| Name: | saussurea lappa root oil |
| CAS Number: | 8023-88-9 |
|
| FDA UNII: | 2WF6750061 |
| MDL: | MFCD01771687 |
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | pale yellow solid (est) |
| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | alcohol | | | water, 9.376 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
| Stability: |
| | non-discoloring in most media |
Organoleptic Properties:
| |
| Odor Type: animal |
| |
| Odor Strength: | medium |
| |
| Substantivity: | 316 hour(s) at 100.00 % |
| |
| | orris green hairy woody melon unripe melon |
Odor Description: at 100.00 %. | orris green hairy woody unripe melons Luebke, William tgsc, (1983) |
| |
| |
| Flavor Type: orris |
| |
| | costus |
Taste Description:
| costus |
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| Firmenich |
| COSTUS EO Kosher for flavor |
| Odor Description: | orris green hairy woody unripe melons |
| Taste Description: | Fatty metallic like herbal For creation in spirits tonalities and brown notes |
| |
| |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | None - None found. |
S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes.
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| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 3400 mg/kg Food and Cosmetics Toxicology. Vol. 12, Pg. 867, 1974.
|
| Dermal Toxicity: |
skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 12, Pg. 867, 1974.
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| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | flavoring agents |
| IFRA Critical Effect: | Dermal sensitization |
| IFRA: | View Standard |
| Recommendation for costus root oil usage levels up to: | | | PROHIBITED: Should not be used as a fragrance ingredient.
|
| |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 3 |
| Click here to view publication 3 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 1.20000 |
| beverages(nonalcoholic): | - | 0.08000 |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | 0.90000 |
| fruit ices: | - | 0.90000 |
| gelatins / puddings: | - | 0.10000 |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | 1.90000 |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | aplotaxis lappa root oil | | | aucklandia costus root oil | | | auklandra costus root oil | | | costus oil | | | costus oil 100 | | | costus root oil (saussurea lappa clarke) | | | saussurea costus root oil | | | saussurea lappa root oil | | | spiral flag root oil (saussurea lappa clarke) |
Articles:
| PubMed: | UPLC/MS/MS method for quantification and cytotoxic activity of sesquiterpene lactones isolated from Saussurea lappa. |
| PubMed: | Volatile constituents of Saussurea costus roots cultivated in Uttarakhand Himalayas, India. |
| PubMed: | Evaluation of anti-resistant activity of Auklandia (Saussurea lappa) root against some human pathogens. |
| PubMed: | Aqueous extract of Saussurea lappa root ameliorate oxidative myocardial injury induced by isoproterenol in rats. |
| PubMed: | Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells. |
| PubMed: | Larvicidal activity of medicinal plant extracts and lignan identified in Phryma leptostachya var. asiatica roots against housefly (Musca domestica L.). |
| PubMed: | Matrix solid-phase dispersion extraction coupled with HPLC-diode array detection method for the analysis of sesquiterpene lactones in root of Saussurea lappa C.B.Clarke. |
| PubMed: | Dehydrocostus lactone prevents mitochondrial dysfunction in osteoblastic MC3T3-E1 cells. |
| PubMed: | A new sesquiterpene and other constituents from Saussurea lappa root. |
| PubMed: | Antihepatotoxic activity of Saussurea lappa extract on D-galactosamine and lipopolysaccharide-induced hepatitis in mice. |
| PubMed: | Apoptosis of DU145 human prostate cancer cells induced by dehydrocostus lactone isolated from the root of Saussurea lappa. |
| PubMed: | Authentication of Saussurea lappa, an endangered medicinal material, by ITS DNA and 5S rRNA sequencing. |
| PubMed: | Effects of Saussurea lappa roots extract in ethanol on leukocyte phagocytic activity, lymphocyte proliferation and interferon-gamma (IFN-gamma). |
| PubMed: | Presence of cholinergic and calcium antagonist constituents in Saussurea lappa explains its use in constipation and spasm. |
| PubMed: | Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells. |
| PubMed: | Costunolide inhibits interleukin-1beta expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells. |
| PubMed: | Cytotoxic sesquiterpene lactones from the root of Saussurea lappa. |
| PubMed: | Germacrenes from fresh costus roots. |
| PubMed: | Costunolide induces apoptosis by ROS-mediated mitochondrial permeability transition and cytochrome C release. |
| PubMed: | Inhibition of inducible nitric oxide synthesis by the herbal preparation Padma 28 in macrophage cell line. |
| PubMed: | Effect of dehydrocostus lactone and costunolide from Saussurea root on the central nervous system in mice. |
| PubMed: | Effect of polyols on heat inactivation of Aspergillus niger van Teighem inulinase. |
| PubMed: | Active compounds from Saussurea lappa Clarks that suppress hepatitis B virus surface antigen gene expression in human hepatoma cells. |
| PubMed: | Saussureamines A, B, C, D, and E, new anti-ulcer principles from Chinese Saussureae Radix. |
| PubMed: | Sesquiterpenoids from costum root oil (Saussurea lappa Clarke) |
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