|
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to pale yellow clear liquid to solid (est) |
| Assay: | 99.00 to 100.00 %
|
| Food Chemicals Codex Listed: | Yes |
| Specific Gravity: | 1.18600 to 1.19200 @ 25.00 °C.
|
| Pounds per Gallon - (est).: | 9.869 to 9.919
|
| Refractive Index: | 1.54000 to 1.58000 @ 20.00 °C.
|
| Melting Point: | 24.00 to 25.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 271.00 to 272.00 °C. @ 760.00 mm Hg
|
| Congealing Point: | 23.00 °C.
|
| Acid Value: | 5.00 max. KOH/g
|
| Vapor Pressure: | 4.000000 mmHg @ 25.00 °C. |
| Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
|
| logP (o/w): | 2.428 (est) |
| Shelf Life: | 24.00 month(s) or longer if stored properly. |
| Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Soluble in: |
| | alcohol | | | water, 3000 mg/L @ 37 °C (exp) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| |
| Odor Type: tonka |
| |
| Odor Strength: | medium , recommend smelling in a 10.00 % solution or less |
| |
| Substantivity: | 228 hour(s) at 100.00 % |
| |
| | sweet tonka coumarinic coconut herbal cinnamon balsamic |
Odor Description: at 10.00 % in dipropylene glycol. | sweet tonka coumarinic coconut herbal cinnamon balsamic Luebke, William tgsc, (1987) |
| |
| | sweet creamy coconut coumarinic vanilla spicy |
Odor Description:
| Sweet, creamy, coconut, coumarin, vanilla with a slight spice nuance Mosciano, Gerard P&F 17, No. 3, 57, (1992) |
| |
| |
| Flavor Type: creamy |
| |
| | creamy coconut coumarinic vanilla cinnamyl balsamic spicy cardamom |
Taste Description:
| creamy coconut coumarinic vanilla cinnamyl balsamic spicy cardamom Luebke, William tgsc, (1987) |
| |
| | sweet creamy vanilla coconut milky |
Taste Description: at 10.00 ppm. | Sweet, creamy, vanilla, coconut and milky Mosciano, Gerard P&F 17, No. 3, 57, (1992) |
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| Sigma-Aldrich |
| Dihydrocoumarin, ≥99%, FCC, FG |
| Odor Description: | almond; coconut; creamy; herbaceous; sweet; vanilla; nutty; tobacco. |
| Taste Description: | sweet creamy vanilla coconut milky |
| |
| Moellhausen |
| DIHYDROCOUMARIN |
| Odor Description: | sweet, cocoa |
| Taste Description: | sweet, vanilla, milk |
| |
| PerfumersWorld |
| Dihydro coumarin |
| Odor Description: | sweet rose coumarin tonka herbal sweet aromatic coumarin coconut |
| |
| Perfumery Laboratory |
| TONCAINOL |
| Odor Description: | Sweet, vanilla with bright notes of beans |
| |
| Indukern F&F |
| DIHYDROCOUMARIN NATURAL |
| Odor Description: | SWEET, AROMATIC, COUMARIN, CINNAMON |
| |
| |
Cosmetic Information:
Suppliers:
| ACS International |
| Dihydrocumarine
Odor: sweet tonka coumarin coconut herbal cinnamon |
| Operational Capabilities |
| Advanced Biotech |
| BENZO DIHYDROPYRONE NATURAL
98% min. Odor: Herbaceous, Woody |
| Advanced Biotech |
| BENZO DIHYDROPYRONE SYNTHETIC
98% min. Odor: Herbaceous, Woody |
| Alfa Biotechnology |
| For experimental / research use only. |
| Hydrocoumarin 98%
|
| Anhui Haibei |
| Dihydro coumarin
Odor: Sweetish, fruity or herbal |
| Augustus Oils |
| Dihydro Coumarin
|
| Services |
| Aurochemicals |
| BENZODIHYDROPYRONE, Natural
|
| Beijing Lys Chemicals |
| Dihydrocoumarin (natural)
|
| Beijing Lys Chemicals |
| Dihydrocoumarin
|
| Bell Flavors & Fragrances |
| Natural Benzodihydropyrone (BDHP)
|
| Berjé |
| Benzo Dihydropyrone
|
| Media |
| BOC Sciences |
| For experimental / research use only. |
| Hydrocoumarin >98%
|
| Citrus and Allied Essences |
| Benzo Dihydropyrone
|
| Market Report |
| Diffusions Aromatiques |
| DIHYDROCOUMARINE
|
| Elan Inc. |
| BENZO DIHYDRO PYRONE
FCC, Kosher |
| EMD Millipore |
| For experimental / research use only. |
| Dihydrocoumarin
|
| Ernesto Ventós |
| DIHYDROCOUMARIN, NATURAL
|
| Ernesto Ventós |
| DIHYDROCOUMARIN
Odor: SWEET,COUMARIN BUT SLIGHTLY BITTER |
| Excellentia International |
| Benzodihydropyrone FCC (Dihydrocoumarin)
|
| ExtraSynthese |
| For experimental / research use only. |
| 3,4-Dihydrocoumarin (GC) ≥95%
|
| Fleurchem |
| benzodihydropyrone
|
| Indukern F&F |
| DIHYDROCOUMARIN NATURAL
Odor: SWEET, AROMATIC, COUMARIN, CINNAMON |
| Indukern F&F |
| DIHYDROCOUMARIN
|
| Jiangyin Healthway |
| Dihydrocoumarin Natural99%
|
| New functional food ingredients |
| K.L. Koh Enterprise |
| DIHYDROCOUMARIN
|
| Lluch Essence |
| DIHYDROCOUMARIN NATURAL 99%
|
| Lluch Essence |
| DIHYDROCOUMARIN
|
| M&U International |
| Dihydrocoumarin, Kosher
|
| M&U International |
| NAT.DIHYDROCOUMARIN
|
| Moellhausen |
| DIHYDROCOUMARIN
Odor: sweet, cocoa Flavor: sweet, vanilla, milk |
