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Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear liquid (est) |
| Assay: | 99.00 to 100.00 % sum of isomers
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.14200 to 1.15200 @ 25.00 °C.
|
| Pounds per Gallon - (est).: | 9.503 to 9.586
|
| Refractive Index: | 1.57500 to 1.58500 @ 20.00 °C.
|
| Boiling Point: | 86.00 °C. @ 10.00 mm Hg
|
| Boiling Point: | 210.00 to 211.00 °C. @ 760.00 mm Hg
|
| Vapor Pressure: | 0.161000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 4.8 ( Air = 1 ) |
| Flash Point: | 193.00 °F. TCC ( 89.44 °C. )
|
| logP (o/w): | 0.153 (est) |
| Soluble in: |
| | alcohol | | | dipropylene glycol | | | water, 3390 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| |
| Odor Type: nutty |
| |
| | nutty earthy peanut musty coffee vegetable |
Odor Description: at 0.10 % in dipropylene glycol. | nutty earthy peanut musty coffee vegetable |
| |
| | toasted popcorn roasted almond hazelnut peanut cashew nutty caramellic corn chip |
Odor Description: at 1.00 %. | Toasted popcorn, roasted almond, hazelnut, peanut and cashew nutty, with a caramellic and corn-chip nuance Mosciano, Gerard P&F 25, No. 3, 25, (2000) |
| |
| |
| Flavor Type: nutty |
| |
| | peanut pecan nutty popcorn corn chip burnt musty |
Taste Description: at 3.00 - 10.00 ppm. | Peanut and pecan nutty, popcorn and corn-chip-like with a burnt musty nuance Mosciano, Gerard P&F 25, No. 3, 25, (2000) |
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| Odor and/or flavor descriptions from others (if found). |
| |
| R C Treatt & Co Ltd |
| 2-Methylthio-3(5/6)-methylpyrazine Kosher |
| Odor Description: | Nutty, roast almonds, hazelnut, toasted cracker notes |
| Taste Description: | nutty Used in roast nut, chocolate and bread flavorus. The COE# 2290 is for 2-methyl-3-thiomethylpyrazine (not the isomeric mixture). Normal use levels in finished consumer product: 0.02-2 ppm. Council of Europe limits: Foods (4 ppm). |
| |
| Kingchem Laboratories |
| 2 METHYLTHIO-3(or 5)-METHYLPYRAZINE |
| Odor Description: | Nut, processed meat, vegetable |
| |
| Alfrebro |
| 2-METHYLTHIO-3(5)-METHYL PYRAZINE |
| Odor Description: | Nutty, Vegetable, Crackers |
| |
| FCI SAS |
| 2-METHYLTHIO-(3 or 5)-METHYL PYRAZINE |
| Odor Description: | roast, coffee, meat odor, pungent |
| |
| |
Cosmetic Information:
Suppliers:
| Advanced Biotech |
| 2 METHYLTHIO 3(5/6) METHYL PYRAZINE
|
| Alfrebro |
| 2-METHYLTHIO-3(5)-METHYL PYRAZINE
Odor: Nutty, Vegetable, Crackers |
| Ambles Nature et Chimie |
| 2-METHYLTHIO-(3or5or6)-METHYL PYRAZINE
|
| Anhui Haibei |
| 2-Methylthio-3 (5/6)-methyl pyrazine
Odor: Nutty, processed meat, vegetable |
| Anhui Suzhou Jinli Aromatic Chemicals |
| 2-Methyllhio-(3or5)-methyl pyrazine
Odor: nut, cooked meat, vegetable |
| Beijing Lys Chemicals |
| 2-Methylthio-3(5/6)-methylpyrazine
|
| Berjé |
| 2-Methyl Thio-3 (5,6) Methyl Pyrazine
|
| Media |
| Charkit Chemical |
