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Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 99.00 to 100.00 % sum of isomers
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.13300 to 1.15300 @ 25.00 °C.
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| Pounds per Gallon - (est).: | 9.428 to 9.594
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| Refractive Index: | 1.57000 to 1.59000 @ 20.00 °C.
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| Boiling Point: | 85.00 to 87.00 °C. @ 10.00 mm Hg
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| Boiling Point: | 213.00 to 214.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.163000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 210.00 °F. TCC ( 98.89 °C. )
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| logP (o/w): | 1.810 |
| Soluble in: |
| | alcohol | | | water, 2379 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xi - Irritant |
R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 - Wear suitable gloves and eye/face protection.
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| Recommendation for 2-methyl-3-(methyl thio) pyrazine usage levels up to: | | | 0.0200 % in the fragrance concentrate.
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| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.68 (μg/capita/day) |
| Threshold of Concern: | 90 (μg/person/day) |
| Structure Class: | III |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 4 |
| Click here to view publication 4 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 4.00000 |
| beverages(nonalcoholic): | - | - |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | 2.00000 |
| fruit ices: | - | 2.00000 |
| gelatins / puddings: | - | 2.00000 |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | 2.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
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| For Odor |
| No odor group found for these |
| | sulfuryl octanoate | FL/FR |
| | methional propylene glycol acetal | |
| | sulfuryl butyrate | FL/FR |
| | sulfuryl decanoate | FL/FR |
| | sulfuryl hexanoate | FL/FR |
| | sulfuryl isobutyrate | FL/FR |
| | sulfuryl propionate | FL/FR |
| | dimethyl trisulfide | FL/FR |
| | methyl furfuryl disulfide | FL/FR |
| animal |
| 5- | methyl-7(H)-cyclopenta[b]pyrazine | |
| | rum ether | FL/FR |
| buttery |
| 3,4- | hexane dione | FL/FR |
| camphoreous |
| | butyrophenone | FL/FR |
| chocolate |
| | chocolate pyrazine A | FL/FR |
| | cocoa hexenal | FL/FR |
| 2,6- | dimethyl pyrazine | FL/FR |
| 2,5- | dimethyl pyrazine | FL/FR |
| 2- | methoxy-3-methyl pyrazine | FL/FR |
| 2,4,5- | trimethyl thiazole | FL/FR |
| cocoa |
| 2-iso | butyl-3,5-(and 3,6)-dimethyl pyrazine | FL/FR |
| coconut |
| | coconut naphthalenone | FL/FR |
| coffee |
| | coffee difuran | FL/FR |
| 2- | methyl-3-,5 or 6-(furfuryl thio) pyrazine | FL/FR |
| corn chip |
