alpha-angelica lactone
4-hydroxy-3-pentenoic acid lactone
Flavouring for baked goods, milk and meat produts
  • Advanced Biotech
    • Advanced Biotech. Inc.
      Inspired by Nature
      A diverse range of products, all meeting our stringent commitment to quality.
      Advanced Biotech is a leading manufacturer and supplier of high-quality Natural flavoring ingredients & botanical extracts for the food/beverage, cosmetic and personal care industries. With over 25 years of experience working with Fermentation processing & botanical extracts, we can help develop new innovative and functional products for todays competitive marketplace. Our company prides itself in the ability to cater to our customers specific needs while maintaining our focus on integrity, honesty and the commitment to high quality product standards. We proudly offer our quality Natural ingredients to companies around the world.
      US Email: Info
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      US Voice: 973-339-6242
      US Fax: 973-256-4101
      Upcoming Events
      1326 ANGELICA LACTONE NATURAL 90% min. (mixed isomers)
  • Alfrebro
    • Alfrebro LLC/ Archer Daniels Midland Company
      Let's get reacquainted
      Building great taste with aroma chemicals, extracts, and distillates
      The Alfrebro brand was established in the early 1900s by Alex Fries & Brothers, a Cincinnati Flavor Company. In 1980, the brand was re-launched as an aroma chemical manufacturer. Since its inception, Alfrebro’s primary focus has been to provide quality natural and high value synthetic chemicals.
      Email: Sarah Forbis
      Email: Sales
      Voice: 513-539-3021
      Fax: 513-539-7372
      US Voice: 513-539-7373
  • BOC Sciences
    • BOC Sciences
      Best of Chemicals Supplier
      Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
      BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services.
      BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
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      Voice: 1-631-504-6093
      Fax: 1-631-614-7828
      US Voice: 1-631-504-6093
      US Fax: 1-631-614-7828
      Get the App!
      591-12-8 alpha-Angelica Lactone >97.0%(GC)
  • CJ Latta & Associates
    • CJ Latta & Associates, LLC
      Extensive Line
      Aromatic Chemicals and Organic Acids.
      CJ Latta & Associates is a distributor of specialty aromatics and organic acids used in the formulation of flavors and fragrance manufactured worldwide. We pride ourselves on our reputation for, fair pricing, quality and reliability. We’ve built our business on successfully sourcing and developing many challenging specialty chemicals and fine ingredients for our clients.
      Email: Info
      US Email: Chip Latta
      Email: Sales
      US Email: Chip Latta
      Voice: (630) 240-8079
  • Lluch Essence
    • Lluch Essence S.L.
      A family company dedicated to sales and distribution
      Flexibility, availability, price and quality.
      Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world.
      Email: Info
      Voice: 34 93 379 38 49
      Fax: 34 93 370 65 04
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      01-34400 a-ANGELICALACTONE
  • Sigma-Aldrich
  • Soda Aromatic
    • Soda Aromatic Co., Ltd.
      Depth of Experience
      We guarantees product safety and quality.
      Our international sales department is happy to design the most suitable flavor & fragrance for specific uses of processed food, cosmetics, and fragrance manufactures all over the world, specializing in Asia.Let us help you with your flavor & fragrance needs.
      Email: Info
      Email: Sales
      Voice: +81-3-5645-7347
      Fax: +81-3-3664-5204
      611200010 alpha-Angelica Lactone
  • Synerzine
    • Synerzine, Inc.
      Innovation. Customization. Aroma Ingredients.
      Synerzine is a leading supplier of flavor and fragrance ingredients.
      Synerzine expresses what we have grown to embody as an organization - the synergy and connection between raw ingredients, science, technology, and the final product. Our experienced team is passionate about bringing our customers high-quality innovative ingredients that they can trust.
      Building upon our 44 year history, the Synerzine team provides customers around the globe with convenient access to over 1200 high-quality aroma ingredients. We actively engage with customers to add a wide array of new products and services on a regular basis. Our aim is to delight every customer with our exceptional services, large product selection, customization and the highest quality and safety standards. We provide our customers with true value designed to help them bring their products to market faster.
      US Email: Customer Service
      US Email: Sales
      US Voice: (404) 524-6744
      US Fax: (404) 577-1651
      Products List: View
      W0121 alpha-Angelicalactone
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 28,000 Reagents available today in benchtop to bulk quantities. Sign up for a TCI account today for fast and free shipping!