| METHYLTHIO-3(5/6)METHYL PYRAZINE, 2- FEMA 3208
|
| De Monchy Aromatics |
| 2-methylthio-3(5,6)-methyl pyrazine
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| Endeavour Specialty Chemicals |
| 2-Methylthio-3(5/6)-methylpyrazine
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| Speciality Chemical Product Groups |
| Ernesto Ventós |
| 2-METHYLTHIO-3(5/6)-METHYLPYRAZINE
Odor: NUT, CARNE, VEGETAL |
| FCI SAS |
| 2-METHYLTHIO-(3 or 5)-METHYL PYRAZINE
Odor: roast, coffee, meat odor, pungent |
| Frutarom |
| 2-METHYLTHIO-(3 OR 6)-METHYLPYRAZINE
KOSHER Flavor: Earthy, Green, Musty, Nutty, Vegetable |
| CBD Offering |
| IFF |
| 2-METHYLTHIO-(3 OR 6)-METHYLPYRAZINE
KOSHER Flavor: Earthy, Green, Musty, Nutty, Vegetable |
| Indukern F&F |
| 2-METHYLTHIO-3(5/6)-METHYL PYRAZINE
Odor: EARTHY, PEANUT, COFFEE, VEGETABLE |
| Jiangyin Healthway |
| 2-Methylthio-3(5/6)-methyl pyrazine
|
| New functional food ingredients |
| Jinan Enlighten Chemical Technology(Wutong Aroma ) |
| 2-Methyl-3(5or6)-(methylthio) pyrazine, Kosherk
|
| Kingchem Laboratories |
| 2 METHYLTHIO-3(or 5)-METHYLPYRAZINE
Odor: Nut, processed meat, vegetable |
| Lluch Essence |
| PYRAZINE 2-METHYLTHIO-3(6)-METHYL
|
| M&U International |
| 2-METHYLTHIO-3(5/6)-METHYL PYRAZINE, Kosher
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| Pearlchem Corporation |
| 2-Methlthio-3(5/6)-methyl Pyrazine
|
| Penta International |
| 2-METHYLTHIO-3,5-METHYLPYRAZINE
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| Phoenix Aromas & Essential Oils |
| Pyrazine, 2-Methyl-3(6)-5-Methyl Thio
|
| R C Treatt & Co Ltd |
| 2-Methylthio-3(5/6)-methylpyrazine
Kosher Odor: Nutty, roast almonds, hazelnut, toasted cracker notes Flavor: nutty Used in roast nut, chocolate and bread flavorus. The COE# 2290 is for 2-methyl-3-thiomethylpyrazine (not the isomeric mixture). Normal use levels in finished consumer product: 0.02-2 ppm. Council of Europe limits: Foods (4 ppm). |
| Riverside Aromatics |
| 2-METHYL-3[5/6]-METHYLTHIOPYRAZINE
|
| Robinson Brothers |
| 2-Methylthio-3(5/6)-methylpyrazine
|
| https://www.robinsonbrothers.uk/chemistry-competences |
| Sigma-Aldrich |
| (Methylthio)methylpyrazine, mixture of isomers, ≥98%, FG
Odor: almond; caramel; musty; coffee; vegetable |
| Certified Food Grade Products |
| Sunaux International |
| 2-Methylthio-3(5/6)-methyl Pyrazine
|
| Taytonn ASCC |
| 2-Methylthio-3(5/6)-methylpyrazine
Odor: Earthy, Green, Musty, Nutty, Vegetable |
| Tengzhou Jitian Aroma Chemiclal |
| 2-Methyl thio-3(5/6)-methyl pyrazine
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| Tengzhou Xiang Yuan Aroma Chemicals |
| 2-Methylthio-3-(5/6)-Methyl Pyrazine
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| Tianjin Danjun International |
| 2-Methylthio-3(5/6)-methylpyrazine
|
| WholeChem |
| 2-Methylthio-3(5/6)-methylpyrazine
|
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xn - Harmful. |
R 22 - Harmful if swallowed. R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
