|
Category: fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to pale yellow crystals (est) |
| Assay: | 98.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 48.00 to 53.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 140.00 °C. @ 10.00 mm Hg
|
| Boiling Point: | 303.00 to 304.00 °C. @ 760.00 mm Hg
|
| Vapor Pressure: | 0.000089 mmHg @ 25.00 °C. (est) |
| Flash Point: | > 212.00 °F. TCC ( > 100.00 °C. )
|
| logP (o/w): | 1.137 (est) |
| Soluble in: |
| | alcohol | | | water, 1592 mg/L @ 25 °C (est) | | | water, 1200 mg/L @ 25 °C (exp) |
| Insoluble in: |
| | water |
| Stability: |
| | detergent | | | soap |
Organoleptic Properties:
| |
| Odor Type: woody |
| |
| Odor Strength: | medium |
| |
| Substantivity: | 48 hour(s) at 100.00 % |
| |
| | phenolic woody mossy |
Odor Description: at 100.00 %. | phenolic woody mossy |
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| Takasago |
| Hinokitiol Crystals ≥98% as Hinokitiol |
| Odor Description: | Phenol-like and woody Can give woody-mossy character in fragrances. Has antibacterial and preservative properties that are useful in drug and cosmetic applications. |
| |
| |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xn - Harmful. |
R 22 - Harmful if swallowed. S 02 - Keep out of the reach of children. S 20/21 - When using do not eat, drink or smoke. S 37/39 - Wear suitable gloves and eye/face protection.
|
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 500 mg/kg BEHAVIORAL: FOOD INTAKE (ANIMAL)
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: OTHER CHANGES National Technical Information Service. Vol. OTS0570591
intravenous-mouse LD50 128 mg/kg BEHAVIORAL: ANALGESIA
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Yakugaku Zasshi. Journal of Pharmacy. Vol. 91, Pg. 550, 1971.
intraperitoneal-mouse LD50 85 mg/kg Journal of Medicinal Chemistry. Vol. 6, Pg. 755, 1963.
|
| Dermal Toxicity: |
skin-rabbit LD50 > 2000 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: FOOD INTAKE (ANIMAL) National Technical Information Service. Vol. OTS0570591
subcutaneous-mouse LD50 541 mg/kg BEHAVIORAL: ANALGESIA
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Yakugaku Zasshi. Journal of Pharmacy. Vol. 91, Pg. 550, 1971.
subcutaneous-guinea pig LD50 500 mg/kg Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 48, Pg. 722, 1959.
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
Safety References:
References:
| | 2-hydroxy-6-propan-2-ylcyclohepta-2,4,6-trien-1-one |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 499-44-5 |
| Pubchem (cid): | 3611 |
| Pubchem (sid): | 134977780 |
Other Information:
Potential Blenders and core components note
| |
| For Odor |
| No odor group found for these |
| | eremophila mitchelli wood oil australia | FR |
|
| | chamaecyparis obtusa wood oil | FR |
| | octanal propylene glycol acetal | FL/FR |
| 10- | undecenoic acid | FL/FR |
| acidic |
| 2- | methyl-2-pentenoic acid | FL/FR |
| amber |
| | amber butanol | FR |
| | amber decane | FR |
| sports | amber fragrance | FR |
| | amber spirolene | FR |
| | ambergris tincture | FL/FR |
| | ambroxide | FL/FR |
| | labdanum oil | FL/FR |
| animal |
| 2-iso | butyl quinoline | FR |
| balsamic |
| | amyris wood oil | FL/FR |
| siam | benzoin absolute | FL/FR |
| dextro,laevo-iso | borneol | FL/FR |
