2-methyl-5-methoxythiazole
thiazole, 5-methoxy-2-methyl-
 
Notes:
Flavouring ingredient
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CAS Number: 38205-64-0Picture of molecule3D/inchi
FDA UNII: 154Z60090O
Nikkaji Web: J59.611F
Beilstein Number: 1209888
CoE Number: 736
XlogP3-AA: 1.70 (est)
Molecular Weight: 129.18199000
Formula: C5 H7 N O S
NMR Predictor: Predict (works with chrome or firefox)
Category: flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
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Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
JECFA Food Flavoring: 1057  2-methyl-5-methoxythiazole
FLAVIS Number: 15.002 (Old)
DG SANTE Food Flavourings: 15.002  2-methyl-5-methoxythiazole
FEMA Number: 3192  2-methyl-5-methoxythiazole
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm: 2-METHYL-5-METHOXYTHIAZOLE
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Physical Properties:
Appearance: yellow amber clear liquid (est)
Assay: 98.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 1.14600 to 1.15400 @  25.00 °C.
Pounds per Gallon - (est).: 9.536 to  9.602
Refractive Index: 1.51500 to 1.52000 @  20.00 °C.
Boiling Point: 117.00 °C. @ 34.00 mm Hg
Vapor Pressure: 1.085000 mm/Hg @ 25.00 °C. (est)
Flash Point: 147.00 °F. TCC ( 63.89 °C. )
logP (o/w): 0.336 (est)
Soluble in:
 alcohol
 water, 3822 mg/L @ 25 °C (est)
Insoluble in:
 water
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Organoleptic Properties:
 
Odor Type: sulfurous
 
Odor Strength: high ,
recommend smelling in a 0.10 % solution or less
 
 green  cabbage  vegetable  sulfurous  
Odor Description:
at 0.10 % in dipropylene glycol. 
green cabbage vegetable sulfurous
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
BOC Sciences
For experimental / research use only.
2-Methyl-5-methoxythiazole
Parchem
2-methyl-5-methoxythiazole
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the CSA
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  1250 mg/kg
(Posternak et al., 1975)

oral-rat LD50  1250 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 487, 1975.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavoring agents
Recommendation for 2-methyl-5-methoxythiazole usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.012 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.01 (μg/capita/day)
Structure Class: III
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 4
Click here to view publication 4
 average usual ppmaverage maximum ppm
baked goods: -4.00000
beverages(nonalcoholic): -2.00000
beverages(alcoholic): --
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: --
fruit ices: --
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -2.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -2.00000
sugar substitutes: --
sweet sauces: --
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Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Flavouring Group Evaluation 21: Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29. Miscellaneous substances from chemical group 30. (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 76, (FGE.76)[1] - Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29, miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21 - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Flavouring Group Evaluation 21, Revision 1 (FGE.21Rev1): Thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 Miscellaneous substances from chemical group 30
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 96 (FGE.96): Consideration of 88 flavouring substances considered by EFSA for which EU production volumes / anticipated production volumes have been submitted on request by DG SANCO. Addendum to FGE. 51, 52, 53, 54, 56, 58, 61, 62, 63, 64, 68, 69, 70, 71, 73, 76, 77, 79, 80, 83, 84, 85 and 87.
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 76, Revision 1 (FGE.76Rev1): Consideration of sulphur-containing heterocyclic compounds evaluated by JECFA (59th meeting) structurally related to thiazoles, thiophene, thiazoline and thienyl derivatives from chemical group 29 and miscellaneous substances from chemical group 30 evaluated by EFSA in FGE.21Rev3
View page or View pdf
EPI System: View
EPA Substance Registry Services (TSCA): 38205-64-0
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 61976
National Institute of Allergy and Infectious Diseases: Data
 5-methoxy-2-methyl-1,3-thiazole
Chemidplus: 0038205640
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References:
 5-methoxy-2-methyl-1,3-thiazole
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 38205-64-0
Pubchem (cid): 61976
Pubchem (sid): 135019377
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Other Information:
(IUPAC): Atomic Weights of the Elements 2009
(IUPAC): Atomic Weights of the Elements 2009 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Everything Added to Food in the United States (EAFUS): View
HMDB (The Human Metabolome Database): HMDB37178
FooDB: FDB016176
Export Tariff Code: 2934.10.0000
ChemSpider: View
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Potential Blenders and core components note
 
