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Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 99.00 to 100.00 % sum of isomers
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 1.13800 to 1.14800 @ 20.00 °C.
|
| Pounds per Gallon - (est).: | 9.480 to 9.564
|
| Refractive Index: | 1.58000 to 1.58600 @ 20.00 °C.
|
| Boiling Point: | 153.00 to 156.00 °C. @ 10.00 mm Hg
|
| Flash Point: | 134.00 °F. TCC ( 56.67 °C. )
|
| logP (o/w): | 1.970 |
| Soluble in: |
| | alcohol | | | water, 198.1 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| |
| Odor Type: coffee |
| |
| | sulfurous nutty coffee roasted coffee cooked meaty |
Odor Description: at 0.10 % in dipropylene glycol. | sulfurous nutty roasted coffee cooked meat |
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| Kingchem Laboratories |
| 2 FURFURYLTHIO-(3 or 5)-METHYLPYRAZINE (2-Methyl-3-(furfurylthio)pyrazine) |
| Odor Description: | Coffee and sesame seed oil |
| |
| |
Cosmetic Information:
Suppliers:
| Advanced Biotech |
| 2 FURFURYLTHIO 3(5/6)METHYL PYRAZINE
|
| Anhui Suzhou Jinli Aromatic Chemicals |
| 2-Furfurylthio-(3 or 5)-methyl pyrazine
Odor: coffee, Fried Sesame |
| Beijing Lys Chemicals |
| 2-Methyl-3(5/6)(furfurylthio)pyrazine
|
| BOC Sciences |
| For experimental / research use only. |
| 2-Furfurylthio-3-methylpyrazine 95%
|
| Charkit Chemical |
| METHYL-3(5/6)FURFURYLTHIO) PYRAZINE, 2- FEMA 3189
|
| FCI SAS |
| 2-FURFURYLTHIO-(3 or 5)-METHYL PYRAZINE
Odor: Roasted coffee, gingili |
| Fleurchem |
| 2-methyl (3-furfuryl-thio) pyrazine
|
| Jiangyin Healthway |
| 2-Furfurylthio-3(5/6)-methyl pyrazine
|
| New functional food ingredients |
| Jinan Enlighten Chemical Technology(Wutong Aroma ) |
| 2-methyl-3(5or6)-Furfurylthio pyrazine, Kosherk
|
| Kingchem Laboratories |
| 2 FURFURYLTHIO-(3 or 5)-METHYLPYRAZINE (2-Methyl-3-(furfurylthio)pyrazine)
Odor: Coffee and sesame seed oil |
| M&U International |
| 2-FURFURYLTHIO-3(5/6)-METHYL PYRAZINE, Kosher
|
| Penta International |
| 2-METHYL-3,5,6-(FURFURYLTHIO)PYRAZINE
|
| Reincke & Fichtner |
| 2-Methyl-3-,5 Or 6-(furfurylthio)pyrazine (mixture Of Isomers)
|
| Sigma-Aldrich |
| 2-Methyl-3(5 or 6)-furfurylthiopyrazine, 97%
|
| Certified Food Grade Products |
| Sunaux International |
| 2-Furfurylthio-3(5/6)-methyl Pyrazine
|
| Synerzine |
| 2-Methyl-3,5 or 6-(Furfurylthio)-Pyrazine
|
| Taytonn ASCC |
| 2-Methyl-3(5/6)(Furfurylthio)
Odor: Coffee, Nutty, Roast |
| Tengzhou Jitian Aroma Chemiclal |
| 2-Furfurylthio-3(5/6)-methyl pyrazine
|
| Tengzhou Xiang Yuan Aroma Chemicals |
| 2-Furfuralthio-3-(5/6)-Methyl Pyrazine
|
| Tianjin Danjun International |
| 2-Methyl-3(5/6)(furfurylthio)pyrazine
|
| WholeChem |
| 2-Methyl-3(5/6)(furfurylthio)pyrazin
|
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xn - Harmful. |
R 10 - Flammable. R 22 - Harmful if swallowed. R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
|
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| Recommendation for 2-methyl-3-,5 or 6-(furfuryl thio) pyrazine usage levels up to: | | | 0.0300 % in the fragrance concentrate.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.37 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.70 (μg/capita/day) |
