2',3-dimethyl-3',4-dioxa-2,8-dithiabicyclo(3.3.0)octane spirocyclopentane
spiro(2,4-dithia-1-methyl-8-oxabicyclo(3.3.0)octane-3,3'-(1'-oxa-2-methyl)cyclopentane)
 
Notes:
Major component (65%) of the meaty flavour ingredient *FEMA 3270*
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      Product(s):
      38325-25-6 Hexahydro-2'3a-dimethylspiro[1,3-dithiolo[4,5-b]furan-2,3'(2'H)-furan] 95%
       
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      Product(s):
      04-86900 SPIRO[2,4-DITHIA-1-METHYL-8-OXABICYCLO-[3.3.0] -OCTANE-3,3-1
       
Synonyms   Articles   Notes   Search
CAS Number: 38325-25-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 253-884-7
FDA UNII: TER5ZXE00D
Nikkaji Web: J294.644K
CoE Number: 2325
XlogP3-AA: 2.10 (est)
Molecular Weight: 232.36592000
Formula: C10 H16 O2 S2
NMR Predictor: Predict (works with chrome or firefox)
EFSA/JECFA Comments: Stereoisomeric composition to be specified. Composition of mixture to be specified. Composition of structural isomers, I: 65 %, II: 35 %. Mixture of stereoisomers (Flavour Industry, 2012c).
Category: flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 1296  spiro[2,4-dithia-1-methyl-8-oxabicyclo(3.3.0)octane-3,3'-(1'-oxa-2'-methyl)-cyclopentane]
DG SANTE Food Flavourings: 15.007  spiro(2,4-dithia-1-methyl-8-oxabicyclo(3.3.0)octane-3,3'-(1'-oxa-2-methyl)cyclopentane)
FEMA Number: 3270 spiro(2,4-dithia-1-methyl-8-oxabicyclo(3.3.0)octane-3,3'-(1'-oxa-2-methyl)cyclopentane)
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):38325-25-6 ; SPIRO(2,4-DITHIA-1-METHYL-8-OXABICYCLO(3.3.0)OCTANE-3,3'-(1'-OXA-2'-METHYL)CYCLOPENTANE)
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Physical Properties:
Appearance: colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 1.20000 to 1.20800 @  25.00 °C.
Pounds per Gallon - (est).: 9.985 to 10.052
Refractive Index: 1.55900 to 1.56500 @  20.00 °C.
Boiling Point: 135.00 to  140.00 °C. @ 3.00 mm Hg
Vapor Pressure: 0.000050 mmHg @ 25.00 °C. (est)
Flash Point: 337.00 °F. TCC ( 169.44 °C. )
logP (o/w): 2.832 (est)
Soluble in:
 alcohol
 water, 68.67 mg/L @ 25 °C (est)
Insoluble in:
 water
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Organoleptic Properties:
 