| iso | bornyl acetate | FL/FR |
| | fir carboxylate | FR |
| | guaiyl butyrate | FR |
| | juniper berry absolute | FL/FR |
| | myrrh resin | FL/FR |
| | opoponax resin (commiphora erythraea var. glabrescens engler) | FL/FR |
| | spruce needle absolute | FL/FR |
| | styrax oil (liquidambar styraciflua) | FL/FR |
| burnt |
| | rum ether | FL/FR |
| camphoreous |
| beta-homo | cyclocitral | FL/FR |
| cheesy |
| 2- | heptanone | FL/FR |
| chocolate |
| 2,5- | dimethyl pyrazine | FL/FR |
| citrus |
| | grapefruit mercaptan | FL/FR |
| (+)- | nootkatone | FL/FR |
| bitter | orange peel oil | FL/FR |
| | tetrahydromyrcenol | FR |
| | tetrahydromyrcenyl acetate | FR |
| earthy |
| (-)-alpha- | fenchol | FL/FR |
| floral |
| | angel essence fragrance | FR |
| | cananga oil china | FL/FR |
| | citronellyl acetate | FL/FR |
| | dihydrojasmone | FL/FR |
| | dihydrolinalool | FL/FR |
| | floral undecenone | FR |
| | hawthorn ethanol | FR |
| beta- | ionone | FL/FR |
| alpha- | irone | FL/FR |
| | linalool | FL/FR |
| | linalyl anthranilate | FL/FR |
| alpha-iso | methyl ionone (70% min.) | FL/FR |
| | methyl ionyl acetate | FL/FR |
| | mimosa concrete france | FL/FR |
| beta- | ocimene | FL/FR |
| | orris rhizome concrete butter (iris pallida) | FL/FR |
| | vetiver pentanone | FR |
| fruity |
| | apple ketal | FL/FR |
| 3- | benzyl-4-heptanone | FL/FR |
| | bread thiophene | FL/FR |
| | cyclohexanone diethyl acetal | FL/FR |
| | fruity butanate | FR |
| | linalool oxide acetates | FL/FR |
| | menthyl isovalerate | FL/FR |
| green |
| | bergoxane | FR |
| | galbanum oleoresin | FL/FR |
| | geranic acid | FL/FR |
| alpha- | hexyl cinnamaldehyde dimethyl acetal | FR |
| para- | methyl hydratropaldehyde | FL/FR |
| (Z)-5- | octen-1-yl propionate | FL/FR |
| | rose leaf absolute (rosa centifolia) | FL/FR |
| | seaweed absolute (fucus vesiculosus et serratus) | FL/FR |
| herbal |
| | apium graveolens seed oil | FL/FR |
| | apium graveolens seed oil india | FL/FR |
| alpha- | cadinol | FL/FR |
| | canarium luzonicum oil | FL/FR |
| | celery seed oil CO2 extract | FL/FR |
| | celery seed oil replacer | FR |
| | celery specialty | FR |
| | herbal dioxane | FR |
| | herbal undecanone | FR |
| | hyssop oil | FL/FR |
| | lavandin water absolute | FL/FR |
| spike | lavender absolute | FL/FR |
| | origanum oil | FL/FR |
| curled | parsley leaf oil | FL/FR |
| curled | parsley seed oil | FL/FR |
| alpha- | pinene | FL/FR |
| | pinocarveol | FL/FR |
| common | tansy flower oil | FR |
| | tea leaf absolute | FL/FR |
| | terpinolene | FL/FR |
| | valerian rhizome oil china | FL/FR |
| melon |
| (Z)-6- | nonenal | FL/FR |
| minty |
| (-)-iso | pulegol | FL/FR |
| mossy |
| | oakmoss concrete | FR |
| | oakmoss phenol | FR |
| | treemoss absolute | FR |
| | veramoss (IFF) | FR |
| musk |
| (E)-12- | musk decenone | FR |
| musty |
| ketoiso | phorone | FL/FR |
| nutty |
| 3- | acetyl pyridine | FL/FR |
| 2,6- | lutidine | FL/FR |
| powdery |
| alpha- | methyl ionone | FL/FR |
| (E)-alpha- | methyl ionone (44-50%) | FL/FR |
| smoky |
| 2,6- | dimethoxyphenol | FL/FR |
| | pyroligneous acids | FL/FR |
| spicy |
| | agarospirol | FR |
| | allspice berry oil | FL/FR |
| | allspice leaf oil | FL/FR |
| | atractylis root oil | FR |
| 4- | carvomenthenol | FL/FR |