| Pearlchem Corporation |
| Dihydro Coumarin
|
| Penta International |
| BENZODIHYDROPYRONE NATURAL
|
| Penta International |
| BENZODIHYDROPYRONE
|
| PerfumersWorld |
| Dihydro coumarin
Odor: sweet rose coumarin tonka herbal sweet aromatic coumarin coconut |
| Perfumery Laboratory |
| TONCAINOL
Odor: Sweet, vanilla with bright notes of beans |
| Phoenix Aromas & Essential Oils |
| Dihydrocoumarin (Benzodihydropyrone)
|
| Prinova |
| Di Hydro Coumarin
|
| R C Treatt & Co Ltd |
| Dihydrocoumarin
|
| Reincke & Fichtner |
| Dihydrocoumarin
|
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Dihydrocoumarin ≥98%
|
| Sigma-Aldrich |
| Dihydrocoumarin, ≥99%, FCC, FG
Odor: almond; coconut; creamy; herbaceous; sweet; vanilla; nutty; tobacco. |
| Certified Food Grade Products |
| SRS Aromatics |
| DIHYDRO COUMARIN EU NATURAL
|
| SRS Aromatics |
| DIHYDRO COUMARIN
|
| Sunaux International |
| Dihydrocoumarin
|
| TCI AMERICA |
| For experimental / research use only. |
| 3,4-Dihydrocoumarin >98.0%(GC)
|
| Tengzhou Xiang Yuan Aroma Chemicals |
| Dihydrocoumarin
|
| The Lermond Company |
| DIHYDRO COUMARIN
|
| The Perfumers Apprentice |
| Dihydrocoumarin 10% (PG)
Odor: Sweet, creamy, vanilla, coconut and milky |
| United International |
| 3,4-Dihydrocoumarin
|
| Universal Preserv-A-Chem Inc. |
| BENZODIHYDROPYRONE
|
| Vigon International |
| Dihydrocoumarin FCC
Odor: Sweet-aromatic like coumarin, with pronounced cinnamon and caramel note |
| Vigon International |
| Dihydrocoumarin Natural
|
| Vistachem |
| Dihydrocoumarin
|
| WEN International |
| BENZODIHYDROPYRONE, natural
|
| WholeChem |
| Dihydrocoumarin
|
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xn - Harmful. |
R 22 - Harmful if swallowed. R 36/38 - Irritating to skin and eyes. S 02 - Keep out of the reach of children. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
|
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Human Experience: |
| 20 % solution: no irritation or sensitization. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 1460 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.
intraperitoneal-mouse LD50 200 mg/kg National Technical Information Service. Vol. AD277-689
oral-guinea pig LD50 1760 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Food and Cosmetics Toxicology. Vol. 2, Pg. 327, 1964.
|
| Dermal Toxicity: |
skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 12, Pg. 521, 1974.
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| IFRA Critical Effect: | Dermal sensitization and systemic toxicity |
| IFRA: | View Standard |
| View IFRA Standards Library for complete information. |
| Please review Amendment 49 IFRA documentation for complete information. |
| IFRA RESTRICTION LIMITS IN THE FINISHED PRODUCT (%): |
| Category 1: Products applied to the lips |
| 0.077 % |
| Category 2: Products applied to the axillae |
| 0.023 % |
| Category 3: Products applied to the face/body using fingertips |
| 0.46 % |
| Category 4: Products related to fine fragrance |
| 0.43 % |
| | Category 5: Products applied to the face and body using the hands (palms), primarily leave-on |
| Category 5A: Body lotion products applied to the body using the hands (palms), primarily leave-on |
| 0.11 % |
| Category 5B: Face moisturizer products applied to the face using the hands (palms), primarily leave-on |
| 0.11 % |
| Category 5C: Hand cream products applied to the hands using the hands (palms), primarily leave-on |
| 0.11 % |
| Category 5D: Baby Creams, baby Oils and baby talc |
| 0.03 % |
| Category 6: Products with oral and lip exposure |
| 0.25 % |
| | Category 7: Products applied to the hair with some hand contact |
| Category 7A: Rinse-off products applied to the hair with some hand contact |
| 0.88 % |
| Category 7B: Leave-on products applied to the hair with some hand contact |
| 0.88 % |
| Category 8: Products with significant anogenital exposure |
| 0.03 % |
| Category 9: Products with body and hand exposure, primarily rinse off |
| 0.84 % |
| | Category 10: Household care products with mostly hand contact |
| Category 10A: Household care excluding aerosol products (excluding aerosol/spray products) |
| 0.84 % |
| Category 10B: Household aerosol/spray products |
| 3.00 % |
| | Category 11: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate |
| Category 11A: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate without UV exposure |
| 0.03 % |
| Category 11B: Products with intended skin contact but minimal transfer of fragrance to skin from inert substrate with potential UV exposure |
| 0.03 % |