| NOEL (No Observed Effect Level): | 1.70 (mg/kg bw per day) |
| Structure Class: | III |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 4 |
| Click here to view publication 4 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 1.00000 |
| beverages(nonalcoholic): | - | 1.00000 |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | 1.00000 |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | 1.00000 |
| fruit ices: | - | 1.00000 |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | - | 1.00000 |
| hard candy: | - | - |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
Scientific Opinion on Flavouring Group Evaluation 13Rev1: Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 View page or View pdf |
Consideration of sulfur-substituted furan derivatives used as flavouring agents evaluated by JECFA (59th meeting) structurally related to a subgroup of substances within the group of “Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14” evaluated by EFSA in FGE.13Rev1 (2009) View page or View pdf |
Flavouring Group Evaluation 67 (FGE.67): Consideration of 40 furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b) and re-evaluated at the 69th meeting (JECFA, 2009c) View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 13, Revision 2 (FGE.13Rev2): Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 67, Revision 1 (FGE.67Rev.1): Consideration of 40 furan-substituted aliphatic hydrocarbons, alcohols, aldehydes, ketones, carboxylic acids and related esters, sulfides, disulfides and ethers evaluated by JECFA at the 65th meeting (JECFA, 2006b) and re-evaluated at the 69th meeting (JECFA, 2009c) View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 65, Revision 1 (FGE.65Rev1): Consideration of sulfur-substituted furan derivatives used as flavouring agents evaluated by JECFA (59th meeting) structurally related to a subgroup of substances within the group of ‘Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14’ evaluated by EFSA in FGE.13Rev2 (2011) View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 13 Revision 3 (FGE.13Rev3): furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14 View page or View pdf |
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 101003 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WISER: | UN 1993 |
| WGK Germany: | 3 |
| | 2-[(furan-2-ylmethyl)sulfanyl]-5-methylpyrazine |
| Chemidplus: | 0059035982 |
References:
Other Information:
Potential Blenders and core components note
| |
| For Odor |
| No odor group found for these |
|
| | semduramicin sodium | |
| | dimethyl trisulfide | FL/FR |
| | methyl furfuryl disulfide | FL/FR |
| balsamic |
| 2- | acetyl furan | FL/FR |
| 2- | ethyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
| (R)-2- | methyl butyraldehyde | |
| | caramel furanone solution | FL/FR |
| | coffee dione | FL/FR |
| | cyclotene | FL/FR |
| | fenugreek oleoresin | FL/FR |
| | malt fragrance | FR |
| 5- | methyl furfural | FL/FR |
| chocolate |
| | cocoa oleoresin | FL/FR |
| 2,6- | dimethyl pyrazine | FL/FR |
