dihydrocoumarin
3,4-dihydrocoumarin
 
Notes:
Isol. from flowers of Melilotus alba (white melilot) Isol. from Melilotus officinalis (sweet clover). Flavouring ingredient
  • ACS International
    • ACS International GmbH
      Creativity Beyond Chemistry
      Production • Distribution • Sourcing • Logistics • Consulting
      Our hybrid business model, combining manufacturing with sourcing and exclusive distribution agreements, results in a superior level of purchasing power that when added to our global warehouse network with locations near all major flavor and fragrance industry compounding centers around the globe, make A.C.S. International your one-stop sourcing partner.
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      Product(s):
      10922 Dihydrocumarine
       
  • Advanced Biotech
    • Advanced Biotech. Inc.
      Inspired by Nature
      A diverse range of products, all meeting our stringent commitment to quality.
      Advanced Biotech is a leading manufacturer and supplier of high-quality Natural flavoring ingredients & botanical extracts for the food/beverage, cosmetic and personal care industries. With over 25 years of experience working with Fermentation processing & botanical extracts, we can help develop new innovative and functional products for today’s competitive marketplace. Our company prides itself in the ability to cater to our customer’s specific needs while maintaining our focus on integrity, honesty and the commitment to high quality product standards. We proudly offer our quality Natural ingredients to companies around the world.
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      1410 BENZO DIHYDROPYRONE NATURAL 98% min.
      SDS
      2233 BENZO DIHYDROPYRONE SYNTHETIC 98% min.
      SDS
       
  • Augustus Oils
    • Augustus Oils Ltd
      The Premier Supplier
      Augustus Oils Ltd, in harmony with nature - to present it at its best...
      A wealth of experience, expertise and knowledge has allowed Augustus to bridge the gulf in expectation and trust between growers and users of natural ingredients. The Company works in partnership with customers on the one hand, and growers, farmers and distillers on the other. Both users and producers can then focus on exactly what they do best, while skilled Augustus technicians closely monitor and control the delivered product. This ensures users can have the confidence that they will receive the best raw materials suited to their requirements.
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      Dihydro Coumarin
       
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
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      Product(s):
      20047 Dihydrocoumarin (natural)
      10749 Dihydrocoumarin
       
  • Berjé
    • Berje Inc.
      Where the world comes to its senses
      Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.
      Berjé is a family-owned business that has been in operation for six decades. The company's origins and strength lie in a profound understanding of the supply and the quality of the diverse raw materials consumed by the flavor and fragrance industries. This base was expanded upon more than two decades ago to include fragrance production. The company's unparalleled raw material expertise is focused on the supply of essential oils and aromatic chemicals. This is supported by our long-standing relationships with a worldwide fabric of producers ensuring the greatest prospects for uninterrupted supply in markets that are often volatile and unpredictable.
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      Benzo Dihydropyrone
       
  • BOC Sciences
    • BOC Sciences
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      Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
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      Product(s):
      119-84-6 Hydrocoumarin >98%
       
  • Elan Inc.
    • Elan Inc.
      Legacy of Innovation
      Highest quality natural and synthetic products.
      Elan Inc. is a privately held business that has been in operation for over 30 years. Our offices and production facility are located in Newark, NJ. We are dedicated to producing the highest quality natural and synthetic products available in the flavor and fragrance industry.
      US Email: Mr. David Pimentel
      US Email: Ms. Isabel Couto
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      BENZO DIHYDRO PYRONE FCC, Kosher
      SDS
       
  • Excellentia International
    • Excellentia International
      Ingredients by Nature
      Exceptional quality and excellence in meeting our customers requirements.
      Excellentia International was founded in 2010 through the merger of Excellentia Flavors LLC and Polarome International. Collectively, these companies account for more than one hundred years of industry experience, and are recognized for exceptional quality and excellence in meeting our customers’ requirements.
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      Product(s):
      Benzodihydropyrone FCC (Dihydrocoumarin)
       
  • Fleurchem
    • Fleurchem, Inc.
      Have A Flavorful Day
      A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.
      Operating out of the 200,000 sq. ft., former Hercules/PFW facility in Middletown, NY; Fleurchem produces a full range of natural isolates, synthetic chemicals & specialities, essential oils and flavors. Additionally, the company performs toll manufacturing, as well as custom chemical synthesis for a wide range of clients.
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      Product(s):
      benzodihydropyrone
       
  • Indukern F&F
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co., Ltd
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
      Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
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      Product(s):
      HLK091 Dihydrocoumarin Natural99%
       
  • Lluch Essence
    • Lluch Essence S.L.
      A family company dedicated to sales and distribution
      Flexibility, availability, price and quality.
      Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world.
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      Product(s):
      DIHYDROCOUMARIN
      DIHYDROCOUMARIN NATURAL 99%
       
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers.
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      Product(s):
      A0037 Dihydrocoumarin, Kosher
      N0170 NAT.DIHYDROCOUMARIN
       
  • Moellhausen
  • Penta International
    • Penta International Corporation
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      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
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      Product(s):
      02-11200 BENZODIHYDROPYRONE
      02-11220 BENZODIHYDROPYRONE NATURAL
       
  • PerfumersWorld
    • PerfumersWorld Ltd.
      feeeel... the smell!
      The one-stop resource for the creative perfumer.
      No minimum orders. Aroma chemicals, essential oils, isolates, pheremones, absolutes, resinoids, FleuressenceTM key bases, PWx FactorTM, solubilizers, kits, creation systems, workshops, training, distance learning, The PerfumersWorld Perfumer's Studio, The Perfumer’s Formulation Bulletin, perfumery software, bespoke creation, analysis, consultancy, project counselling, trouble-shooting, unperfumed product bases, bottles, smelling strips, scales, distillation, equipment and inspiration!
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      Product(s):
      1VD00148 Dihydro coumarin
       
  • Sigma-Aldrich
  • SRS Aromatics
    • SRS Aromatics Ltd
      For over 25 years
      Bringing flavour and fragrance into your world.
      As suppliers / distributors of ingredients to the fragrance and flavour industries, our goal is to provide high quality materials at competitive prices with an exceptional level of service. Established in 1984, SRS Aromatics Ltd is an independent family owned business which has become very well-respected within the fragrance and flavour industry as a reliable and trustworthy partner. Over the years this has allowed the company to develop strong relationships with many global manufacturers; several of whom we represent in the UK. A core aim of our business is to work extremely closely with both our suppliers and customers to maximise service levels with minimum disruption to supply.
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      DIHYDRO COUMARIN
      DIHYDRO COUMARIN EU NATURAL
       
