2-ethyl-6-methyl pyrazine
Found in roast peanuts, coffee beans, barley and cocoa butter. Flavouring agent for baked goods, confectionery and meat products
  • Axxence Aromatic
    • Axxence Aromatic GmbH
      We bring nature to your flavour
      Dedicated to provide the best possible quality and supply service of natural aroma ingredients.
      Axxence Aromatic is entirely dedicated to provide the best possible quality and supply service of natural aroma ingredients to the Flavour & Fragrance Industry worldwide.
      Email: Service
      Voice: +49.2822.68561.0
      Fax: +49.2822.68561.39
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      391910 2-ETHYL-6-METHYL PYRAZINE Natural Kosher
  • BOC Sciences
    • BOC Sciences
      Best of Chemicals Supplier
      Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
      BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services.
      BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
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      13925-03-6 Pyrazine,2-ethyl-6-methyl-
  • CSA
  • Excellentia International
  • Lluch Essence
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers.
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      US Email: Sales
      Voice: +86-21-32515501 60762991 60762992
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      US Voice: 908-359-9000
      US Fax: 908-359-9002
      H0208 2-Ethyl-6-Methyl Pyrazine
  • Myrazine
    • Myrazine LLC
      EU Natural Ingredients from Fermentation
      All the materials are sourced from fermentation.
      Myrazine LLC,formerly known as Cheng Smith LLC, and Abioco, started its search for Natural materials in 2000, when we started to import natural alcohols from China. China's liquor fermentation technology is as old as the country. Chinese liquor is? unique, because it is fermented from grains, such as rice, wheat, sorghum, and barleys. With bacteria or microorganism present in the fermentaiton, Chinese liquor is rich in flavours. It is reported that there are over 100 flavour materials in the liquor fermentation broth. During the production, the "good" liquor is distilled out, and the "bad" alcohols are dumped as "wastes" before 1980s. Fusel oil is regarded and dumped as the "bad" one during the production. Today, every single ton of the liquor fermentation "wastes" --- fusel oil, has been physically distilled. Alcohols from these distillations are methyl alcohol, ethanol, propanol, butanol, iso-butanol, iso-amyl alcohol, etc. Most of the alcohols are used by the flavour and fragrances industry as raw materials, which eventually go into the beverages, food, and some daily products. According to the US and EU regulations about natural ingredients, materials from fermentation are regarded as "natural".
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      Voice: +1.623 565 7047
      2-Ethyl-6-methylpyrazine/EU Nat.
  • Penta International
  • Synerzine
    • Synerzine, Inc.
      Innovation. Customization. Aroma Ingredients.
      Synerzine is a leading supplier of flavor and fragrance ingredients.
      Synerzine expresses what we have grown to embody as an organization - the synergy and connection between raw ingredients, science, technology, and the final product. Our experienced team is passionate about bringing our customers high-quality innovative ingredients that they can trust.
      Building upon our 44 year history, the Synerzine team provides customers around the globe with convenient access to over 1200 high-quality aroma ingredients. We actively engage with customers to add a wide array of new products and services on a regular basis. Our aim is to delight every customer with our exceptional services, large product selection, customization and the highest quality and safety standards. We provide our customers with true value designed to help them bring their products to market faster.
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      N725 natural 2-Ethyl-6-methylpyrazine
  • WholeChem
    • WholeChem, LLC
      Connecting Innovators To the Building Blocks Of the Universe
      Custom manufacturer and distributor of specialty ingredients. We make global local.
      SQF-Certified Supplier
      We owe our success to our integrity, our dedication to the industry, and our commitment to our clients. We invite your inquiries regarding our current product list and any other products you may be having trouble sourcing.
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Synonyms   Articles   Notes   Search
CAS Number: 13925-03-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 237-692-0
Nikkaji Web: J121.830A
CoE Number: 11331
XlogP3-AA: 1.00 (est)
Molecular Weight: 122.17070000
Formula: C7 H10 N2
NMR Predictor: Predict (works with chrome or firefox)
EFSA/JECFA Comments: Mixture of positional isomers (2-Ethyl-5/6-ethylpyrazine), 2-5- (66 %) and 2-6-isomers (33%) (sum 97 %) (EFFA, 2010a). 95% (sum of 2,5- and 2,6-isomers); 60-63% 2,5-isomer and 30-35% 2,6-isomer. (EFSA)
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 769  2-ethyl-6-methylpyrazine
DG SANTE Food Flavourings: 14.114  2-ethyl-6-methylpyrazine
FEMA Number: 3919 2-methyl-6-ethylpyrazine
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):13925-03-6 ; 2-ETHYL-6-METHYLPYRAZINE
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Physical Properties:
Appearance: colorless to pale yellow clear liquid (est)
Assay: 95.00 to 100.00 % sum of isomers
Additional Assay Information: sum of 2,3- 2,5- and 2,6- isomers
Food Chemicals Codex Listed: No
Specific Gravity: 0.96700 to 0.98000 @  25.00 °C.
Pounds per Gallon - (est).: 8.046 to  8.155
Refractive Index: 1.48700 to 1.49700 @  20.00 °C.
Boiling Point: 80.00 °C. @ 50.00 mm Hg
Boiling Point: 170.00 to  171.00 °C. @ 760.00 mm Hg
Vapor Pressure: 1.975000 mmHg @ 25.00 °C. (est)
Flash Point: 145.00 °F. TCC ( 62.78 °C. )
logP (o/w): 1.197 (est)
Soluble in:
 water, 4903 mg/L @ 25 °C (est)
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Organoleptic Properties:
Odor Type: potato
 roasted  potato  
Odor Description:
at 0.10 % in dipropylene glycol. 
roasted potato
Flavor Type: nutty
 roasted  hazelnut  hazelnut roasted hazelnut  nutty  
Taste Description:
roasted hazelnut
Odor and/or flavor descriptions from others (if found).