| beta- | caryophyllene alcohol | FL/FR |
| alpha- | caryophyllene alcohol | FL/FR |
| | cassia leaf oil | FL/FR |
| | cinnamon leaf oil ceylon | FL/FR |
| | clove bud absolute | FL/FR |
| | clove bud oil | FL/FR |
| | clove bud oil CO2 extract | FL/FR |
| 4- | ethyl guaiacol | FL/FR |
| | eugenol | FL/FR |
| | eugenyl acetate | FL/FR |
| | galangal root oil | FL/FR |
| | ginger root oil china | FL/FR |
| | nutmeg oil | FL/FR |
| terpenic |
| | cypress leaf oil | FR |
| | juniper branch oil | FR |
| | pine needle oil dwarf | FL/FR |
| thujonic |
| alpha- | thujone | FR |
| vanilla |
| | vanillin propylene glycol acetal | FL/FR |
| waxy |
| | tridecanoic acid | FL/FR |
| woody |
| | amber formate | FR |
| | bois de rose leaf oil brazil | FL/FR |
| iso | bornyl isovalerate | FL/FR |
| | bornyl valerate | FL/FR |
| 2-tert- | butyl cyclohexanone | FR |
| (+)- | camphene | FL/FR |
| beta- | caryophyllene oxide | FL/FR |
| | cedarwood oil atlanta | FR |
| | cedarwood oil himalaya | FR |
| | cedarwood oil virginia | FR |
| alpha- | cedrene epoxide | FR |
| | cedrol methyl ether | FR |
| | cistus twig/leaf oil | FL/FR |
| | copaiba balsam | FL/FR |
| | dacrydium franklinii wood oil | FR |
| | dihydro-alpha-terpinyl acetate | FR |
| (E)- | ethyl geranate | FR |
| | frankincense resin | FL/FR |
| (E)- | germacrene D | FL/FR |
| | guaiacwood acetates | FR |
| | guaiene | FL/FR |
| | labdanum concrete | FR |
| | longifolene | FL/FR |
| | marine formate | FR |
| | methyl cedryl ketone | FL/FR |
| | methyl sandal | FR |
| 2- | methyl-1-(5',5',6'-trimethyl bicyclo(2.2.1)hept-2'-yl) propan-2-ol | FR |
| | patchouli hexanol | FR |
| | rhubarb oxirane | FR |
| | sandal hexanol | FR |
| | sandal pentenone | FR |
| | sandalwood oil west australia (santalum spicatum) | FR |
| alpha- | santalol | FL/FR |
| | santalyl butyrate | FL/FR |
| | thuja occidentalis leaf oil | FL/FR |
| | tobacco nonene | FR |
| | treemoss resinoid replacer | FR |
| | verdoxan | FR |
| | violet propanol | FR |
| | woody cyclohexanone | FR |
| | woody ether | FR |
| | woody nonane (ethoxy) | FR |
| |
| For Flavor |
| |
| No flavor group found for these |
| | ambergris tincture | FL/FR |
| | ambroxide | FL/FR |
| alpha- | cadinol | FL/FR |
| (+)- | camphene | FL/FR |
| alpha- | caryophyllene alcohol | FL/FR |
| beta- | caryophyllene alcohol | FL/FR |
| | cyclohexanone diethyl acetal | FL/FR |
| (E)- | germacrene D | FL/FR |
| | linalool oxide acetates | FL/FR |
| (E)-alpha- | methyl ionone (44-50%) | FL/FR |
| | octanal propylene glycol acetal | FL/FR |
| alpha- | santalol | FL/FR |
| | santalyl butyrate | FL/FR |
| | seaweed absolute (fucus vesiculosus et serratus) | FL/FR |
| | tridecanoic acid | FL/FR |
| 10- | undecenoic acid | FL/FR |
| amber |
| | labdanum oil | FL/FR |
| balsamic |
| | juniper berry absolute | FL/FR |
| | myrrh resin | FL/FR |
| | opoponax resin (commiphora erythraea var. glabrescens engler) | FL/FR |
| | spruce needle absolute | FL/FR |
| | styrax oil (liquidambar styraciflua) | FL/FR |
| burnt |
| | rum ether | FL/FR |
| camphoreous |
| dextro,laevo-iso | borneol | FL/FR |
| (-)-alpha- | fenchol | FL/FR |
| | pinocarveol | FL/FR |
| cheesy |
| 2- | heptanone | FL/FR |
| citrus |
| | grapefruit mercaptan | FL/FR |
| | linalool | FL/FR |
| (+)- | nootkatone | FL/FR |
