoE Number: | 693 | |
| XlogP3: | 1.60 (est) | |
| Molecular Weight: | 138.12242000 | |
| Formula: | C7 H6 O3 | |
| BioActivity Summary: | listing | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 957 4-hydroxybenzoic acid |
| DG SANTE Food Flavourings: | 08.040 4-hydroxybenzoic acid |
| DG SANTE Food Contact Materials: | 4-hydroxybenzoic acid |
| FEMA Number: | 3986 4-hydroxybenzoic acid |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 99-96-7 ; 4-HYDROXYBENZOIC ACID |
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 99.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 213.00 to 215.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 334.00 to 335.00 °C. @ 760.00 mm Hg |
| Flash Point: | > 212.00 °F. TCC ( > 100.00 °C. ) |
| logP (o/w): | 1.580 |
| Soluble in: | |
| alcohol | |
| water, 1.45e+004 mg/L @ 25 °C (est) | |
| Insoluble in: | |
| water | |
Organoleptic Properties:
| Odor Type: phenolic | |
| phenolic nutty | |
| Odor Description: at 100.00 %. | phenolic nutty |
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
preservatives |
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| p-Hydroxybenzoic acid |
| Beijing Lys Chemicals |
| 4-Hydroxybenzoic acid |
| BOC Sciences |
| For experimental / research use only. |
| 4-Hydroxybenzoic acid 98% |
| Charkit Chemical |
| HYDROXYBENZOIC ACID, P- POLYMER GRADE |
| Charkit Chemical |
| HYDROXYBENZOIC ACID,4- PURIFIED CLEAN ROOM |
| EMD Millipore |
| For experimental / research use only. |
| 4-Hydroxybenzoic Acid |
| ExtraSynthese |
| For experimental / research use only. |
| 4-Hydroxybenzoic acid (HPLC) ≥90% |
| Parchem |
| para-salicylic acid |
| Penta International |
| p-HYDROXYBENZOIC ACID |
| Prodasynth |
| PARA-HYDROXYBENZOIC ACID
(> 99%) |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| p-Salicylic Acid |
| Sigma-Aldrich |
| 4-Hydroxybenzoic acid, ≥99%, FG |
| Certified Food Grade Products |
| TCI AMERICA |
| For experimental / research use only. |
| 4-Hydroxybenzoic Acid >99.0%(GC)(T) |
Safety Information:
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xn - Harmful. | |
|
R 22 - Harmful if swallowed. R 36/38 - Irritating to skin and eyes. R 41 - Risk of serious damage to eyes. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 22 - Do not breath dust. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
oral-mouse LD50 2200 mg/kg (Sokol, 1952) intraperitoneal-rat LD50 340 mg/kg BEHAVIORAL: MUSCLE WEAKNESS Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(1), Pg. 85, 1986. intraperitoneal-mouse LD50 210 mg/kg BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956. oral-mouse LD50 2200 mg/kg Drug Standards. Vol. 20, Pg. 89, 1952. oral-rat LD50 > 10000 mg/kg LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE WEAKNESS Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(7), Pg. 53, 1984. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 1050 mg/kg Archives Internationales de Pharmacodynamie et de Therapie. Vol. 128, Pg. 135, 1960. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavoring agents | ||
| Recommendation for para-salicylic acid usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 16.00 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 17.00 (μg/capita/day) | ||
| Structure Class: | I | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 20 | |||
| Click here to view publication 20 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 60.00000 | 360.00000 | |
| beverages(nonalcoholic): | 20.00000 | 100.00000 | |
| beverages(alcoholic): | 50.00000 | 300.00000 | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | 30.00000 | 200.00000 | |
| fish products: | - | - | |
| frozen dairy: | 50.00000 | 300.00000 | |
| fruit ices: | 50.00000 | 300.00000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | - | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | 50.00000 | 300.00000 | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | 50.00000 | 300.00000 | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| Flavor & Extract Manufacturers Association (FEMA) reference(s): | |
| The FEMA GRAS assessment of hydroxyl- and alkoxy-substituted benzyl derivatives used as flavor ingredients. View pdf | |
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): | |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf | |
| Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf | |
| Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf | |
| Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf | |
| Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009) View page or View pdf | |