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 60 years of synthesis experience and multi-purpose plants enable TCI to offer more than 28,000 products as well as custom synthesis. TCI has established overseas facilities in North America, Europe, China and India to serve customers worldwide.
      US Email: Sales
      Email: Technical Support
      Voice: 1-800-423-8616
      Fax: 1- 888-520-1075
      A1090 alpha-Angelicalactone >98.0%(GC)
  • R C Treatt & Co Ltd
    • R C Treatt and Co Ltd
      Innovative ingredient solutions
      World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.
      We offer innovative and trend-setting product concepts for our customers, collaborating with them to create true value for their products.
      Email: Enquiries
      US Email: Enquiries
      Voice: +44 (0) 1284 702500
      Fax: +44 (0) 1284 703809
      US Voice: +1 863 668 9500
      US Fax: +1 863 668 3388
      Angelica lactone NI, Kosher
  • United International
    • Qingdao Free Trade Zone United International Co Ltd
      Quality Products
      A partner in your supply chain solution.
      Qingdao Free Trade Zone United International Trade Co., Ltd.was founded in 1996, specializing in the production and import and export of food additives,flavor raw materials and pharmaceutical and chemical raw materials. The company has experienced R&D and business personnel,product quality, low price, efficient service and fast insight and grasp the latest market information.
      Email: Info
      Email: Sales
      Voice: +86-532-83893699
      Fax: +86-532-83893695
      7027 alpha-Angelica lactone
Synonyms   Articles   Notes   Search
CAS Number: 591-12-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 209-701-8
Nikkaji Web: J13.666B
Beilstein Number: 0108394
MDL: MFCD00005375
CoE Number: 731
XlogP3-AA: 0.60 (est)
Molecular Weight: 98.10122000
Formula: C5 H6 O2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 221  4-hydroxy-3-pentenoic acid lactone
DG SANTE Food Flavourings: 10.012  5-methylfuran-2(3H)-one
FEMA Number: 3293 alpha-angelica lactone
FDA:No longer provide for the use of these seven synthetic flavoring substances
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Physical Properties:
Appearance: white crystals (est)
Assay: 98.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 1.08800 to 1.11000 @  25.00 °C.
Pounds per Gallon - (est).: 9.053 to  9.236
Refractive Index: 1.44000 to 1.46000 @  20.00 °C.
Melting Point: 18.00 to  20.00 °C. @ 760.00 mm Hg
Boiling Point: 55.00 to  56.00 °C. @ 12.00 mm Hg
Boiling Point: 167.00 to  170.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.023000 mmHg @ 25.00 °C. (est)
Flash Point: 155.00 °F. TCC ( 68.33 °C. )
logP (o/w): 0.236 (est)
Shelf Life: 12.00 month(s) or longer if stored properly.
Storage: store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
 water, 5.00E+04 mg/L @ 15 °C (exp)
Insoluble in:
Similar Items: note
beta-angelica lactone
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Type: coconut
Odor Strength: medium ,
recommend smelling in a 10.00 % solution or less
Substantivity: > 356 hour(s) at 100.00 %
 sweet  solvent  nutty  tonka  coumarinic  tobacco  
Odor Description:
at 10.00 % in dipropylene glycol. 
sweet solvent nutty tonka coumarin tobacco
Luebke, William tgsc, (1996)
 sweet  solvent  oily  coconut  nutty  coumarinic  tobacco  
Odor Description:
Sweet, solvent-like, oily, coconut, nutty with coumarin, tobacco nuances
Mosciano, Gerard P&F 15, No. 2, 69, (1990)
Flavor Type: creamy
 sweet  creamy  coconut  vanilla  hay  coumarinic  
Taste Description:
at 100.00 ppm.  
Sweet, creamy, coconut, vanilla hay and coumarin-like nuances
Mosciano, Gerard P&F 15, No. 2, 69, (1990)
Odor and/or flavor descriptions from others (if found).
Angelica Lactone Alpha ≥98%
Odor Description: Sweet-herbaceous
Used in oral care formulations to round out mint notes and in coffee flavors.