  • Sunaux International
    • Sunaux International
      Buy With Confidence
      We have industry leading processes and procedures to ensure nothing but the most reliable product.
      Sunaux International was founded in 2012 by the owner Mr.John Felton after spending 18 years involved in developing global business in the aromatic chemicals, fragrance and flavour compounds business.
      Email: John Felton
      Email: Stephen Zhou (Sales)
      Voice: 0512-57995626
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      Product(s):
      A0039 Dihydrocoumarin
       
  • TCI AMERICA
    • TCI AMERICA
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping!
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis.
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      Product(s):
      D1223 3,4-Dihydrocoumarin >98.0%(GC)
      SDS
       
  • The Lermond Company
    • The Lermond Company
      Your Sourcing Resource
      The Lermond family has been sourcing raw materials for the flavor and fragrance industry for nearly 7 decades.
      The Lermond Company is a women-owned distributor of raw materials primarily servicing the flavor and fragrance industry. For three generations, members of the Lermond family have been integral sourcing partners for the North American flavor and fragrance industry. We supply high quality essential oils, aroma chemicals, absolutes, concretes, resinoids and floral waters from around the world to the global industry.
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      Email: Tara
      Email: Erica
      Voice: 201-896-3300
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      Product(s):
      17807 DIHYDRO COUMARIN
       
  • R C Treatt & Co Ltd
    • R C Treatt and Co Ltd
      Innovative ingredient solutions
      World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.
      We offer innovative and trend-setting product concepts for our customers, collaborating with them to create true value for their products.
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      US Email: Enquiries
      Voice: +44 (0) 1284 702500
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      Product(s):
      Dihydrocoumarin
       
  • United International
    • Qingdao Free Trade Zone United International Co Ltd
      Quality Products
      A partner in your supply chain solution.
      Qingdao Free Trade Zone United International Trade Co., Ltd.was founded in 1996, specializing in the production and import and export of food additives,flavor raw materials and pharmaceutical and chemical raw materials. The company has experienced R&D and business personnel,product quality, low price, efficient service and fast insight and grasp the latest market information.
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      Voice: +86-532-83893699
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      Product(s):
      7173 3,4-Dihydrocoumarin
       
  • Ernesto Ventós
  • Vigon International
    • Vigon International
      Passion for Simplicity
      Manufacturer and supplier of high quality flavor and fragrance ingredients.
      The growth and success of Vigon is due in large part to a unique corporate concept that Vigon has developed and established within the industry: Creative Partnerships. This partnership concept has been and continues to be the foundation and guiding principle for all of Vigon's activities.
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      Product(s):
      500789 Dihydrocoumarin FCC
      504757 Dihydrocoumarin Natural
       
  • WholeChem
    • WholeChem, LLC
      Connecting Innovators To the Building Blocks Of the Universe
      Custom manufacturer and distributor of specialty ingredients. We make global local.
      SQF-Certified Supplier
      We owe our success to our integrity, our dedication to the industry, and our commitment to our clients. We invite your inquiries regarding our current product list and any other products you may be having trouble sourcing.
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      Product(s):
      Dihydrocoumarin
       
Synonyms   Articles   Notes   Search
Fragrance Demo Formulas    Flavor Demo Formulas
CAS Number: 119-84-6Picture of molecule3D/inchi
Other(deleted CASRN): 1341-36-2
ECHA EINECS - REACH Pre-Reg: 204-354-9
FDA UNII: NM5K1Y1BT2
Nikkaji Web: J36.832F
Beilstein Number: 0004584
MDL: MFCD00006881
CoE Number: 535
XlogP3-AA: 1.60 (est)
Molecular Weight: 148.16116000
Formula: C9 H8 O2
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome, Edge or firefox)
Category: flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 1171  dihydrocoumarin
DG SANTE Food Flavourings: 13.009  3,4-dihydrocoumarin
FEMA Number: 2381 dihydrocoumarin
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):119-84-6 ; DIHYDROCOUMARIN
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: colorless to pale yellow clear liquid to solid (est)
Assay: 99.00 to 100.00 % 
Food Chemicals Codex Listed: Yes
Specific Gravity: 1.18600 to 1.19200 @  25.00 °C.
Pounds per Gallon - (est).: 9.869 to  9.919
Refractive Index: 1.54000 to 1.58000 @  20.00 °C.
Melting Point: 24.00 to  25.00 °C. @ 760.00 mm Hg
Boiling Point: 271.00 to  272.00 °C. @ 760.00 mm Hg
Congealing Point: 23.00 °C.
Acid Value: 5.00 max. KOH/g
Vapor Pressure: 4.000000 mmHg @ 25.00 °C.
Flash Point: > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w): 2.428 (est)
Shelf Life: 24.00 month(s) or longer if stored properly.
Storage: store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in:
 alcohol
 water, 3000 mg/L @ 37 °C (exp)
Insoluble in:
 water
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
 
Odor Type: tonka
 
Odor Strength: medium ,
recommend smelling in a 10.00 % solution or less
 
Substantivity: 228 hour(s) at 100.00 %
 
 sweet  tonka  coumarinic  coconut  herbal  cinnamon  balsamic  
Odor Description:
at 10.00 % in dipropylene glycol. 
sweet tonka coumarinic coconut herbal cinnamon balsamic
Luebke, William tgsc, (1987)
 
 sweet  creamy  coconut  coumarinic  vanilla  spicy  
Odor Description:
Sweet, creamy, coconut, coumarin, vanilla with a slight spice nuance
Mosciano, Gerard P&F 17, No. 3, 57, (1992)
 
 
Flavor Type: creamy
 
 creamy  coconut  coumarinic  vanilla  cinnamyl  balsamic  spicy  cardamom  
Taste Description:
creamy coconut coumarinic vanilla cinnamyl balsamic spicy cardamom
Luebke, William tgsc, (1987)
 
 sweet  creamy  vanilla  coconut  milky  
Taste Description:
at 10.00 ppm.  
Sweet, creamy, vanilla, coconut and milky
Mosciano, Gerard P&F 17, No. 3, 57, (1992)
 
Odor and/or flavor descriptions from others (if found).
 
