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Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white crystallin powder (est) |
| Assay: | 98.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 48.00 to 50.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 244.00 to 245.00 °C. @ 760.00 mm Hg
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| Congealing Point: | 47.50 °C.
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| Acid Value: | 1.00 max. KOH/g
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| Vapor Pressure: | 0.016000 mmHg @ 25.00 °C. (est) |
| Flash Point: | > 230.00 °F. TCC ( > 110.00 °C. )
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| logP (o/w): | 2.270 |
| Soluble in: |
| | alcohol | | | water, 643 mg/L 20 °C (exp) |
| Insoluble in: |
| | water |
| Similar Items: note |
| methyl 3-methoxybenzoate |
| methyl 2-methoxybenzoate |
| ethyl para-anisate |
| hexyl para-anisate |
Organoleptic Properties:
| |
| Odor Type: anisic |
| |
| | herbal anise sweet |
Odor Description: at 100.00 %. | herbal anise sweet |
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | None - None found. |
S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes.
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Human Experience: |
| 4 % solution: no irritation or sensitization. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 > 5000 mg/kg (Levenstein, 1975k)
oral-rat LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 14, Pg. 481, 1976.
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| Dermal Toxicity: |
skin-rabbit LD50 > 5000 mg/kg Food and Cosmetics Toxicology. Vol. 14, Pg. 481, 1976.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| Recommendation for methyl para-anisate usage levels up to: | | | 3.0000 % in the fragrance concentrate.
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| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 0.97 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA): | 0.01 (μg/capita/day) |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 3 |
| Click here to view publication 3 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 6.20000 |
| beverages(nonalcoholic): | - | 2.70000 |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | 3.00000 |
| fruit ices: | - | 3.00000 |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | 8.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
| Flavor & Extract Manufacturers Association (FEMA) reference(s): |
| The FEMA GRAS assessment of hydroxyl- and alkoxy-substituted benzyl derivatives used as flavor ingredients. View pdf |
| European Food Safety Athority(EFSA): | Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies... |
| European Food Safety Authority (EFSA) reference(s): |
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 20 (FGE.20): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical group 23 View page or View pdf |
Flavouring Group Evaluation 52 (FGE.52): Consideration of hydroxy- and alkoxy-substituted benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters evaluated by EFSA in FGE.20 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) View page or View pdf |
Flavouring Group Evaluation 54 (FGE.54)[1] - Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20 (2005) - Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food View page or View pdf |
Flavouring Group Evaluation 20, Revision 1 (FGE.20Rev1): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters from chemical group 23 View page or View pdf |
Flavouring Group Evaluation 54, Revision 1 (FGE.54Rev1): Consideration of benzyl derivatives evaluated by JECFA (57th meeting) structurally related to benzyl alcohols, benzaldehydes, a related acetal, benzoic acids and related esters evaluated by EFSA in FGE.20Rev1 (2009) View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 20, Revision 2 (FGE.20Rev2): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
