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Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | pale yellow to yellow clear liquid (est) |
| Assay: | 98.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.07700 to 1.08100 @ 25.00 °C.
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| Pounds per Gallon - (est).: | 8.962 to 8.995
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| Specific Gravity: | 1.06800 to 1.07900 @ 25.00 °C.
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| Pounds per Gallon - est.: | 8.887 to 8.978
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| Refractive Index: | 1.51200 to 1.51600 @ 20.00 °C.
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| Boiling Point: | 220.00 to 221.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 54.00 to 56.00 °C. @ 1.00 mm Hg
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| Vapor Pressure: | 0.026000 mmHg @ 25.00 °C. (est) |
| Flash Point: | > 212.00 °F. TCC ( > 100.00 °C. )
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| logP (o/w): | 0.026 (est) |
| Soluble in: |
| | alcohol | | | water | | | water, 2.072e+004 mg/L @ 25 °C (est) |
| Similar Items: note |
| 2-acetyl-6-ethyl pyrazine |
Organoleptic Properties:
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| Odor Type: nutty |
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| | earthy potato chip nutty popcorn corn |
Odor Description: at 1.00 % in propylene glycol. | earthy potato chip nutty popcorn corn |
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| | earthy nutty musty potato corn |
Odor Description: at 2.00 %. | Earthy, nutty, musty, potato and corn-like Mosciano, Gerard P&F 23, No. 3, 55, (1998) |
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| Flavor Type: nutty |
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| | musty nutty cocoa peanut vegetable potato beany |
Taste Description: at 2.00 ppm. | Musty, nutty, cocoa and peanut, with a vegetative, potato and bean nuance Mosciano, Gerard P&F 23, No. 3, 55, (1998) |
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| Odor and/or flavor descriptions from others (if found). |
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| R C Treatt & Co Ltd |
| 2-Acetyl-3-ethylpyrazine Halal, Kosher |
| Odor Description: | Potato chip, nutty, popcorn, hazelnut, meaty notes |
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| Pell Wall Perfumes |
| Chip Pyrazine |
| Odor Description: | Earthy, nutty, musty, potato-chip, corn Naturally present in cocoa, chocolate as well as cooked meats, this is a more versatile material than you might expect, and an ideal component of the dank, earthy accords that have become popular recently in the more adventurous fine fragrances. |
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Cosmetic Information:
Suppliers:
| Ambles Nature et Chimie |
| 2-ACETYL-3-ETHYL PYRAZINE
|
| Anhui Haibei |
| 2-Acetyl-3-ethyl Pyrazine
Odor: Earthy potato chip nutty popcorn corn |
| Beijing Lys Chemicals |
| 2-Acetyl-3-ethylpyrazine
|
| BOC Sciences |
| For experimental / research use only. |
| 2-Acetyl-3-ethylpyrazine
|
| Endeavour Specialty Chemicals |
| 2-Acetyl-3-ethylpyrazine 99% F&F
|
| Speciality Chemical Product Groups |
| Ernesto Ventós |
| 2-ACETYL-3-ETHYLPYRAZINE
Odor: EARTHY, NUTTY, POTATO, ROAST |
| FCI SAS |
| 2-ACETYL-3-ETHYLPYRAZINE
|
| Frutarom |
| 2-ACETYL-3-ETHYLPYRAZINE
KOSHER Flavor: Earthy, Nutty, Corn, Musty |
| CBD Offering |
| IFF |
| 2-ACETYL-3-ETHYLPYRAZINE