Sigma-Aldrich
Dihydrocoumarin, ≥99%, FCC, FG
Odor Description: almond; coconut; creamy; herbaceous; sweet; vanilla; nutty; tobacco.
Taste Description: sweet creamy vanilla coconut milky
 
Moellhausen
DIHYDROCOUMARIN
Odor Description: sweet, cocoa
Taste Description: sweet, vanilla, milk
 
PerfumersWorld
Dihydro coumarin
Odor Description: sweet rose coumarin tonka herbal sweet aromatic coumarin coconut
 
Perfumery Laboratory
TONCAINOL
Odor Description: Sweet, vanilla with bright notes of beans
 
Indukern F&F
DIHYDROCOUMARIN NATURAL
Odor Description: SWEET, AROMATIC, COUMARIN, CINNAMON
 
 
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: not used anymore
Synonyms   Articles   Notes   Search   Top
Suppliers:
ACS International
Dihydrocumarine
Odor: sweet tonka coumarin coconut herbal cinnamon
Operational Capabilities
Advanced Biotech
BENZO DIHYDROPYRONE NATURAL
98% min.
Odor: Herbaceous, Woody
Advanced Biotech
BENZO DIHYDROPYRONE SYNTHETIC
98% min.
Odor: Herbaceous, Woody
Alfa Biotechnology
For experimental / research use only.
Hydrocoumarin 98%
Anhui Haibei
Dihydro coumarin
Odor: Sweetish, fruity or herbal
Augustus Oils
Dihydro Coumarin
Services
Aurochemicals
BENZODIHYDROPYRONE, Natural
Beijing Lys Chemicals
Dihydrocoumarin (natural)
Beijing Lys Chemicals
Dihydrocoumarin
Bell Flavors & Fragrances
Natural Benzodihydropyrone (BDHP)
Berjé
Benzo Dihydropyrone
Media
BOC Sciences
For experimental / research use only.
Hydrocoumarin >98%
Citrus and Allied Essences
Benzo Dihydropyrone
Market Report
Diffusions Aromatiques
DIHYDROCOUMARINE
Elan Inc.
BENZO DIHYDRO PYRONE
FCC, Kosher
EMD Millipore
For experimental / research use only.
Dihydrocoumarin
Ernesto Ventós
DIHYDROCOUMARIN, NATURAL
Ernesto Ventós
DIHYDROCOUMARIN
Odor: SWEET,COUMARIN BUT SLIGHTLY BITTER
Excellentia International
Benzodihydropyrone FCC (Dihydrocoumarin)
ExtraSynthese
For experimental / research use only.
3,4-Dihydrocoumarin (GC) ≥95%
Fleurchem
benzodihydropyrone
Indukern F&F
DIHYDROCOUMARIN NATURAL
Odor: SWEET, AROMATIC, COUMARIN, CINNAMON
Indukern F&F
DIHYDROCOUMARIN
Jiangyin Healthway
Dihydrocoumarin Natural99%
New functional food ingredients
K.L. Koh Enterprise
DIHYDROCOUMARIN
Lluch Essence
DIHYDROCOUMARIN NATURAL 99%
Lluch Essence
DIHYDROCOUMARIN
M&U International
Dihydrocoumarin, Kosher
M&U International
NAT.DIHYDROCOUMARIN
Moellhausen
DIHYDROCOUMARIN
Odor: sweet, cocoa
Flavor: sweet, vanilla, milk
Pearlchem Corporation
Dihydro Coumarin
Penta International
BENZODIHYDROPYRONE NATURAL
Penta International
BENZODIHYDROPYRONE
PerfumersWorld
Dihydro coumarin
Odor: sweet rose coumarin tonka herbal sweet aromatic coumarin coconut
Perfumery Laboratory
TONCAINOL
Odor: Sweet, vanilla with bright notes of beans
Phoenix Aromas & Essential Oils
Dihydrocoumarin (Benzodihydropyrone)
Prinova
Di Hydro Coumarin
R C Treatt & Co Ltd
Dihydrocoumarin
Reincke & Fichtner
Dihydrocoumarin
Santa Cruz Biotechnology
For experimental / research use only.
Dihydrocoumarin ≥98%
Sigma-Aldrich
Dihydrocoumarin, ≥99%, FCC, FG
Odor: almond; coconut; creamy; herbaceous; sweet; vanilla; nutty; tobacco.
Certified Food Grade Products
SRS Aromatics
DIHYDRO COUMARIN EU NATURAL
SRS Aromatics
DIHYDRO COUMARIN
Sunaux International
Dihydrocoumarin
TCI AMERICA
For experimental / research use only.
3,4-Dihydrocoumarin >98.0%(GC)
Tengzhou Xiang Yuan Aroma Chemicals
Dihydrocoumarin
The Lermond Company
DIHYDRO COUMARIN
The Perfumers Apprentice
Dihydrocoumarin 10% (PG)
Odor: Sweet, creamy, vanilla, coconut and milky
United International
3,4-Dihydrocoumarin
Universal Preserv-A-Chem Inc.
BENZODIHYDROPYRONE
Vigon International
Dihydrocoumarin FCC
Odor: Sweet-aromatic like coumarin, with pronounced cinnamon and caramel note
Vigon International
Dihydrocoumarin Natural
Vistachem
Dihydrocoumarin
WEN International
BENZODIHYDROPYRONE, natural
WholeChem
Dihydrocoumarin
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Human Experience:
20 % solution: no irritation or sensitization.
Oral/Parenteral Toxicity:
oral-rat LD50  1460 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

intraperitoneal-mouse LD50  200 mg/kg
National Technical Information Service. Vol. AD277-689

oral-guinea pig LD50  1760 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.

Dermal Toxicity:
skin-rabbit LD50 > 5000 mg/kg
Food and Cosmetics Toxicology. Vol. 12, Pg. 521, 1974.

Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
IFRA Critical Effect: Dermal sensitization and systemic toxicity
IFRA: View Standard
View IFRA Standards Library for complete information.
Please review Amendment 49 IFRA documentation for complete information.
IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%):
Category 1: Products applied to the lips
0.077 %
Category 2: Products applied to the axillae
0.023 %
Category 3: Products applied to the face/body using fingertips
0.46 %
Category 4: Products related to fine fragrance
0.43 %
 Category 5: Products applied to the face and body using the hands (palms), primarily leave-on
Category 5A: Body lotion products applied to the body using the hands (palms), primarily leave-on
0.11 %
Category 5B: Face moisturizer products applied to the face using the hands (palms), primarily leave-on
0.11 %
Category 5C: Hand cream products applied to the hands using the hands (palms), primarily leave-on
0.11 %
Category 5D: Baby Creams, baby Oils and baby talc
0.03 %
Category 6: Products with oral and lip exposure
0.25 %
 Category 7: Products applied to the hair with some hand contact
Category 7A: Rinse-off products applied to the hair with some hand contact
0.88 %
Category 7B: Leave-on products applied to the hair with some hand contact
0.88 %
Category 8: Products with significant anogenital exposure
0.03 %
Category 9: Products with body and hand exposure, primarily rinse off
0.84 %
 Category 10: Household care products with mostly hand contact
Category 10A: Household care excluding aerosol products (excluding aerosol/spray products)
0.84 %
Category 10B: Household aerosol/spray products
3.00 %
 Category 11: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate
Category 11A: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure
0.03 %
Category 11B: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure
0.03 %
Category 12: Products not intended for direct skin contact, minimal or insignificant transfer to skin
No Restriction
 Notes:
IFRA FLAVOR REQUIREMENTS:

Due to the possible ingestion of small amounts of fragrance ingredients from their use in products in Categories 1 and 6, materials must not only comply with IFRA Standards but must also be recognized as safe as a flavoring ingredient as defined by the IOFI Code of Practice (www.iofi.org). For more details see chapter 1 of the Guidance for the use of IFRA Standards.