Scientific Opinion on Flavouring Group Evaluation 20, Revision 3(FGE.20Rev3): Benzyl alcohols, benzaldehydes, a related acetal, benzoic acids, and related esters from chemical groups 23 and 30 View page or View pdf |
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 121-98-2 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 8499 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| | methyl 4-methoxybenzoate |
| Chemidplus: | 0000121982 |
| RTECS: | BZ4925000 for cas# 121-98-2 |
References:
Other Information:
Potential Blenders and core components note
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| For Odor |
| No odor group found for these |
| | dehydro-ar-ionene | |
| animal |
| para- | cresyl caprylate | FL/FR |
| anise |
| | anise oleoresin | FL/FR |
| | anise seed oil | FL/FR |
| star | anise seed oil china | FL/FR |
| | anise seed oil colombia | FL/FR |
| star | anise seed oil terpeneless | FL/FR |
| sweet | fennel absolute | FL/FR |
| sweet | fennel oleoresin | FL/FR |
| sweet | fennel seed oil | FL/FR |
| anisic |
| para- | acetanisole | FL/FR |
| ortho- | acetanisole | FL/FR |
| | amyl furoate | FL/FR |
| (Z)- | anethol | |
| ortho- | anisaldehyde | FL/FR |
| para- | anisaldehyde | FL/FR |
| para- | anisyl phenyl acetate | FL/FR |
| para- | anisyl propanal | FR |
| | dihydroanethol | FL/FR |
| | ethyl para-anisate | FL/FR |
| | ocimum basilicum herb oil | FL/FR |
| | ocimum basilicum leaf oil america | FL/FR |
| | sassafras acetate | FL/FR |
| balsamic |
| | cinnamyl alcohol | FL/FR |
| | geranyl benzoate | FL/FR |
| | phenethyl cinnamate | FL/FR |
| | prenyl benzoate | FL/FR |
| | terpinyl benzoate | FR |
| berry |
| | raspberry ketone methyl ether | FL/FR |
| chocolate |
| | vanillyl ethyl ether | FL/FR |
| fatty |
| 2,4- | decadien-1-ol | FL/FR |
| (E,E)-2,4- | decadien-1-ol | FL/FR |
| floral |
| | acetophenone | FL/FR |
| para- | anisaldehyde / methyl anthranilate schiff's base | FR |
| para- | anisaldehyde dimethyl acetal | FR |
| | anise indene | FR |
| para- | anisyl acetaldehyde | FL/FR |
| para- | anisyl nitrile | FR |
| | anisyl propanal / methyl anthranilate schiff's base | FR |
| | autumn carboxylate | FR |
| | boronia absolute | FL/FR |
| | champaca absolute | FR |
| | cuminyl acetaldehyde | FL/FR |
| | earthy indane | FR |
| para- | ethyl acetophenone | FL/FR |
| | ethyl ortho-anisate | FL/FR |
| | geranyl phenyl acetate | FL/FR |
| | hawthorn acetate | FR |
| | hawthorn carbinol | FL/FR |
| | heliotropin | FL/FR |
| | heliotropyl acetate | FL/FR |
| | heliotropyl acetone | FL/FR |
| para- | methyl acetophenone | FL/FR |
| | orris rhizome resinoid (iris pallida) | FL/FR |
| | phenethyl salicylate | FL/FR |
| (R)-2- | phenyl propyl alcohol | FL/FR |
| | propiophenone | FL/FR |
| iso | propyl anthranilate | FL/FR |
| | tuberose absolute (from concrete) | FL/FR |
| | tuberose absolute (from pommade) | FL/FR |
| | tuberose acetate | FR |
| | wallflower absolute | FR |
| fruity |
| para- | anisyl methyl ketone | FL/FR |
| | benzyl methyl ether | FL/FR |
| | berry hexanoate | FR |
| | diethyl sebacate | FL/FR |
| | diethyl succinate | FL/FR |
| (E,E)- | ethyl sorbate | FL/FR |
| | grapefruit acetal | FR |
| green |
| (E,Z)-3,6- | nonadien-1-yl acetate | FL/FR |
| 3,6- | nonadien-1-yl acetate | FL/FR |
| | tiglaldehyde | FL/FR |
| herbal |
| | acorn acetate | FR |
| | floral nitrile | FR |
| | tricyclodecenyl isobutyrate | FR |
| licorice |
| (E)- | anethol | FL/FR |
| | clausena anisata leaf oil | |
| melon |
| | melon heptenal | FL/FR |
| minty |
| bitter | fennel flower oil lithuania | |
| bitter | fennel seed oil lithuania | CS |
| naphthyl |
| para- | methyl anisole | FL/FR |
| beta- | naphthyl methyl ether | FL/FR |
| phenolic |
| | anisole | FL/FR |
| powdery |
| para- | anisyl alcohol | FL/FR |
| smoky |
| | propyl paraben | CS |
| spicy |
| | croton eluteria bark oil | FL/FR |
| sweet |
| | vanilla oleoresin bali | FL/FR |
| terpenic |
| | angelica seed oil | FL/FR |