| 2,4,5- | trimethyl thiazole | FL/FR |
| cocoa |
| 2- | methyl butyraldehyde | FL/FR |
| coffee |
| | cappuccino fragrance | FR |
| | cichorium intybus root extract | FL/FR |
| | cichorium intybus root solid extract | FL/FR |
| | coffea arabica fruit extract | FL/FR |
| roasted | coffea arabica seed extract | FL/FR |
| | coffea arabica seed extract | FL/FR |
| | coffea arabica seed oil | FL/FR |
| | coffee absolute | FL/FR |
| arabica | coffee bean butter | FL/FR |
| roasted arabica | coffee bean essence | FL/FR |
| roasted | coffee bean extract | FL/FR |
| roasted arabica | coffee bean oil | FL/FR |
| roasted arabica | coffee bean oil CO2 extract | FL/FR |
| | coffee bean oil extract | FL/FR |
| | coffee difuran | FL/FR |
| | coffee fragrance | FR |
| | coffee resinoid | FL/FR |
| | furfuryl mercaptan | FL/FR |
| 1- | hydroxy-2-butanone | FL/FR |
| | nutty pyrazine | FL/FR |
| (S)-2- | methyl butyraldehyde | |
| | tropical thiazole | FL/FR |
| herbal |
| | wormwood oil america | FL/FR |
| | wormwood oil italy | FL/FR |
| | wormwood oil poland | FL/FR |
| | wormwood oil replacer | FR |
| medicinal |
| 2,6- | xylenol | FL/FR |
| moldy |
| | strawberry furanone methyl ether | FL/FR |
| | menthofuran | FL/FR |
| 3,5- | cocoa pyrazine | FL/FR |
| 3,6- | cocoa pyrazine | FL/FR |
| 2,3- | dimethyl pyrazine | FL/FR |
| 4,5- | dimethyl-2-ethyl-3-thiazoline | FL/FR |
| 2- | ethyl pyrazine | FL/FR |
| 2- | ethyl-4-methyl thiazole | FL/FR |
| | filbert heptenone | FL/FR |
| | filbert heptenone B | FL/FR |
| | hazelnut fragrance | FR |
| 5- | methyl quinoxaline | FL/FR |
| 2- | methyl-3-(methyl thio) pyrazine | FL/FR |
| | sesame absolute | FL/FR |
| | sesame absolute CO2 extract | FL/FR |
| 2,3,5,6- | tetramethyl pyrazine | FL/FR |
| phenolic |
| para-alpha- | dimethyl styrene | FL/FR |
| popcorn |
| 2- | acetyl pyrazine | FL/FR |
| | fenugreek resinoid | FL/FR |
| | trigonella foenum-graecum seed oil CO2 extract | FL/FR |
| savory |
| laevo- | methionyl glycine | |
| sulfurous |
| | benzothiazole | FL/FR |
| | dodecyl mercaptan | |
| | furfuryl thioacetate | FL/FR |
| S- | furfuryl thioformate | FL/FR |
| 2- | mercaptopropionic acid | FL/FR |
| 2- | methyl 5-(methyl thio) furan | FL/FR |
| 3- | thiohexanol | FL/FR |
| sweet |
| 2- | hydroxy-3,4,5-trimethyl-2-cyclopenten-1-one | FL/FR |
| vegetable |
| 1- | furfuryl pyrrole | FL/FR |
| woody |
| | juniper berry oleoresin | FL/FR |
| 2- | methyl-3-isopropyl pyrazine | |
| |
| For Flavor |
| |
| No flavor group found for these |
| 2- | acetyl-6-methyl pyrazine | FL |
| 1,2- | butane dithiol | FL |
| | coffea arabica fruit extract | FL/FR |
| | dimethyl dihydrocyclopentapyrazine | FL |
| (Z+E)-2,5- | dimethyl-3-tetrahydrofuran thiol | FL |
| (Z+E)-2,5- | dimethyl-3-thioacetoxytetrahydrofuran | FL |
| 2,5- | dimethyl-3-thiofuroyl furan | FL |
| 3-( | ethyl thio) butanol | FL |
| 2- | ethyl-3-methyl thiopyrazine | FL |
| 2- | ethyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
| (Z+E)-5- | ethyl-4-methyl-2-(2-butyl) thiazoline | FL |
| (Z+E)-5- | ethyl-4-methyl-2-(2-methyl propyl) thiazoline | FL |
| 2- | ethyl-5(or6)-methyl pyrazine | FL |
| 2- | formyl pyrrole | FL |