 
Maximised Survey-derived Daily Intakes (MSDI-EU): 1200.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 1111.00 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3. Update in publication number(s): 29
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: 141.00000165.00000
beverages(nonalcoholic): 25.0000028.00000
beverages(alcoholic): 0.300002.00000
breakfast cereal: --
cheese: --
chewing gum: 20.00000250.00000
condiments / relishes: 10.0000015.00000
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 95.00000104.00000
fruit ices: --
gelatins / puddings: 116.00000132.00000
granulated sugar: --
gravies: --
hard candy: 8.0000044.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: 111.00000131.00000
soups: --
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of lactones used as flavor ingredients. View pdf
European Food Safety Athority(EFSA): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Flavouring Group Evaluation 80 (FGE.80) - Consideration of alicyclic, alicyclic-fused and aromatic-fused ring lactones evaluated by JECFA (61st meeting) structurally related to a aromatic lactone evaluated by EFSA in FGE.27 (2008)
View page or View pdf
Flavouring Group Evaluation 80, Revision 1 (FGE.80Rev1): Consideration of alicyclic, alicyclic-fused and aromatic-fused ring lactones evaluated by JECFA (61st meeting) structurally related to a aromatic lactone evaluated by EFSA in FGE.27 (2008)
View page or View pdf
Scientific Opinion on the safety and efficacy of alicyclic and aromatic lactones (chemical group 11) when used as flavourings for all animal species
View page or View pdf
EPI System: View
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
Carcinogenic Potency Database: Search
EPA Substance Registry Services (TSCA): 119-84-6
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 660
National Institute of Allergy and Infectious Diseases: Data
SCCNFP: opinion
WGK Germany: 3
 chroman-2-one
Chemidplus: 0000119846
EPA/NOAA CAMEO: hazardous materials
RTECS: MW5775000 for cas# 119-84-6
Synonyms   Articles   Notes   Search   Top
References:
 chroman-2-one
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 119-84-6
Pubchem (cid): 660
Pubchem (sid): 134974732
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
CHEBI: View
CHEMBL: View
Metabolomics Database: Search
UM BBD: Search
KEGG (GenomeNet): C02274
HMDB (The Human Metabolome Database): HMDB36626
FooDB: FDB015543
Export Tariff Code: 2932.20.4500
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
For Odor
aldehydic
aldehydic
 acetyl nonyrylFL/FR
amber
 angelica root oilFL/FR
 cistus ladaniferus resinoidFL/FR
animal
 animal carbolactoneFR
 civet absoluteFL/FR
 costus valerolactoneFR
 indoleFL/FR
6-methyl quinolineFL/FR
anisic
para-anisaldehydeFL/FR
balsamic
 amyris wood oilFL/FR
sumatra benzoin resinoidFL/FR
siam benzoin resinoidFL/FR
 benzyl cinnamateFL/FR
 benzyl salicylateFL/FR
isobutyl cinnamateFL/FR
 copaiba balsam oilFL/FR
 ethyl cinnamateFL/FR
 fir balsam absoluteFR
 methyl cinnamateFL/FR
 peru balsam oilFL/FR
 pine needle absoluteFL/FR
berry
 raspberry ketoneFL/FR
buttery
 acetoinFL/FR
 acetyl butyrylFL/FR
 acetyl isobutyrylFL/FR
 acetyl propionylFL/FR
 butyl butyryl lactateFL/FR
caramellic
2-oxobutyric acidFL/FR
 ethyl maltolFL/FR
 fenugreek absoluteFL/FR
 immortelle absoluteFL/FR
 strawberry furanone acetateFL/FR
cheesy
 butyric acidFL/FR
2-heptanoneFL/FR
citrus
 lime oil expressed floridaFL/FR
coconut
alpha-angelica lactoneFL/FR
 coconut decanone methylFR
 coconut naphthalenoneFL/FR
delta-decalactoneFL/FR
delta-2-dodecenolactoneFL/FR
gamma-heptalactoneFL/FR
delta-heptalactoneFL/FR
delta-nonalactoneFL/FR
gamma-nonalactone (aldehyde C-18 (so-called))FL/FR
gamma-octalactoneFL/FR
delta-octalactoneFL/FR
 propyl octanoateFL/FR
 tetrahydrojasmoneFR
delta-undecalactoneFL/FR
 wine lactoneFL/FR
coumarinic
 coumaneFL/FR
 phthalideFL/FR
 tonka bean oleoresinFR
 tonka bean resinoidFR
 tonka furanoneFL/FR
 tonka ketoneFR
 tonkavertFR
creamy
gamma-butyrolactoneFL/FR
 creamy lactoneFL/FR
3-heptyl dihydro-5-methyl-2(3H)-furanoneFL/FR
para-vanillic acidFL/FR
para-vanillyl alcoholFL/FR
earthy
1-nonen-3-olFL/FR
fatty
(Z)-dairy lactoneFL/FR
 ethyl undecylenateFL/FR
4-methyl octanoic acidFL/FR
fermented
 butyl laevo-lactateFL/FR
floral
 acetophenoneFL/FR
isoamyl salicylateFL/FR
para-anisyl nitrileFR
isobutyl salicylateFL/FR
 cananga oilFL/FR
 dihydrojasmoneFL/FR
 dihydrojasmone lactoneFL/FR
 floral pyranolFR
 heliotropinFL/FR
 heliotropyl acetoneFL/FR
 heliotropyl diethyl acetalFR
 hexenyl cyclopentanoneFR
alpha-hexyl cinnamaldehydeFL/FR
 hydroxycitronellalFL/FR
 jasmin lactone (IFF)FL/FR
 lavender oilFL/FR
para-methyl acetophenoneFL/FR
 nerolidolFL/FR
 ocean propanalFL/FR
 orris rhizome absolute (iris pallida)FL/FR
 palmarosa oilFL/FR
2-pentyl cyclopentanoneFR
 phenethyl phenyl acetateFL/FR
fruity
 acetoin acetateFL/FR
 amyl heptanoateFL/FR
isoamyl octanoateFL/FR
 benzaldehydeFL/FR
 cherry propanolFL/FR
gamma-decalactoneFL/FR
 farnesyl acetoneFL/FR
4-hydroxybenzyl alcoholFL/FR
 methyl (Z)-5-octenoateFL/FR
 octyl butyrateFL/FR
isopropyl octanoateFL/FR
 tolualdehydes (mixed o,m,p)FL/FR
gamma-undecalactone (aldehyde C-14 (so-called))FL/FR
green
isobutyl benzyl carbinolFL/FR
 butyl lactateFL/FR
alpha-decalactoneFL/FR
 diphenyl methaneFL/FR
 galbanum oilFL/FR
(Z)-4-hepten-1-olFL/FR
(Z)-4-heptenalFL/FR
(Z)-4-heptenal diethyl acetalFL/FR
 heptyl heptanoateFL/FR
3-phenyl propionaldehydeFL/FR
 syringaldehydeFL/FR
hay
 hay absoluteFR
herbal
 apium graveolens seed oil indiaFL/FR
 immortelle flower oilFL/FR
abrialis lavandin oilFL/FR
 linalyl acetateFL/FR
 origanum oil greeceFL/FR
melon
 watermelon ketoneFR
mossy
 oakmoss absoluteFL/FR
 treemoss absoluteFR
 veramoss (IFF)FR
mushroom
3-octen-2-olFL/FR
musty
2-acetyl pyrroleFL/FR
naphthyl
2,4-dimethyl benzaldehydeFL/FR
beta-naphthyl ethyl etherFL/FR
beta-naphthyl methyl etherFL/FR
nutty
2-acetyl-5-methyl furanFL/FR
phenolic
ortho-guaiacolFL/FR
powdery
para-anisyl acetateFL/FR
para-anisyl alcoholFL/FR
soapy
 ethyl undecanoateFL/FR
spicy
 benzyl isoeugenolFL/FR
 croton eluteria bark oilFL/FR
 cubeb oilFL/FR
isoeugenyl acetateFL/FR
 ginger root oil chinaFL/FR
 levisticum officinale root oilFL/FR
para-methoxy-alpha-methyl cinnamaldehydeFL/FR
para-methoxycinnamaldehydeFL/FR
alpha-methyl cinnamaldehydeFL/FR
 methyl heptadienoneFL/FR
alpha-methyl-(E)-cinnamaldehydeFL/FR
 myrtenalFL/FR
 nutmeg oilFL/FR
sweet
 vanilla oleoresin baliFL/FR
thujonic
 armoise oilFR
tonka
6-amyl-alpha-pyroneFL/FR
 coumarinFR
 deertongue absoluteFR
 deertongue oleoresinFR
 flouve absoluteFR
gamma-hexalactoneFL/FR
 melilot absoluteFR
7-methyl coumarinCS
 mint lactoneFL/FR
 octahydrocoumarinFL/FR
 tonka bean absoluteFR
 tonka undecanoneFR
 whiskey lactoneFL/FR
tropical
delta-dodecalactoneFL/FR
 glyceryl 5-hydroxydecanoateFL/FR
 glyceryl 5-hydroxydodecanoateFL/FR
vanilla
ortho-dimethyl hydroquinoneFL/FR
 ethyl vanillinFL/FR
 ethyl vanillin isobutyrateFL/FR
 ethyl vanillin propylene glycol acetalFL/FR
 methyl vanillateFL/FR
 propenyl guaetholFL/FR
 vanilla bean absolute (vanilla planifolia)FL/FR
 vanillinFL/FR
 vanillyl acetateFL/FR
 vanillyl isobutyrateFL/FR
 vanillylidene acetoneFL/FR
vegetable
 methionalFL/FR
waxy
 allyl nonanoateFL/FR
1-dodecanolFL/FR
 ethyl palmitateFL/FR
 methyl laurateFL/FR
 myristyl alcoholFL/FR
2-nonanolFL/FR
 octyl isobutyrateFL/FR
delta-tetradecalactoneFL/FR
2-tridecanoneFL/FR
 undecanoic acidFL/FR
woody
 guaiacwood oilFL/FR
 methyl cedryl ketoneFL/FR
 patchouli ethanoneFR
 patchouli oilFL/FR
 sandalwood oilFL/FR
 santallFR
 spruce needle oil canadaFL/FR
 tobacarol (IFF)FR
 vetiver oil haitiFL/FR
 vetiverolFL/FR
 woody acetateFR
(Z)-woody amyleneFR
 woody propanolFR
 