| bitter | orange peel oil | FL/FR |
| ketoiso | phorone | FL/FR |
| cooling |
| 4- | carvomenthenol | FL/FR |
| beta-homo | cyclocitral | FL/FR |
| floral |
| | bois de rose leaf oil brazil | FL/FR |
| | cananga oil china | FL/FR |
| | citronellyl acetate | FL/FR |
| | dihydrojasmone | FL/FR |
| | dihydrolinalool | FL/FR |
| | linalyl anthranilate | FL/FR |
| alpha-iso | methyl ionone (70% min.) | FL/FR |
| | mimosa concrete france | FL/FR |
| | orris rhizome concrete butter (iris pallida) | FL/FR |
| fruity |
| | apple ketal | FL/FR |
| 3- | benzyl-4-heptanone | FL/FR |
| | bread thiophene | FL/FR |
| | menthyl isovalerate | FL/FR |
| alpha- | methyl ionone | FL/FR |
| | valerian rhizome oil china | FL/FR |
| green |
| | canarium luzonicum oil | FL/FR |
| | galbanum oleoresin | FL/FR |
| | geranic acid | FL/FR |
| para- | methyl hydratropaldehyde | FL/FR |
| (Z)-6- | nonenal | FL/FR |
| beta- | ocimene | FL/FR |
| (Z)-5- | octen-1-yl propionate | FL/FR |
| | rose leaf absolute (rosa centifolia) | FL/FR |
| herbal |
| | apium graveolens seed oil | FL/FR |
| | apium graveolens seed oil india | FL/FR |
| | celery seed oil CO2 extract | FL/FR |
| | hyssop oil | FL/FR |
| | lavandin water absolute | FL/FR |
| spike | lavender absolute | FL/FR |
| | origanum oil | FL/FR |
| curled | parsley leaf oil | FL/FR |
| curled | parsley seed oil | FL/FR |
| medicinal |
| 2,6- | dimethoxyphenol | FL/FR |
| minty |
| (-)-iso | pulegol | FL/FR |
| musty |
| 2,5- | dimethyl pyrazine | FL/FR |
| nutty |
| 3- | acetyl pyridine | FL/FR |
| 2,6- | lutidine | FL/FR |
| pine |
| | pine needle oil dwarf | FL/FR |
| smoky |
| | pyroligneous acids | FL/FR |
| sour |
| 2- | methyl-2-pentenoic acid | FL/FR |
| spicy |
| | allspice berry oil | FL/FR |
| | allspice leaf oil | FL/FR |
| siam | benzoin absolute | FL/FR |
| | cassia leaf oil | FL/FR |
| | cinnamon leaf oil ceylon | FL/FR |
| | clove bud absolute | FL/FR |
| | clove bud oil | FL/FR |
| | clove bud oil CO2 extract | FL/FR |
| | eugenol | FL/FR |
| | eugenyl acetate | FL/FR |
| | galangal root oil | FL/FR |
| | ginger root oil china | FL/FR |
| | nutmeg oil | FL/FR |
| tea |
| | tea leaf absolute | FL/FR |
| vanilla |
| | vanillin propylene glycol acetal | FL/FR |
| woody |
| | amyris wood oil | FL/FR |
| iso | bornyl acetate | FL/FR |
| iso | bornyl isovalerate | FL/FR |
| | bornyl valerate | FL/FR |
| beta- | caryophyllene oxide | FL/FR |
| | cistus twig/leaf oil | FL/FR |
| | copaiba balsam | FL/FR |
| 4- | ethyl guaiacol | FL/FR |
| | frankincense resin | FL/FR |
| | guaiene | FL/FR |
| beta- | ionone | FL/FR |
| alpha- | irone | FL/FR |
| | longifolene | FL/FR |
| | methyl cedryl ketone | FL/FR |
| | methyl ionyl acetate | FL/FR |
| alpha- | pinene | FL/FR |
| | terpinolene | FL/FR |
| | thuja occidentalis leaf oil | FL/FR |
