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Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
Organoleptic Properties:
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| Odor Type: sulfurous |
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| | sulfurous garlic onion egg nog coffee |
Odor Description: at 0.10 % in propylene glycol. | sulfury garlic onion egg coffee |
| |
| | sulfurous fatty beefy roasted beefy onion cooked onion egg nog coffee garlic |
Odor Description:
| Sulfureous, fatty, stewed beef, sauteed onion, egg, coffee and garlic Mosciano, Gerard P&F 23, No. 1, 33, (1998) |
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| Flavor Type: sulfurous |
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| | sulfurous vegetable savory meaty garlic onion |
Taste Description: at 1.00 ppm. | Sulfureous, vegetative, savory meaty, garlic and onion Mosciano, Gerard P&F 23, No. 1, 33, (1998) |
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| Odor and/or flavor descriptions from others (if found). |
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| Sigma-Aldrich |
| 1-Butanethiol, ≥98% |
| Odor Description: | alliaceous (onion, garlic) |
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Cosmetic Information:
Suppliers:
| Advanced Biotech |
| BUTYL MERCAPTAN SYNTHETIC
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| Beijing Lys Chemicals |
| 1-Butanethiol
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| Chevron Phillips |
| n-Butyl Mercaptan
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| DeLong Chemicals America |
| 1-Butanethiol, Kosher
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| EMD Millipore |
| For experimental / research use only. |
| 1-Butanethiol
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| Jinan Enlighten Chemical Technology(Wutong Aroma ) |
| n-Butyl mercaptan, Kosherk
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| Natural Advantage |
| Butanethiol, 1- Nat
Flavor: alliaceous, dairy, meaty, poultry, sulphurous |
| Riverside Aromatics LTD.is the exclusive distributor for Europe in UK for any non-US based inquiries |
| Penta International |
| 1-BUTANETHIOL NATURAL
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| Penta International |
| 1-BUTANETHIOL
|
| Riverside Aromatics |
| 1-BUTANETHIOL, NATURAL
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| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 1-Butanethiol
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| Sigma-Aldrich |
| 1-Butanethiol, ≥98%
Odor: alliaceous (onion, garlic) |
| Certified Food Grade Products |
| Synerzine |
| 1-Butanethiol
|
| Taytonn ASCC |
| Butyl Mercaptan
Odor: Cabbage, Earthy, Onion, Sulphurous |
| TCI AMERICA |
| For experimental / research use only. |
| 1-Butanethiol >97.0%(GC)
|
| Tengzhou Jitian Aroma Chemiclal |
| Butyl Mercaptan
|
| United International |
| 1-Butanethiol
|
| WholeChem |
| 1-Butanethiol
|
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xn - Harmful. |
R 11 - Highly flammable. R 20/22 - Harmful by inhalation and if swallowed. R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 20/21 - When using do not eat, drink or smoke. S 23 - Do not breath vapour. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
gavage-rat LD50 1500 mg/kg (Fairchild & Stokinger, 1958)
intraperitoneal-rat LD50 399 mg/kg BEHAVIORAL: COMA
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY American Industrial Hygiene Association Journal. Vol. 19, Pg. 171, 1958.
oral-mouse LD50 3000 mg/kg "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol.Pg.982, 1986
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
inhalation-rat LC50 4020 ppm/4H LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE American Industrial Hygiene Association Journal. Vol. 19, Pg. 171, 1958.
inhalation-mouse LC50 2500 ppm/4H BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE American Industrial Hygiene Association Journal. Vol. 19, Pg. 171, 1958.