gavage-rat LD50 1970 mg/kg (Posternak et al., 1975)
|
| Dermal Toxicity: |
|
Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| Recommendation for 2-methyl thio-3,5 or 6-methyl pyrazine usage levels up to: | | | 0.1000 % in the fragrance concentrate.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 6.30 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 13.00 (μg/capita/day) |
| Structure Class: | III |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 4 |
| Click here to view publication 4 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 4.00000 |
| beverages(nonalcoholic): | - | - |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | 2.00000 |
| fruit ices: | - | 2.00000 |
| gelatins / puddings: | - | 2.00000 |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | 2.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
| Flavor & Extract Manufacturers Association (FEMA) reference(s): |
| The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. View pdf |
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1] View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010) View page or View pdf |
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 67952-65-2 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 100930 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | 2-methyl-3-methylsulfanylpyrazine |
| Chemidplus: | 0067952652 |
| RTECS: | UQ3900000 for cas# 67952-65-2 |
References:
Other Information:
Potential Blenders and core components note
| |
| For Odor |
| No odor group found for these |
| 1- | propanoyl pyrrole | |
| | sulfuryl octanoate | FL/FR |
|
| | sulfuryl butyrate | FL/FR |
| | sulfuryl decanoate | FL/FR |
| | sulfuryl hexanoate | FL/FR |
| | sulfuryl isobutyrate | FL/FR |
| | sulfuryl propionate | FL/FR |
| alcoholic |
| | propyl alcohol | FL/FR |
| balsamic |
| 2- | acetyl furan | FL/FR |
| buttery |
| | acetyl butyryl | FL/FR |
| | acetyl propionyl | FL/FR |
| 3,4- | hexane dione | FL/FR |
| camphoreous |
| | butyrophenone | FL/FR |
| chocolate |
| | chocolate pyrazine A | FL/FR |
| | cocoa hexenal | FL/FR |
| 2,5- | dimethyl pyrazine | FL/FR |
| 2- | methoxy-3-methyl pyrazine | FL/FR |
| 2,4,5- | trimethyl thiazole | FL/FR |
| cocoa |
| 2-iso | butyl-3,5-(and 3,6)-dimethyl pyrazine | FL/FR |
| coconut |
| | coconut naphthalenone | FL/FR |
| gamma- | octalactone | FL/FR |
| coffee |
| 1- | hydroxy-2-butanone | FL/FR |
| | popcorn pyrimidine | FL/FR |
| earthy |
| | nutty pyrazine | FL/FR |
| fruity |
| | nonyl isovalerate | FL/FR |
| 2- | heptyl furan | FL/FR |
| | hazelnut pyrazine | FL/FR |
| nutty |
| 3- | acetyl pyridine | FL/FR |
| 2- | acetyl-3-ethyl pyrazine | FL/FR |
| 2- | acetyl-3-methyl pyrazine | FL/FR |
| 2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
| 2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
| 3,6- | cocoa pyrazine | FL/FR |
| 3,5- | cocoa pyrazine | FL/FR |
| 2,3- | dimethyl pyrazine | FL/FR |
| 2- | ethyl pyrazine | FL/FR |