| |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2,4,6- | cycloheptatrien-1-one, 2-hydroxy-4-(1-methylethyl)- | | 2,4,6- | cycloheptatrien-1-one, 2-hydroxy-4-isopropyl- | | 2,4,6- | cycloheptatrien-1-one, 2-hydroxy-6-(1-methylethyl)- | | | hinokitiol | | | hinokitiol crystals | | | hinokitiol crystals (takasago) | | | hinokitol | | 2- | hydroxy-4-(1-methyl ethyl)-2,4,6-cycloheptatrien-1-one | | 2- | hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one | | 2- | hydroxy-4-(methylethyl)cyclohepta-2,4,6-trien-1-one | | 2- | hydroxy-4-isopropyl-2,4, 6-cycloheptatrien-1-one | | 2- | hydroxy-4-isopropyl-2,4,6-cyclohepta-2,4,6-trien-1-one | | 2- | hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one | | 2- | hydroxy-4-isopropyl-cyclohepta-2,4,6-trienone | | 2- | hydroxy-4-isopropylcyclohepta-2,4,6-trien-1-one | | 2- | hydroxy-4-isopropylcyclohepta-2,4,6-trienone | | 2- | hydroxy-6-(propan-2-yl)cyclohepta-2,4,6-trien-1-one | | 2- | hydroxy-6-isopropyl-2,4,6-cycloheptatrien-1-one | | 2- | hydroxy-6-propan-2-ylcyclohepta-2,4,6-trien-1-one | | beta-iso | propyl tropolon | | 4-iso | propyl tropolone | | iso | propyl tropolone | | 4-iso | propyltropolone | | beta- | thujaplicin | | beta- | thujaplicine | | | tropolone, 4-isopropyl- |
Articles:
| PubMed: | Toxicity of hiba oil constituents and spray formulations to American house dust mites and copra mites. |
| PubMed: | A novel synthetic pathway for tropolone ring formation via the olefin monoterpene intermediate terpinolene in cultured Cupressus lusitanica cells. |
| PubMed: | Hinokitiol inhibits cell growth through induction of S-phase arrest and apoptosis in human colon cancer cells and suppresses tumor growth in a mouse xenograft experiment. |
| PubMed: | Hinokitiol, a natural tropolone derivative, offers neuroprotection from thromboembolic stroke in vivo. |
| PubMed: | Determination of hinokitiol in skin lotion by high-performance liquid chromatography-ultraviolet detection after precolumn derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole. |
| PubMed: | Effect of mouth cleaning with hinokitiol-containing gel on oral malodor: a randomized, open-label pilot study. |
| PubMed: | Tetsuo Nozoe's "Autograph Books by Chemists 1953-1994": an essay. |
| PubMed: | Hinokitiol inhibits platelet activation ex vivo and thrombus formation in vivo. |
| PubMed: | In vitro antimicrobial and anticancer potential of hinokitiol against oral pathogens and oral cancer cell lines. |
| PubMed: | Stress-related activities induced by predator odor may become indistinguishable by hinokitiol odor. |
| PubMed: | In vitro and in vivo anti-plasmodial activity of essential oils, including hinokitiol. |
| PubMed: | The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs. |
| PubMed: | In vitro and in vivo therapeutics of β-thujaplicin on LPS-induced inflammation in macrophages and septic shock in mice. |
| PubMed: | Preventive effects of β-thujaplicin against UVB-induced MMP-1 and MMP-3 mRNA expressions in skin fibroblasts. |
| PubMed: | Effects of a combination of hinokitiol (β-thujaplicin) and an organic acid mixture on ruminal fermentation in heifers fed a high-grain diet. |
| PubMed: | In vitro Na+/K+-ATPase inhibitory activity and antimicrobial activity of sesquiterpenes isolated from Thujopsis dolabrata. |
| PubMed: | A 13-week subchronic toxicity study of hinokitiol administered in the diet to F344 rats. |
| PubMed: | Zinc-dependent effects of small molecules on the insulin-sensitive transcription factor FOXO1a and gluconeogenic genes. |
| PubMed: | Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins. |
| PubMed: | Inhibitory effects of hinokitiol on tyrosinase activity and melanin biosynthesis and its antimicrobial activities. |
