vanilmandelic acid
hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid
 
Notes:
Vanillylmandelic acid is one of the products of the catabolism of catecholamines (epinephrine, norepinephrine and dopamine). High levels of vanillylmandelic acid can indicate an adrenal gland tumor (pheochromocytoma) or another type of tumor that produces catecholamines. (WebMD) [HMDB]
  • BOC Sciences
    • BOC Sciences
      Best of Chemicals Supplier
      Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
      BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services.
      BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
      Email: Marketing
      US Email: Marketing
      Email: Sales
      US Email: Sales
      Voice: 1-631-504-6093
      Fax: 1-631-614-7828
      US Voice: 1-631-504-6093
      US Fax: 1-631-614-7828
      Europe44-203-286-1088
      Facebook
      Twitter
      Linkedin
      Blog
      Get the App!
      Product(s):
      55-10-7 Adrenaline Related Compound 2 > 95%
      VMA is an impurity of Epinephrine. Epinephrine is a natural neurotransmitter that is released from the adrenal medulla and activates adrenoceptors
       
       
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      Product(s):
      08-64600 HYDROXY(4-HYDROXY-3-METHOXYPHENYL)ACETIC ACID
      22-37000 VANILMANDELIC ACID
       
  • TCI AMERICA
    • TCI AMERICA
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 28,000 Reagents available today in benchtop to bulk quantities. Sign up for a TCI account today for fast and free shipping!
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 60 years of synthesis experience and multi-purpose plants enable TCI to offer more than 28,000 products as well as custom synthesis. TCI has established overseas facilities in North America, Europe, China and India to serve customers worldwide.
      US Email: Sales
      Email: Technical Support
      Voice: 1-800-423-8616
      Fax: 1- 888-520-1075
      Facebook
      Twitter
      Instagram
      Linkedin
      RSS
      Product(s):
      H0268 DL-4-Hydroxy-3-methoxymandelic Acid >99.0%(T)
       