| | popcorn pyrimidine | FL/FR |
| | nutty pyrazine | FL/FR |
| fatty |
| 5- | butyl oxazole | |
| fermented |
| | ethyl crotonate | FL/FR |
| fruity |
| | nonyl isovalerate | FL/FR |
| | tropical thiazole | FL/FR |
| | tropical trithiane | FL/FR |
| green |
| 2- | heptyl furan | FL/FR |
| (R)-1- | hexen-3-ol | |
| (E,Z)-2,6- | nonadienal | FL/FR |
| | meaty dithiane | FL/FR |
| 4- | methyl nonanoic acid | FL/FR |
| (R)-4- | methyl octanoic acid | |
| (S)-4- | methyl octanoic acid | |
| | sulfurol | FL/FR |
| | sulfuryl acetate | FL/FR |
| moldy |
| | strawberry furanone methyl ether | FL/FR |
| | hazelnut pyrazine | FL/FR |
| mutton |
| (S)-4- | methyl nonanoic acid | |
| nutty |
| 3- | acetyl pyridine | FL/FR |
| 2- | acetyl-3-ethyl pyrazine | FL/FR |
| 2- | acetyl-3-methyl pyrazine | FL/FR |
| 2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
| 2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
| 3,6- | cocoa pyrazine | FL/FR |
| 3,5- | cocoa pyrazine | FL/FR |
| 2,3- | dimethyl pyrazine | FL/FR |
| 2,4- | dimethyl-5-ethyl thiazole | |
| 2- | ethyl pyrazine | FL/FR |
| 2- | ethyl-4-methyl thiazole | FL/FR |
| | filbert heptenone | FL/FR |
| | filbert pyrazine | FL/FR |
| 2- | methyl pyrazine | FL/FR |
| 5- | methyl quinoxaline | FL/FR |
| 2- | methyl-3-ethoxypyrazine | FL/FR |
| 2- | methyl-3-pentenoic acid | FL/FR |
| | nutty quinoxaline | FL/FR |
| 2,3,5- | trimethyl pyrazine | FL/FR |
| phenolic |
| 2,3- | dimethyl benzofuran | FL/FR |
| ortho- | guaiacol | FL/FR |
| 4- | vinyl phenol | FL/FR |
| popcorn |
| 2- | acetyl pyrazine | FL/FR |
| 2- | acetyl pyridine | FL/FR |
| 2- | acetyl thiazole | FL/FR |
| roasted |
| 2- | acetyl-2-pyrroline | |
| savory |
| laevo- | methionyl glycine | |
| smoky |
| | bacon fragrance | FR |
| | pyroligneous acids | FL/FR |
| | benzothiazole | FL/FR |
| | dodecyl mercaptan | |
| | ethyl 2-mercaptopropionate | FL/FR |
| | ethyl 3-mercaptopropionate | FL/FR |
| | fish thiol | FL/FR |
| | furfuryl thioacetate | FL/FR |
| 2- | mercaptopropionic acid | FL/FR |
| 4- | methyl 4-mercaptopentan-2-one 1% solution | FL/FR |
| 2-( | methyl thio) phenol | FL/FR |
| 1- | phenethyl mercaptan | FL/FR |
| tobacco |
| | methyl benzoxole | FL/FR |
| tonka |
| | whiskey lactone | FL/FR |
| waxy |
| | butyl laurate | FL/FR |
| woody |
| | cedrenyl acetate | FR |
| 4- | hydroxybenzaldehyde | FL/FR |
| 2- | methoxy-4-vinyl phenol | FL/FR |
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| For Flavor |
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| No flavor group found for these |
| 4- | acetyl-2-methyl pyrimidine | FL |
| 2- | acetyl-2-pyrroline | |
| 2- | acetyl-5-methyl pyrazine | FL |
| 2- | acetyl-6-methyl pyrazine | FL |
| (E)- | aconitic acid | FL |
| | amyl mercaptan | FL |
| 1,2- | butane dithiol | FL |
| 5- | butyl oxazole | |
| 2-iso | butyl-3,5-(and 3,6)-dimethyl pyrazine | FL/FR |