| PubMed: | Hinokitiol activates the hypoxia-inducible factor (HIF) pathway through inhibition of HIF hydroxylases. |
| PubMed: | Time-kill assay results for a linalool-hinokitiol-based eyelid cleanser for lid hygiene. |
| PubMed: | In vitro skin permeation of hinokitiol loaded in vesicles composed of behenyltrimethylammonium chloride and stearic acid. |
| PubMed: | Synthesis of tropolone derivatives and evaluation of their in vitro neuroprotective activity. |
| PubMed: | High-performance liquid chromatography with dual-wavelength ultraviolet detection for measurement of hinokitiol in personal care products. |
| PubMed: | p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function. |
| PubMed: | Effects of leaching on fungal growth and decay of western redcedar. |
| PubMed: | Volatile and non-volatile monoterpenes produced by elicitor-stimulated Cupressus lusitanica cultured cells. |
| PubMed: | Antiviral activity of the zinc ionophores pyrithione and hinokitiol against picornavirus infections. |
| PubMed: | High production of beta-thujaplicin glycosides by immobilized plant cells of Nicotiana tabacum. |
| PubMed: | Hinokitiol, a natural tropolone derivative, inhibits TNF-alpha production in LPS-activated macrophages via suppression of NF-kappaB. |
| PubMed: | In vivo hair growth promotion effects of cosmetic preparations containing hinokitiol-loaded poly(epsilon-caprolacton) nanocapsules. |
| PubMed: | Antifungal mechanism of hinokitiol against Candida albicans. |
| PubMed: | In vitro permeation study of hinokitiol: effects of vehicles and enhancers. |
| PubMed: | Antifungal properties of ethanolic extract and its active compounds from Calocedrus macrolepis var. formosana (Florin) heartwood. |
| PubMed: | The mechanism of the bactericidal activity of hinokitiol. |
| PubMed: | Growth inhibitory effect of shelf life extending agents on Bacillus subtilis IAM 1026. |
| PubMed: | Reactive oxygen species, nitric oxide, and their interactions play different roles in Cupressus lusitanica cell death and phytoalexin biosynthesis. |
| PubMed: | Analysis of western redcedar (Thuja plicata Donn) heartwood components by HPLC as a possible screening tool for trees with enhanced natural durability. |
| PubMed: | Lack of hinokitiol (beta-thujaplicin) carcinogenicity in F344/DuCrj rats. |
| PubMed: | Hinokitiol, a metal chelator derived from natural plants, suppresses cell growth and disrupts androgen receptor signaling in prostate carcinoma cell lines. |
| PubMed: | The excellence of Aomori Hiba (Hinokiasunaro) in its use as building materials of Buddhist temples and Shinto shrines. |
| PubMed: | Differential regulation of melanosomal proteins after hinokitiol treatment. |
| PubMed: | Therapeutic effects of beta-thujaplicin eardrops on canine Malassezia-related otitis externa. |
| PubMed: | Mosquito larvicidal activity of active constituent derived from Chamaecyparis obtusa leaves against 3 mosquito species. |
| PubMed: | Effects of beta-thujaplicin on anti-Malassezia pachydermatis remedy for canine otitis externa. |
| PubMed: | Human metallothionein gene expression is upregulated by beta-thujaplicin: possible involvement of protein kinase C and reactive oxygen species. |
| PubMed: | Prooxidant action of hinokitiol: hinokitiol-iron dependent generation of reactive oxygen species. |
