Articles:
| None found yet. Try the PubMed Search. |
2,4,6-triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine
Notes:
Used as a food additive [EAFUS]
-
Alfrebro LLC/ Archer Daniels Midland Company Let's get reacquainted Building great taste with aroma chemicals, extracts, and distillates The Alfrebro brand was established in the early 1900s by Alex Fries & Brothers, a Cincinnati Flavor Company. In 1980, the brand was re-launched as an aroma chemical manufacturer. Since its inception, Alfrebro’s primary focus has been to provide quality natural and high value synthetic chemicals. Email: Sarah Forbis Email: Sales Voice: 513-539-3021 Fax: 513-539-7372 US Voice: 513-539-7373 Newsroom Product(s): BACON THIAZOLE NATURAL 1% IN ETHANOL
-
-
BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 74595-94-1 2,4,6-Truisobutyl-5,6-dihydro-1,3,5-dithiazine
-
-
Charkit Chemical Corporation The Specialty Chemical Specialists Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you. about: Since 1982, Charkit has been committed to expanding the markets we serve as our roster of products and services continues to grow with us. Our substantial portfolio of personal care ingredients now include a wide array of luxury and exotic components to compliment the key products we have always offered. We have expanded our offerings to the nutraceutical, industrial, and resin markets with a growing roster of versatile and unique ingredients. We continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions. Please contact us to learn how we can help you reach your goals. Email: Sales Voice: 203-299-3220 Fax: 203-299-1355 Facebook Twitter Linkedin Latest News Events Blog Products List: View Product(s): TRIISOBUTYLDITHIAZINE FEMA 4017
-
-
FRUTAROM USA INC, Flavor & Specialty Ingredients Your preferred partner for flavour and fragrance success. Our broad and diverse product portfolio is designed to provide and cater for every flavor and taste profile required by our customer base and incorporates historic, and iconic, market leading products. Email: Info US Email: Info- USA Email: Sales Voice: +44 (0) 1429 863 222 CBD Offering Products List: View Product(s): 441NCT1876 TRIISOBUTYLDITHIAZINE KOSHER
-
-
Natural Advantage Manufacturer of natural flavor ingredients With over 25 years experience in the flavor and food ingredient industries. Technology Improving Taste Natural Advantage was formed over seventeen years ago to supply the growing demand for natural food and flavor ingredients. We employ a wide range of multi-disciplined scientists who are dedicated to high quality service, customer satisfaction and creating an outstanding value for our clients. Email: Info Email: Customer service Voice: 318-215-1456 Fax: 318-335-1579 Facebook Twitter Instagram Linkedin Who We Are Technology Riverside Aromatics LTD.is the exclusive distributor for Europe in UK for any non-US based inquiries Products List: View Product(s): NA4017-10OH Bacon Dithiazine Nat, 10% in OH NA4017-10Tri Bacon Dithiazine Nat, 10% in Triacetin NA4017-10Tri-U Bacon Dithiazine Nat, 10% in Triacetin Nat USOC
-
-
O'Laughlin Industries Inc. Manufacturer of chemicals and ingredients used in flavors, fragrances, food, beverages and cosmetics Leading the Flavor and Fragrance Industry since 1980. O'Laughlin was established in 1980 by its owner and chief executive Michael O'Laughlin, when he moved to Beijing, China and established a small office. Since then it has grown to be a world class producer of chemicals, with significant production facilities in China, and distribution and sales in all major world markets. Email: Sales US Email: John Gick Voice: (852) 2527-1031 Fax: (852) 2529-0231 US Voice: (973) 376-4600 US Fax: (973) 376-4630 Product(s): 772-3057 BACON DITHIAZINE
-
-
Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 20-74000 2,4,6-TRIISOBUTYL-5,6-DIHYDRO-4H-1,3,5-DITHIAZINE 20-74005 2,4,6-TRIISOBUTYL-5,6-DIHYDRO-4H-1,3,5-DITHIAZINE 1% IN ETOH 20-74025 2,4,6-TRIISOBUTYL-5,6-DIHYDRO-4H-1,3,5-DITHIAZINE NATURAL 1% ETOH