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Safety in Use Information:
| Category: | flavoring agents |
| Recommendation for butyl mercaptan usage levels up to: | | | not for fragrance use.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.39 (μg/capita/day) |
| Structure Class: | I |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 10 |
| Click here to view publication 10 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | - |
| beverages(nonalcoholic): | - | - |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | - |
| fruit ices: | - | - |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | - | 0.02000 |
| hard candy: | - | - |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | 0.02000 |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | 0.02000 |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | 0.02000 |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
Flavouring Group Evaluation 8 (FGE.08)[1]: Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical group 20 View page or View pdf |
Flavouring Group Evaluation 8, Revision 1 (FGE.08Rev1): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 8, Revision 3 (FGE.08Rev3): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 08, Revision 4 (FGE.08Rev4): Aliphatic and alicyclic mono-, di-, tri-, and polysulphides with or without additional oxygenated functional groups from chemical groups 20 and 30 View page or View pdf |
| EPI System: | View |
| NIOSH International Chemical Safety Cards: | search |
| NIOSH Pocket Guide: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 109-79-5 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 8012 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WISER: | UN 3336 |
| WGK Germany: | 3 |
| | butane-1-thiol |
| Chemidplus: | 0000109795 |
| EPA/NOAA CAMEO: | hazardous materials |
| RTECS: | 109-79-5 |
References:
Other Information:
Potential Blenders and core components note
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| For Odor |
| alliaceous |
| | dibutyl sulfide | FL/FR |
| | dimethyl trisulfide | FL/FR |
| | methyl furfuryl disulfide | FL/FR |
| chocolate |
| 2,5- | dimethyl pyrazine | FL/FR |
| 2,6- | dimethyl pyrazine | FL/FR |
| fermented |
| | ethyl (E)-2-crotonate | FL/FR |
| herbal |
| | trigonella foenum-graecum seed extract | FL/FR |
| | sulfurol | FL/FR |
| | sulfuryl acetate | FL/FR |
| moldy |
| | strawberry furanone methyl ether | FL/FR |
| 2,4,5- | trimethyl oxazole | FL/FR |
| spicy |
| | ethyl vinyl ketone | FL/FR |
| | ethyl 2-mercaptopropionate | FL/FR |
| | ethyl methyl mercaptopropionate | FL/FR |
| | furfuryl thioacetate | FL/FR |
| 2- | methyl 5-(methyl thio) furan | FL/FR |
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| For Flavor |
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| No flavor group found for these |
| gamma- | aminobutyric acid | FL |
| | benzyl methyl sulfide | FL |
| 2-( | methyl thio) methyl-2-butenal | FL |
| 1,9- | nonane dithiol | FL |
|
| N-(2-(3,4- | dimethoxyphenyl)ethyl)-3,4-dimethoxycinnamic acid amide | FL |
| 2,4- | dimethyl-3-oxazoline | FL |
| 1-(2- | thienyl) butanone | FL |
| alliaceous |
| | allyl disulfide | FL |
| | allyl mercaptan | FL |
| | allyl thiopropionate | FL |
| | cyclopentyl mercaptan | FL |
| | dicyclohexyl disulfide | FL |
| | dimethyl trisulfide | FL/FR |
| 3- | mercapto-2-pentanone | FL |
| 2- | methyl thioacetaldehyde | FL |
| 3- | tetrahydrothiophenone | FL |
| | truffle sulfide | FL |
| bready |
| | trigonella foenum-graecum seed extract | FL/FR |
| burnt |
| 2,4,5- | trimethyl oxazole | FL/FR |
| chemical |
| 2,5- | dimethyl furan | FL |
| coffee |
| 2,4- | dimethyl thiazole | FL |
| | methyl furfuryl disulfide | FL/FR |
| green |