| Category 12: Products not intended for direct skin contact, minimal or insignificant transfer to skin |
| No Restriction |
| | Notes: |
| IFRA FLAVOR REQUIREMENTS: |
Due to the possible ingestion of small amounts of fragrance ingredients from their use in products in Categories 1 and 6, materials must not only comply with IFRA Standards but must also be recognized as safe as a flavoring ingredient as defined by the IOFI Code of Practice (www.iofi.org). For more details see chapter 1 of the Guidance for the use of IFRA Standards. |
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 1200.00 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 1111.00 (μg/capita/day) |
| Structure Class: | III |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 3. Update in publication number(s): 29 |
| Click here to view publication 3 |
| | average usual ppm | average maximum ppm |
| baked goods: | 141.00000 | 165.00000 |
| beverages(nonalcoholic): | 25.00000 | 28.00000 |
| beverages(alcoholic): | 0.30000 | 2.00000 |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | 20.00000 | 250.00000 |
| condiments / relishes: | 10.00000 | 15.00000 |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | 95.00000 | 104.00000 |
| fruit ices: | - | - |
| gelatins / puddings: | 116.00000 | 132.00000 |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | 8.00000 | 44.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | 111.00000 | 131.00000 |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
| |
| For Odor |
| aldehydic |
| aldehydic |
| | acetyl nonyryl | FL/FR |
| amber |
| | angelica root oil | FL/FR |
| | cistus ladaniferus resinoid | FL/FR |
| animal |
| | animal carbolactone | FR |
| | civet absolute | FL/FR |
| | costus valerolactone | FR |
| | indole | FL/FR |
| 6- | methyl quinoline | FL/FR |
| anisic |
| para- | anisaldehyde | FL/FR |
| balsamic |
| | amyris wood oil | FL/FR |
| sumatra | benzoin resinoid | FL/FR |
| siam | benzoin resinoid | FL/FR |
| | benzyl cinnamate | FL/FR |
| | benzyl salicylate | FL/FR |
| iso | butyl cinnamate | FL/FR |
| | copaiba balsam oil | FL/FR |
| | ethyl cinnamate | FL/FR |
| | fir balsam absolute | FR |
| | methyl cinnamate | FL/FR |
| | peru balsam oil | FL/FR |
| | pine needle absolute | FL/FR |
| berry |
| | raspberry ketone | FL/FR |
| buttery |
| | acetoin | FL/FR |
| | acetyl butyryl | FL/FR |
| | acetyl isobutyryl | FL/FR |
| | acetyl propionyl | FL/FR |
| | butyl butyryl lactate | FL/FR |
| caramellic |
| 2-oxo | butyric acid | FL/FR |
| | ethyl maltol | FL/FR |
| | fenugreek absolute | FL/FR |
| | immortelle absolute | FL/FR |
| | strawberry furanone acetate | FL/FR |
| cheesy |
| | butyric acid | FL/FR |
| 2- | heptanone | FL/FR |
| citrus |
| | lime oil expressed florida | FL/FR |
| coconut |
| alpha- | angelica lactone | FL/FR |
| | coconut decanone methyl | FR |
| | coconut naphthalenone | FL/FR |
| delta- | decalactone | FL/FR |
| delta-2- | dodecenolactone | FL/FR |
| gamma- | heptalactone | FL/FR |
| delta- | heptalactone | FL/FR |
| delta- | nonalactone | FL/FR |
| gamma- | nonalactone (aldehyde C-18 (so-called)) | FL/FR |
| gamma- | octalactone | FL/FR |
| delta- | octalactone | FL/FR |
| | propyl octanoate | FL/FR |
| | tetrahydrojasmone | FR |
| delta- | undecalactone | FL/FR |
| | wine lactone | FL/FR |
| coumarinic |
| | coumane | FL/FR |
| | phthalide | FL/FR |
| | tonka bean oleoresin | FR |
| | tonka bean resinoid | FR |
| | tonka furanone | FL/FR |
| | tonka ketone | FR |
| | tonkavert | FR |
| creamy |
| gamma- | butyrolactone | FL/FR |
| | creamy lactone | FL/FR |
| 3- | heptyl dihydro-5-methyl-2(3H)-furanone | FL/FR |
| para- | vanillic acid | FL/FR |
| para- | vanillyl alcohol | FL/FR |
| earthy |
| 1- | nonen-3-ol | FL/FR |
| fatty |
| (Z)- | dairy lactone | FL/FR |
| | ethyl undecylenate | FL/FR |
| 4- | methyl octanoic acid | FL/FR |
| fermented |
| | butyl laevo-lactate | FL/FR |
| floral |
| | acetophenone | FL/FR |
| iso | amyl salicylate | FL/FR |
| para- | anisyl nitrile | FR |
| iso | butyl salicylate | FL/FR |
| | cananga oil | FL/FR |
| | dihydrojasmone | FL/FR |
| | dihydrojasmone lactone | FL/FR |
| | floral pyranol | FR |
| | heliotropin | FL/FR |
| | heliotropyl acetone | FL/FR |
| | heliotropyl diethyl acetal | FR |
| | hexenyl cyclopentanone | FR |
| alpha- | hexyl cinnamaldehyde | FL/FR |
| | hydroxycitronellal | FL/FR |
| | jasmin lactone (IFF) | FL/FR |
| | lavender oil | FL/FR |
| para- | methyl acetophenone | FL/FR |
| | nerolidol | FL/FR |
| | ocean propanal | FL/FR |
| | orris rhizome absolute (iris pallida) | FL/FR |