-
-
Riverside Aromatics Ltd. Speciality Aroma Chemicals, Naturals and Synthetics A specialist supplier of raw materials to the flavour industry. Peter Cannon & David Rowe established Riverside Aromatics in 2006 in Poole, UK, to offer a new type of specialist raw material supplier to the Flavour & Fragrance Industry. We bring together over 40 years of commercial & technical experience in the F&F industry which allows us to understand the needs of the Global F&F business and especially that of the West European Market. Email: Info Email: Peter Cannon (sales) Voice: +44 (0) 1202 679532 Fax: +44 (0) 1202 679532 Products List: View Product(s): NB1010 BACON DITHIAZINE, NATURAL, 10% IN TRIACETIN
-
-
Sigma-Aldrich Complete Supply Chain The perfect blend of products and services that bring your creativity to life. Sigma-Aldrich is a leading Life Science and High Technology company dedicated to providing high-quality, safe and certified flavor ingredients with transparent and easily accessible documentation to customers around the globe. Sigma-Aldrich also provides a suite of analytical tools that allow food analysts to simplify sample preparation, cleanup and analysis steps, while increasing sensitivity to trace ingredients and harmful substances to meet regulations and quality standards. Email: Information US Email: Sales US Voice: 800-244-1173 US Fax: 800-368-4661 Facebook Twitter Instagram Linkedin Flavors and Fragrances Analysis FandF Newsletter Subscription Flavors and Fragrances Learning Center Certified Food Grade Products Product(s): W401755 Bacon Dithiazine solution in EtOH SDS
-
-
Symrise AG Always Insiring More Symrise aroma molecules & cosmetic ingredients for unique and innovative fragrances, flavors and cosmetics. We are globally recognized as a leading provider of fragrances, flavors and active ingredients as well as aroma chemicals for the perfume, cosmetic, pharmaceutical, food and beverage industries. We combine our knowledge about consumers’ ever- changing needs with creativity and ground-breaking technologies. In doing so, we concentrate on the development of solutions that provide our customers with added value. We ensure sustained value creation by allowing our employees and shareholders to share our Company’s success. US Email: Life Essentials Email: Aroma Molecules Voice: +49 5531 90 0 Twitter Linkedin Youtube Newsroom RSS Feed Product(s): 600082 Triisobutyl dihydrodithiazine
Useful in: savory allium, savory meat.
-
-
Taytonn ASCC Pte Ltd Supplying Asia Pacific We fully understand the demands of the F&F industry and we endeavour to supply quality products, with ready availability and a personalised service. Since 2001 TAYTONN has been distributing key ingredients to the Fragrance and Flavor industry in Asia. We work closely with customers, principals and vendors. Together we forecast demand and match it with supply of aroma chemicals, essential oils and natural isolates & extracts. Sourced from around the world, our F&F ingredient inventory in Singapore is ready to ship to any location in Asia and beyond. Time and again, we help our principals introduce new discoveries to the F&F market - stimulating creativity and bringing value added proposition to our customers. Email: Info Email: Sales Voice: + 65 - 6861 8113 Fax: + 65 - 6861 8115 Linkedin Product(s): 2,4,6-Triisobutyl-5,6-Dihydro-1,3,5-Dithiazine
-
| CAS Number: | 74595-94-1 |  3D/inchi
|
| FDA UNII: | Z24510S94G | |
| Nikkaji Web: | J2.571.049E | |
| XlogP3-AA: | 6.40 (est) | |
| Molecular Weight: | 289.54907000 | |
| Formula: | C15 H31 N S2 | |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) | |
| EFSA/JECFA Comments: | JECFA evaluated 2,4,6-triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine (CASrn as in Register). (R)- or (S)- enantiomer not specified by CASrn in Register. According to JECFA: Min. assay value is ”95 % (mixture of 3 stereoisomers).” Mixture of diastereoisomers, each of them racemic (EFFA, 2013b). | |
