Articles:
| US Patents: | 3,952,024 - Furfurylthioacetone |
| US Patents: | Certain 2,5-dimethyl-3-thiopyrazines |
2-isopropyl-5-methylpyrazine
Notes:
Present in boiled potato, coffee aroma, cocoa butter, fish sauce and roasted earth-almond (Cyperus esculentus)
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Chemical sources Association Inc Exchange of knowledge Need This Item for Flavor? You can contact the Chemical Sources Association. Events Links Product(s):
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| CAS Number: | 13925-05-8 |  3D/inchi
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| FDA UNII: | 818RIW504V | |
| Nikkaji Web: | J101.205C | |
| CoE Number: | 2268 | |
| XlogP3-AA: | 1.30 (est) | |
| Molecular Weight: | 136.19764000 | |
| Formula: | C8 H12 N2 | |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) | |
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 772 2-methyl-5-isopropylpyrazine |
| DG SANTE Food Flavourings: | 14.026 2-isopropyl-5-methylpyrazine |
| FEMA Number: | 3554 2-methyl-5-isopropylpyrazine |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 13925-05-8 ; 2-METHYL-5-ISOPROPYLPYRAZINE |
Physical Properties:
| Appearance: | colorless to pale yellow clear liquid (est) |
| Assay: | 97.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.97700 to 0.98400 @ 25.00 °C. |
| Pounds per Gallon - (est).: | 8.130 to 8.188 |
| Refractive Index: | 1.49200 to 1.49800 @ 20.00 °C. |
| Boiling Point: | 190.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 0.850000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 159.00 °F. TCC ( 70.56 °C. ) |
| logP (o/w): | 1.626 (est) |
| Soluble in: | |
| alcohol | |
| water | |
| water, 1901 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor Type: roasted | |
| green coffee nutty earthy | |
| Odor Description: at 0.10 % in dipropylene glycol. | green coffee nutty earthy |
| Flavor Type: green | |
| green | |
| Taste Description: | green |
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| Ambles Nature et Chimie |
| 2-ETHYL-(5or6)-METHYL PYRAZINE |
| Axsyn |
| For experimental / research use only. |
| Pyrazine,2-methyl-5-(1-methylethyl)- |
| BOC Sciences |
| For experimental / research use only. |
| 2-isoPropyl-5-methylpyrazine 95% |
| Parchem |
| 2-methyl-5-isopropyl pyrazine |
| Chemical Sources Association |
| Need This Item for Flavor/Food?: You can contact the CSA |
Safety Information:
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| Not determined | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavoring agents | ||
| Recommendation for 2-methyl-5-isopropyl pyrazine usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.024 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.40 (μg/capita/day) | ||
| Structure Class: | II | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 11 | |||
| Click here to view publication 11 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 4.00000 | |
| beverages(nonalcoholic): | - | 4.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 4.00000 | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | 4.00000 | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | - | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | 4.00000 | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| Flavor & Extract Manufacturers Association (FEMA) reference(s): | |
| The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. View pdf | |
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): | |
| Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf | |
| Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf | |
| Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1] View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24 View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010) View page or View pdf | |
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 13925-05-8 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 61700 |
| National Institute of Allergy and Infectious Diseases: | Data |
| 2-methyl-5-propan-2-ylpyrazine | |
| Chemidplus: | 0013925058 |
References:
| 2-methyl-5-propan-2-ylpyrazine | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 61700 |
| Pubchem (sid): | 135017897 |
| Flavornet: | 13925-05-8 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| HMDB (The Human Metabolome Database): | HMDB37151 |
| FooDB: | FDB016146 |
| YMDB (Yeast Metabolome Database): | YMDB01446 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
Potential Blenders and core components note
Potential Uses:
| coffee | FL | |
| green | FL | |
| nut | FL |
Occurrence (nature, food, other): note
| cocoa butter Search Trop Picture | |
| coffee Search PMC Picture | |
| cyperus esculentus roasted Search Trop Picture | |
| fish sauce Search PMC Picture | |
| potato boiled potato Search PMC Picture | |
| trassi Search Picture |
Synonyms:
| 2- | methyl-5-(1-methyl ethyl) pyrazine |
| 2- | methyl-5-(1-methylethyl)pyrazine |
| 2- | methyl-5-(propan-2-yl)pyrazine |
| 2- | methyl-5-isopropylpyrazine |
| 2- | methyl-5-propan-2-yl pyrazine |
| 2- | methyl-5-propan-2-ylpyrazine |
| 5-iso | propyl-2-methyl pyrazine |
| 5-iso | propyl-2-methylpyrazine |
| 2-iso | propyl-5-methyl pyrazine |
| 2-iso | propyl-5-methylpyrazine |
| pyrazine, 2-isopropyl-5-methyl- | |
| pyrazine, 2-methyl-5-(1-methylethyl)- |