Synonyms   Articles   Notes   Search
CAS Number: 55-10-7Picture of molecule3D/inchi
Other: 2394-20-9
ECHA EINECS - REACH Pre-Reg: 200-224-0
FDA UNII: 0DQI268449
Nikkaji Web: J27.583B
Beilstein Number: 2213227
MDL: MFCD00004235
XlogP3: -0.20 (est)
Molecular Weight: 198.17470000
Formula: C9 H10 O5
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
EFSA/JECFA Comments: Racemate. Register name to be changed to: 4-Hydroxy-3-methoxymandelic acid.
Category: flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 2020  hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid
DG SANTE Food Flavourings: 08.134  4-hydroxy-3-methoxymandelic acid
FEMA Number: 4660 hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):55-10-7 ; HYDROXY(4-HYDROXY-3-METHOXYPHENYL)ACETIC ACID
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: white to pale yellow powder (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: 132.00 °C. @ 760.00 mm Hg
Boiling Point: 421.33 °C. @ 760.00 mm Hg (est)
Flash Point: 344.00 °F. TCC ( 173.33 °C. )
logP (o/w): -0.212 (est)
Shelf Life: 12.00 month(s) or longer if stored properly.
Storage: refrigerate in tightly sealed containers.
Soluble in:
 alcohol, slightly
 water, slightly
 water, 4.267e+005 mg/L @ 25 °C (est)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
None found
Synonyms   Articles   Notes   Search   Top
Suppliers:
BOC Sciences
For experimental / research use only.
Adrenaline Related Compound 2 > 95%
Odor: characteristic
Use: VMA is an impurity of Epinephrine. Epinephrine is a natural neurotransmitter that is released from the adrenal medulla and activates adrenoceptors
Penta International
HYDROXY(4-HYDROXY-3-METHOXYPHENYL)ACETIC ACID
Penta International
VANILMANDELIC ACID
Santa Cruz Biotechnology
For experimental / research use only.
4-Hydroxy-3-methoxymandelic acid ≥98%
Sigma-Aldrich: Sigma
For experimental / research use only.
DL-4-Hydroxy-3-methoxymandelic acid ≥98%
TCI AMERICA
For experimental / research use only.
DL-4-Hydroxy-3-methoxymandelic Acid >99.0%(T)
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 36/38 - Irritating to skin and eyes.
S 02 - Keep out of the reach of children.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36 - Wear suitable protective clothing.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: flavoring agents
Recommendation for vanilmandelic acid usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 120.00 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 5000 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 24
Click here to view publication 24
 average usual ppmaverage maximum ppm
baked goods: 10.0000020.00000
beverages(nonalcoholic): 5.0000010.00000
beverages(alcoholic): 10.0000020.00000
breakfast cereal: 10.0000020.00000
cheese: --
chewing gum: 5.0000010.00000
condiments / relishes: --
confectionery froastings: 10.0000020.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: 10.00000100.00000
fruit ices: 10.0000020.00000
gelatins / puddings: 20.0000050.00000
granulated sugar: --
gravies: --
hard candy: 5.0000010.00000
imitation dairy: 10.0000020.00000
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: 10.0000050.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: 10.0000020.00000
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 10.0000050.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): --
Edible ices, including sherbet and sorbet (03.0): 10.00000100.00000
Processed fruit (04.1): --
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 10.0000020.00000
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 10.0000020.00000
Bakery wares (07.0): 10.0000020.00000
Meat and meat products, including poultry and game (08.0): --
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): --