| | filbert heptenone | FL/FR |
| | filbert pyrazine | FL/FR |
| (E)- | filbertone | FL/FR |
| | methoxymethyl pyrazine | FL/FR |
| 2- | methyl pyrazine | FL/FR |
| 5- | methyl quinoxaline | FL/FR |
| 2- | methyl-3-ethoxypyrazine | FL/FR |
| 2- | methyl-3-pentenoic acid | FL/FR |
| | nutty quinoxaline | FL/FR |
| | peanut fragrance | FR |
| 2,3,5,6- | tetramethyl pyrazine | FL/FR |
| 2,3,5- | trimethyl pyrazine | FL/FR |
| phenolic |
| 2-iso | propyl phenol | FL/FR |
| popcorn |
| 2- | acetyl pyrazine | FL/FR |
| 2- | acetyl pyridine | FL/FR |
| 2- | acetyl thiazole | FL/FR |
| roasted |
| 2- | acetyl-2-pyrroline | |
| | furfuryl thioacetate | FL/FR |
| tonka |
| | whiskey lactone | FL/FR |
| waxy |
| | butyl laurate | FL/FR |
| woody |
| | cedrenyl acetate | FR |
| 2- | methoxy-4-vinyl phenol | FL/FR |
| |
| For Flavor |
| |
| No flavor group found for these |
| 2- | acetyl-2-pyrroline | |
| 2- | acetyl-5-methyl pyrazine | FL |
| 2- | acetyl-6-methyl pyrazine | FL |
| (E)- | aconitic acid | FL |
| 2-iso | butyl-3,5-(and 3,6)-dimethyl pyrazine | FL/FR |
| 2(4)-iso | butyl-4(2),6-dimethyl dihydro-4H-1,3,5-dithiazine | FL |
| | butyrophenone | FL/FR |
| | chocolate pyrazine A | FL/FR |
| | chocolate pyrazine B | FL |
| | coconut naphthalenone | FL/FR |
| 6,7- | dihydro-2,3-dimethyl-5H-cyclopentapyrazine | FL |
| | dimethyl dihydrocyclopentapyrazine | FL |
| 2,5- | dimethyl thiazole | FL |
| 4,5- | dimethyl-2-ethyl thiazole | FL |
| | ethyl dimethyl pyrazine | FL |
| (E)- | filbertone | FL/FR |
| | methyl 2-(methyl thio) acetate | FL |
| 2- | methyl-3-ethoxypyrazine | FL/FR |
| 2- | methyl-3-pentenoic acid | FL/FR |
| | nonyl isovalerate | FL/FR |
| | peanut dithiazine | FL |
| 2- | propionyl pyrrole | FL |
| 2-iso | propyl-4-methyl-3-thiazoline | FL |
| | pyrazines mixture | FL |
| | sulfuryl butyrate | FL/FR |
| | sulfuryl decanoate | FL/FR |
| | sulfuryl hexanoate | FL/FR |
| | sulfuryl isobutyrate | FL/FR |
|
| | sulfuryl formate | FL |
| | sulfuryl octanoate | FL/FR |
| | sulfuryl propionate | FL/FR |
| alcoholic |
| | propyl alcohol | FL/FR |
| alliaceous |
| | shallot oil | FL |
| astringent |
| 1- | propanoyl pyrrole | |
| bready |
| 2- | propionyl thiazole | FL |
| brown |
| 1- | hydroxy-2-butanone | FL/FR |
| burnt |
| 2- | methyl quinoxaline | FL |
| buttery |
| | butter pecan flavor | FL |
| 3,4- | hexane dione | FL/FR |
| cocoa |
| | cocoa hexenal | FL/FR |
| corn chip |
| 2- | acetyl pyridine | FL/FR |
| 2- | acetyl thiazole | FL/FR |
| 2- | acetyl-2-thiazoline | FL |
| | popcorn pyrimidine | FL/FR |
| creamy |
| | acetyl butyryl | FL/FR |
| fatty |
| 2- | heptyl furan | FL/FR |
| fishy |
| 4,5- | dimethyl thiazole | FL |
| green |
| | dihydroxyacetophenone (mixed isomers) | FL |
| lactonic |
| gamma- | octalactone | FL/FR |
| metallic |
| 2,5- | dihydroxy-1,4-dithiane | FL |
| musty |
| 2,5- | dimethyl pyrazine | FL/FR |
| 2- | ethoxythiazole | FL |
| | hazelnut pyrazine | FL/FR |
| 2,3,5- | trimethyl pyrazine | FL/FR |