 
Flavor Type: meaty
 
 meaty  
Taste Description:
meaty
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
BOC Sciences
For experimental / research use only.
Hexahydro-2'3a-dimethylspiro[1,3-dithiolo[4,5-b]furan-2,3'(2'H)-furan] 95%
Parchem
2',3-dimethyl-3',4-dioxa-2,8-dithiabicyclo(3.3.0)octane spirocyclopentane
Penta International
SPIRO[2,4-DITHIA-1-METHYL-8-OXABICYCLO-[3.3.0] -OCTANE-3,3-1
Shijiazhuang Donglian Nankai Aroma Chemicals
Hexahydro-2'3a-dimethylspiro[1,3-dithiolo[4,5-b]furan-2,3'(2'h)-furan]
Odor: Aromatic meat
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the CSA
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: flavoring agents
Recommendation for 2',3-dimethyl-3',4-dioxa-2,8-dithiabicyclo(3.3.0)octane spirocyclopentane usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 6.10 (μg/capita/day)
Threshold of Concern:90 (μg/person/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 5
Click here to view publication 5
 average usual ppmaverage maximum ppm
baked goods: --
beverages(nonalcoholic): -0.04500
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: -2.40000
fish products: --
frozen dairy: -0.25000
fruit ices: -0.25000
gelatins / puddings: --
granulated sugar: --
gravies: -0.07000
hard candy: -0.10000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -0.07000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -0.07000
sugar substitutes: --
sweet sauces: --
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Safety References:
European Food Safety Athority(EFSA): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on Flavouring Group Evaluation 8, Revision 3 (FGE.08Rev3): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 08, Revision 4 (FGE.08Rev4): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 08, Revision 5 (FGE.08Rev5): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30
View page or View pdf
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 38325-25-6
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 61979
National Institute of Allergy and Infectious Diseases: Data
 2',3a-dimethylspiro[6,6a-dihydro-5H-[1,3]dithiolo[4,5-b]furan-2,3'-oxolane]
Chemidplus: 0038325256
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References:
 2',3a-dimethylspiro[6,6a-dihydro-5H-[1,3]dithiolo[4,5-b]furan-2,3'-oxolane]
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 38325-25-6
Pubchem (cid): 61979
Pubchem (sid): 135019523
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
HMDB (The Human Metabolome Database): HMDB37809
FooDB: FDB016954
ChemSpider: View
EFSA Update of results on the monitoring of furan levels in food: Read Report
EFSA Previous report: Results on the monitoring of furan levels in food: Read Report
EFSA Report of the CONTAM Panel on provisional findings on furan in food: Read Report
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
For Odor
alliaceous
 dimethyl trisulfideFL/FR
 rum etherFL/FR
 strawberry furanoneFL/FR
2,6-dimethyl pyrazineFL/FR
coffee
 coffee difuranFL/FR
 furfuryl mercaptanFL/FR
2-methyl-3-,5 or 6-(furfuryl thio) pyrazineFL/FR
fresh
10-undecen-1-yl acetateFL/FR
fruity
3-mercaptohexyl acetateFL/FR
(E)-7-methyl-3-octen-2-oneFL/FR
 prunus amygdalus amara seed extractFL/FR
(E)-2-undecenalFL/FR
green
(E,Z)-2,6-nonadienalFL/FR
 meaty dithianeFL/FR
4-methyl nonanoic acidFL/FR
 sulfurolFL/FR
 sulfuryl acetateFL/FR
moldy
 strawberry furanone methyl etherFL/FR
 hazelnut pyrazineFL/FR
4,5-dimethyl-2-ethyl-3-thiazolineFL/FR
2-ethyl-4-methyl thiazoleFL/FR
 filbert heptenoneFL/FR
2,6-lutidineFL/FR
2-methyl pyrazineFL/FR
2-methyl-3-(methyl thio) pyrazineFL/FR
 trigonella foenum-graecum seed oil CO2 extractFL/FR
smoky
2,6-dimethoxyphenolFL/FR
 pyroligneous acidsFL/FR
 benzothiazoleFL/FR
 ethyl 3-mercaptopropionateFL/FR
 fish thiolFL/FR
 furfuryl thioacetateFL/FR
2-mercaptopropionic acidFL/FR
4-methyl 4-mercaptopentan-2-one 1% solutionFL/FR
 methyl mercaptanFL/FR
2-(methyl thio) phenolFL/FR
1-phenethyl mercaptanFL/FR
 