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: perfuming agents
Synonyms   Articles   Notes   Search   Top
For experimental / research use only.
a-Angelica Lactone
Advanced Biotech
90% min. (mixed isomers)
Odor: Tobacco
BOC Sciences
For experimental / research use only.
alpha-Angelica Lactone >97.0%(GC)
CJ Latta & Associates
Diffusions Aromatiques
Lluch Essence
Penn A Kem
a-Angelica Lactone
Penta International
Penta International
Phoenix Aromas & Essential Oils
Alpha-Angelica Lactone
R C Treatt & Co Ltd
Angelica lactone
NI, Kosher
Santa Cruz Biotechnology
For experimental / research use only.
a-Angelica Lactone
a-Angelica lactone, 98%, FG
Odor: oily; nutty
Certified Food Grade Products
a-Angelica lactone, natural (US), ≥90%, sum of isomers
Odor: nutty; sweet; tobacco
Soda Aromatic
alpha-Angelica Lactone
Angelica Lactone Alpha
Odor: Sweet-herbaceous
Use: Used in oral care formulations to round out mint notes and in coffee flavors.
The Fragrance Museum
For experimental / research use only.
alpha-Angelicalactone >98.0%(GC)
United International
alpha-Angelica lactone
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Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
None - None found.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  3900 mg/kg
National Technical Information Service. Vol. OTS0571138

gavage-mouse LD50  [sex: M,F] 2800 mg/kg
(Moran et al., 1980)

intraperitoneal-mouse LD50  3000 mg/kg
Acta Pharmacologica et Toxicologica. Vol. 2, Pg. 109, 1946.

oral-mouse LD50  2800 mg/kg
Drug and Chemical Toxicology. Vol. 3, Pg. 249, 1980.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor and fragrance agents
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for alpha-angelica lactone usage levels up to:
  0.5000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU): 300.00 (μg/capita/day)
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 5
Click here to view publication 5
 average usual ppmaverage maximum ppm
baked goods: -4.00000
beverages(nonalcoholic): --
beverages(alcoholic): --
breakfast cereal: -2.00000
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -0.20000
fruit ices: -0.20000
gelatins / puddings: -2.00000
granulated sugar: --
gravies: -2.00000
hard candy: -2.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -2.00000
milk products: -0.20000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -2.00000
sugar substitutes: --
sweet sauces: --
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Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of lactones used as flavor ingredients. View pdf
European Food Safety Athority(EFSA): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to - Flavouring Group Evaluation 10: Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Flavouring Group Evaluation 10, Revision 1 (FGE10 Rev1)[1] - Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 64 (FGE.64): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (57th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30 evaluated by EFSA in FGE.10Rev1 (EFSA, 2008ab)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 92 (FGE.92): Consideration of aliphatic acyclic diols, triols, and related substances evaluated by JECFA (68th meeting) structurally related to aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones evaluated by EFSA in FGE.10Rev1 (2009)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 10, Revision 2 (FGE.10Rev2): Aliphatic primary and secondary saturated and unsaturated alcohols, aldehydes, acetals, carboxylic acids and esters containing an additional oxygenated functional group and lactones from chemical groups 9, 13 and 30
View page or View pdf
EPI System: View
Chemical Carcinogenesis Research Information System: Search
EPA Substance Registry Services (TSCA): 591-12-8
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 11559
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 2
Chemidplus: 0000591128
RTECS: LU5075000 for cas# 591-12-8
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NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 591-12-8
Pubchem (cid): 11559
Pubchem (sid): 134977084
Pherobase: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
HMDB (The Human Metabolome Database): HMDB29609
FooDB: FDB000776
Export Tariff Code: 2932.20.5050
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