For Flavor
 
No flavor group found for these
 allyl methyl trisulfideFL
 cistus ladaniferus resinoidFL/FR
 coconut naphthalenoneFL/FR
 coumaneFL/FR
alpha-decalactoneFL/FR
6-decenoic acidFL
(S)-dihydroactinidiolideFL
 dimethyl benzofuranoneFL
ortho-dimethyl hydroquinoneFL/FR
delta-2-dodecenolactoneFL/FR
 farnesyl acetoneFL/FR
 fig leaf absoluteFL
2-furfurylidene butyraldehydeFL
 jasmin lactone (IFF)FL/FR
 melilot oleoresinFL
para-methoxy-alpha-methyl cinnamaldehydeFL/FR
7-methoxycoumarinFL
 methyl vanillateFL/FR
 myristyl alcoholFL/FR
4-octen-3-oneFL
 pine needle absoluteFL/FR
 propyl octanoateFL/FR
(R)-tonka furanoneFL
 tonka furanoneFL/FR
 wine lactoneFL/FR
aldehydic
 acetyl nonyrylFL/FR
amber
isobutyl benzyl carbinolFL/FR
animal
 civet absoluteFL/FR
 indoleFL/FR
6-methyl quinolineFL/FR
balsamic
sumatra benzoin resinoidFL/FR
siam benzoin resinoidFL/FR
 benzyl salicylateFL/FR
isobutyl cinnamateFL/FR
 copaiba balsam oilFL/FR
 ethyl cinnamateFL/FR
 peru balsam oilFL/FR
 vanillylidene acetoneFL/FR
berry
 heliotropyl acetoneFL/FR
 raspberry ketoneFL/FR
bitter
 glyceryl tributyrateFL
brown
2-oxobutyric acidFL/FR
buttery
 butter cream frosting flavorFL
 butyl laevo-lactateFL/FR
 diacetylFL
cabbage
 methyl 2-thiofuroateFL
caramellic
 caramel furanoneFL
 ethyl maltolFL/FR
 fenugreek absoluteFL/FR
 strawberry furanone acetateFL/FR
cheesy
2-heptanoneFL/FR
cherry
 heliotropinFL/FR
para-methoxycinnamaldehydeFL/FR
citrus
 lime oil expressed floridaFL/FR
cocoa
 syringaldehydeFL/FR
coconut
delta-decalactoneFL/FR
(R)-massoia lactoneFL
6-methyl coumarinFL
gamma-nonalactone (aldehyde C-18 (so-called))FL/FR
 octahydrocoumarinFL/FR
delta-octalactoneFL/FR
cooling
isobutyl salicylateFL/FR
coumarinic
 phthalideFL/FR
creamy
 acetoinFL/FR
 acetyl butyrylFL/FR
 acetyl isobutyrylFL/FR
6-amyl-alpha-pyroneFL/FR
alpha-angelica lactoneFL/FR
para-anisaldehydeFL/FR
 butyl butyryl lactateFL/FR
 creamy lactoneFL/FR
5,5-dibutyl dihydrofuran-2(3H)-oneFL
delta-dodecalactoneFL/FR
 glyceryl 5-hydroxydecanoateFL/FR
 glyceryl 5-hydroxydodecanoateFL/FR
gamma-hexalactoneFL/FR
 massoia lactoneFL
para-methyl acetophenoneFL/FR
 mint lactoneFL/FR
delta-nonalactoneFL/FR
 octyl isobutyrateFL/FR
delta-undecalactoneFL/FR
gamma-undecalactone (aldehyde C-14 (so-called))FL/FR
para-vanillic acidFL/FR
para-vanillyl alcoholFL/FR
dairy
 methyl (Z)-5-octenoateFL/FR
earthy
1-nonen-3-olFL/FR
fatty
(Z)-dairy lactoneFL/FR
 ethyl undecylenateFL/FR
4-methyl octanoic acidFL/FR
2,4-octadien-1-olFL
2-tridecanoneFL/FR
floral
 cananga oilFL/FR
 dihydrojasmoneFL/FR
 linalyl acetateFL/FR
 ocean propanalFL/FR
fruity
 acetoin acetateFL/FR
 acetyl isovalerylFL
 amyl heptanoateFL/FR
isoamyl octanoateFL/FR
para-anisyl acetateFL/FR
para-anisyl alcoholFL/FR
 benzaldehydeFL/FR
 cherry propanolFL/FR
gamma-decalactoneFL/FR
3-heptyl dihydro-5-methyl-2(3H)-furanoneFL/FR
4-hydroxybenzyl alcoholFL/FR
isopropyl octanoateFL/FR
 tolualdehydes (mixed o,m,p)FL/FR
grassy
 palmarosa oilFL/FR
green
isoamyl salicylateFL/FR
 angelica root oilFL/FR
 butyl lactateFL/FR
 diphenyl methaneFL/FR
 galbanum oilFL/FR
 heptanal 2,3-butane diol acetalFL
(Z)-4-hepten-1-olFL/FR
(Z)-4-heptenalFL/FR
(Z)-4-heptenal diethyl acetalFL/FR
 heptyl heptanoateFL/FR
 immortelle absoluteFL/FR
 methyl heptadienoneFL/FR
 nerolidolFL/FR
 oakmoss absoluteFL/FR
3-phenyl propionaldehydeFL/FR
herbal
 apium graveolens seed oil indiaFL/FR
 immortelle flower oilFL/FR
abrialis lavandin oilFL/FR
 lavender oilFL/FR
 massoia bark oilFL
 origanum oil greeceFL/FR
honey
 phenethyl phenyl acetateFL/FR
lactonic
gamma-heptalactoneFL/FR
delta-heptalactoneFL/FR
gamma-octalactoneFL/FR
meaty
4-allyl-2,6-dimethoxyphenolFL
milky
gamma-butyrolactoneFL/FR
minty
(1R)-(-)-myrtenalFL
 myrtenalFL/FR
mushroom
3-octen-2-olFL/FR
naphthyl
2,4-dimethyl benzaldehydeFL/FR
beta-naphthyl methyl etherFL/FR
nutty
2-acetyl pyrroleFL/FR
2-acetyl-5-methyl furanFL/FR
powdery
 acetophenoneFL/FR
beta-naphthyl ethyl etherFL/FR
 powdery ketoneFL
soapy
1-dodecanolFL/FR
sour
 butyric acidFL/FR
spicy
 benzyl cinnamateFL/FR
 benzyl isoeugenolFL/FR
 benzylidene acetoneFL
 croton eluteria bark oilFL/FR
 cubeb oilFL/FR
isoeugenyl acetateFL/FR
 ginger root oil chinaFL/FR
 levisticum officinale oleoresinFL
 levisticum officinale root oilFL/FR
alpha-methyl cinnamaldehydeFL/FR
 methyl cinnamateFL/FR
alpha-methyl-(E)-cinnamaldehydeFL/FR
 nutmeg oilFL/FR
 root beer float flavorFL
sweet
 ethyl 3-(2-hydroxyphenyl) propionateFL
 orange vanilla cream flavorFL
 orris rhizome absolute (iris pallida)FL/FR
 vanilla oleoresin baliFL/FR
toasted
 acetyl propionylFL/FR
tomato
 methionalFL/FR
vanilla
 ethyl vanillinFL/FR
 ethyl vanillin isobutyrateFL/FR
 ethyl vanillin propylene glycol acetalFL/FR
vanilla ice cream flavorFL
 propenyl guaetholFL/FR
 vanilla bean absolute (vanilla planifolia)FL/FR
 vanillinFL/FR
 vanillyl acetateFL/FR
 vanillyl isobutyrateFL/FR
waxy
 allyl nonanoateFL/FR
 dihydrojasmone lactoneFL/FR
 ethyl palmitateFL/FR
 ethyl undecanoateFL/FR
alpha-hexyl cinnamaldehydeFL/FR
 hydroxycitronellalFL/FR
 methyl laurateFL/FR
2-nonanolFL/FR
 octyl 2-furoateFL
 octyl butyrateFL/FR
delta-tetradecalactoneFL/FR
 undecanoic acidFL/FR
woody
 amyris wood oilFL/FR
ortho-guaiacolFL/FR
 guaiacwood oilFL/FR
 methyl cedryl ketoneFL/FR
 patchouli oilFL/FR
 sandalwood oilFL/FR
 spruce needle oil canadaFL/FR
 vetiver oil haitiFL/FR
 vetiverolFL/FR
 whiskey lactoneFL/FR
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 aldehydicFR
 almondFL
 amberFR
 balsamFR
 briar woodFR
 caramelFL
 chocolate cocoaFL
 chypreFR
 cinnamonFL
 cloverFR
 coconutFL
 fernFR
 hawthornFR
 hay new mown hayFR