| | dibutyl sulfide | FL/FR |
| meaty |
| 2,6- | dimethyl pyrazine | FL/FR |
| 3- | mercapto-2-butanone | FL |
| (R,S)-2- | mercapto-3-butanol | FL |
| 2- | methyl 3-(methyl thio) furan | FL |
| bis(2- | methyl-3-furyl) disulfide | FL |
| 2- | methyl-3-tetrahydrofuran thiol | FL |
| 2- | pyridinyl methane thiol | FL |
| | sulfurol | FL/FR |
| | sulfuryl acetate | FL/FR |
| ortho- | thiocresol | FL |
| moldy |
| | strawberry furanone methyl ether | FL/FR |
| musty |
| 2,5- | dimethyl pyrazine | FL/FR |
| | ethyl (E)-2-crotonate | FL/FR |
| 2- | methyl 5-(methyl thio) furan | FL/FR |
| nutty |
| | nutty thiazole | FL |
| onion |
| | ethyl 2-mercaptopropionate | FL/FR |
| | furfuryl isopropyl sulfide | FL |
| | methionol | FL |
| | methyl propyl disulfide | FL |
| | methyl propyl trisulfide | FL |
| | propyl thioacetate | FL |
| roasted |
| | furfuryl thioacetate | FL/FR |
| | hexyl mercaptan | FL |
| savory |
| N1-(2- | methoxy-4-methyl benzyl)-N2-2(2-(5-methyl pyridin-2-yl)ethyl) oxalamide | FL |
| seafood |
| 1,4- | dithiane | FL |
| spicy |
| | ethyl vinyl ketone | FL/FR |
| sulfurous |
| | allyl sulfide | FL |
| | ethyl methyl mercaptopropionate | FL/FR |
| | ethyl methyl sulfide | FL |
| S- | ethyl thioacetate | FL |
| | furfuryl thiopropionate | FL |
| 3- | mercapto-2-methyl pentanal | FL |
| | methyl 2-methyl-3-furyl disulfide | FL |
| | methyl benzyl disulfide | FL |
| 3- | methyl-2-butane thiol | FL |
| | roasted butanol | FL |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | bear skunk | | 1- | butane thiol | | | butane-1-thiol | | 1- | butanethiol | | 1- | butyl mercaptan | | N- | butyl mercaptan | | | butyl mercaptan synthetic | | | butyl sulfide | | | butyl sulphide | | | butyl thioalcohol | | | butyl thiol | | N- | butyl-sulfide | | 1- | mercaptobutane | | | thiobutyl alcohol |
Articles:
| PubMed: | Development of a quantitative approach using surface-enhanced Raman chemical imaging: first step for the determination of an impurity in a pharmaceutical model. |
| PubMed: | Community Health Assessment Following Mercaptan Spill: Eight Mile, Mobile County, Alabama, September 2012. |
| PubMed: | Stability of volatile sulfur compounds (VSCs) in sampling bags - impact of temperature. |
| PubMed: | Determination of Lewisites and their hydrolysis products in aqueous and multiphase samples by in-sorbent tube butyl thiolation followed by thermal desorption-gas chromatography-full scan mass spectrometry. |
| PubMed: | Oxygen attachment on alkanethiolate SAMs induced by low-energy electron irradiation. |
| PubMed: | Electrochemical gas sensors based on paper-supported room-temperature ionic liquids for improved analysis of acid vapours. |
| PubMed: | Analysis of thiols by microchip capillary electrophoresis for in situ planetary investigations. |
| PubMed: | Ion-molecule reactions for the differentiation of primary, secondary and tertiary hydroxyl functionalities in protonated analytes in a tandem mass spectrometer. |
| PubMed: | An electrochemical gas sensor based on paper supported room temperature ionic liquids. |
| PubMed: | Aqueous photoreduction of oxidized mercury species in presence of selected alkanethiols. |
| PubMed: | A cataluminescence gas sensor based on nanosized V2O5 for tert-butyl mercaptan. |
| PubMed: | Synthesis of thiol capped CdS nanocrystallites using microwave irradiation and studies on their steady state and time resolved photoluminescence. |
| PubMed: | Principles of detecting vaporous thiols using liquid crystals and metal ion microarrays. |
| PubMed: | Kinetic and theoretical study of the reaction of Cl atoms with a series of linear thiols. |
| PubMed: | A new efficient enantioselective synthesis of (+)-cis-2-methyl-4-propyl-1,3-oxathiane, a valuable ingredient for the aroma of passion fruit. |