| | palmarosa oil | FL/FR |
| 2- | pentyl cyclopentanone | FR |
| | phenethyl phenyl acetate | FL/FR |
| fruity |
| | acetoin acetate | FL/FR |
| | amyl heptanoate | FL/FR |
| iso | amyl octanoate | FL/FR |
| | benzaldehyde | FL/FR |
| | cherry propanol | FL/FR |
| gamma- | decalactone | FL/FR |
| | farnesyl acetone | FL/FR |
| 4- | hydroxybenzyl alcohol | FL/FR |
| | methyl (Z)-5-octenoate | FL/FR |
| | octyl butyrate | FL/FR |
| iso | propyl octanoate | FL/FR |
| | tolualdehydes (mixed o,m,p) | FL/FR |
| gamma- | undecalactone (aldehyde C-14 (so-called)) | FL/FR |
| green |
| iso | butyl benzyl carbinol | FL/FR |
| | butyl lactate | FL/FR |
| alpha- | decalactone | FL/FR |
| | diphenyl methane | FL/FR |
| | galbanum oil | FL/FR |
| (Z)-4- | hepten-1-ol | FL/FR |
| (Z)-4- | heptenal | FL/FR |
| (Z)-4- | heptenal diethyl acetal | FL/FR |
| | heptyl heptanoate | FL/FR |
| 3- | phenyl propionaldehyde | FL/FR |
| | syringaldehyde | FL/FR |
| hay |
| | hay absolute | FR |
| herbal |
| | apium graveolens seed oil india | FL/FR |
| | immortelle flower oil | FL/FR |
| abrialis | lavandin oil | FL/FR |
| | linalyl acetate | FL/FR |
| | origanum oil greece | FL/FR |
| melon |
| | watermelon ketone | FR |
| mossy |
| | oakmoss absolute | FL/FR |
| | treemoss absolute | FR |
| | veramoss (IFF) | FR |
| mushroom |
| 3- | octen-2-ol | FL/FR |
| musty |
| 2- | acetyl pyrrole | FL/FR |
| naphthyl |
| 2,4- | dimethyl benzaldehyde | FL/FR |
| beta- | naphthyl ethyl ether | FL/FR |
| beta- | naphthyl methyl ether | FL/FR |
| nutty |
| 2- | acetyl-5-methyl furan | FL/FR |
| phenolic |
| ortho- | guaiacol | FL/FR |
| powdery |
| para- | anisyl acetate | FL/FR |
| para- | anisyl alcohol | FL/FR |
| soapy |
| | ethyl undecanoate | FL/FR |
| spicy |
| | benzyl isoeugenol | FL/FR |
| | croton eluteria bark oil | FL/FR |
| | cubeb oil | FL/FR |
| iso | eugenyl acetate | FL/FR |
| | ginger root oil china | FL/FR |
| | levisticum officinale root oil | FL/FR |
| para- | methoxy-alpha-methyl cinnamaldehyde | FL/FR |
| para- | methoxycinnamaldehyde | FL/FR |
| alpha- | methyl cinnamaldehyde | FL/FR |
| | methyl heptadienone | FL/FR |
| alpha- | methyl-(E)-cinnamaldehyde | FL/FR |
| | myrtenal | FL/FR |
| | nutmeg oil | FL/FR |
| sweet |
| | vanilla oleoresin bali | FL/FR |
| thujonic |
| | armoise oil | FR |
| tonka |
| 6- | amyl-alpha-pyrone | FL/FR |
| | coumarin | FR |
| | deertongue absolute | FR |
| | deertongue oleoresin | FR |
| | flouve absolute | FR |
| gamma- | hexalactone | FL/FR |
| | melilot absolute | FR |
| 7- | methyl coumarin | CS |
| | mint lactone | FL/FR |
| | octahydrocoumarin | FL/FR |
| | tonka bean absolute | FR |
| | tonka undecanone | FR |
| | whiskey lactone | FL/FR |
| tropical |
| delta- | dodecalactone | FL/FR |
| | glyceryl 5-hydroxydecanoate | FL/FR |
| | glyceryl 5-hydroxydodecanoate | FL/FR |
| vanilla |
| ortho- | dimethyl hydroquinone | FL/FR |
| | ethyl vanillin | FL/FR |
| | ethyl vanillin isobutyrate | FL/FR |
| | ethyl vanillin propylene glycol acetal | FL/FR |
| | methyl vanillate | FL/FR |
| | propenyl guaethol | FL/FR |
| | vanilla bean absolute (vanilla planifolia) | FL/FR |
| | vanillin | FL/FR |
| | vanillyl acetate | FL/FR |
| | vanillyl isobutyrate | FL/FR |
| | vanillylidene acetone | FL/FR |
| vegetable |
| | methional | FL/FR |
| waxy |
| | allyl nonanoate | FL/FR |
| 1- | dodecanol | FL/FR |
| | ethyl palmitate | FL/FR |
| | methyl laurate | FL/FR |
| | myristyl alcohol | FL/FR |
| 2- | nonanol | FL/FR |
| | octyl isobutyrate | FL/FR |
| delta- | tetradecalactone | FL/FR |
| 2- | tridecanone | FL/FR |
| | undecanoic acid | FL/FR |
| woody |
| | guaiacwood oil | FL/FR |
| | methyl cedryl ketone | FL/FR |
| | patchouli ethanone | FR |
| | patchouli oil | FL/FR |
| | sandalwood oil | FL/FR |
| | santall | FR |
| | spruce needle oil canada | FL/FR |
| | tobacarol (IFF) | FR |
| | vetiver oil haiti | FL/FR |
| | vetiverol | FL/FR |
| | woody acetate | FR |
| (Z)- | woody amylene | FR |
| | woody propanol | FR |
| |
| For Flavor |
| |
| No flavor group found for these |
| | allyl methyl trisulfide | FL |
| | cistus ladaniferus resinoid | FL/FR |
| | coconut naphthalenone | FL/FR |
| | coumane | FL/FR |
| alpha- | decalactone | FL/FR |
| 6- | decenoic acid | FL |
| (S)- | dihydroactinidiolide | FL |
| | dimethyl benzofuranone | FL |
| ortho- | dimethyl hydroquinone | FL/FR |
| delta-2- | dodecenolactone | FL/FR |
| | farnesyl acetone | FL/FR |
| | fig leaf absolute | FL |
| 2- | furfurylidene butyraldehyde | FL |
| | jasmin lactone (IFF) | FL/FR |
| | melilot oleoresin | FL |