 heatherFR
 lavandinFR
 maltFL
 orientalFR
 roseFL
 spiceFL
 tobaccoFR
 tonka beanFR
 vanillaFL
 woodruffFR
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 cherry sour cherry plant
Search Trop  Picture
 clover sweet clover
Search  PMC Picture
 clover yellow sweet clover
Search Trop  Picture
 deertongue
Search Trop  Picture
 tarragon plant
Search Trop  Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
 benzo dihydro pyrone
 benzo dihydropyrone
 benzo dihydropyrone natural
 benzo dihydropyrone synthetic
 benzodihydropyrone
1,2-benzodihydropyrone
 benzodihydropyrone FCC
 benzodihydropyrone, natural
2H-1-benzopyran-2-one, 3,4-dihydro-
 benzopyranone, dihydro-
2-oxo-chroman
oxochroman
 chroman-2-one
 chroman, 2-oxo-
2-chromanone
 coumarin, 3,4-dihydro-
 coumarin, dihydro-
 di hydro coumarin
 dihydro coumarin
3,4-dihydro-1-benzopyran-2-one
3,4-dihydro-2H-1-benzopyran-2-one
3,4-dihydro-2H-chromen-2-on
3,4-dihydro-2H,1-benzopyran-2-one
 dihydrobenzopyrone
3,4-dihydrocoumarin
 dihydrocoumarin (benzodihydropyrone)
 dihydrocoumarin FCC
 hydrocinnamic acid, o-hydroxy-, d-lactone
 hydrocoumarin
o-hydroxydihydrocinnamic acid delta-lactone
ortho-hydroxydihydrocinnamic acid delta-lactone
2-hydroxydihydrocinnamic acid lactone
 hydroxydihydrocinnamic acid lactone, o-
 melilotic acid lactone
 melilotic lactone
 melilotin
 melilotine
 melilotol
 meliotine
Synonyms   Articles   Notes   Search   Top
Articles:
Info: EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS
PubMed: Tandem ruthenium-catalyzed transfer-hydrogenative cyclization/intramolecular Diels-Alder reaction of enediynes affording dihydrocoumarin-fused polycycles.
PubMed: Study of possible mechanisms involved in the inhibitory effects of coumarin derivatives on neutrophil activity.
PubMed: Effect of the nutritional supplement ALAnerv® on the serum PON1 activity in post-acute stroke patients.
PubMed: Serum lactonase and arylesterase activities in alcoholic hepatitis and hepatitis B.
PubMed: N-heterocyclic carbene-catalyzed [4 + 2] cycloaddition of ketenes and 3-aroylcoumarins: highly enantioselective synthesis of dihydrocoumarin-fused dihydropyranones.
PubMed: Cancer chemoprevention and nutriepigenetics: state of the art and future challenges.
PubMed: Synthesis and biological evaluation of α-methylidene-δ-lactones with 3,4-dihydrocoumarin skeleton.
PubMed: [Determination of five coumarins in toys by high performance liquid chromatography-tandem mass spectrometry].
PubMed: Novel associations of nonstructural Loci with paraoxonase activity.
PubMed: Oxidative potential of some endophytic fungi using 1-indanone as a substrate.
PubMed: Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1.
PubMed: Facile synthesis of 4-substituted 3,4-dihydrocoumarins via an organocatalytic double decarboxylation process.
PubMed: An enantioselective approach toward 3,4-dihydroisocoumarin through the bromocyclization of styrene-type carboxylic acids.
PubMed: High-Density Real-Time PCR-Based in Vivo Toxicogenomic Screen to Predict Organ-Specific Toxicity.
PubMed: Asymmetric synthesis of 3,4-dihydrocoumarin motif with an all-carbon quaternary stereocenter via a Michael-acetalization sequence with bifunctional amine-thiourea organocatalysts.
PubMed: Atom arrangement strategy for designing a turn-on 1H magnetic resonance probe: a dual activatable probe for multimodal detection of hypochlorite.
PubMed: Chemical composition, anti-inflammatory, molluscicidal and free-radical scavenging activities of the leaves of Ficus radicans 'Variegata' (Moraceae).
PubMed: Development and validation of two methods based on high-performance liquid chromatography-tandem mass spectrometry for determining 1,2-benzopyrone, dihydrocoumarin, o-coumaric acid, syringaldehyde and kaurenoic acid in guaco extracts and pharmaceutical preparations.
PubMed: Coumarin metabolic routes in Aspergillus spp.
PubMed: Paraoxonase 2 (PON2) in the mouse central nervous system: a neuroprotective role?
PubMed: Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins).
PubMed: Different effect of two synthetic coumarin-stilbene hybrid compounds on phagocyte activity.
PubMed: Cancer chemoprevention by targeting the epigenome.
PubMed: Organocatalytic asymmetric tandem Michael addition-hemiacetalization: a route to chiral dihydrocoumarins, chromanes, and 4H-chromenes.
PubMed: A reinvestigation of the reaction of coumarins with superoxide in the liposomal bilayer: correlation between depth and reactivity.
PubMed: Lactonases with organophosphatase activity: structural and evolutionary perspectives.
PubMed: The thioesterase Bhp is involved in the formation of beta-hydroxytyrosine during balhimycin biosynthesis in Amycolatopsis balhimycina.
PubMed: Interaction between human serum esterases and environmental metal compounds.
PubMed: Determinants of variation in human serum paraoxonase activity.
PubMed: Asymmetric cycloadditions of o-quinone methides employing chiral ammonium fluoride precatalysts.
PubMed: A novel method for the synthesis of substituted 3,4-dihydrocoumarin derivatives via isocyanide-based three-component reaction.
PubMed: Synthesis, spectroscopy and alkylating properties of Pd(II) complexes of phosphorohydrazones of coumarin and chromone with potential antibacterial activity.
PubMed: Novel isocyanide-based four-component reaction: a facile synthesis of fully substituted 3,4-dihydrocoumarin derivatives.
PubMed: AlCl3-mediated direct carbon-carbon bond-forming reaction of alpha-hydroxyketene-S,S-acetals with arenes and synthesis of 3,4-disubstituted dihydrocoumarin derivatives.