| PubMed: | Conformationally specific vacuum ultraviolet mass-analyzed threshold ionization spectroscopy of alkanethiols: structure and ionization of conformational isomers of ethanethiol, isopropanethiol, 1-propanethiol, tert-butanethiol, and 1-butanethiol. |
| PubMed: | Determination of volatile organic sulfur compounds in the air at sewage management areas by thermal desorption and gas chromatography-mass spectrometry. |
| PubMed: | A micromachined surface stress sensor with electronic readout. |
| PubMed: | [Determination and distribution of sulfur compounds in coked gasoline by gas chromatography-sulfur chemiluminescence detection]. |
| PubMed: | Electrochemical factors controlling the patterning of metals on SAM-coated substrates. |
| PubMed: | Synthesis of hydroxy thio-ether derivatives of vegetable oil. |
| PubMed: | [Determination of sulfur compounds in fluid catalytic cracking gasoline by gas chromatography with a sulfur chemiluminescence detector]. |
| PubMed: | On-column derivatization-capillary electrochromatography with o-phthalaldehyde/alkylthiol for assay of biogenic amines. |
| PubMed: | Volatile components in defensive spray of the hooded skunk, Mephitis macroura. |
| PubMed: | NEXAFS study of 1-butanethiol adsorbed on Cu(111) and square root of 7 x square root of 7 R19.1 degrees S/Cu(111). |
| PubMed: | Effects of the sniffing port air makeup in gas chromatography-olfactometry. |
| PubMed: | Inter- and intramolecular pathways for the formation of tetrahydrofurans from beta-(Phosphatoxy)alkyl radicals. Evidence for a dissociative mechanism |
| PubMed: | Determination of sulphur compounds in beer using headspace solid-phase microextraction and gas chromatographic analysis with pulsed flame photometric detection. |
| PubMed: | [Hygienic assessment of damaging exposure of schoolchildren to butyl mercaptan]. |
| PubMed: | Mortality following cotton defoliation: San Joaquin Valley, California, 1970-1990. |
| PubMed: | Metabolic fate of S,S,S-tributyl phosphorotrithioate (DEF) in the lactating goat. |
| PubMed: | Volatile components in defensive spray of the hog-nosed skunk,Conepatus mesoleucus. |
| PubMed: | Volatile components in defensive spray of the spotted skunk,Spilogale putorius. |
| PubMed: | New components in defensive secretion of the striped skunk,Mephitis mephitis. |
| PubMed: | Oxidation of thiols by sodium N-haloarylsulphonamides. |
| PubMed: | Mercaptans decrease selenium-dependent glutathione peroxidase activity in the chick. |
| PubMed: | Inhalation teratology studies of n-butyl mercaptan in rats and mice. |
| PubMed: | Antioxidant enzyme activities and malondialdehyde, glutathione and methemoglobin concentrations in channel catfish exposed to DEF and n-butyl mercaptan. |
| PubMed: | Liquid chromatographic-fluorescence determination of ammonia from nitrogenase reactions: a 2-min assay. |
| PubMed: | Heinz body production and hematological changes in the hen after administration of a single oral dose of n-butyl mercaptan and n-butyl disulfide. |
| PubMed: | Butyl mercaptan poisoning in the Parnell civil defence emergency: fact or fiction. |
| PubMed: | Reactions of mercaptans with cytochrome c oxidase and cytochrome c. |
| PubMed: | Delayed neurotoxic, late acute and cholinergic effects of S,S,S-tributyl phosphorotrithioate (DEF): subchronic (90 days) administration in hens. |
| PubMed: | Specific inhibition of sclerotium formation by 2-mercaptoethanol and related sulfhydryl compounds in Sclerotium rolfsii. |
| PubMed: | The incidence and probable inheritance of smell blindness to normal butyl mercaptan. |
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