| PubMed: | Inhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesis. |
| PubMed: | Signal transduction and metabolic flux of beta-thujaplicin and monoterpene biosynthesis in elicited Cupressus lusitanica cell cultures. |
| PubMed: | In vitro inhibitory effects of hinokitiol on proliferation of Chlamydia trachomatis. |
| PubMed: | Oxidative stress in plant cell culture: a role in production of beta-thujaplicin by Cupresssus lusitanica suspension culture. |
| PubMed: | Fungal diversity from western redcedar fences and their resistance to beta-thujaplicin. |
| PubMed: | Acaricidal activity of active constituent isolated in Chamaecyparis obtusa leaves against Dermatophagoides spp. |
| PubMed: | Protection by tropolones against H2O2-induced DNA damage and apoptosis in cultured Jurkat cells. |
| PubMed: | Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones. |
| PubMed: | Biological activity of beta-dolabrin, gamma-thujaplicin, and 4-acetyltropolone, hinokitiol-related compounds. |
| PubMed: | Biological activity of alpha-thujaplicin, the isomer of hinokitiol. |
| PubMed: | Cytotoxic activity of deferiprone, maltol and related hydroxyketones against human tumor cell lines. |
| PubMed: | (-)-Epigallocatechin-3-gallate and hinokitiol reduce melanin synthesis via decreased MITF production. |
| PubMed: | Jasmonate and ethylene signalling and their interaction are integral parts of the elicitor signalling pathway leading to beta-thujaplicin biosynthesis in Cupressus lusitanica cell cultures. |
| PubMed: | Beta-thujaplicin: new quantitative CZE method and adsorption to goethite. |
| PubMed: | Evaluation of developmental toxicity of beta-thujaplicin (hinokitiol) following oral administration during organogenesis in rats. |
| PubMed: | Rapid accumulation and metabolism of polyphosphoinositol and its possible role in phytoalexin biosynthesis in yeast elicitor-treated Cupressus lusitanica cell cultures. |
| PubMed: | Transmission electron microscopy of Schistosoma mansoni cercariae treated with hinokitiol (beta-thujaplicin), a compound for potential skin application against cercarial penetration. |
| PubMed: | [Antimicrobial activity of hinokitiol against Legionella pneumophila]. |
| PubMed: | Synthesis and structural characterization of silver(I), aluminium(III) and cobalt(II) complexes with 4-isopropyltropolone (hinokitiol) showing noteworthy biological activities. Action of silver(I)-oxygen bonding complexes on the antimicrobial activities. |
| PubMed: | Monoterpenes produced by Cupressus lusitanica cultured cells including a novel monoterpene (1R, 2S, 6S)-(+)-1,6-epoxy-4(8)-p-menthen-2-ol [corrected]. |
| PubMed: | Generation of reactive oxygen species from Hinokitiol under near-UV irradiation. |
| PubMed: | Multiple signalling pathways mediate fungal elicitor-induced beta-thujaplicin biosynthesis in Cupressus lusitanica cell cultures. |
| PubMed: | Antibacterial effect of beta-thujaplicin on staphylococci isolated from atopic dermatitis: relationship between changes in the number of viable bacterial cells and clinical improvement in an eczematous lesion of atopic dermatitis. |
| PubMed: | Biological activity of 4-acetyltropolone, the minor component of Thujopsis dolabrata SIeb. et Zucc. hondai Mak. |
