|
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to pale yellow clear liquid (est) |
| Assay: | 95.00 to 100.00 % sum of isomers
|
| Additional Assay Information: | sum of 2,3- 2,5- and 2,6- isomers |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.96700 to 0.98000 @ 25.00 °C.
|
| Pounds per Gallon - (est).: | 8.046 to 8.155
|
| Refractive Index: | 1.48700 to 1.49700 @ 20.00 °C.
|
| Boiling Point: | 80.00 °C. @ 50.00 mm Hg
|
| Boiling Point: | 170.00 to 171.00 °C. @ 760.00 mm Hg
|
| Vapor Pressure: | 1.975000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 145.00 °F. TCC ( 62.78 °C. )
|
| logP (o/w): | 1.197 (est) |
| Soluble in: |
| | alcohol | | | water | | | water, 4903 mg/L @ 25 °C (est) |
Organoleptic Properties:
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | flavoring agents |
| Recommendation for 2-ethyl-6-methyl pyrazine usage levels up to: | | | not for fragrance use.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.37 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.40 (μg/capita/day) |
| Structure Class: | II |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 19 |
| Click here to view publication 19 |
| | average usual ppm | average maximum ppm |
| baked goods: | 3.00000 | 6.00000 |
| beverages(nonalcoholic): | 1.00000 | 3.00000 |
| beverages(alcoholic): | 0.10000 | 1.00000 |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | 2.00000 | 3.00000 |
| fruit ices: | - | - |
| gelatins / puddings: | 1.00000 | 3.00000 |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | - |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | 1.00000 | 5.00000 |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | 2.00000 | 5.00000 |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
| Flavor & Extract Manufacturers Association (FEMA) reference(s): |
| The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. View pdf |
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000) View page or View pdf |
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1] View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010) View page or View pdf |
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 26332 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WISER: | UN 1993 |
| WGK Germany: | 3 |
| | 2-ethyl-6-methylpyrazine |
| Chemidplus: | 0013925036 |
References:
Other Information:
Potential Blenders and core components note
| |
| For Odor |
| chocolate |
| chocolate |
| | cocoa hexenal | FL/FR |
| earthy |
| 2- | ethyl-3-methoxypyrazine | FL/FR |
| | nutty pyrazine | FL/FR |
| fruity |
| | allyl 2-ethyl butyrate | FL/FR |
| nutty |
| 2- | acetyl-3-ethyl pyrazine | FL/FR |
| 2- | acetyl-3-methyl pyrazine | FL/FR |
| 2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
| 2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
| 3,6- | cocoa pyrazine | FL/FR |
| | filbert heptenone | FL/FR |
| | filbert heptenone B | FL/FR |
| (+)-(E,S)- | filbertone | FL/FR |
| (-)-(E,R)- | filbertone | FL/FR |
| european | hazelnut absolute | FL/FR |
| roasted | hazelnut infusions | FL/FR |
| european | hazelnut oil CO2 extract | FL/FR |
| 2,4,5- | trimethyl oxazole | FL/FR |
| tobacco |
| 3- | ethyl pyridine | FL/FR |
| | methyl benzoxole | FL/FR |
| vegetable |
| | methional | FL/FR |
| |
| For Flavor |
| |
| No flavor group found for these |
| 2- | ethyl-3-methoxypyrazine | FL/FR |
| | green pea pyrazine | FL |
| 2- | methoxy-3-propyl pyrazine | FL |
| | methyl 2-(methyl thio) acetate | FL |
| 4-( | methyl thio) butanol | FL |
| alliaceous |
| 3- | mercapto-2-pentanone | FL |
| 2- | methyl thioacetaldehyde | FL |
| astringent |
| 2- | methyl pyridine | FL |
| burnt |
| 2- | methyl quinoxaline | FL |
| 2,4,5- | trimethyl oxazole | FL/FR |
| caramellic |
| 3- | ethyl pyridine | FL/FR |
| chocolate |
| | chocolate hazelnut flavor | FL |
| cocoa |
| | cocoa hexenal | FL/FR |
| earthy |
| (±)-2- | mercapto-5-methylheptan-4-one | FL |
| ethereal |
| | allyl 2-ethyl butyrate | FL/FR |
| green |
| 2,5- | dimethyl-4-ethyl oxazole | FL |
| 3- | methyl pyridine | FL |
| 1-(5- | methyl-2-furyl) propan-1-one | FL |
| | propylene glycol acetone ketal | FL |
| milky |
| dextro,laevo-3-( | methyl thio) butanone | FL |
| nutty |
| 3- | acetyl-2,5-dimethyl thiophene | FL |
| 2- | acetyl-3-ethyl pyrazine | FL/FR |
| 2- | acetyl-3-methyl pyrazine | FL/FR |
| 2- | acetyl-3,5-dimethyl pyrazine | FL/FR |
| 2- | acetyl-3,5(or 6)-dimethyl pyrazine | FL/FR |
| | almond hazelnut flavor | FL |
| 3,5(6)- | cocoa pyrazine | FL |
| 3,6- | cocoa pyrazine | FL/FR |
| 2,5- | diethyl pyrazine | FL |
| 2,5- | diethyl-3-methyl pyrazine | FL |
| | filbert flavor | FL |
| | filbert heptenone | FL/FR |
| | filbert heptenone B | FL/FR |
| (-)-(E,R)- | filbertone | FL/FR |
| (+)-(E,S)- | filbertone | FL/FR |
| european | hazelnut absolute | FL/FR |
| toasted | hazelnut cream flavor | FL |
| european | hazelnut distillates | FL |
| | hazelnut flavor | FL |
| roasted | hazelnut infusions | FL/FR |
| european | hazelnut oil CO2 extract | FL/FR |
| european | hazelnut oleoresin | FL |
| | hazelnut paste | FL |
| | methyl benzoxole | FL/FR |
| | nutty pyrazine | FL/FR |
| spicy |
| | chocolate cinnamon hazelnut flavor | FL |
| | cinnamon hazelnut cappuccino flavor | FL |
| | cinnamon hazelnut cream flavor | FL |
| | cinnamon hazelnut flavor | FL |
| sulfurous |
| | potato butanone | FL |
| tomato |
| | methional | FL/FR |
| vanilla |
| | vanilla hazelnut flavor | FL |
| vegetable |
| | potato butyraldehyde | FL |
| winey |
| 5- | ethyl-2-methyl pyridine | FL |
| |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2- | ethyl-6-methyl pyrazine natural | | 2- | ethyl-6-methyl-1,4-diazine | | 2- | ethyl-6-methylpyrazine | | 2- | ethyl-6-methylpyrazine natural | | 6- | methyl-2-ethyl pyrazine | | 2- | methyl-6-ethyl pyrazine | | 2- | methyl-6-ethylpyrazine | | | pyrazine, 2-ethyl-6-methyl- |
Articles:
|