| 2(4)-iso | butyl-4(2),6-dimethyl dihydro-4H-1,3,5-dithiazine | FL |
| 2-(2- | butyl)-4,5-dimethyl-3-thiazoline | FL |
| | butyrophenone | FL/FR |
| | chocolate pyrazine A | FL/FR |
| | chocolate pyrazine B | FL |
| | coconut naphthalenone | FL/FR |
| 2,5- | diethyl thiazole | FL |
| 6,7- | dihydro-2,3-dimethyl-5H-cyclopentapyrazine | FL |
| | dihydro-2,4,6-trimethyl-1,3,5(4H)-dithiazine | FL |
| | dimethyl dihydrocyclopentapyrazine | FL |
| | dimethyl tetrasulfide | FL |
| 2,5- | dimethyl thiazole | FL |
| 4,5- | dimethyl-2-ethyl thiazole | FL |
| 2,6- | dimethyl-3-((2-methyl-3-furyl)thio)-4-heptanone | FL |
| bis(2,5- | dimethyl-3-furyl) disulfide | FL |
| (Z+E)-2,5- | dimethyl-3-tetrahydrofuran thiol | FL |
| (Z+E)-2,5- | dimethyl-3-thioacetoxytetrahydrofuran | FL |
| 2,5- | dimethyl-3-thiofuroyl furan | FL |
| 2,4- | dimethyl-5-ethyl thiazole | |
| S- | ethyl 2-acetyl aminoethane thioate | FL |
| | ethyl 3-mercaptopropionate | FL/FR |
| | ethyl dimethyl pyrazine | FL |
| 2- | ethyl-3-methyl thiopyrazine | FL |
| (Z+E)-5- | ethyl-4-methyl-2-(2-butyl) thiazoline | FL |
| (Z+E)-5- | ethyl-4-methyl-2-(2-methyl propyl) thiazoline | FL |
| 2,4- | heptadien-1-ol | FL |
| (E,E)-2,4- | heptadien-1-ol | FL |
| (R)-1- | hexen-3-ol | |
| 2- | hexyl thiophene | FL |
| 1-(3- | hydroxy-5-methyl-2-thienyl) ethanone | FL |
| 3- | mercapto-3-methyl butyl formate | FL |
| 4- | mercapto-3-methyl-2-butanol | FL |
| | methional propylene glycol acetal | |
| laevo- | methionyl glycine | |
| | methyl 2-(methyl thio) acetate | FL |
| 4- | methyl 4-mercaptopentan-2-one 1% solution | FL/FR |
| | methyl dihydrofuran thiol | FL |
| (S)-4- | methyl nonanoic acid | |
| (R)-4- | methyl octanoic acid | |
| (S)-4- | methyl octanoic acid | |
| 2- | methyl thiazolidine | FL |
| 2- | methyl-1-butane thiol | FL |
| 4- | methyl-2-(methyl thiomethyl)-2-hexenal | FL |
| 2- | methyl-2-thiazoline | FL |
| 2- | methyl-3-,5 or 6-(furfuryl thio) pyrazine | FL/FR |
| 2- | methyl-3-ethoxypyrazine | FL/FR |
| 3-((2- | methyl-3-furyl)thio)-4-heptanone | FL |
| 4-((2- | methyl-3-furyl)thio)-5-nonanone | FL |
| 2- | methyl-3-pentenoic acid | FL/FR |
| 5- | methyl-7(H)-cyclopenta[b]pyrazine | |
| 1,9- | nonane dithiol | FL |
| | nonyl isovalerate | FL/FR |
| | peanut dithiazine | FL |
| 1- | phenethyl mercaptan | FL/FR |
| 2- | propionyl pyrrole | FL |
| iso | propyl disulfide | FL |
| 2-iso | propyl-3-(methyl thio) pyrazine | FL |
| | sulfuryl butyrate | FL/FR |
| | sulfuryl decanoate | FL/FR |
| | sulfuryl hexanoate | FL/FR |
| | sulfuryl isobutyrate | FL/FR |
| | thiazole | FL |
| 3- | thienyl mercaptan | FL |
| | thioacetic acid | FL |
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| 3,5- | diisopropyl-1,2,4-trithiolane | FL |
| 3,5- | dimethyl-1,2,4-trithiolane | FL |
| 3,7- | dimethyl-2,6-octadien-1-yl cyclopropyl carboxamide | FL |
| 2,4- | dimethyl-3-oxazoline | FL |
| 4- | mercapto-2-pentanone 1% in acetoin | FL |