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 10.0000020.00000
Foodstuffs intended for particular nutritional uses (13.0): --
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 5.0000010.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 10.0000020.00000
Ready-to-eat savouries (15.0): --
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 20.0000050.00000
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(efsa): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25
View page or View pdf
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 55-10-7
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 1245
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetic acid
Chemidplus: 0000055107
Synonyms   Articles   Notes   Search   Top
References:
 2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetic acid
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 55-10-7
Pubchem (cid): 1245
Pubchem (sid): 134972108
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
CHEBI: View
CHEMBL: View
Golm Metabolome Database: Search
Metabolomics Database: Search
KEGG (GenomeNet): C05584
HMDB (The Human Metabolome Database): HMDB00291
FooDB: FDB021931
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
FAO: Hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
For Odor
anisic
para-acetanisoleFL/FR
para-anisaldehydeFL/FR
ortho-anisaldehydeFL/FR
 methyl para-anisateFL/FR
balsamic
siam benzoin absoluteFL/FR
 benzoin absolute replacerFL/FR
sumatra benzoin gumFL/FR
siam benzoin resinFL/FR
sumatra benzoin resinFL/FR
sumatra benzoin resinoidFL/FR
siam benzoin resinoidFL/FR
1-benzoyl acetoneFL/FR
 peru balsam absoluteFL/FR
 peru balsam oilFL/FR
 peru balsam resinoidFL/FR
berry
 raspberry ketone methyl etherFL/FR
caramellic
 levulinic acidFL/FR
chocolate
 vanillyl ethyl etherFL/FR
coconut
alpha-angelica lactoneFL/FR
coumarinic
 coumaneFL/FR
creamy
 butyl lactateFL/FR
para-vanillic acidFL/FR
para-vanillyl alcoholFL/FR
 veratraldehydeFL/FR
floral
 acetophenoneFL/FR
para-cresyl laurateFL/FR
 heliotropinFL/FR
para-methyl acetophenoneFL/FR
fruity
para-anisyl propionateFL/FR
 ethyl methyl-para-tolyl glycidateFL/FR
 guaiacyl propionateFL/FR
 tolualdehydes (mixed o,m,p)FL/FR
musk
omega-pentadecalactoneFL/FR
naphthyl
2,4-dimethyl benzaldehydeFL/FR
nutty
 nutty cyclohexenoneFL/FR
2,3,5,6-tetramethyl pyrazineFL/FR
phenolic
ortho-guaiacolFL/FR
powdery
para-anisyl acetateFL/FR
smoky
alpha-ethoxy-ortho-cresolFL/FR
spicy
para-anisyl formateFL/FR
4-ethyl guaiacolFL/FR
3-(2-furyl) acroleinFL/FR
(E)-para-methoxycinnamaldehydeFL/FR
para-methoxycinnamaldehydeFL/FR
4-methyl guaiacolFL/FR
 spicy acetoacetateFL/FR
 zingeroneFL/FR
sweet
 vanilla bean absolute (vanilla spp.)FL/FR
 vanilla oleoresin baliFL/FR
 vanilla resinoidFL/FR
 vanilla tahitensis fruit extractFL/FR
tonka
 mint lactoneFL/FR
 octahydrocoumarinFL/FR
tropical
 curcuma amada roxb. rhizome oil CO2 extractFL/FR
vanilla
 acetovanilloneFL/FR
ortho-dimethyl hydroquinoneFL/FR
 ethyl vanillinFL/FR
 ethyl vanillin isobutyrateFL/FR
 ethyl vanillin propylene glycol acetalFL/FR
 heliotropyl alcoholFL/FR
 methyl vanillateFL/FR
 propenyl guaetholFL/FR
 vanilla aromatica fruit extractFL/FR
 vanilla bean absolute (vanilla planifolia)FL/FR
 vanilla bean absolute CO2 extract (vanilla planifolia)FL/FR
 vanilla bean oil (vanilla tahitensis)FL/FR
 vanilla bean oil CO2 extractFL/FR
 vanilla extractFL/FR
 vanilla oleoresin bourbonFL/FR
 vanilla planifolia fruit extractFL/FR
 vanilla planifolia fruit waterFL/FR
 vanillinFL/FR
 vanillin 2,3-butylene glycol acetalFL/FR
 vanillin propylene glycol acetalFL/FR
 vanillyl acetateFL/FR
 vanillyl isobutyrateFL/FR
 vanillylidene acetoneFL/FR
woody
4-hydroxybenzaldehydeFL/FR
 