| 2- | hydroxy-3,4,5-trimethyl-2-cyclopenten-1-one | FL/FR |
| 3- | mercapto-3-methyl butyl formate | FL |
| 4- | mercapto-3-methyl-2-butanol | FL |
| laevo- | methionyl glycine | |
| (S)-2- | methyl butyraldehyde | |
| (R)-2- | methyl butyraldehyde | |
| | methyl dihydrofuran thiol | FL |
| 2- | methyl thiazolidine | FL |
| 2- | methyl-3-(methyl thio) pyrazine | FL/FR |
| 3-((2- | methyl-3-furyl)thio)-4-heptanone | FL |
| 1,9- | nonane dithiol | FL |
| | pyrazines mixture | FL |
| | semduramicin sodium | |
| 3- | thienyl mercaptan | FL |
|
| 5- | acetyl-2,3-dihydro-1,4-thiazine | FL |
| 3,7- | dimethyl-2,6-octadien-1-yl cyclopropyl carboxamide | FL |
| 2- | methyl-1-methyl thio-2-butene | FL |
| | pyrrolidino-(1,2E)-4H-2,4-dimethyl-1,3,5-dithiazine | FL |
| alliaceous |
| | benzyl mercaptan | FL |
| | dicyclohexyl disulfide | FL |
| | dimethyl trisulfide | FL/FR |
| | tropical thiazole | FL/FR |
| brown |
| | fenugreek oleoresin | FL/FR |
| 1- | hydroxy-2-butanone | FL/FR |
| 5- | methyl furfural | FL/FR |
| burnt |
| | furfuryl alcohol | FL |
| 2- | methyl quinoxaline | FL |
| 2,6- | xylenol | FL/FR |
| caramellic |
| | caramel furanone | FL |
| | caramel furanone solution | FL/FR |
| | cyclotene | FL/FR |
| | fenugreek resinoid | FL/FR |
| chocolate |
| | cocoa oleoresin | FL/FR |
| coffee |
| | cichorium intybus root extract | FL/FR |
| | cichorium intybus root solid extract | FL/FR |
| roasted | coffea arabica seed extract | FL/FR |
| | coffea arabica seed extract | FL/FR |
| | coffea arabica seed oil | FL/FR |
| | coffee absolute | FL/FR |
| arabica | coffee bean butter | FL/FR |
| roasted arabica | coffee bean essence | FL/FR |
| roasted | coffee bean extract | FL/FR |
| roasted arabica | coffee bean oil CO2 extract | FL/FR |
| | coffee bean oil extract | FL/FR |
| | coffee difuran | FL/FR |
| | coffee dione | FL/FR |
| | coffee distillates | FL |
| | coffee pyrazine | FL |
| | coffee resinoid | FL/FR |
| | difurfuryl ether | FL |
| | diisoamyl thiomalate | FL |
| 2,4- | dimethyl thiazole | FL |
| 2- | ethyl-4-methyl thiazole | FL/FR |
| | furfuryl mercaptan | FL/FR |
| | methyl furfuryl disulfide | FL/FR |
| | methyl furfuryl thiol | FL |
| 2- | thiophene thiol | FL |
| earthy |
| | difurfuryl sulfide | FL |
| 2- | methyl-3-isopropyl pyrazine | |
| fruity |
| | furfuryl isobutyrate | FL |
| | furfuryl isovalerate | FL |
| | furfuryl propionate | FL |
| fusel |
| 2- | methyl butyraldehyde | FL/FR |
| green |
| 2- | methyl-5-isopropyl pyrazine | FL |
| herbal |
| | wormwood oil america | FL/FR |
| | wormwood oil italy | FL/FR |
| | wormwood oil poland | FL/FR |
| meaty |
| | benzothiazole | FL/FR |
| 2,6- | dimethyl pyrazine | FL/FR |
| 2,6- | dimethyl thiophenol | FL |
| | dodecyl mercaptan | |
| 1,1- | ethane dithiol 1% in ethanol 94.5% / ethyl acetate 4% | FL |
| 3- | mercapto-2-butanone | FL |
| (R,S)-2- | mercapto-3-butanol | FL |
| 2- | mercaptopropionic acid | FL/FR |
| 2- | methyl 3-(methyl thio) furan | FL |
| 12- | methyl tridecanal | FL |
| bis(2- | methyl-3-furyl) disulfide | FL |
| S-(2- | methyl-3-furyl) ethane thioate | FL |
| | propyl 2-mercaptopropionate | FL |