| 2- | methyl-1-methyl thio-2-butene | FL |
| | pyrrolidino-(1,2E)-4H-2,4-dimethyl-1,3,5-dithiazine | FL |
| | sulfuryl formate | FL |
| | sulfuryl octanoate | FL/FR |
| | sulfuryl propionate | FL/FR |
| 1-(2- | thienyl) butanone | FL |
| alliaceous |
| | allyl disulfide | FL |
| | allyl mercaptan | FL |
| 1,3- | butane dithiol | FL |
| | cyclopentyl mercaptan | FL |
| | dimethyl trisulfide | FL/FR |
| 3- | mercapto-2-pentanone | FL |
| 3- | tetrahydrothiophenone | FL |
| | tropical thiazole | FL/FR |
| bready |
| 2- | propionyl thiazole | FL |
| burnt |
| | bacon dithiazine | FL |
| 1,6- | hexane dithiol | FL |
| 2- | methyl quinoxaline | FL |
| | rum ether | FL/FR |
| buttery |
| 3,4- | hexane dione | FL/FR |
| chemical |
| 2,3- | dimethyl benzofuran | FL/FR |
| 2,5- | dimethyl furan | FL |
| cocoa |
| | cocoa hexenal | FL/FR |
| coffee |
| | coffee difuran | FL/FR |
| 2- | ethyl-4-methyl thiazole | FL/FR |
| | methyl furfuryl disulfide | FL/FR |
| corn |
| 2- | acetyl pyridine | FL/FR |
| 2- | acetyl thiazole | FL/FR |
| | popcorn pyrimidine | FL/FR |
| creamy |
| 4- | hydroxybenzaldehyde | FL/FR |
| earthy |
| | difurfuryl sulfide | FL |
| 1,8- | octane dithiol | FL |
| eggy |
| iso | propyl mercaptan | FL |
| fatty |
| 2- | heptyl furan | FL/FR |
| 4- | methyl nonanoic acid | FL/FR |
| 2- | pentyl thiophene | FL |
| fishy |
| 4,5- | dimethyl thiazole | FL |
| fruity |
| 2,4- | hexadien-1-ol | FL |
| | tropical trithiane | FL/FR |
| green |
| 4- | methyl thiazole | FL |
| (E,Z)-2,6- | nonadienal | FL/FR |
| 4- | penten-1-yl acetate | FL |
| meaty |
| 4- | allyl-2,6-dimethoxyphenol | FL |
| | benzothiazole | FL/FR |
| 2,6- | dimethyl pyrazine | FL/FR |
| 2,6- | dimethyl thiophenol | FL |
| 2,5- | dimethyl-3-furan thiol | FL |
| | dodecyl mercaptan | |
| 1,1- | ethane dithiol 1% in ethanol 94.5% / ethyl acetate 4% | FL |
| | furfuryl 2-methyl-3-furyl disulfide | FL |
| | meaty dithiane | FL/FR |
| 3- | mercapto-2-butanone | FL |
| (R,S)-2- | mercapto-3-butanol | FL |
| 2- | mercaptomethyl pyrazine | FL |
| 2- | mercaptopropionic acid | FL/FR |
| 2- | methyl 3-(methyl thio) furan | FL |
| 2-( | methyl thio) phenol | FL/FR |
| | methyl thiofuryl butanal | FL |
| 12- | methyl tridecanal | FL |
| bis(2- | methyl-3-furyl) disulfide | FL |
| S-(2- | methyl-3-furyl) ethane thioate | FL |
| 2- | methyl-3-tetrahydrofuran thiol | FL |
| 2- | methyl-3-thioacetoxytetrahydrofuran | FL |
| | phenyl mercaptan | FL |
| | propyl 2-mercaptopropionate | FL |
| | pyrazinyl ethane thiol | FL |
| 2- | pyridinyl methane thiol | FL |
| | sulfurol | FL/FR |
| | sulfuryl acetate | FL/FR |
| | thialdine | FL |
| ortho- | thiocresol | FL |
| ortho- | thioguaiacol | FL |
| metallic |
| 2,5- | dihydroxy-1,4-dithiane | FL |
| moldy |
| | strawberry furanone methyl ether | FL/FR |
| musty |
| 2,5- | dimethyl pyrazine | FL/FR |
| 2- | ethoxythiazole | FL |
| | hazelnut pyrazine | FL/FR |