| para- | methoxy-alpha-methyl cinnamaldehyde | FL/FR |
| 7- | methoxycoumarin | FL |
| | methyl vanillate | FL/FR |
| | myristyl alcohol | FL/FR |
| 4- | octen-3-one | FL |
| | pine needle absolute | FL/FR |
| | propyl octanoate | FL/FR |
| (R)- | tonka furanone | FL |
| | tonka furanone | FL/FR |
| | wine lactone | FL/FR |
| aldehydic |
| | acetyl nonyryl | FL/FR |
| amber |
| iso | butyl benzyl carbinol | FL/FR |
| animal |
| | civet absolute | FL/FR |
| | indole | FL/FR |
| 6- | methyl quinoline | FL/FR |
| balsamic |
| sumatra | benzoin resinoid | FL/FR |
| siam | benzoin resinoid | FL/FR |
| | benzyl salicylate | FL/FR |
| iso | butyl cinnamate | FL/FR |
| | copaiba balsam oil | FL/FR |
| | ethyl cinnamate | FL/FR |
| | peru balsam oil | FL/FR |
| | vanillylidene acetone | FL/FR |
| berry |
| | heliotropyl acetone | FL/FR |
| | raspberry ketone | FL/FR |
| bitter |
| | glyceryl tributyrate | FL |
| brown |
| 2-oxo | butyric acid | FL/FR |
| buttery |
| | butter cream frosting flavor | FL |
| | butyl laevo-lactate | FL/FR |
| | diacetyl | FL |
| cabbage |
| | methyl 2-thiofuroate | FL |
| caramellic |
| | caramel furanone | FL |
| | ethyl maltol | FL/FR |
| | fenugreek absolute | FL/FR |
| | strawberry furanone acetate | FL/FR |
| cheesy |
| 2- | heptanone | FL/FR |
| cherry |
| | heliotropin | FL/FR |
| para- | methoxycinnamaldehyde | FL/FR |
| citrus |
| | lime oil expressed florida | FL/FR |
| cocoa |
| | syringaldehyde | FL/FR |
| coconut |
| delta- | decalactone | FL/FR |
| (R)- | massoia lactone | FL |
| 6- | methyl coumarin | FL |
| gamma- | nonalactone (aldehyde C-18 (so-called)) | FL/FR |
| | octahydrocoumarin | FL/FR |
| delta- | octalactone | FL/FR |
| cooling |
| iso | butyl salicylate | FL/FR |
| coumarinic |
| | phthalide | FL/FR |
| creamy |
| | acetoin | FL/FR |
| | acetyl butyryl | FL/FR |
| | acetyl isobutyryl | FL/FR |
| 6- | amyl-alpha-pyrone | FL/FR |
| alpha- | angelica lactone | FL/FR |
| para- | anisaldehyde | FL/FR |
| | butyl butyryl lactate | FL/FR |
| | creamy lactone | FL/FR |
| 5,5- | dibutyl dihydrofuran-2(3H)-one | FL |
| delta- | dodecalactone | FL/FR |
| | glyceryl 5-hydroxydecanoate | FL/FR |
| | glyceryl 5-hydroxydodecanoate | FL/FR |
| gamma- | hexalactone | FL/FR |
| | massoia lactone | FL |
| para- | methyl acetophenone | FL/FR |
| | mint lactone | FL/FR |
| delta- | nonalactone | FL/FR |
| | octyl isobutyrate | FL/FR |
| delta- | undecalactone | FL/FR |
| gamma- | undecalactone (aldehyde C-14 (so-called)) | FL/FR |
| para- | vanillic acid | FL/FR |
| para- | vanillyl alcohol | FL/FR |
| dairy |
| | methyl (Z)-5-octenoate | FL/FR |
| earthy |
| 1- | nonen-3-ol | FL/FR |
| fatty |
| (Z)- | dairy lactone | FL/FR |
| | ethyl undecylenate | FL/FR |
| 4- | methyl octanoic acid | FL/FR |
| 2,4- | octadien-1-ol | FL |
| 2- | tridecanone | FL/FR |
| floral |
| | cananga oil | FL/FR |
| | dihydrojasmone | FL/FR |
| | linalyl acetate | FL/FR |
| | ocean propanal | FL/FR |
| fruity |
| | acetoin acetate | FL/FR |
| | acetyl isovaleryl | FL |
| | amyl heptanoate | FL/FR |
| iso | amyl octanoate | FL/FR |
| para- | anisyl acetate | FL/FR |
| para- | anisyl alcohol | FL/FR |
| | benzaldehyde | FL/FR |
| | cherry propanol | FL/FR |
| gamma- | decalactone | FL/FR |
| 3- | heptyl dihydro-5-methyl-2(3H)-furanone | FL/FR |
| 4- | hydroxybenzyl alcohol | FL/FR |
| iso | propyl octanoate | FL/FR |
| | tolualdehydes (mixed o,m,p) | FL/FR |
| grassy |
| | palmarosa oil | FL/FR |
| green |
| iso | amyl salicylate | FL/FR |
| | angelica root oil | FL/FR |
| | butyl lactate | FL/FR |
| | diphenyl methane | FL/FR |
| | galbanum oil | FL/FR |
| | heptanal 2,3-butane diol acetal | FL |
| (Z)-4- | hepten-1-ol | FL/FR |
| (Z)-4- | heptenal | FL/FR |
| (Z)-4- | heptenal diethyl acetal | FL/FR |
| | heptyl heptanoate | FL/FR |
| | immortelle absolute | FL/FR |
| | methyl heptadienone | FL/FR |
| | nerolidol | FL/FR |
| | oakmoss absolute | FL/FR |
| 3- | phenyl propionaldehyde | FL/FR |
| herbal |
| | apium graveolens seed oil india | FL/FR |
| | immortelle flower oil | FL/FR |
| abrialis | lavandin oil | FL/FR |
| | lavender oil | FL/FR |
| | massoia bark oil | FL |
| | origanum oil greece | FL/FR |
| honey |
| | phenethyl phenyl acetate | FL/FR |
| lactonic |
| gamma- | heptalactone | FL/FR |
| delta- | heptalactone | FL/FR |
| gamma- | octalactone | FL/FR |
| meaty |
| 4- | allyl-2,6-dimethoxyphenol | FL |
| milky |
| gamma- | butyrolactone | FL/FR |
| minty |
| (1R)-(-)- | myrtenal | FL |
| | myrtenal | FL/FR |
| mushroom |
| 3- | octen-2-ol | FL/FR |
| naphthyl |
| 2,4- | dimethyl benzaldehyde | FL/FR |