EFSA Update of results on the monitoring of furan levels in food: Read Report
EFSA Previous report: Results on the monitoring of furan levels in food: Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food: Read Report
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
For Odor
 coffee furanoneFL/FR
 shoyu furanoneFL/FR
 toffee furanoneFL/FR
 coconut decanone methylFR
 coconut naphthalenoneFL/FR
 waxy lactoneFL/FR
para-cresyl laurateFL/FR
 methyl (Z)-5-octenoateFL/FR
 tolualdehydes (mixed o,m,p)FL/FR
gamma-undecalactone (aldehyde C-14 (so-called))FL/FR
2-acetyl pyrroleFL/FR
 filbert pyrazineFL/FR
2-acetyl pyrazineFL/FR
 deertongue absolute replacerFR
7-methyl coumarinCS
 mint lactoneFL/FR
 whiskey lactoneFL/FR
laevo-glutamic acidCS
For Flavor
No flavor group found for these
 coconut naphthalenoneFL/FR
 fig leaf absoluteFL
2-propionyl thiazoleFL
 furfuryl alcoholFL
 shoyu furanoneFL/FR
 toffee furanoneFL/FR
 massoia bark oil CO2 extractFL
(R)-massoia lactoneFL
6-methyl coumarinFL
 diisoamyl thiomalateFL
corn chip
5,5-dibutyl dihydrofuran-2(3H)-oneFL
 massoia lactoneFL
 mint lactoneFL/FR
gamma-undecalactone (aldehyde C-14 (so-called))FL/FR
 waxy lactoneFL/FR
 methyl (Z)-5-octenoateFL/FR
 banana coconut cream flavorFL
 tolualdehydes (mixed o,m,p)FL/FR
2-acetyl pyrroleFL/FR
 coffee furanoneFL/FR
 filbert pyrazineFL/FR
2-acetyl pyrazineFL/FR
para-cresyl laurateFL/FR
 furfuryl octanoateFL
 whiskey lactoneFL/FR
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Potential Uses:
 chocolate cocoaFL
 tonka beanFR
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Occurrence (nature, food, other): note
 almond seed
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 bread white bread
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a-angelic lactone
a-angelica lactone
alpha-angelica lactone
delta(2)-angelica lactone
delta(sup 2)-angelica lactone
 angelica lactone natural
a-angelicalactone naturalal
 furan-2(3H)-one, 2,3-dihydro-5-methyl-
2(3H)-furanone, 5-methyl-
4-hydroxy-3-pentenoic acid g-lactone
4-hydroxy-3-pentenoic acid lactone
4-hydroxypent-3-enoic acid lactone
5-methyl furan-2(3H)-one
5-methyl furanone
3-pentenoic acid, 4-hydroxy,lactone a-angelica-lactone
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PubMed: Efficient, solvent-free hydrogenation of ╬▒-angelica lactone catalysed by Ru/C at atmospheric pressure and room temperature.
PubMed: Thermochemistry and kinetics of angelica and cognate lactones.
PubMed: Direct catalytic asymmetric vinylogous conjugate addition of unsaturated butyrolactones to ╬▒,╬▓-unsaturated thioamides.
PubMed: Hydrodeoxygenation of the angelica lactone dimer, a cellulose-based feedstock: simple, high-yield synthesis of branched C7 -C10 gasoline-like hydrocarbons.
PubMed: [Comparison on content of ligustilides in different danggui samples].
PubMed: An automated dual-gradient liquid chromatography-MS/MS method for the simultaneous determination of ferulic acid, ligustrazine and ligustilide in rat plasma and its application to a pharmacokinetic study.
PubMed: Identification of multiple ingredients for a Traditional Chinese Medicine preparation (bu-yang-huan-wu-tang) by liquid chromatography coupled with tandem mass spectrometry.
PubMed: Synthesis of both enantiomers of 12-methyl-13-tridecanolide and 14-methyl-15-pentadecanolide (muscolide).
PubMed: Radix Angelica Sinensis that contains the component Z-ligustilide promotes adult neurogenesis to mediate recovery from cognitive impairment.
PubMed: [Effects of conjunctive application of Chinese herbal medicine residue compost and chemical fertilizer on ferulic acid and ligustilide contents in Angelica sinensis].
PubMed: Z-ligustilide activates the Nrf2/HO-1 pathway and protects against cerebral ischemia-reperfusion injury in vivo and in vitro.
PubMed: Effects of natural phytochemicals in Angelica sinensis (Danggui) on Nrf2-mediated gene expression of phase II drug metabolizing enzymes and anti-inflammation.
PubMed: [Study on quality evaluation of Angelica sinensis by grey incidence degree method].
PubMed: [Study on the dynamic variations of Z-ligustilide and n-butylidenephthalide content in essential oil of radix angelicae sinensis from different growth period].
PubMed: Epigenetic reactivation of Nrf2 in murine prostate cancer TRAMP C1 cells by natural phytochemicals Z-ligustilide and Radix angelica sinensis via promoter CpG demethylation.