PubMed: Aging and anti-aging: unexpected side effects of everyday medication through sirtuin1 modulation.
PubMed: Lack of evidence for allergenic properties of coumarin in a fragrance allergy mouse model.
PubMed: Biocatalytic production of dihydrocoumarin from coumarin by Saccharomyces cerevisiae.
PubMed: Xenobiotic reductase A in the degradation of quinoline by Pseudomonas putida 86: physiological function, structure and mechanism of 8-hydroxycoumarin reduction.
PubMed: The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases.
PubMed: Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera.
PubMed: Cloning, purification, and refolding of human paraoxonase-3 expressed in Escherichia coli and its characterization.
PubMed: Cloning, high level expression of human paraoxonase-3 in Sf9 cells and pharmacological characterization of its product.
PubMed: Regioselective synthesis and estrogenicity of (+/-)-8-alkyl-5,7-dihydroxy-4-(4-hydroxyphenyl)-3,4-dihydrocoumarins.
PubMed: Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the liver.
PubMed: Chromanones and dihydrocoumarins from Calophyllum blancoi.
PubMed: Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress.
PubMed: Role of Acinetobacter calcoaceticus 3,4-dihydrocoumarin hydrolase in oxidative stress defence against peroxoacids.
PubMed: Enzymatic preparation of D-beta-acetylthioisobutyric acid and cetraxate hydrochloride using a stereo- and/or regioselective hydrolase, 3,4-dihydrocoumarin hydrolase from Acinetobacter calcoaceticus.
PubMed: Coupling of the lactone-ring conformation with crystal symmetry in 6-hydroxy-4,4,5,7,8-pentamethyl-3,4-dihydrocoumarin.
PubMed: Lactone-ring-cleaving enzymes of microorganisms: their diversity and applications.
PubMed: Purification and characterization of a novel lactonohydrolase from Agrobacterium tumefaciens.
PubMed: 3,4-Dihydrocoumarin hydrolase with haloperoxidase activity from Acinetobacter calcoaceticus F46.
PubMed: A "cephalosporin-like" cyclic depsipeptide: synthesis and reaction with beta-lactam-recognizing enzymes.
PubMed: Selective Clara cell injury in mouse lung following acute administration of coumarin.
PubMed: Intraperitoneal administration of coumarin causes tissue-selective depletion of cytochromes P450 and cytotoxicity in the olfactory mucosa.
PubMed: Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds.
PubMed: New metabolites in the degradation of fluorene by Arthrobacter sp. strain F101.
PubMed: Natural ingredients based cosmetics. Content of selected fragrance sensitizers.
PubMed: Structure-activity relationship of coumarins in xanthine oxidase inhibition.
PubMed: HPLC analysis of tonka bean extracts.
PubMed: Comparison of the hepatic effects of coumarin, 3,4-dimethylcoumarin, dihydrocoumarin and 6-methylcoumarin in the rat.
PubMed: NTP Toxicology and Carcinogenesis Studies of Coumarin (CAS No. 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
PubMed: NTP Toxicology and Carcinogenesis Studies of 3,4-Dihydrocoumarin (CAS No. 119-84-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies).
PubMed: Structural requirements for the direct and cytochrome P450-dependent reaction of cyclic alpha,beta-unsaturated carbonyl compounds with glutathione: a study with coumarin and related compounds.
PubMed: Purification and characterization of a novel lactonohydrolase, catalyzing the hydrolysis of aldonate lactones and aromatic lactones, from Fusarium oxysporum.
PubMed: Isolation and characterization of a fluorene-degrading bacterium: identification of ring oxidation and ring fission products.
PubMed: Toxicity of coumarin and various methyl derivatives in cultures of rat hepatocytes and V79 cells.
PubMed: Anamnestic responses to contact allergens: application in the murine local lymph node assay.
PubMed: Amine prodrugs which utilize hydroxy amide lactonization. II. A potential esterase-sensitive amide prodrug.
PubMed: Acyloxybenzyl halides, inhibitors of elastases.
PubMed: A prospective toxicity evaluation (COMPACT) on 40 chemicals currently being tested by the National Toxicology Program.
PubMed: Reaction of thrombin and proteinases of the fibrinolytic system with a mechanism-based inhibitor, 3,4-dihydro-3-benzyl-6-chloromethylcoumarin.
PubMed: Studies on the mechanism of coumarin-induced toxicity in rat hepatocytes: comparison with dihydrocoumarin and other coumarin metabolites.
PubMed: Constituents of Justicia pectoralis Jacq. 2. Gas chromatography/mass spectrometry of simple coumarins, 3-phenylpropionic acids and their hydroxy and methoxy derivatives.
PubMed: The sensitizing capacity of coumarins (II).
PubMed: The epicutaneous maximization test.
PubMed: Inactivation of human high- and low-molecular-weight urokinases. Analysis of their active site.
PubMed: Reactions in selected patients to 22 fragrance materials.
PubMed: Comparative study of methods chosen by the Association Française de Normalisation (AFNOR) for evaluating sensitizing potential in the albino guinea-pig.
PubMed: Degradation of 3-phenylbutyric acid by Pseudomonas sp.
PubMed: Further studies of effects of vehicles and elicitation concentration in experimental contact sensitization testing in humans.
PubMed: Physiologically active substances from marine sponges V: Isolation of physiologically active compounds from the sponge Verongia archeri.
PubMed: The metabolism of aromatic compounds in higher plants. V. Purification and properties of dihydrocoumarin hydrolase of Melilotus alba.
PubMed: [Application of Baeyer-Villiger reaction in synthesis of dihydrocoumarin].
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