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4,5-dimethyl-2-isobutyl-3-thiazoline
Notes:
Component of cooked beef aroma. Flavouring ingredient
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Beijing Lys Chemicals Co, LTD. From Grams to Tons Fine chemical high-tech company which contains R&D, production, and sales. BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services. Email: Mr. Jia Email: Mr. Guo Voice: 86-10-68418738 Fax: 86-10-68418739 Mr. Guo 86-10-68483445 Mr. Guo 86-10-68418739 News Product(s): 10176 4,5-Dimethyl-2-isobutyl-3-thaizoline
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 65894-83-9 4,5-Dimethyl-2-isobutyl-3-thiazoline
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Endeavour Specialty Chemicals Ltd Expertise in high impact aroma chemicals Endeavour Speciality Chemicals offers high-impact aroma chemicals, at small to medium scale. Speciality Chemical has more than 25 years experience of manufacturing high-impact aroma chemicals. With our core expertise in sulfur and heterocyclic chemistries, Endeavours products have applications in a range of industry sectors including flavours and fragrances, pharmaceutical research and material sciences. Endeavour also offer custom synthesis and contract manufacturing services at their UK manufacturing site. Email: Info Email: Sales Voice: +44 (0)1327 310 079 Fax: +44 (0)1327 310 701 Twitter Linkedin News Speciality Chemical Product Groups Product(s): TZ0190 4,5-Dimethyl-2-isobutyl-3-thiazoline 97% F&F
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Firmenich Inc. We Create We create perfumes and flavors for the World's most desirable brands. Firmenich is the largest privately-owned company in the perfume and flavor business. Swiss and family owned, we have created many of the world’s favorite perfumes for over 100 years and produced a number of the most well known flavors we enjoy each day. US Email: Fred Keifer US Voice: +1 609 452 1000 US Fax: +1 609 452 6077 Facebook Twitter Instagram Linkedin Product(s): 987646 Thiazoline Nat 1 TRIAC
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Jiangyin Healthway International Trade Co., Ltd Independent Ingredients Supplier We provide custom synthesis and contract manufacturing from milligrams to metric tonnes. Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals. Email: Info Email: Sales Voice: 86-510-86023169 Fax: 86-510-86023170 Mobile 0086-13093133011 Services Biochemical Natural Food Colour New functional food ingredients Product(s): HL0153 4,5-Dimethyl-2-isobutyl-3-thiazoline
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M&U International LLC Steady supply & demand Meeting customers increasing demands at home as well as abroad. M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. Email: Sales US Email: Sales Voice: +86-21-32515501 60762991 60762992 Fax: +86-21-32515502 64204960 US Voice: 908-359-9000 US Fax: 908-359-9002 News Product(s): H0080 4,5-DIMETHYL-2-ISOBUTYL-3-THIAZOLINE, Kosher
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 04-50000 4,5-DIMETHYL-2-ISOBUTYL-3-THIAZOLINE
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Robinson Brothers Limited Providing Excellence in Chemistry Award-winning UK chemical manufacturer of chemical intermediates and high-impact aroma chemicals. Based in the UK, Robinson Brothers is an award-winning chemical manufacturer of chemical intermediates and high-impact aroma chemicals. Robinson Brothers serve many industry sectors across the globe, include: flavour/fragrance, pharmaceutical, agrochemical and material sciences. Our team of Chemists are experts in custom synthesis, contract manufacture and process optimisation. Email: Info Email: Sales Voice: +44 (0)121 553 2451 Fax: +44 (0)121 500 5183 Twitter Linkedin News And Exhibitions Custom Synthesis Industries And Applications https://www.robinsonbrothers.uk/chemistry-competences Products List: View Product(s): TZ0190 4,5-Dimethyl-2-isobutyl-3-thiazoline F&F
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Sunaux International Buy With Confidence We have industry leading processes and procedures to ensure nothing but the most reliable product. Sunaux International was founded in 2012 by the owner Mr.John Felton after spending 18 years involved in developing global business in the aromatic chemicals, fragrance and flavour compounds business. Email: John Felton Email: Stephen Zhou (Sales) Voice: 0512-57995626 Fax: 0512-57570299 Sales 0512-57995626 Sales 0512-57570299 News Product(s): H0080 4,5-Dimethyl-2-isobutyl-3-thiazoline