KOSHER Flavor: Earthy, Nutty, Corn, Musty |
| Jinan Enlighten Chemical Technology(Wutong Aroma ) |
| 2-Acetyl-3-ethyl pyrazine, Kosherk
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| Kingchem Laboratories |
| 2 ACETYL-3-ETHYLPYRAZINE
Odor: Nutty |
| Lluch Essence |
| PYRAZINE 2-ACETHYL-3-ETHYL
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| M&U International |
| 2-ACETYL-3-ETHYL PYRAZINE, Kosher
|
| Pearlchem Corporation |
| 2-Acetyl-3-ethyl Pyrazine
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| Pell Wall Perfumes |
| Chip Pyrazine
Odor: Earthy, nutty, musty, potato-chip, corn Use: Naturally present in cocoa, chocolate as well as cooked meats, this is a more versatile material than you might expect, and an ideal component of the dank, earthy accords that have become popular recently in the more adventurous fine fragrances. |
| Penta International |
| 2-ACETYL-3-ETHYL PYRAZINE
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| R C Treatt & Co Ltd |
| 2-Acetyl-3-ethylpyrazine
Halal, Kosher Odor: Potato chip, nutty, popcorn, hazelnut, meaty notes |
| Reincke & Fichtner |
| 2-Acetyl-3-ethylpyrazine
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| Robinson Brothers |
| 2-Acetyl-3-ethylpyrazine F&F
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| https://www.robinsonbrothers.uk/chemistry-competences |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 2-Acetyl-3-ethylpyrazine
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| Sigma-Aldrich |
| 2-Acetyl-3-ethylpyrazine, 98%, FG
Odor: oily; meaty; nutty; vegetable |
| Certified Food Grade Products |
| Sunaux International |
| 2-Acetyl-3-ethyl Pyrazine
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| Synerzine |
| 2-Acetyl-3-Ethylpyrazine
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| Taytonn ASCC |
| 2-Acetyl-3-ethylpyrazine
Odor: Earthy, Nutty, Potatoes, Roast |
| TCI AMERICA |
| For experimental / research use only. |
| 2-Acetyl-3-ethylpyrazine >98.0%(GC)
|
| Tengzhou Jitian Aroma Chemiclal |
| 2-Acetyl-3-ethyl Pyrazine
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| Tengzhou Xiang Yuan Aroma Chemicals |
| 2-Acetyl-3-ethyl Pyrazine
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| United International |
| 2-Acetyl-3-Ethyl pyrazine
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| WholeChem |
| 2-Acetyl-3-ethylpyrazine
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Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xi - Irritant |
R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
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| Dermal Toxicity: |
|
Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| Recommendation for 2-acetyl-3-ethyl pyrazine usage levels up to: | | | 0.2000 % in the fragrance concentrate.
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| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.73 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.10 (μg/capita/day) |
| Structure Class: | II |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 5 |
| Click here to view publication 5 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 10.00000 |
| beverages(nonalcoholic): | - | 10.00000 |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | 10.00000 |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | 10.00000 |
| fruit ices: | - | 10.00000 |
| gelatins / puddings: | - | 10.00000 |
| granulated sugar: | - | - |
| gravies: | - | 10.00000 |
| hard candy: | - | 10.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | 10.00000 |