| nutty |
| 2- | acetyl furan | FL/FR |
| 3- | acetyl pyridine | FL/FR |
| 2- | acetyl-3-ethyl pyrazine | FL/FR |
| 2- | acetyl-3-methyl pyrazine | FL/FR |
| 2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
| 2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
| | aconitic acid | FL |
| | arachis hypogaea fruit extract | FL |
| 3,6- | cocoa pyrazine | FL/FR |
| 3,5- | cocoa pyrazine | FL/FR |
| 3,5(6)- | cocoa pyrazine | FL |
| 2,5- | diethyl-3-methyl pyrazine | FL |
| 2,3- | dimethyl pyrazine | FL/FR |
| 2- | ethyl pyrazine | FL/FR |
| | filbert heptenone | FL/FR |
| | filbert pyrazine | FL/FR |
| european | hazelnut oleoresin | FL |
| 2- | methoxy-3-methyl pyrazine | FL/FR |
| | methoxymethyl pyrazine | FL/FR |
| 2- | methyl pyrazine | FL/FR |
| 5- | methyl quinoxaline | FL/FR |
| | nutty pyrazine | FL/FR |
| | nutty quinoxaline | FL/FR |
| | peanut brittle flavor | FL |
| | peanut flavor | FL |
| roasted | peanut flavor | FL |
| 2,3,5,6- | tetramethyl pyrazine | FL/FR |
| 2,4,5- | trimethyl thiazole | FL/FR |
| popcorn |
| 2- | propionyl-2-thiazoline | FL |
| roasted |
| 2- | acetyl pyrazine | FL/FR |
| | furfuryl thioacetate | FL/FR |
| smoky |
| 2- | methoxy-4-vinyl phenol | FL/FR |
| solvent |
| 2-iso | propyl phenol | FL/FR |
| toasted |
| | acetyl propionyl | FL/FR |
| waxy |
| | butyl laurate | FL/FR |
| woody |
| | whiskey lactone | FL/FR |
| |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | methyl 2-thio 3-methyl pyrazine | | | methyl 3,5 or 6-methyl thiopyrazine | | | methyl 3,5 or 6-methylthiopyrazine | | 2- | methyl thio-3 (5,6) methyl pyrazine | | 3(5 or 6)-( | methyl thio)-2-methyl pyrazine | | ( | methyl thio)-3,5 or 6-methyl pyrazine | | 2-( | methyl thio)-3(5 or 6)methyl pyrazine | | 2- | methyl-3-methylsulfanylpyrazine | | 2- | methyl-3,(5 or 6)-methyl thiopyrazine | | 2- | methyl-3,(5 or 6)-methylthiopyrazine | | | methyl-3,5 or 6-(methyl thio) pyrazine | | | methyl-3,5 or 6-(methylthio)pyrazine | | 2- | methyl-3,5 or 6-methylthiopyrazine | | 2- | methyllhio-(3or5)-methyl pyrazine | | 2-[( | methylsulfanyl)methyl]pyrazine | | (3, 5 or 6)- | methylthio-2-methylpyrazine | | 2- | methylthio-3 (5/6) -methyl pyrazine | | 2- | methylthio-3(5/6) methyl pyrazine | | 2- | methylthio-3(5/6)-methyl pyrazine | | 2- | methylthio-3(5/6)-methylpyrazine | | 2- | methylthio-3(6)methyl pyrazine | | 2 | methylthio-3(or 5)-methylpyrazine | | 3(5 or 6)-( | methylthio)-2-methylpyrazine | | ( | methylthio)-3,5 or 6-methylpyrazine | | 2-( | methylthio)-3(5 or 6)methylpyrazine | | (( | methylthio)methyl)pyrazine | | 2-(( | methylthio)methyl)pyrazine | | ( | methylthio)methylpyrazine | | | popcorn thiopyrazine | | | pyrazine, ((methylthio)methyl)- | | | pyrazine, [(methylthio)methyl]- | | | pyrazine, 2-(methylthiomethyl)- | | | pyrazine, 2-[(methylthio)methyl]- | | | pyrazine, 2-methyl-3(6)-5-methyl thio | | | pyrazinylmethyl methyl sulfide |
Articles:
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