| 2,3,5- | trimethyl pyrazine | FL/FR |
| nutty |
| 3- | acetyl pyridine | FL/FR |
| 3- | acetyl-2,5-dimethyl thiophene | FL |
| 2- | acetyl-3-ethyl pyrazine | FL/FR |
| 2- | acetyl-3-methyl pyrazine | FL/FR |
| 2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
| 2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
| 2- | acetyl-4-methyl thiazole | FL |
| 3,6- | cocoa pyrazine | FL/FR |
| 3,5- | cocoa pyrazine | FL/FR |
| 3,5- | diethyl-2-methyl pyrazine | FL |
| 2,5- | diethyl-3-methyl pyrazine | FL |
| 2,3- | dimethyl pyrazine | FL/FR |
| 2- | ethyl pyrazine | FL/FR |
| | filbert heptenone | FL/FR |
| | filbert pyrazine | FL/FR |
| european | hazelnut oleoresin | FL |
| 2- | methoxy-3-methyl pyrazine | FL/FR |
| | methyl benzoxole | FL/FR |
| 2- | methyl pyrazine | FL/FR |
| 5- | methyl quinoxaline | FL/FR |
| | nutty pyrazine | FL/FR |
| | nutty quinoxaline | FL/FR |
| | nutty thiazole | FL |
| 2,4,5- | trimethyl thiazole | FL/FR |
| onion |
| | ethyl 2-mercaptopropionate | FL/FR |
| | furfuryl isopropyl sulfide | FL |
| phenolic |
| 2- | ethyl benzene thiol | FL |
| 4- | vinyl phenol | FL/FR |
| popcorn |
| 2- | propionyl-2-thiazoline | FL |
| radish |
| 3-( | methyl thio) propyl mercaptoacetate | FL |
| roasted |
| 2- | acetyl pyrazine | FL/FR |
| | furfuryl thioacetate | FL/FR |
| | hexyl mercaptan | FL |
| rummy |
| | ethyl crotonate | FL/FR |
| smoky |
| 2- | methoxy-4-vinyl phenol | FL/FR |
| | prosopis juliflora wood extract | FL |
| | pyroligneous acids | FL/FR |
| sulfurous |
| 2,3- | butane dithiol | FL |
| | ethyl methyl sulfide | FL |
| S- | ethyl thioacetate | FL |
| | fish thiol | FL/FR |
| | methyl 2-methyl-3-furyl disulfide | FL |
| 3- | methyl-2-butane thiol | FL |
| 2- | naphthyl mercaptan | FL |
| | roasted butanol | FL |
| vegetable |
| | tyramine | FL |
| wasabi |
| 2-( | methyl thio) ethyl acetate | FL |
| waxy |
| | butyl laurate | FL/FR |
| woody |
| ortho- | guaiacol | FL/FR |
| | whiskey lactone | FL/FR |
| yeasty |
| | faex extracts | FL |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2- | methyl 3-methyl thio pyrazine | | 2- | methyl mercapto-3-methyl pyrazine | | 2- | methyl thio-3-methyl pyrazine | | 2-( | methyl thio)-3-methyl pyrazine | | 3- | methyl-2-methyl thiopyrazine | | 3- | methyl-2-methylthiopyrazine | | 2- | methyl-3-(methyl thio) pyrazine | | 2- | methyl-3-(methylmercapto)pyrazine | | 2- | methyl-3-(methylsulfanyl)pyrazine | | 2- | methyl-3-(methylthio)pyrazine | | 2- | methyl-3-methyl mercaptopyrazine | | 2- | methyl-3-methyl sulfanyl pyrazine | | 2- | methyl-3-methylsulfanylpyrazine | | 2- | methyl-3-methylthiopyrazine | | 2- | methylmercapto-3-methylpyrazine | | 2- | methylthio-3-methyl pyrazine | | 2- | methylthio-3-methylpyrazine | | 2-( | methylthio)-3-methylpyrazine | | | pyrazine, 2-methyl-3-(methylthio)- | | | pyrazine, methyl(methylthio)- |
Articles:
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