| beta- | naphthyl methyl ether | FL/FR |
| nutty |
| 2- | acetyl pyrrole | FL/FR |
| 2- | acetyl-5-methyl furan | FL/FR |
| powdery |
| | acetophenone | FL/FR |
| beta- | naphthyl ethyl ether | FL/FR |
| | powdery ketone | FL |
| soapy |
| 1- | dodecanol | FL/FR |
| sour |
| | butyric acid | FL/FR |
| spicy |
| | benzyl cinnamate | FL/FR |
| | benzyl isoeugenol | FL/FR |
| | benzylidene acetone | FL |
| | croton eluteria bark oil | FL/FR |
| | cubeb oil | FL/FR |
| iso | eugenyl acetate | FL/FR |
| | ginger root oil china | FL/FR |
| | levisticum officinale oleoresin | FL |
| | levisticum officinale root oil | FL/FR |
| alpha- | methyl cinnamaldehyde | FL/FR |
| | methyl cinnamate | FL/FR |
| alpha- | methyl-(E)-cinnamaldehyde | FL/FR |
| | nutmeg oil | FL/FR |
| | root beer float flavor | FL |
| sweet |
| | ethyl 3-(2-hydroxyphenyl) propionate | FL |
| | orange vanilla cream flavor | FL |
| | orris rhizome absolute (iris pallida) | FL/FR |
| | vanilla oleoresin bali | FL/FR |
| toasted |
| | acetyl propionyl | FL/FR |
| tomato |
| | methional | FL/FR |
| vanilla |
| | ethyl vanillin | FL/FR |
| | ethyl vanillin isobutyrate | FL/FR |
| | ethyl vanillin propylene glycol acetal | FL/FR |
| vanilla | ice cream flavor | FL |
| | propenyl guaethol | FL/FR |
| | vanilla bean absolute (vanilla planifolia) | FL/FR |
| | vanillin | FL/FR |
| | vanillyl acetate | FL/FR |
| | vanillyl isobutyrate | FL/FR |
| waxy |
| | allyl nonanoate | FL/FR |
| | dihydrojasmone lactone | FL/FR |
| | ethyl palmitate | FL/FR |
| | ethyl undecanoate | FL/FR |
| alpha- | hexyl cinnamaldehyde | FL/FR |
| | hydroxycitronellal | FL/FR |
| | methyl laurate | FL/FR |
| 2- | nonanol | FL/FR |
| | octyl 2-furoate | FL |
| | octyl butyrate | FL/FR |
| delta- | tetradecalactone | FL/FR |
| | undecanoic acid | FL/FR |
| woody |
| | amyris wood oil | FL/FR |
| ortho- | guaiacol | FL/FR |
| | guaiacwood oil | FL/FR |
| | methyl cedryl ketone | FL/FR |
| | patchouli oil | FL/FR |
| | sandalwood oil | FL/FR |
| | spruce needle oil canada | FL/FR |
| | vetiver oil haiti | FL/FR |
| | vetiverol | FL/FR |
| | whiskey lactone | FL/FR |
| |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzo dihydro pyrone | | | benzo dihydropyrone | | | benzo dihydropyrone natural | | | benzo dihydropyrone synthetic | | | benzodihydropyrone | | 1,2- | benzodihydropyrone | | | benzodihydropyrone FCC | | | benzodihydropyrone, natural | | 2H-1- | benzopyran-2-one, 3,4-dihydro- | | | benzopyranone, dihydro- | | 2-oxo- | chroman | | oxo | chroman | | | chroman-2-one | | | chroman, 2-oxo- | | 2- | chromanone | | | coumarin, 3,4-dihydro- | | | coumarin, dihydro- | | | di hydro coumarin | | | dihydro coumarin | | 3,4- | dihydro-1-benzopyran-2-one | | 3,4- | dihydro-2H-1-benzopyran-2-one | | 3,4- | dihydro-2H-chromen-2-on | | 3,4- | dihydro-2H,1-benzopyran-2-one | | | dihydrobenzopyrone | | 3,4- | dihydrocoumarin | | | dihydrocoumarin (benzodihydropyrone) | | | dihydrocoumarin FCC | | | hydrocinnamic acid, o-hydroxy-, d-lactone | | | hydrocoumarin | | o- | hydroxydihydrocinnamic acid delta-lactone | | ortho- | hydroxydihydrocinnamic acid delta-lactone | | 2- | hydroxydihydrocinnamic acid lactone | | | hydroxydihydrocinnamic acid lactone, o- | | | melilotic acid lactone | | | melilotic lactone | | | melilotin | | | melilotine | | | melilotol | | | meliotine |
Articles:
| Info: | EVALUATION OF CERTAIN FOOD ADDITIVES AND CONTAMINANTS |
| PubMed: | Tandem ruthenium-catalyzed transfer-hydrogenative cyclization/intramolecular Diels-Alder reaction of enediynes affording dihydrocoumarin-fused polycycles. |
| PubMed: | Study of possible mechanisms involved in the inhibitory effects of coumarin derivatives on neutrophil activity. |
| PubMed: | Effect of the nutritional supplement ALAnerv® on the serum PON1 activity in post-acute stroke patients. |
| PubMed: | Serum lactonase and arylesterase activities in alcoholic hepatitis and hepatitis B. |
| PubMed: | N-heterocyclic carbene-catalyzed [4 + 2] cycloaddition of ketenes and 3-aroylcoumarins: highly enantioselective synthesis of dihydrocoumarin-fused dihydropyranones. |
| PubMed: | Cancer chemoprevention and nutriepigenetics: state of the art and future challenges. |
| PubMed: | Synthesis and biological evaluation of α-methylidene-δ-lactones with 3,4-dihydrocoumarin skeleton. |
| PubMed: | [Determination of five coumarins in toys by high performance liquid chromatography-tandem mass spectrometry]. |
| PubMed: | Novel associations of nonstructural Loci with paraoxonase activity. |