| | pyrazinyl ethane thiol | FL |
| 2- | pyridinyl methane thiol | FL |
| | thialdine | FL |
| molasses |
| | molasses blackstrap | FL |
| moldy |
| | strawberry furanone methyl ether | FL/FR |
| mustard |
| | furfuryl methyl ether | FL |
| musty |
| 2- | ethoxythiazole | FL |
| | menthofuran | FL/FR |
| 2- | methyl 5-(methyl thio) furan | FL/FR |
| nutty |
| 2- | acetyl furan | FL/FR |
| 2- | acetyl-4-methyl thiazole | FL |
| 2- | butyl-2-butenal | FL |
| 3,6- | cocoa pyrazine | FL/FR |
| 3,5- | cocoa pyrazine | FL/FR |
| 2,3- | dimethyl pyrazine | FL/FR |
| 4,5- | dimethyl-2-ethyl-3-thiazoline | FL/FR |
| 2- | ethyl pyrazine | FL/FR |
| 1- | ethyl-2-acetyl pyrrole | FL |
| | filbert heptenone | FL/FR |
| | filbert heptenone B | FL/FR |
| 5- | methyl quinoxaline | FL/FR |
| | nutty pyrazine | FL/FR |
| | nutty thiazole | FL |
| | sesame absolute | FL/FR |
| | sesame absolute CO2 extract | FL/FR |
| 2,3,5,6- | tetramethyl pyrazine | FL/FR |
| 2,4,5- | trimethyl thiazole | FL/FR |
| onion |
| | furfuryl isopropyl sulfide | FL |
| popcorn |
| 2- | propionyl-2-thiazoline | FL |
| roasted |
| 2- | acetyl pyrazine | FL/FR |
| roasted arabica | coffee bean oil | FL/FR |
| | ethyl 3-(furfuryl thio) propionate | FL |
| | furfuryl thioacetate | FL/FR |
| | trigonella foenum-graecum seed oil CO2 extract | FL/FR |
| solvent |
| 2- | ethyl furan | FL |
| spicy |
| para-alpha- | dimethyl styrene | FL/FR |
| sulfurous |
| 2,3- | butane dithiol | FL |
| | butyl mercaptan | FL |
| | ethyl methyl sulfide | FL |
| S- | ethyl thioacetate | FL |
| S- | furfuryl thioformate | FL/FR |
| | furfuryl thiopropionate | FL |
| 3- | methyl-2-butane thiol | FL |
| | roasted butanol | FL |
| 2- | thienyl mercaptan | FL |
| 3- | thiohexanol | FL/FR |
| vegetable |
| 1- | furfuryl pyrrole | FL/FR |
| woody |
| | juniper berry oleoresin | FL/FR |
| |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2-[( | furan-2-ylmethyl)sulfanyl]-5-methylpyrazine | | 2-( | furan-2-ylmethylsulfanyl)-3-methylpyrazine | | ((2- | furanylmethyl)thio)methylpyrazine | | 2- | furfuryl thio-3(5/6)methyl pyrazine | | 2- | furfuryl thio-5-methyl pyrazine | | 2- | furfuryl thio-6-methyl pyrazine | | 2- | furfurylthio 3(5/6)methyl pyrazine | | 2 | furfurylthio-(3 or 5)-methylpyrazine (2-methyl-3-(furfurylthio)pyrazine) | | 2- | furfurylthio-3-methylpyrazine | | 2- | furfurylthio-3(5/6)-methyl pyrazine | | 2- | furfurylthio-5-methylpyrazine | | 2- | furfurylthio-6-methylpyrazine | | 2- | methyl-3 or 5 or 6-(furfurylthio)pyrazine (mixture of isomers) | | 2- | methyl-3-, 5- or 6-(furfurylthio)pyrazine | | 2- | methyl-3-,5 or 6-(furfurylthio) pyrazine | | 2- | methyl-3-(furfurylthio)pyrazine | | 2- | methyl-3,5 and 6-(furfurylthio)pyrazine | | 2- | methyl-3,5 or 6-(furfurylthio)-pyrazine | | 2- | methyl-3,5 or 6-(furfurylthio)pyrazine | | 2- | methyl-3,5,6-(furfurylthio)pyrazine | | 2- | methyl-3(5/6)(furfurylthio) | | 2- | methyl-3(or 5 or 6)-(furfurylthio)pyrazine | | | pyrazine, ((2-furanylmethyl)thio)methyl- | | | pyrazine, 2-((2-furanylmethyl)thio)-3-methyl- |
Articles:
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