For Odor
alliaceous
 propyl mercaptanFL/FR
cheesy
S-(methyl thio) butyrateFL/FR
coffee
 coffee difuranFL/FR
 tropical thiazoleFL/FR
(Z)-4-heptenalFL/FR
(Z)-3-hexen-1-yl (E)-crotonateFL/FR
4-hexenolFL/FR
2-octen-1-olFL/FR
1-penten-3-olFL/FR
melon
(Z)-6-nonen-1-olFL/FR
minty
isopropyl tiglateFL/FR
 cassis pentanoneFL/FR
 dimethyl disulfideFL/FR
 dimethyl sulfideFL/FR
 grapefruit menthaneFL/FR
 lychee mercaptan acetateFL/FR
 mango thiolFL/FR
 methyl mercaptanFL/FR
3-(methyl thio) hexanolFL/FR
2-phenethyl isothiocyanateFL/FR
S-tropical 2-thiobutyrateFL/FR
tropical
cis-galbanum oxathianeFL/FR
 
For Flavor
 
No flavor group found for these
 butyl isothiocyanateFL
 ethyl 2-(methyl thio) acetateFL
2-ethyl-4,5-dimethyl oxazoleFL
(Z)-3-hexen-1-yl (E)-crotonateFL/FR
(E)-4-hexenalFL
 mercaptoacetaldehydeFL
2-methyl thiazoleFL
4-(methyl thio) butanolFL
2-(methyl thio) methyl-2-butenalFL
4-methyl thiobutyl isothiocyanateFL
5-methyl thiopentyl isothiocyanateFL
2-phenethyl isothiocyanateFL/FR
isopropyl disulfideFL
 propyl mercaptanFL/FR
2-isopropyl-3-(methyl thio) pyrazineFL
 tetrahydrothiopheneFL
S-tropical 2-thiobutyrateFL/FR
alliaceous
 dipropyl trisulfideFL
3-tetrahydrothiophenoneFL
 tropical thiazoleFL/FR
 truffle sulfideFL
coffee
 coffee difuranFL/FR
fatty
2-octen-1-olFL/FR
fruity
 methionyl butyrateFL
green
 cassis pentanoneFL/FR
 dihydroxyacetophenone (mixed isomers)FL
cis-galbanum oxathianeFL/FR
(Z)-4-heptenalFL/FR
(E)-2-heptenalFL
3-(5-methyl-2-furyl) butanalFL
2,4-octadienalFL
1-penten-3-olFL/FR
2-propyl pyrazineFL
isopropyl tiglateFL/FR
 propylene glycol acetone ketalFL
juicy
 lychee mercaptan acetateFL/FR
meaty
 pyrazinyl ethane thiolFL
metallic
4-hexenolFL/FR
3-(methyl thio) hexanolFL/FR
musty
S-(methyl thio) butyrateFL/FR
onion
 propyl thioacetateFL
sulfurous
 diallyl trisulfideFL
 dimethyl disulfideFL/FR
 dimethyl sulfideFL/FR
 ethyl methyl sulfideFL
 grapefruit menthaneFL/FR
 mango thiolFL/FR
 methyl 4-(methyl thio) butyrateFL
 methyl benzyl disulfideFL
 methyl mercaptanFL/FR
 methyl thioacetateFL
vegetable
 potato butyraldehydeFL
waxy
(Z)-6-nonen-1-olFL/FR
 
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Potential Uses:
 cabbageFL
 greenFL
 vegetableFL
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
5-methoxy-2-methyl thiazole
5-methoxy-2-methyl-1,3-thiazole
5-methoxy-2-methylthiazole
 thiazole, 5-methoxy-2-methyl-
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