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 1048 2,4,6-triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine |
| DG SANTE Food Flavourings: | 15.113 5,6-dihydro-2,4,6-tris(2-methyl propyl)4H-1,3,5-dithiazine |
| FEMA Number: | 4017 2,4,6-triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 74595-94-1 ; DIHYDRO-2,4,6-TRIS(2-METHYLPROPYL)-4H-1,3,5-DITHIAZINE |
Physical Properties:
| Appearance: | pale yellow to yellow crystals (est) |
| Assay: | 95.00 to 100.00 % sum of isomers |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 33.00 to 35.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 385.23 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 210.00 °F. TCC ( 98.89 °C. ) |
| logP (o/w): | 6.081 (est) |
| Soluble in: | |
| alcohol | |
| oils | |
| propylene glycol | |
| triacetin | |
| water, 2.184 mg/L @ 25 °C (est) | |
| Insoluble in: | |
| water | |
Organoleptic Properties:
| Odor Type: meaty | |
| meaty smoky bacon fatty chocolate | |
| Odor Description: at 0.10 % in propylene glycol. | meaty smoked bacon |
| Flavor Type: burnt | |
| burnt roasted bacon | |
| Taste Description: | burnt roasted crispy bacon |
| Odor and/or flavor descriptions from others (if found). | |
| Symrise | |
| Triisobutyl dihydrodithiazine | |
| Odor Description: | meaty smoked bacon |
| Taste Description: | Bacon, Roasted, Fried Egg, Sulfurous Useful in: savory allium, savory meat. |
| Alfrebro | |
| BACON THIAZOLE NATURAL 1% IN ETHANOL | |
| Odor Description: | Pork, Fatty, Meaty |
| Symrise | |
| Triisobutyl dihydrodithiazine natural 15% VTG | |
| Odor Description: | meaty smoked bacon |
| Taste Description: | burnt, roasted, crispy bacon Useful in: savory allium, savory meat |
| Blue Marble Biomaterials | |
| Bacon Dithiazine - Natural US/EU Natural, Food Grade, Non-GMO, Vegan | |
| Odor Description: | smoky, meaty, crispy, bacon |
| Taste Description: | meaty, burnt, crispy, bacon |
Cosmetic Information:
| None found |
Suppliers:
Safety Information:
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xi - Irritant | |
|
R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| Not determined | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavoring agents | ||
| Recommendation for bacon dithiazine usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 2.40 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 2.60 (μg/capita/day) | ||
| Structure Class: | II | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 20 | |||
| Click here to view publication 20 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | 0.20000 | 2.00000 | |
| beverages(nonalcoholic): | - | - | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | 0.10000 | 1.00000 | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | 0.10000 | 1.00000 | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | 0.20000 | 2.00000 | |
| fish products: | 0.04000 | 0.40000 | |
| frozen dairy: | - | - | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | 0.20000 | 2.00000 | |
| hard candy: | - | - | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | 0.10000 | 1.00000 | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | 0.04000 | 0.40000 | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | 0.04000 | 0.40000 | |
| reconstituted vegetables: | 0.04000 | 0.40000 | |
| seasonings / flavors: | - | - | |
| snack foods: | 0.04000 | 0.40000 | |
| soft candy: | - | - | |
| soups: | 0.10000 | 1.00000 | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): | |
| Flavouring Group Evaluation 21: Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf | |
| Flavouring Group Evaluation 76, (FGE.76)[1] - Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf | |
| Flavouring Group Evaluation 21, Revision 1 (FGE.21Rev1): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 Miscellaneous substances from chemical group 30 View page or View pdf | |
| Statement on List of Representative Substances for Testing.