| Scientific Report of EFSA on the risk assessment of salts of authorised acids, phenols or alcohols for use in food contact materials [1] View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf | |
| EPI System: | View |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 99-96-7 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 135 |
| National Institute of Allergy and Infectious Diseases: | Data |
| SCCNFP: | opinion |
| WGK Germany: | 1 |
| 4-hydroxybenzoic acid | |
| Chemidplus: | 0000099967 |
| RTECS: | DH1925000 for cas# 99-96-7 |
References:
| 4-hydroxybenzoic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 99-96-7 |
| Pubchem (cid): | 135 |
| Pubchem (sid): | 134972218 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| Metabolomics Database: | Search |
| UM BBD: | Search |
| KEGG (GenomeNet): | C00156 |
| HMDB (The Human Metabolome Database): | HMDB00500 |
| FooDB: | FDB010508 |
| YMDB (Yeast Metabolome Database): | YMDB00495 |
| Export Tariff Code: | 2918.29.2200 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| preservatives |
Occurrence (nature, food, other): note
| apple fruit Search Trop Picture | |
| arrowroot leaf Search Trop Picture | |
| barley seed Search Trop Picture | |
| bean black bean root Search Trop Picture | |
| bean fava bean shoot Search Trop Picture | |
| bean field bean root Search Trop Picture | |
| beet root Search Trop Picture | |
| bilberry fruit Search Trop Picture | |
| bilberry fruit juice Search Trop Picture | |
| bilberry leaf Search Trop Picture | |
| blueberry plant Search Trop Picture | |
| broccoli asparagus broccoli leaf Search Trop Picture | |
| buckwheat testa Search Trop Picture | |
| cacao bean Search Trop Picture | |
| cantaloupe plant Search Trop Picture | |
| cardamom leaf Search Trop Picture | |
| carrot root Search Trop Picture | |
| cashew leaf Search Trop Picture | |
| cherry sour cherry plant Search Trop Picture | |
| chicory leaf Search Trop Picture | |
| coconut leaf Search Trop Picture | |
| coffee Search PMC Picture | |
| coriander fruit Search Trop Picture | |
| coriander plant Search Trop Picture | |
| coriander seed Search Trop Picture | |
| corn tissue culture Search Trop Picture | |
| currant red currant fruit Search Trop Picture | |
| date palm stem Search Trop Picture | |
| evening-primrose plant Search Trop Picture | |
| fennel seed Search Trop Picture | |
| flax sprout Search Trop Picture | |
| garlic bulb Search Trop Picture | |
| garlic plant Search Trop Picture | |
| ginger plant Search Trop Picture | |
| ginkgo biloba leaf Search Trop Picture | |
| ginkgo biloba plant Search Trop Picture | |
| grape Search Trop Picture | |
| grape hull husk Search Trop Picture | |
| grape leaf Search Trop Picture | |
| grape root Search Trop Picture | |
| horseradish root Search Trop Picture | |
| oat seed Search Trop Picture | |
| olive fruit Search Trop Picture | |
| onion bulb Search Trop Picture | |
| onion leaf Search Trop Picture | |
| onion root Search Trop Picture | |
| oregano leaf Search Trop Picture | |
| oregano plant Search Trop Picture | |
| pea root Search Trop Picture | |
| pea seed Search Trop Picture | |
| peanut seed Search Trop Picture | |
| poppy opium poppy pericarp Search Trop Picture | |
| raspberry red raspberry fruit juice Search Trop Picture | |
| raspberry red raspberry juice Search Trop Picture | |
| raspberry red raspberry plant Search Trop Picture | |
| rice plant Search Trop Picture | |
| rubus spectabilis leaf Search Trop Picture | |
| sage Search Trop Picture | |
| salmonberry leaf Search Trop Picture | |
| soybean leaf Search Trop Picture | |
| soybean root Search Trop Picture | |
| soybean seed Search Trop Picture | |
| sunflower seed Search Trop Picture | |
| tarragon leaf Search Trop Picture | |
| thyme plant Search Trop Picture | |
| walnut black walnut nut Search Trop Picture | |
| wheat seed Search Trop Picture |
Synonyms:
| benzoic acid, 4-hydroxy- | |
| benzoic acid, p-hydroxy- | |
| 4- | carboxyphenol |
| p- | carboxyphenol |
| para- | hydroxy benzoic acid |
| 4- | hydroxy-benzoic acid |
| p- | hydroxy-benzoic acid |
| hydroxybenzene carboxylic acid | |
| p- | hydroxybenzoate |
| para- | hydroxybenzoate |
| 4- | hydroxybenzoic acid |
| p- | hydroxybenzoic acid |
| para- | hydroxybenzoic acid |
| hydroxybenzoic acid, para | |
| 4- | hydroxybenzoicacid |
| p- | hydroxylbenzoic acid |
| paraben-acid | |
| 4- | salicylic acid |
| p- | salicylic acid |
| para- | salicylic acid |
| p- | salicylicacid |