| PubMed: | Oxidative potential of some endophytic fungi using 1-indanone as a substrate. |
| PubMed: | Catalytic versatility and backups in enzyme active sites: the case of serum paraoxonase 1. |
| PubMed: | Facile synthesis of 4-substituted 3,4-dihydrocoumarins via an organocatalytic double decarboxylation process. |
| PubMed: | An enantioselective approach toward 3,4-dihydroisocoumarin through the bromocyclization of styrene-type carboxylic acids. |
| PubMed: | High-Density Real-Time PCR-Based in Vivo Toxicogenomic Screen to Predict Organ-Specific Toxicity. |
| PubMed: | Asymmetric synthesis of 3,4-dihydrocoumarin motif with an all-carbon quaternary stereocenter via a Michael-acetalization sequence with bifunctional amine-thiourea organocatalysts. |
| PubMed: | Atom arrangement strategy for designing a turn-on 1H magnetic resonance probe: a dual activatable probe for multimodal detection of hypochlorite. |
| PubMed: | Chemical composition, anti-inflammatory, molluscicidal and free-radical scavenging activities of the leaves of Ficus radicans 'Variegata' (Moraceae). |
| PubMed: | Development and validation of two methods based on high-performance liquid chromatography-tandem mass spectrometry for determining 1,2-benzopyrone, dihydrocoumarin, o-coumaric acid, syringaldehyde and kaurenoic acid in guaco extracts and pharmaceutical preparations. |
| PubMed: | Coumarin metabolic routes in Aspergillus spp. |
| PubMed: | Paraoxonase 2 (PON2) in the mouse central nervous system: a neuroprotective role? |
| PubMed: | Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins). |
| PubMed: | Different effect of two synthetic coumarin-stilbene hybrid compounds on phagocyte activity. |
| PubMed: | Cancer chemoprevention by targeting the epigenome. |
| PubMed: | Organocatalytic asymmetric tandem Michael addition-hemiacetalization: a route to chiral dihydrocoumarins, chromanes, and 4H-chromenes. |
| PubMed: | A reinvestigation of the reaction of coumarins with superoxide in the liposomal bilayer: correlation between depth and reactivity. |
| PubMed: | Lactonases with organophosphatase activity: structural and evolutionary perspectives. |
| PubMed: | The thioesterase Bhp is involved in the formation of beta-hydroxytyrosine during balhimycin biosynthesis in Amycolatopsis balhimycina. |
| PubMed: | Interaction between human serum esterases and environmental metal compounds. |
| PubMed: | Determinants of variation in human serum paraoxonase activity. |
| PubMed: | Asymmetric cycloadditions of o-quinone methides employing chiral ammonium fluoride precatalysts. |
| PubMed: | A novel method for the synthesis of substituted 3,4-dihydrocoumarin derivatives via isocyanide-based three-component reaction. |
| PubMed: | Synthesis, spectroscopy and alkylating properties of Pd(II) complexes of phosphorohydrazones of coumarin and chromone with potential antibacterial activity. |
| PubMed: | Novel isocyanide-based four-component reaction: a facile synthesis of fully substituted 3,4-dihydrocoumarin derivatives. |
| PubMed: | AlCl3-mediated direct carbon-carbon bond-forming reaction of alpha-hydroxyketene-S,S-acetals with arenes and synthesis of 3,4-disubstituted dihydrocoumarin derivatives. |
| PubMed: | Aging and anti-aging: unexpected side effects of everyday medication through sirtuin1 modulation. |
| PubMed: | Lack of evidence for allergenic properties of coumarin in a fragrance allergy mouse model. |
| PubMed: | Biocatalytic production of dihydrocoumarin from coumarin by Saccharomyces cerevisiae. |
| PubMed: | Xenobiotic reductase A in the degradation of quinoline by Pseudomonas putida 86: physiological function, structure and mechanism of 8-hydroxycoumarin reduction. |
| PubMed: | The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases. |
| PubMed: | Isolation, structure elucidation, antioxidative and immunomodulatory properties of two novel dihydrocoumarins from Aloe vera. |
| PubMed: | Cloning, purification, and refolding of human paraoxonase-3 expressed in Escherichia coli and its characterization. |
| PubMed: | Cloning, high level expression of human paraoxonase-3 in Sf9 cells and pharmacological characterization of its product. |
| PubMed: | Regioselective synthesis and estrogenicity of (+/-)-8-alkyl-5,7-dihydroxy-4-(4-hydroxyphenyl)-3,4-dihydrocoumarins. |
| PubMed: | Senescence marker protein-30 is a unique enzyme that hydrolyzes diisopropyl phosphorofluoridate in the liver. |
| PubMed: | Chromanones and dihydrocoumarins from Calophyllum blancoi. |
| PubMed: | Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress. |