The current Statement lays down a list of substances in sub-groups with representative substances for which additional data are required prior to their evaluation through the Procedure (Regulation (EC) No 1565/2000). View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 21, Revision 4 (FGE.21Rev4): Thiazoles, thiophenes, thiazoline and thienyl derivatives from chemical groups 29 and 30 View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1): Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev3 View page or View pdf | |
| Safety and efficacy of thiazoles, thiophene and thiazoline belonging to chemical group 29 when used as flavourings for all animal species View page or View pdf | |
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 46941523 |
| National Institute of Allergy and Infectious Diseases: | Data |
| 2,4,6-tris(2-methylpropyl)-1,3,5-dithiazinane | |
| Chemidplus: | 0074595941 |
References:
| 2,4,6-tris(2-methylpropyl)-1,3,5-dithiazinane | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 46941523 |
| Pubchem (sid): | 131325381 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| HMDB (The Human Metabolome Database): | HMDB32221 |
| FooDB: | FDB009292 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
Potential Blenders and core components note
| For Odor | ||
| coffee | ||
| coffee | ||
| roasted arabica | coffee bean oil CO2 extract | FL/FR |
| furfuryl mercaptan | FL/FR | |
| 4- | methyl nonanoic acid | FL/FR |
| nutty | ||
| 3- | acetyl pyridine | FL/FR |
| phenolic | ||
| 2,5- | xylenol | FL/FR |
| smoky | ||
| 2,6- | dimethoxyphenol | FL/FR |
| pyroligneous acids | FL/FR | |
| spicy | ||
| 4- | ethyl guaiacol | FL/FR |
| For Flavor | ||
| No flavor group found for these | ||
| amyl mercaptan | FL | |
| 3,5- | diisopropyl-1,2,4-trithiolane | FL |
| burnt | ||
| 1,6- | hexane dithiol | FL |
| 2- | methyl quinoxaline | FL |
| chemical | ||
| 2,5- | dimethyl furan | FL |
| coffee | ||
| roasted arabica | coffee bean oil CO2 extract | FL/FR |
| furfuryl mercaptan | FL/FR | |
| fatty | ||
| 4- | methyl nonanoic acid | FL/FR |
| garlic | ||
| garlic oleoresin | FL | |
| meaty | ||
| 4- | allyl-2,6-dimethoxyphenol | FL |
| ortho- | thioguaiacol | FL |
| medicinal | ||
| 2,6- | dimethoxyphenol | FL/FR |
| musty | ||
| 2,5- | xylenol | FL/FR |
| nutty | ||
| 3- | acetyl pyridine | FL/FR |
| phenolic | ||
| 2- | ethyl benzene thiol | FL |
| radish | ||
| 3-( | methyl thio) propyl mercaptoacetate | FL |
| roasted | ||
| 3,5- | diisobutyl-1,2,4-trithiolane | FL |
| hexyl mercaptan | FL | |
| smoky | ||
| prosopis juliflora wood extract | FL | |
| pyroligneous acids | FL/FR | |
| woody | ||
| 4- | ethyl guaiacol | FL/FR |
Potential Uses:
| bacon | FL | |
| chocolate | FL | |
| chocolate cocoa | FL | |
| meat | FL | |
| meat smoked meat | FL |
Occurrence (nature, food, other): note
| found in nature |
Synonyms:
| bacon thiazole (Alfrebro) | |
| dihydro-2,4,6-triisobutyl-4H-1,3,5-dithiazine | |
| 5,6- | dihydro-2,4,6-tris(2-methyl propyl)4H-1,3,5-dithiazine |
| 2,4,6-tris(2- | methylpropyl)-1,3,5-dithiazinane |
| triisobutyl dihydrodithiazine | |
| triisobutyl dihydrodithiazine natural 15% VTG | |
| 2,4,6- | triisobutyl-1,3,5-dithiazine |
| 2,4,6- | triisobutyl-5,6-dihydro-1,3,5-dithiazine |
| 2,4,6- | triisobutyl-5,6-dihydro-4H-1,3,5-dithiazine |
| triisobutyldihydrodithiazine |