For Flavor
 
No flavor group found for these
para-anisyl propionateFL/FR
1-benzoyl acetoneFL/FR
 coumaneFL/FR
ortho-dimethyl hydroquinoneFL/FR
alpha-ethoxy-ortho-cresolFL/FR
3-(2-furyl) acroleinFL/FR
 glucoethyl vanillinFL
 glucovanillinFL
 guaiacyl propionateFL/FR
 heliotropyl alcoholFL/FR
(E)-para-methoxycinnamaldehydeFL/FR
4-methoxysalicylaldehydeFL
 methyl para-anisateFL/FR
 methyl vanillateFL/FR
acidic
 levulinic acidFL/FR
anisic
para-acetanisoleFL/FR
ortho-anisaldehydeFL/FR
balsamic
 benzoin absolute replacerFL/FR
sumatra benzoin gumFL/FR
siam benzoin resinFL/FR
sumatra benzoin resinFL/FR
sumatra benzoin resinoidFL/FR
siam benzoin resinoidFL/FR
 peru balsamFL
 peru balsam absoluteFL/FR
 peru balsam oilFL/FR
 peru balsam resinoidFL/FR
 vanillylidene acetoneFL/FR
berry
 raspberry ketone methyl etherFL/FR
bready
2-propionyl thiazoleFL
cherry
 heliotropinFL/FR
para-methoxycinnamaldehydeFL/FR
coconut
6-methyl coumarinFL
 octahydrocoumarinFL/FR
creamy
alpha-angelica lactoneFL/FR
para-anisaldehydeFL/FR
 divanillinFL
4-hydroxybenzaldehydeFL/FR
para-methyl acetophenoneFL/FR
 mint lactoneFL/FR
para-vanillic acidFL/FR
para-vanillyl alcoholFL/FR
 veratraldehydeFL/FR
dairy
 butyl lactateFL/FR
fruity
para-anisyl acetateFL/FR
 ethyl methyl-para-tolyl glycidateFL/FR
 tolualdehydes (mixed o,m,p)FL/FR
meaty
4-allyl-2,6-dimethoxyphenolFL
naphthyl
2,4-dimethyl benzaldehydeFL/FR
nutty
 furfural acetoneFL
 nutty cyclohexenoneFL/FR
2,3,5,6-tetramethyl pyrazineFL/FR
powdery
 acetophenoneFL/FR
 powdery ketoneFL
rummy
 vanillyl ethyl etherFL/FR
spicy
para-anisyl formateFL/FR
siam benzoin absoluteFL/FR
 spicy acetoacetateFL/FR
 zingeroneFL/FR
sweet
 vanilla bean absolute (vanilla spp.)FL/FR
 vanilla oleoresin baliFL/FR
 vanilla resinoidFL/FR
 vanilla tahitensis fruit extractFL/FR
tropical
 curcuma amada roxb. rhizome oil CO2 extractFL/FR
vanilla
 acetovanilloneFL/FR
 ethyl vanillinFL/FR
 ethyl vanillin isobutyrateFL/FR
 ethyl vanillin propylene glycol acetalFL/FR
4-methyl guaiacolFL/FR
omega-pentadecalactoneFL/FR
 propenyl guaetholFL/FR
 vanilla aromatica fruit extractFL/FR
 vanilla bean absolute (vanilla planifolia)FL/FR
 vanilla bean absolute CO2 extract (vanilla planifolia)FL/FR
 vanilla bean oil (vanilla tahitensis)FL/FR
 vanilla bean oil CO2 extractFL/FR
 vanilla extractFL/FR
 vanilla oleoresin bourbonFL/FR
 vanilla planifolia fruit extractFL/FR
 vanilla planifolia fruit waterFL/FR
 vanillinFL/FR
 vanillin 2,3-butylene glycol acetalFL/FR
 vanillin propylene glycol acetalFL/FR
 vanillyl acetateFL/FR
 vanillyl isobutyrateFL/FR
waxy
para-cresyl laurateFL/FR
woody
4-ethyl guaiacolFL/FR
ortho-guaiacolFL/FR
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
None Found
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 found in nature
Synonyms   Articles   Notes   Search   Top
Synonyms:
 benzeneacetic acid, a,4-dihydroxy-3-methoxy-
alpha-4-dihydroxy-3-methoxybenzeneacetic acid
4-hydroxy 3-methoxymandelic acid
2-hydroxy-2-(4-hydroxy-3-methoxyphenyl)acetic acid
DL-4-hydroxy-3-methoxy mandelic acid
4-hydroxy-3-methoxy-DL-mandelic acid
(±)-4-hydroxy-3-methoxymandelic acid
4-hydroxy-3-methoxymandelic acid
dextro,laevo-4-hydroxy-3-methoxymandelic acid
DL-4-hydroxy-3-methoxymandelic acid
4-hydroxy-3-methoxymandelicacid
4-hydroxy-3-methoxyphenyl(hydroxy)acetic acid
(4-hydroxy-3-methoxyphenyl) glycolic acid
(4-hydroxy-3-methoxyphenyl)glycolic acid
 hydroxy(4-hydroxy-3-methoxyphenyl)acetic acid
 mandelic acid, 4-hydroxy-3-methoxy-
3-methoxy-4-hydroxyphenylhydroxyacetic acid
 nibovan
 vanillinemandelic acid
 vanillomandelic acid
 vanillyl mandelic acid
 vanillylmandelic acid
(±)-vanillylmandelic acid
(±)-vanilmandelic acid
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Effectiveness of green tea on weight reduction in obese Thais: A randomized, controlled trial.
PubMed: Evaluation of plasma 3,4-dihydroxyphenylacetic acid (DOPAC) and plasma 3,4-dihydroxyphenylalanine (DOPA) as tumor markers in children with neuroblastoma.
PubMed: Increased urinary HVA levels in neuroblastoma screens related to diet, not tumor.
PubMed: Energy expenditure during carbohydrate overfeeding in obese and nonobese adolescents.
PubMed: Simultaneous determination of the major acidic metabolites of catecholamines and serotonin in urine by liquid chromatography with electrochemical detection after a one-step sample clean-up on Sephadex G-10; influence of vanilla and banana ingestion.
PubMed: Diethylstilbestrol on urinary catecholamines and on food intake in castrated male rats.
PubMed: [Circadian rhythm of 3-methoxy-4-hydroxymandelic acid and 3-methoxy-4-hydroxyphenylacetic acid in the urine].
PubMed: Effects of diet on urinary excretion of MHPG in normal preadolescent boys.
PubMed: Random one-hour urine catecholamine and 4-hydroxy-3-methoxymandelic acid assays for diagnosis of pheochromocytoma.
PubMed: The effect of refeeding after semistarvation on catecholamine and thyroid metabolism.
PubMed: Urinary excretion values in 2-day food-deprived, unrestrained chimpanzees.
Synonyms   Articles   Notes   Search   Top
Please share your Comments.
Email Address:
 
 
 
 
Top of Page Home
Copyright © 1980-2020 Perflavory ™ Disclaimer Privacy Policy