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Synerzine, Inc. Innovation. Customization. Aroma Ingredients. Synerzine is a leading supplier of flavor and fragrance ingredients. Synerzine expresses what we have grown to embody as an organization - the synergy and connection between raw ingredients, science, technology, and the final product. Our experienced team is passionate about bringing our customers high-quality innovative ingredients that they can trust. Building upon our 44 year history, the Synerzine team provides customers around the globe with convenient access to over 1200 high-quality aroma ingredients. We actively engage with customers to add a wide array of new products and services on a regular basis. Our aim is to delight every customer with our exceptional services, large product selection, customization and the highest quality and safety standards. We provide our customers with true value designed to help them bring their products to market faster. US Email: Customer Service US Email: Sales US Voice: (404) 524-6744 US Fax: (404) 577-1651 Inquiry Products List: View Product(s): T234 4,5-Dimethyl-2-Isobutyl-3-Thiazoline
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TCI AMERICA Moving Your Chemistry Forward We continuously strive to advance our technology. With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping! Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis. US Email: Sales Email: Technical Support Voice: 1-800-423-8616 Fax: 1- 888-520-1075 Facebook Twitter Instagram Linkedin Product(s): I0737 2-Isobutyl-4,5-dimethyl-3-thiazoline (mixture of isomers) >95.0%(GC)
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Tianjin Danjun International Trade Co., LTD. Quality Products We know the Chinese chemical market well. Tianjin danjun international trade co., LTD. is an organic chemicals trading company approved by the relevant state authorities to register. We have about 300 kinds of products (natural aroma chemicals, synthetic aroma chemicals and pharmaceutical intermediates). Most of the products are used in flavor and fragrance industry. We know the Chinese chemical market well and we have close relationship with many of the main manufacturers, and to provide our customers with quality goods together with comprehensive service. Email: Info Email: Sales Voice: +86-15822601686 Products List: View Product(s): B-049 4,5-Dimethyl-2-isobutyl-3-thaizoline
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R C Treatt and Co Ltd Innovative ingredient solutions World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries. We offer innovative and trend-setting product concepts for our customers, collaborating with them to create true value for their products. Email: Enquiries US Email: Enquiries Voice: +44 (0) 1284 702500 Fax: +44 (0) 1284 703809 US Voice: +1 863 668 9500 US Fax: +1 863 668 3388 Twitter Linkedin Youtube News Product(s): 2-Isobutyl-4,5-dimethyl-3-thiazoline Halal, Kosher
Used in bakery, desserts, and confectionery at 2ppm, and meat products soups and sauces at 0.5ppm.
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Qingdao Free Trade Zone United International Co Ltd Quality Products A partner in your supply chain solution. Qingdao Free Trade Zone United International Trade Co., Ltd.was founded in 1996, specializing in the production and import and export of food additives,flavor raw materials and pharmaceutical and chemical raw materials. The company has experienced R&D and business personnel,product quality, low price, efficient service and fast insight and grasp the latest market information. Email: Info Email: Sales Voice: +86-532-83893699 Fax: +86-532-83893695 Product(s): 2015 4,5-Dimethyl-2-Isobutyl Thiazoline
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| CAS Number: | 65894-83-9 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 265-969-6 | |
| FDA UNII: | IJC76KB65W | |
| Nikkaji Web: | J349.293A | |
| Beilstein Number: | 0774665 | |
| MDL: | MFCD01680822 | |
| XlogP3-AA: | 2.60 (est) | |
| Molecular Weight: | 171.30649000 | |
| Formula: | C9 H17 N S | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
| EFSA/JECFA Comments: | JECFA evaluated 4,5-dimethyl-2-isobutyl-3-thiazoline (CASrn as in Register). (R)- or (S)- enantiomer not specified by CASrn in Register. According to JECFA: Min. assay value is ”97 %” and ”60:40 mix of cis and trans isomers”. Mixture of diastereoisomers, each of them racemic (EFFA, 2013b). | |
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 1045 4,5-dimethyl-2-isobutyl-3-thiazoline |
| DG SANTE Food Flavourings: | 15.032 4,5-dimethyl-2-isobutyl-3-thiazoline |
| FEMA Number: | 3621 4,5-dimethyl-2-isobutyl-3-thiazoline |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 65894-83-9 ; 4,5-DIMETHYL-2-ISOBUTYL-3-THIAZOLINE |
Physical Properties:
| Appearance: | colorless to pale yellow clear liquid (est) |
| Assay: | 97.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.93300 to 0.93700 @ 25.00 °C. |
| Pounds per Gallon - (est).: | 7.763 to 7.797 |
| Refractive Index: | 1.48300 to 1.48900 @ 20.00 °C. |
| Boiling Point: | 206.00 to 208.00 °C. @ 760.00 mm Hg |
| Vapor Pressure: | 0.085000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 189.00 °F. TCC ( 87.22 °C. ) |
| logP (o/w): | 3.949 (est) |
| Soluble in: | |
| alcohol | |