For Flavor
 
No flavor group found for these
4-acetyl-2-methyl pyrimidineFL
gamma-aminobutyric acidFL
 amyl mercaptanFL
1,2-butane dithiolFL
2-(2-butyl)-4,5-dimethyl-3-thiazolineFL
 cyclopropyl (E,Z)-2,6-nonadienamideFL
2,5-diethyl thiazoleFL
 dimethyl tetrasulfideFL
2,6-dimethyl-3-((2-methyl-3-furyl)thio)-4-heptanoneFL
bis(2,5-dimethyl-3-furyl) disulfideFL
(Z+E)-2,5-dimethyl-3-tetrahydrofuran thiolFL
(Z+E)-2,5-dimethyl-3-thioacetoxytetrahydrofuranFL
2,5-dimethyl-3-thiofuroyl furanFL
 ethyl (E,Z)-2,6-nonadienamideFL
S-ethyl 2-acetyl aminoethane thioateFL
 ethyl 3-mercaptopropionateFL/FR
 ethyl 4-(acetyl thio) butyrateFL
(Z+E)-5-ethyl-4-methyl-2-(2-butyl) thiazolineFL
(Z+E)-5-ethyl-4-methyl-2-(2-methyl propyl) thiazolineFL
4-methyl 4-mercaptopentan-2-one 1% solutionFL/FR
 methyl dihydrofuran thiolFL
2-methyl thiazolidineFL
2-(methyl thio) ethanolFL
2-methyl-3-,5 or 6-(furfuryl thio) pyrazineFL/FR
2-methyl-3-(methyl thio) pyrazineFL/FR
2-methyl-3-furyl tetrasulfideFL
3-((2-methyl-3-furyl)thio)-4-heptanoneFL
4-((2-methyl-3-furyl)thio)-5-nonanoneFL
1,9-nonane dithiolFL
 peanut dithiazineFL
1-phenethyl mercaptanFL/FR
1,3-propane dithiolFL
 propyl 2-methyl-3-furyl disulfideFL
isopropyl disulfideFL
3-thienyl mercaptanFL
N-(2-(3,4-dimethoxyphenyl)ethyl)-3,4-dimethoxycinnamic acid amideFL
3,7-dimethyl-2,6-octadien-1-yl cyclopropyl carboxamideFL
4-mercapto-2-pentanone 1% in acetoinFL
2-methyl-1-methyl thio-2-buteneFL
3-methyl-1,2,4-trithianeFL
 pyrrolidino-(1,2E)-4H-2,4-dimethyl-1,3,5-dithiazineFL
1-(2-thienyl) butanoneFL
alliaceous
 allyl disulfideFL
 allyl mercaptanFL
1,3-butane dithiolFL
 cyclopentyl mercaptanFL
 dicyclohexyl disulfideFL
 dimethyl trisulfideFL/FR
 garlic oil extendersFL
3-mercapto-2-pentanoneFL
3-tetrahydrothiophenoneFL
bacon
 bacon reaction crispyFL
burnt
 bacon dithiazineFL
1,6-hexane dithiolFL
 rum etherFL/FR
caramellic
 strawberry furanoneFL/FR
chemical
2,5-dimethyl furanFL
cocoa
 butyraldehydeFL
coffee
 coffee difuranFL/FR
2-ethyl-4-methyl thiazoleFL/FR
 furfuryl mercaptanFL/FR
 methyl furfuryl mercaptopropionateFL
 methyl furfuryl thiolFL
earthy
 difurfuryl sulfideFL
(±)-2-mercapto-5-methylheptan-4-oneFL
1,8-octane dithiolFL
2-thienyl disulfideFL
eggy
isopropyl mercaptanFL
fatty
(E,E)-2,4-decadienalFL
pork fat extractFL
4-methyl nonanoic acidFL/FR
(E)-7-methyl-3-octen-2-oneFL/FR
fruity
2-ethyl-2,5-dihydro-4-methyl thiazoleFL
greasy
10-undecen-1-yl acetateFL/FR
green
4-methyl thiazoleFL
(E,Z)-2,6-nonadienalFL/FR
4-penten-1-yl acetateFL
herbal
 massoia bark oilFL
meaty
4-allyl-2,6-dimethoxyphenolFL
 bacon flavorFL
 beef broth flavorFL
BBQ beef flavorFL
 beef flavorFL
roast beef flavorFL
 beef flavor baseFL
 benzothiazoleFL/FR
 chicken bone extractFL
 chicken extractFL
 chicken flavorFL
grilled chicken flavorFL
 chicken keyFL
2,6-dimethyl pyrazineFL/FR
2,6-dimethyl thiophenolFL
2,5-dimethyl-3-furan thiolFL
1,1-ethane dithiol 1% in ethanol 94.5% / ethyl acetate 4%FL
 ethyl 2-hydroxyethyl sulfideFL
 furfuryl 2-methyl-3-furyl disulfideFL
4-furfuryl thio-2-pentanoneFL
 ham enhancersFL
 ham flavorFL
 hot dog flavorFL
 lamb flavorFL
 liver flavorFL
 meat broth concentratesFL
 meat flavorsFL
 meaty dithianeFL/FR
 meaty enhancersFL
3-mercapto-2-butanoneFL