PubMed: [Research progress studies on pharmacology and pharmacokinetics of ligustilide].
PubMed: Antioxidant properties of cis-Z,Z'-3a.7a',7a.3a'-dihydroxyligustilide on human umbilical vein endothelial cells in vitro.
PubMed: Ligustilide alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion.
PubMed: Anti-inflammatory effects of Z-ligustilide nanoemulsion.
PubMed: Anti-inflammatory effects of (Z)-ligustilide through suppression of mitogen-activated protein kinases and nuclear factor-╬║B activation pathways.
PubMed: Targeting mTOR pathways in human malignancies.
PubMed: Bioactivity-guided fractionation of the volatile oil of Angelica sinensis radix designed to preserve the synergistic effects of the mixture followed by identification of the active principles.
PubMed: Chemometric classification of morphologically similar Umbelliferae medicinal herbs by DART-TOF-MS fingerprint.
PubMed: Asymmetric assembly of 2-oxindole and ╬▒-angelica lactone units to construct vicinal quaternary chiral centers.
PubMed: Z-ligustilide isolated from Radix Angelicae sinensis ameliorates the memory impairment induced by scopolamine in mice.
PubMed: Catalytic asymmetric vinylogous Mannich-type (AVM) reaction of nonactivated ╬▒-angelica lactone.
PubMed: Identification of novel pregnane X receptor activators from traditional Chinese medicines.
PubMed: Ligustilide prevents LPS-induced iNOS expression in RAW 264.7 macrophages by preventing ROS production and down-regulating the MAPK, NF-╬║B and AP-1 signaling pathways.
PubMed: Treatment with Z-ligustilide, a component of Angelica sinensis, reduces brain injury after a subarachnoid hemorrhage in rats.
PubMed: [Study on feasibility of cutting process of fresh Angelica sinensis Radix].
PubMed: Effects of ligustilide on lipopolysaccharide-induced endotoxic shock in rabbits.
PubMed: Inhibitory effects of Angelica sinensis ethyl acetate extract and major compounds on NF-kappaB trans-activation activity and LPS-induced inflammation.
PubMed: Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis.
PubMed: Z-ligustilide extracted from Radix Angelica Sinensis decreased platelet aggregation induced by ADP ex vivo and arterio-venous shunt thrombosis in vivo in rats.
PubMed: Optimization and comparison of five methods for extraction of coniferyl ferulate from Angelica sinensis.
PubMed: Bioactivity-guided fractionation and GC/MS fingerprinting of Angelica sinensis and Angelica archangelica root components for antifungal and mosquito deterrent activity.
PubMed: [Development of gas chromatographic-mass spectrometry-pattern recognition method for the quality control of Chinese Angelica].
PubMed: Angelica sinensis and its alkylphthalides induce the detoxification enzyme NAD(P)H: quinone oxidoreductase 1 by alkylating Keap1.
PubMed: Lead compounds for anti-inflammatory drugs isolated from the plants of the traditional oriental medicine in Korea.
PubMed: Dynamic nature of the ligustilide complex.
PubMed: Application of analytical and preparative high-speed counter-current chromatography for the separation of Z-ligustilide from a crude extract of Angelica sinensis.
PubMed: Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats.
PubMed: Protection against hydrogen peroxide-induced injury by Z-ligustilide in PC12 cells.
PubMed: A new procedure for the preparative separation and isolation of Z-ligustilide from the roots of Angelica sinensis.
PubMed: Fast determination of Z-ligustilide in plasma by gas chromatography/mass spectrometry following headspace single-drop microextraction.
PubMed: Ligustilide reduces phenylephrine induced-aortic tension in vitro but has no effect on systolic pressure in spontaneously hypertensive rats.
PubMed: [High performance liquid chromatography-mass spectrometry analysis of radix Angelica sciensis].
PubMed: 14-Methylpentadecano-15-lactone (muscolide): a new macrocyclic lactone from the oil of Angelica archangelica L.
PubMed: Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice.
PubMed: Ligustilide inhibits spontaneous and agonists- or K+ depolarization-induced contraction of rat uterus.
PubMed: Live cell extraction and HPLC-MS analysis for predicting bioactive components of traditional Chinese medicines.
PubMed: [The new progress of the study about volatile oil of the angelica].