| water, 7.73 mg/L @ 25 °C (est) | |
| Insoluble in: | |
| water | |
Organoleptic Properties:
| Odor Type: sulfurous | |
| green nut skin sulfurous burnt cocoa corn | |
| Odor Description: at 1.00 % in propylene glycol. | green nut skin sulfurous burnt cocoa corn Luebke, William tgsc, (2007) |
| Flavor Type: malty | |
| malty cocoa chocolate hops nut skin cornmeal yeasty meaty | |
| Taste Description: | malty cocoa chocolate hops nut skin cornmeal yeasty meaty Luebke, William tgsc, (2007) |
| Odor and/or flavor descriptions from others (if found). | |
| R C Treatt & Co Ltd | |
| 2-Isobutyl-4,5-dimethyl-3-thiazoline Halal, Kosher | |
| Odor Description: | meaty, vegetable, spicy |
| Taste Description: | meaty Used in bakery, desserts, and confectionery at 2ppm, and meat products soups and sauces at 0.5ppm. |
| Firmenich | |
| Thiazoline Nat 1 TRIAC | |
| Odor Description: | green nut skin sulfurous burnt cocoa corn |
| Taste Description: | Malt, cocoa, hop and tropical fruit notes |
Cosmetic Information:
| None found |
Suppliers:
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
gavage-mouse LD50 [sex: M,F] 3067 mg/kg (Moran et al., 1980) oral-mouse LD50 3067 mg/kg Drug and Chemical Toxicology. Vol. 3, Pg. 249, 1980. | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavoring agents | ||
| Recommendation for yeast thiazoline usage levels up to: | |||
| not for fragrance use. | |||
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.012 (μg/capita/day) | ||
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 4.00 (μg/capita/day) | ||
| Structure Class: | III | ||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 12 | |||
| Click here to view publication 12 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 2.00000 | |
| beverages(nonalcoholic): | - | - | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | 2.00000 | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | - | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | 2.00000 | |
| granulated sugar: | - | - | |
| gravies: | - | 0.50000 | |
| hard candy: | - | - | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | 0.50000 | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | 0.50000 | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): | |
| Flavouring Group Evaluation 21: Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf | |
| Flavouring Group Evaluation 76, (FGE.76)[1] - Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf | |
| Flavouring Group Evaluation 21, Revision 1 (FGE.21Rev1): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 Miscellaneous substances from chemical group 30 View page or View pdf | |
| Statement on List of Representative Substances for Testing.
The current Statement lays down a list of substances in sub-groups with representative substances for which additional data are required prior to their evaluation through the Procedure (Regulation (EC) No 1565/2000). View page or View pdf | |
| Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1): Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev3 View page or View pdf | |
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 65894-83-9 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 4120025 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WISER: | UN 1993 |
| WGK Germany: | 2 |
| 4,5-dimethyl-2-(2-methylpropyl)-2,5-dihydro-1,3-thiazole | |
| Chemidplus: | 0065894839 |
| RTECS: | XJ6642800 for cas# 65894-83-9 |
References:
| 4,5-dimethyl-2-(2-methylpropyl)-2,5-dihydro-1,3-thiazole | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 65894-83-9 |
| Pubchem (cid): | 4120025 |
| Pubchem (sid): | 135267708 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| HMDB (The Human Metabolome Database): | HMDB37159 |
| FooDB: | FDB016154 |
| Export Tariff Code: | 2934.10.0090 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
Potential Blenders and core components note
Potential Uses:
| bread | FL | |
| meat | FL | |
| nut | FL | |
| taco | FL | |
| vegetable | FL | |
| yeast | FL |
Occurrence (nature, food, other): note
| beef cooked beef Search PMC Picture |
Synonyms:
| 2-iso | butyl-4,5-dimethyl-2,5-dihydro-1,3-thiazole |
| 2-iso | butyl-4,5-dimethyl-2,5-dihydrothiazole |
| 2-iso | butyl-4,5-dimethyl-3-thiazoline |
| iso | butyl-4,5-dimethyl-3-thiazoline |
| 2,5- | dihydro-2-isobutyl-4,5-dimethylthiazole |
| 2,5- | dihydro-4,5-dimethyl-2-(2-methyl propyl) thiazole |
| 2,5- | dihydro-4,5-dimethyl-2-(2-methylpropyl) thiazole |
| 2,5- | dihydro-4,5-dimethyl-2-(2-methylpropyl)thiazole |
| 2,5- | dihydro-4,5-dimethyl-2-2-methyl propyl thiazole |
| 2,5- | dihydro-4,5-dimethyl-2-2-methylpropylthiazole |
| dimethyl 2 6 isobutyl thiazoline | |
| 4,5- | dimethyl-2-(2-methylpropyl)-1,3-thiazoline |
| 4,5- | dimethyl-2-(2-methylpropyl)-2,5-dihydro-1,3-thiazole |
| 4,5- | dimethyl-2-isobutyl-3-thaizoline |
| 4,5- | dimethyl-2-isobutyl-3-thiazoline |
| 3- | thiazoline, 2-isobutyl-4,5-dimethyl- |