(R,S)-2-mercapto-3-butanolFL
3-mercapto-3-methyl butanolFL
2-mercaptomethyl pyrazineFL
2-mercaptopropionic acidFL/FR
2-methyl 3-(methyl thio) furanFL
2-(methyl thio) phenolFL/FR
 methyl thiofuryl butanalFL
12-methyl tridecanalFL
bis(2-methyl-3-furyl) disulfideFL
S-(2-methyl-3-furyl) ethane thioateFL
2-methyl-3-tetrahydrofuran thiolFL
2-methyl-3-thioacetoxytetrahydrofuranFL
 phenyl mercaptanFL
roasted pork flavorFL
grilled pork flavorFL
 pork flavorFL
 propyl 2-mercaptopropionateFL
 pyrazinyl ethane thiolFL
2-pyridinyl methane thiolFL
 rabbit flavorFL
grilled steak flavorFL
 sulfurolFL/FR
 sulfuryl acetateFL/FR
 thialdineFL
ortho-thiocresolFL
ortho-thioguaiacolFL
smoked turkey flavorFL
roast turkey flavorFL
 turkey flavorFL
 veal flavorFL
 venison flavorFL
medicinal
2,6-dimethoxyphenolFL/FR
metallic
2,5-dihydroxy-1,4-dithianeFL
moldy
 strawberry furanone methyl etherFL/FR
musty
2-ethoxythiazoleFL
 hazelnut pyrazineFL/FR
nutty
2-acetyl-4-methyl thiazoleFL
3,5-diethyl-2-methyl pyrazineFL
2,5-diethyl-3-methyl pyrazineFL
4,5-dimethyl-2-ethyl-3-thiazolineFL/FR
 filbert heptenoneFL/FR
2,6-lutidineFL/FR
2-methyl pyrazineFL/FR
 nutty thiazoleFL
 prunus amygdalus amara seed extractFL/FR
onion
 furfuryl isopropyl sulfideFL
 methionolFL
phenolic
2-ethyl benzene thiolFL
popcorn
2-propionyl-2-thiazolineFL
roasted
3,5-diisobutyl-1,2,4-trithiolaneFL
 furfuryl thioacetateFL/FR
 hexyl mercaptanFL
 trigonella foenum-graecum seed oil CO2 extractFL/FR
savory
N-(2,4-dimethoxybenzyl)-N2-(2-(pyridin-2-yl)ethyl) oxalamideFL
N-(heptan-4-yl)benzo(D)(1,3)dioxole-5-carboxamideFL
N1-(2-methoxy-4-methyl benzyl)-N2-(2-(pyridin-2-yl)ethyl) oxalamideFL
N1-(2-methoxy-4-methyl benzyl)-N2-2(2-(5-methyl pyridin-2-yl)ethyl) oxalamideFL
2,4,6-triethyl tetrahydro-1,3,5-dithiazineFL
smoky
 pyroligneous acidsFL/FR
spicy
hot spicy beef flavorFL
sulfurous
2,3-butane dithiolFL
 butyl mercaptanFL
S-ethyl thioacetateFL
 fish thiolFL/FR
 furfuryl thiopropionateFL
 methyl 2-methyl-3-furyl disulfideFL
 methyl mercaptanFL/FR
3-methyl-2-butane thiolFL
2-naphthyl mercaptanFL
3-pentane thiolFL
 roasted butanolFL
tropical
3-mercaptohexyl acetateFL/FR
vegetable
 tyramineFL
waxy
(E)-2-undecenalFL/FR
yeasty
 faex extractsFL
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 meatFL
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
2',3a-dimethyl spiro[6,6a-dihydro-5H-[1,3]dithiolo[4,5-b]furan-2,3'-oxolane]
2',3a-dimethylspiro[6,6a-dihydro-5H-[1,3]dithiolo[4,5-b]furan-2,3'-oxolane]
 hexahydro-2',3a-dimethylspiro(1,3-dithiolo(4,5-b)furan-2,3'(2'H)-furan)
 hexahydro-2',3a-dimethylspiro[1,3-dithiolo[4,5-b]furan-2,3'(2'H)-furan]
 hexahydro-2'3a-dimethyl spiro(1,3-dithiolo(4,5-b)furan-2,3'(2'H)-furan)
 hexahydro-2'3a-dimethylspiro(1,3-dithiolo(4,5-b)furan-2,3'(2'H)-furan)
 hexahydro-2'3a-dimethylspiro[1,3-dithiolo[4,5-b]furan-2,3'(2'H)-furan]
 spiro(1,3-dithiolo(4,5-b)furan-2,3'(2'H)-furan), hexahydro-2',3a-dimethyl-
 spiro(2,4-dithia-1-methyl-8-oxabicyclo(3.3.0)octane-3,3'-(1'-oxa-2-methyl)cyclopentane)
 spiro(2,4-dithia-1-methyl-8-oxabicyclo(3.3.0)octane-3,3'-(1'-oxa-2'-methyl)cyclopentane)
 spiro[2,4-dithia-1-methyl-8-oxabicyclo(3.3.0)octane-3,3'-(1'-oxa-2'-methyl)-cyclopentane]
 spirobeef
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