| meat products: | - | 10.00000 |
| milk products: | - | 10.00000 |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | 10.00000 |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
| Flavor & Extract Manufacturers Association (FEMA) reference(s): |
| The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. View pdf |
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1] View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010) View page or View pdf |
Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species View page or View pdf |
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 32974-92-8 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 61918 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | 1-(3-ethylpyrazin-2-yl)ethanone |
| Chemidplus: | 0032974928 |
References:
Other Information:
Potential Blenders and core components note
| |
| For Odor |
| balsamic |
| balsamic |
| | amyl phenyl acetate | FL/FR |
| | butyl cinnamate | FL/FR |
| | prenyl benzoate | FL/FR |
| caramellic |
| | geranyl crotonate | FR |
| chocolate |
| iso | amyl phenyl acetate | FL/FR |
| iso | butyl phenyl acetate | FL/FR |
| | chocolate pyrazine A | FL/FR |
| | cocoa hexenal | FL/FR |
| | cocoa oleoresin | FL/FR |
| 2,5- | dimethyl pyrazine | FL/FR |
| 2,4,5- | trimethyl thiazole | FL/FR |
| | popcorn pyrimidine | FL/FR |
| earthy |
| 2- | ethyl-3-methoxypyrazine | FL/FR |
| | nutty pyrazine | FL/FR |
| floral |
| alpha- | amyl cinnamyl acetate | FL/FR |
| | amyl salicylate | FL/FR |
| | autumn carboxylate | FR |
| green |
| 2-sec- | butyl-3-methoxypyrazine | FL/FR |
| | geranium thiazole | FL/FR |
| herbal |
| | acorn acetate | FR |
| | tricyclodecenyl isobutyrate | FR |
| honey |
| | butyl phenyl acetate | FL/FR |
| | phenyl acetic acid | FL/FR |
| medicinal |
| | quinoline | CS |
| musty |
| 2- | acetyl pyrrole | FL/FR |
| 3- | acetyl-2,5-dimethyl furan | FL/FR |
| | cocoa butenal | FL/FR |
| | hazelnut pyrazine | FL/FR |
| | menthofuran | FL/FR |
| nutty |
| 3- | acetyl pyridine | FL/FR |
| 2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
| 2- | acetyl-5-methyl furan | FL/FR |
| 3,6- | cocoa pyrazine | FL/FR |
| 4,5- | dimethyl-2-ethyl-3-thiazoline | FL/FR |
| 2- | ethyl pyrazine | FL/FR |
| | filbert pyrazine | FL/FR |
| 2- | methyl pyrazine | FL/FR |
| 5- | methyl quinoxaline | FL/FR |
| 2- | methyl thio-3,5 or 6-methyl pyrazine | FL/FR |
| | nutty cyclohexenone | FL/FR |
| | nutty quinoxaline | FL/FR |
| 2,3,5,6- | tetramethyl pyrazine | FL/FR |
| 2,3,5- | trimethyl pyrazine | FL/FR |
| | vinyl sulfurol | FL/FR |
| popcorn |
| 2- | acetyl pyrazine | FL/FR |
| 2- | acetyl pyridine | FL/FR |
| 2- | acetyl thiazole | FL/FR |
| sulfurous |
| | dimethyl sulfide | FL/FR |
| truffle |
| 2- | methyl acetoin | |
| vanilla |
| | ethyl vanillin isobutyrate | FL/FR |
| | vanillin | FL/FR |
| | vanillyl isobutyrate | FL/FR |
| vegetable |
| | mesityl oxide | FL/FR |
| | methional | FL/FR |
| waxy |
| 2- | tridecanone | FL/FR |
| woody |
| 4- | hydroxybenzaldehyde | FL/FR |
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| For Flavor |
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| No flavor group found for these |
| 2- | acetyl-5-methyl pyrazine | FL |
| 2- | acetyl-6-methyl pyrazine | FL |
| | amyl phenyl acetate | FL/FR |
| | butyl cinnamate | FL/FR |
| | chocolate pyrazine A | FL/FR |
| | chocolate pyrazine B | FL |
| | dimethyl dihydrocyclopentapyrazine | FL |
| 6,7- | dimethyl dihydrocyclopentapyrazine | FL |