PubMed: Optimization of pressurized liquid extraction for Z-ligustilide, Z-butylidenephthalide and ferulic acid in Angelica sinensis.
PubMed: LC-DAD-APCI-MS-based screening and analysis of the absorption and metabolite components in plasma from a rabbit administered an oral solution of danggui.
PubMed: Development of pressurized hot water extraction followed by headspace solid-phase microextraction and gas chromatography-mass spectrometry for determination of ligustilides in Ligusticum chuanxiong and Angelica sinensis.
PubMed: [Study on preparation of refined Xiong-gui sustained release pills].
PubMed: [New dimeric phthalide derivative from Angelica sinensis].
PubMed: [Isolation and identification of the ligustilide compounds from the root of Angelica sinensis].
PubMed: Induction of rat hepatic and intestinal UDP-glucuronosyltransferases by naturally occurring dietary anticarcinogens.
PubMed: Triflic anhydride mediated cyclization of 5-hydroxy-substituted pyrrolidinones for the preparation of alpha-trifluoromethylsulfonamido furans.
PubMed: Enhancement of glutathione and g-glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2.
PubMed: Anti-acne effects of Oriental herb extracts: a novel screening method to select anti-acne agents.
PubMed: [Constituent analysis of essential oils from radix of Angelica acutiloba].
PubMed: The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.
PubMed: Regulation of rat glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B(1)-induced preneoplasia.
PubMed: Effects of chemoprotective agents on the metabolic activation of the carcinogenic arylamines PhIP and 4-aminobiphenyl in human and rat liver microsomes.
PubMed: Effects of dietary anticarcinogens on rat gastrointestinal glutathione S-transferase theta 1-1 levels.
PubMed: Effects of methylenechloride-soluble fraction of Japanese angelica root extract, ligustilide and butylidenephthalide, on pentobarbital sleep in group-housed and socially isolated mice.
PubMed: Chemoprotection against the formation of colon DNA adducts from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat.
PubMed: Ab Initio Study of Endo/Exo and Diastereofacial Selectivities in Diels-Alder Reactions between Chiral Butenolides and Cyclopentadiene.
PubMed: Enhancement of rat hepatic and gastrointestinal glutathione and glutathione S-transferases by alpha-angelicalactone and flavone.
PubMed: Quantification of induction of rat oesophageal, gastric and pancreatic glutathione and glutathione S-transferases by dietary anticarcinogens.
PubMed: Induction of rat hepatic and intestinal glutathione s-transferases and glutathione by dietary naturally-occurring anticarcinogens.
PubMed: [Studies on the antiasthmatic action of ligustilide of dang-gui, Angelica sinensis (Oliv.) Diels].
PubMed: Enhancement of glutathione S-transferase activity of the esophagus by phenols, lactones, and benzyl isothiocyanate.
PubMed: Effect of butylated hydroxyanisole, alpha-angelica lactone, and beta-naphthoflavone on benzo(alpha)pyrene:DNA adduct formation in vivo in the forestomach, lung, and liver of mice.
PubMed: Glutathione S-transferase activity: enhancement by compounds inhibiting chemical carcinogenesis and by dietary constituents.
PubMed: Enhancement of glutathione S-transferase activity of the mouse forestomach by inhibitors of Benzo[a]pyrene-induced neoplasia of the forestomach.
PubMed: Inhibition of chemical carcinogen-induced neoplasia by coumarins and alpha-angelicalactone.
PubMed: Chemical composition of angelica root oil.
PubMed: The influence of ouabain and alpha angelica lactone on calcium metabolism of dog cardiac microsomes.
PubMed: The inhibition of ribonuclease by extract of privet leaves and by alpha-angelica lactone.
PubMed: The anti-fibrillatory action of 2-pentene 1-4-olide (alaph-beta unsaturated angelica lactone) on the electrically induced ventricular fibrillation of the cat's heart.
PubMed: [Action of beta Angelica lactone and digitalic substances on the heart of Bufo arenarum Hensel].
PubMed: [Effect of beta gamma lactones of Angelica and Digitalis on the heart of toad Bufo arenarum Hensel].
PubMed: The action of angelica lactones on the toxicity of digitoxin and on the cardiac irregularities produced by digitoxin and barium.
PubMed: [Not Available].
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