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Cosmetic Information:
None found
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Axxence Aromatic
BOC Sciences
For experimental / research use only.
Excellentia International
2-Ethyl-6-Methyl Pyrazine (Pyrazine Mix. # 10, 12, 14, 16, 18, 22, 26) Natural
Lluch Essence
Lluch Essence
M&U International
2-Ethyl-6-Methyl Pyrazine
2-Ethyl-6-methylpyrazine/EU Nat.
Odor: roasted potato, Taste: roasted hazelnut
2-ethyl-6-methyl pyrazine
Penta International
Penta International
natural 2-Ethyl-6-methylpyrazine
Chemical Sources Association
Need This Item for Flavor/Food?: You can contact the CSA
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Safety Information:
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavoring agents
Recommendation for 2-ethyl-6-methyl pyrazine usage levels up to:
 not for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.37 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 0.40 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 19
Click here to view publication 19
 average usual ppmaverage maximum ppm
baked goods: 3.000006.00000
beverages(nonalcoholic): 1.000003.00000
beverages(alcoholic): 0.100001.00000
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 2.000003.00000
fruit ices: --
gelatins / puddings: 1.000003.00000
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: 1.000005.00000
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: 2.000005.00000
soups: --
sugar substitutes: --
sweet sauces: --
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Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. View pdf
European Food Safety Athority(EFSA): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 26332
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 1993
WGK Germany: 3
Chemidplus: 0013925036
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NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 13925-03-6
Pubchem (cid): 26332
Pubchem (sid): 134990415
Pherobase: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
HMDB (The Human Metabolome Database): HMDB41569
FooDB: FDB021559
Typical G.C.
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
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Potential Blenders and core components note
For Odor
 cocoa hexenalFL/FR
 nutty pyrazineFL/FR
 allyl 2-ethyl butyrateFL/FR
2-acetyl-3-ethyl pyrazineFL/FR
2-acetyl-3-methyl pyrazineFL/FR
2-acetyl-3,5-dimethyl pyrazineFL/FR
2-acetyl-3,5(or 6)-dimethyl pyrazineFL/FR
3,6-cocoa pyrazineFL/FR
 filbert heptenoneFL/FR
 filbert heptenone BFL/FR
european hazelnut absoluteFL/FR
roasted hazelnut infusionsFL/FR
european hazelnut oil CO2 extractFL/FR
2,4,5-trimethyl oxazoleFL/FR
3-ethyl pyridineFL/FR
 methyl benzoxoleFL/FR
For Flavor
No flavor group found for these
 green pea pyrazineFL
2-methoxy-3-propyl pyrazineFL
 methyl 2-(methyl thio) acetateFL
4-(methyl thio) butanolFL
2-methyl thioacetaldehydeFL
2-methyl pyridineFL
2-methyl quinoxalineFL
2,4,5-trimethyl oxazoleFL/FR
3-ethyl pyridineFL/FR
 chocolate hazelnut flavorFL
 cocoa hexenalFL/FR
 allyl 2-ethyl butyrateFL/FR
2,5-dimethyl-4-ethyl oxazoleFL
3-methyl pyridineFL
1-(5-methyl-2-furyl) propan-1-oneFL
 propylene glycol acetone ketalFL
dextro,laevo-3-(methyl thio) butanoneFL
3-acetyl-2,5-dimethyl thiopheneFL
2-acetyl-3-ethyl pyrazineFL/FR
2-acetyl-3-methyl pyrazineFL/FR
2-acetyl-3,5-dimethyl pyrazineFL/FR
2-acetyl-3,5(or 6)-dimethyl pyrazineFL/FR
 almond hazelnut flavorFL
3,5(6)-cocoa pyrazineFL
3,6-cocoa pyrazineFL/FR
2,5-diethyl pyrazineFL
2,5-diethyl-3-methyl pyrazineFL
 filbert flavorFL
 filbert heptenoneFL/FR
 filbert heptenone BFL/FR
european hazelnut absoluteFL/FR
toasted hazelnut cream flavorFL
european hazelnut distillatesFL
 hazelnut flavorFL
roasted hazelnut infusionsFL/FR
european hazelnut oil CO2 extractFL/FR
european hazelnut oleoresinFL
 hazelnut pasteFL
 methyl benzoxoleFL/FR
 nutty pyrazineFL/FR
 chocolate cinnamon hazelnut flavorFL
 cinnamon hazelnut cappuccino flavorFL
 cinnamon hazelnut cream flavorFL
 cinnamon hazelnut flavorFL
 potato butanoneFL
 vanilla hazelnut flavorFL
 potato butyraldehydeFL
5-ethyl-2-methyl pyridineFL
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Potential Uses:
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Occurrence (nature, food, other): note
Search Trop  Picture
 cocoa butter
Search Trop  Picture
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 lavender oil spike spain @ 0.112%
Data  GC  Search Trop  Picture
 peanut roasted peanut
Search Trop  Picture
 tea leaf
Search Trop  Picture
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2-ethyl-6-methyl pyrazine natural
2-ethyl-6-methylpyrazine natural
6-methyl-2-ethyl pyrazine
2-methyl-6-ethyl pyrazine
 pyrazine, 2-ethyl-6-methyl-
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