| | ethyl dimethyl pyrazine | FL |
| 2- | ethyl-3-methoxypyrazine | FL/FR |
| | green pea pyrazine | FL |
| 2- | methoxy-3-propyl pyrazine | FL |
| | methyl 2-(methyl thio) acetate | FL |
| 2- | methyl acetoin | |
| 4-( | methyl thio) butanol | FL |
| | prenyl benzoate | FL/FR |
| 2- | propionyl pyrrole | FL |
| alliaceous |
| 3- | mercapto-2-pentanone | FL |
| 2- | methyl thioacetaldehyde | FL |
| ammoniacal |
| 2- | methyl piperidine | FL |
| aromatic |
| | amyl salicylate | FL/FR |
| bitter |
| | methyl ethoxypyrazine | FL |
| | paullinia cupana seed extract | FL |
| bready |
| 2- | propionyl thiazole | FL |
| chocolate |
| | cocoa oleoresin | FL/FR |
| | cocoa propanal | FL |
| cocoa |
| iso | butyl phenyl acetate | FL/FR |
| | butyraldehyde | FL |
| | cocoa hexenal | FL/FR |
| 2- | methyl furan | FL |
| coffee |
| | difurfuryl ether | FL |
| corn |
| 2- | acetyl pyridine | FL/FR |
| 2- | acetyl thiazole | FL/FR |
| 2- | acetyl-2-thiazoline | FL |
| | popcorn pyrimidine | FL/FR |
| creamy |
| 4- | hydroxybenzaldehyde | FL/FR |
| earthy |
| alpha- | amyl cinnamyl acetate | FL/FR |
| fatty |
| 2- | tridecanone | FL/FR |
| floral |
| iso | amyl phenyl acetate | FL/FR |
| | phenyl acetic acid | FL/FR |
| green |
| | cocoa butenal | FL/FR |
| | dihydroxyacetophenone (mixed isomers) | FL |
| | geranium thiazole | FL/FR |
| 2- | methyl-5-isopropyl pyrazine | FL |
| | propylene glycol acetone ketal | FL |
| honey |
| | butyl phenyl acetate | FL/FR |
| malty |
| | yeast thiazoline | FL |
| milky |
| dextro,laevo-3-( | methyl thio) butanone | FL |
| musty |
| 2,5- | dimethyl pyrazine | FL/FR |
| | hazelnut pyrazine | FL/FR |
| | menthofuran | FL/FR |
| | propionaldehyde | FL |
| 2,3,5- | trimethyl pyrazine | FL/FR |
| nutty |
| 3- | acetyl pyridine | FL/FR |
| 2- | acetyl pyrrole | FL/FR |
| 3- | acetyl-2,5-dimethyl furan | FL/FR |
| 2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
| 2- | acetyl-5-methyl furan | FL/FR |
| 3,6- | cocoa pyrazine | FL/FR |
| 4,5- | dimethyl-2-ethyl-3-thiazoline | FL/FR |
| 2- | ethyl pyrazine | FL/FR |
| 2- | ethyl-6-methyl pyrazine | FL |
| | filbert pyrazine | FL/FR |
| 2- | methyl pyrazine | FL/FR |
| 5- | methyl quinoxaline | FL/FR |
| 2- | methyl thio-3,5 or 6-methyl pyrazine | FL/FR |
| | nutty cyclohexenone | FL/FR |
| | nutty pyrazine | FL/FR |
| | nutty quinoxaline | FL/FR |
| | nutty thiazole | FL |
| | peanut oxazole | FL |
| 2,3,5,6- | tetramethyl pyrazine | FL/FR |
| 2,4,5- | trimethyl thiazole | FL/FR |
| | vinyl sulfurol | FL/FR |
| potato |
| | mesityl oxide | FL/FR |
| roasted |
| 2- | acetyl pyrazine | FL/FR |
| sulfurous |
| | dimethyl sulfide | FL/FR |
| | potato butanone | FL |
| tomato |
| | methional | FL/FR |
| vanilla |
| | ethyl vanillin isobutyrate | FL/FR |
| | vanillin | FL/FR |
| | vanillyl isobutyrate | FL/FR |
| vegetable |
| 2-sec- | butyl-3-methoxypyrazine | FL/FR |
| | potato butyraldehyde | FL |
| winey |
| 5- | ethyl-2-methyl pyridine | FL |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2- | acetyl-3-ethyl-1,4-diazine | | 2- | acetyl-3-ethylpyrazine | | 2 | acetyl-3-ethylpyrazine | | 2- | acetyl-3-ethylpyrazine 99% | | | chip pyrazine | | | ethanone, 1-(3-ethyl-2-pyrazinyl)- | | | ethanone, 1-(3-ethylpyrazinyl)- | | 1-(3- | ethyl pyrazinyl)ethan-1-one | | 3- | ethyl-2-pyrazinyl methyl ketone | | 3- | ethyl-2-pyrazinylmethyl ketone | | 1-(3- | ethylpyrazin-2-yl)ethanone | | 1-(3- | ethylpyrazinyl)ethan-1-one |
Articles:
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