| PubMed: | Role of Acinetobacter calcoaceticus 3,4-dihydrocoumarin hydrolase in oxidative stress defence against peroxoacids. |
| PubMed: | Enzymatic preparation of D-beta-acetylthioisobutyric acid and cetraxate hydrochloride using a stereo- and/or regioselective hydrolase, 3,4-dihydrocoumarin hydrolase from Acinetobacter calcoaceticus. |
| PubMed: | Coupling of the lactone-ring conformation with crystal symmetry in 6-hydroxy-4,4,5,7,8-pentamethyl-3,4-dihydrocoumarin. |
| PubMed: | Lactone-ring-cleaving enzymes of microorganisms: their diversity and applications. |
| PubMed: | Purification and characterization of a novel lactonohydrolase from Agrobacterium tumefaciens. |
| PubMed: | 3,4-Dihydrocoumarin hydrolase with haloperoxidase activity from Acinetobacter calcoaceticus F46. |
| PubMed: | A "cephalosporin-like" cyclic depsipeptide: synthesis and reaction with beta-lactam-recognizing enzymes. |
| PubMed: | Selective Clara cell injury in mouse lung following acute administration of coumarin. |
| PubMed: | Intraperitoneal administration of coumarin causes tissue-selective depletion of cytochromes P450 and cytotoxicity in the olfactory mucosa. |
| PubMed: | Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds. |
| PubMed: | New metabolites in the degradation of fluorene by Arthrobacter sp. strain F101. |
| PubMed: | Natural ingredients based cosmetics. Content of selected fragrance sensitizers. |
| PubMed: | Structure-activity relationship of coumarins in xanthine oxidase inhibition. |
| PubMed: | HPLC analysis of tonka bean extracts. |
| PubMed: | Comparison of the hepatic effects of coumarin, 3,4-dimethylcoumarin, dihydrocoumarin and 6-methylcoumarin in the rat. |
| PubMed: | NTP Toxicology and Carcinogenesis Studies of Coumarin (CAS No. 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies). |
| PubMed: | NTP Toxicology and Carcinogenesis Studies of 3,4-Dihydrocoumarin (CAS No. 119-84-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies). |
| PubMed: | Structural requirements for the direct and cytochrome P450-dependent reaction of cyclic alpha,beta-unsaturated carbonyl compounds with glutathione: a study with coumarin and related compounds. |
| PubMed: | Purification and characterization of a novel lactonohydrolase, catalyzing the hydrolysis of aldonate lactones and aromatic lactones, from Fusarium oxysporum. |
| PubMed: | Isolation and characterization of a fluorene-degrading bacterium: identification of ring oxidation and ring fission products. |
| PubMed: | Toxicity of coumarin and various methyl derivatives in cultures of rat hepatocytes and V79 cells. |
| PubMed: | Anamnestic responses to contact allergens: application in the murine local lymph node assay. |
| PubMed: | Amine prodrugs which utilize hydroxy amide lactonization. II. A potential esterase-sensitive amide prodrug. |
| PubMed: | Acyloxybenzyl halides, inhibitors of elastases. |
| PubMed: | A prospective toxicity evaluation (COMPACT) on 40 chemicals currently being tested by the National Toxicology Program. |
| PubMed: | Reaction of thrombin and proteinases of the fibrinolytic system with a mechanism-based inhibitor, 3,4-dihydro-3-benzyl-6-chloromethylcoumarin. |
| PubMed: | Studies on the mechanism of coumarin-induced toxicity in rat hepatocytes: comparison with dihydrocoumarin and other coumarin metabolites. |
| PubMed: | Constituents of Justicia pectoralis Jacq. 2. Gas chromatography/mass spectrometry of simple coumarins, 3-phenylpropionic acids and their hydroxy and methoxy derivatives. |
| PubMed: | The sensitizing capacity of coumarins (II). |
| PubMed: | The epicutaneous maximization test. |
| PubMed: | Inactivation of human high- and low-molecular-weight urokinases. Analysis of their active site. |
| PubMed: | Reactions in selected patients to 22 fragrance materials. |
| PubMed: | Comparative study of methods chosen by the Association Française de Normalisation (AFNOR) for evaluating sensitizing potential in the albino guinea-pig. |
| PubMed: | Degradation of 3-phenylbutyric acid by Pseudomonas sp. |
| PubMed: | Further studies of effects of vehicles and elicitation concentration in experimental contact sensitization testing in humans. |
| PubMed: | Physiologically active substances from marine sponges V: Isolation of physiologically active compounds from the sponge Verongia archeri. |
| PubMed: | The metabolism of aromatic compounds in higher plants. V. Purification and properties of dihydrocoumarin hydrolase of Melilotus alba. |
| PubMed: | [Application of Baeyer-Villiger reaction in synthesis of dihydrocoumarin]. |
|