| vanilla |
| | ethyl vanillin isobutyrate | FL/FR |
| | vanillin | FL/FR |
| | vanillin propylene glycol acetal | FL/FR |
| woody |
| | cyperus root oil (cyperus rotundus) | FR |
| | patchouli ethanone | FR |
| |
| For Flavor |
| |
| No flavor group found for these |
| | amyl furoate | FL/FR |
| (Z)- | anethol | |
| para- | anisyl acetaldehyde | FL/FR |
| | clausena anisata leaf oil | |
| | dehydro-ar-ionene | |
| para- | ethyl acetophenone | FL/FR |
| 4- | ethyl anisole | FL |
| | ethyl ortho-anisate | FL/FR |
| bitter | fennel flower oil lithuania | |
| | geranyl benzoate | FL/FR |
| (R)-2- | phenyl propyl alcohol | FL/FR |
| | prenyl benzoate | FL/FR |
| iso | propyl anthranilate | FL/FR |
|
| 4'- | hydroxyacetophenone | FL |
| amber |
| | angelica seed oil | FL/FR |
| animal |
| para- | cresyl caprylate | FL/FR |
| anise |
| (E)- | anethol | FL/FR |
| | anise oleoresin | FL/FR |
| | anise seed oil | FL/FR |
| star | anise seed oil china | FL/FR |
| | anise seed oil colombia | FL/FR |
| star | anise seed oil terpeneless | FL/FR |
| | ethyl para-anisate | FL/FR |
| sweet | fennel absolute | FL/FR |
| sweet | fennel oleoresin | FL/FR |
| sweet | fennel seed oil | FL/FR |
| anisic |
| para- | acetanisole | FL/FR |
| ortho- | anisaldehyde | FL/FR |
| para- | anisyl phenyl acetate | FL/FR |
| aromatic |
| | anisole | FL/FR |
| balsamic |
| | phenethyl cinnamate | FL/FR |
| berry |
| | heliotropyl acetone | FL/FR |
| | raspberry ketone methyl ether | FL/FR |
| cherry |
| | heliotropin | FL/FR |
| cocoa |
| | cocoa distillates | FL |
| creamy |
| para- | anisaldehyde | FL/FR |
| para- | methyl acetophenone | FL/FR |
| fatty |
| 2,4- | decadien-1-ol | FL/FR |
| (E,E)-2,4- | decadien-1-ol | FL/FR |
| floral |
| | geranyl phenyl acetate | FL/FR |
| | heliotropyl acetate | FL/FR |
| | orris rhizome resinoid (iris pallida) | FL/FR |
| | tuberose absolute (from concrete) | FL/FR |
| | tuberose absolute (from pommade) | FL/FR |
| fruity |
| para- | anisyl alcohol | FL/FR |
| | benzyl methyl ether | FL/FR |
| | boronia absolute | FL/FR |
| | diethyl sebacate | FL/FR |
| | diethyl succinate | FL/FR |
| (E,E)- | ethyl sorbate | FL/FR |
| | propiophenone | FL/FR |
| | tiglaldehyde | FL/FR |
| green |
| | cinnamyl alcohol | FL/FR |
| | cuminyl acetaldehyde | FL/FR |
| | melon heptenal | FL/FR |
| (E,Z)-3,6- | nonadien-1-yl acetate | FL/FR |
| 3,6- | nonadien-1-yl acetate | FL/FR |
| herbal |
| | dihydroanethol | FL/FR |
| | ocimum basilicum herb oil | FL/FR |
| | ocimum basilicum leaf oil america | FL/FR |
| licorice |
| 2- | butyl-3-methyl pyrazine | FL |
| medicinal, |
| | phenethyl salicylate | FL/FR |
| naphthyl |
| para- | methyl anisole | FL/FR |
| beta- | naphthyl methyl ether | FL/FR |
| powdery |
| ortho- | acetanisole | FL/FR |
| | acetophenone | FL/FR |
| | powdery ketone | FL |
| rummy |
| | vanillyl ethyl ether | FL/FR |
| spicy |
| para- | anisyl methyl ketone | FL/FR |
| | croton eluteria bark oil | FL/FR |
| | hawthorn carbinol | FL/FR |
| 4- | methyl biphenyl | FL |
| sulfurous |
| O- | ethyl S-1-methoxyhexan-3-yl carbonothioate | FL |
| sweet |
| | vanilla oleoresin bali | FL/FR |
| tarragon |
| | sassafras acetate | FL/FR |
| vanilla |
| | ethyl vanillin isobutyrate | FL/FR |
| | vanillin | FL/FR |
| | vanillin propylene glycol acetal | FL/FR |
| |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| p- | anisic acid methyl ester | | para- | anisic acid methyl ester | | p- | anisic acid, methyl ester | | | benzoic acid, 4-methoxy-, methyl ester | | | menthyll anisate | | 4- | methoxybenzoic acid methyl ester | | para- | methoxybenzoic acid methyl ester | | | methyl 4-methoxybenzoate | | | methyl anisate | | nat. | methyl anisate | | | methyl anisate natural | | | methyl p-anisate | | | methyl p-methoxy benzoate | | | methyl p-methoxybenzoate | | | methyl para-methoxybenzoate | | | methyl-4-methoxybenzoate |
Articles:
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