| PubMed: | Feedback regulation of beta-thujaplicin production and formation of its methyl ether in a suspension culture of Cupressus lusitanica. |
| PubMed: | Fungicidal activity of beta-thujaplicin analogues. |
| PubMed: | Production of beta-thujaplicin in Cupressus lusitanica suspension cultures fed with organic acids and monoterpenes. |
| PubMed: | Biological activity of alpha-thujaplicin, the minor component of Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO. |
| PubMed: | Cytotoxic effects of beta-thujaplicin on rat thymocytes and prevention by the compound in tributyltin-induced thymocyte damage. |
| PubMed: | Improved beta-thujaplicin production in Cupressus lusitanica suspension cultures by fungal elicitor and methyl jasmonate. |
| PubMed: | Cytotoxicity of the hinokitiol-related compounds, gamma-thujaplicin and beta-dolabrin. |
| PubMed: | Identification of a compound in Chamaecyparis taiwanensis inhibiting the ice-nucleating activity of Pseudomonas fluorescens KUIN-1. |
| PubMed: | Hinokitiol, a selective inhibitor of the platelet-type isozyme of arachidonate 12-lipoxygenase. |
| PubMed: | Antifungal activity of Hinokitiol-related compounds on wood-rotting fungi and their insecticidal activities. |
| PubMed: | Phytogrowth-Inhibitory activities of beta-dolabrin and gamma-thujaplicin, hinokitiol-related compounds and constituents of Thujopsis dolabrata Sieb. et Zucc. var hondai Makino. |
| PubMed: | Apoptosis during iron chelator-induced differentiation in F9 embryonal carcinoma cells. |
| PubMed: | Teratogenicity of thujaplicin in ICR mice. |
| PubMed: | Antimicrobial activity and metalloprotease inhibition of hinokitiol-related compounds, the constituents of Thujopsis dolabrata S. and Z. hondai MAK. |
| PubMed: | Multi-enzymatic glucosylation using Eucalyptus UDP-glucosyltransferase coupled UDPglucose-fermentation by bakers' yeast. |
| PubMed: | Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3. |
| PubMed: | Beta-thujaplicin zinc chelate induces apoptosis in mouse high metastatic melanoma B16BL6 cells. |
| PubMed: | Mechanism of mitochondrial dysfunction and cytotoxicity induced by tropolones in isolated rat hepatocytes. |
| PubMed: | Thujaplicin-copper chelates inhibit replication of human influenza viruses. |
| PubMed: | Effects of zinc oxide on the attachment of Staphylococcus aureus strains. |
| PubMed: | Inhibitory effect of beta-thujaplicin on ultraviolet B-induced apoptosis in mouse keratinocytes. |
| PubMed: | Biological activity of purpurogallin. |
| PubMed: | Induction of differentiation of embryonal carcinoma F9 cells by iron chelators. |
| PubMed: | Hinokitiol induces differentiation of teratocarcinoma F9 cells. |
| PubMed: | [On the antibacterial effect of hinokitiol against Staphylococcus aureus showing double zone phenomenon]. |
| PubMed: | Cytotoxic effect of hinokitiol and tropolone on the growth of mammalian cells and on blastogenesis of mouse splenic T cells. |
| PubMed: | [Study on the development of biological-active compounds after the model of natural products]. |
| PubMed: | High-performance liquid chromatographic determination of hinokitiol in cosmetics by the formation of difluoroborane compounds. |
| PubMed: | [A clinical re-evaluation of an Hinoporon on periodontal disease using the double blind method]. |
| PubMed: | [Methylation of hinokitiol and 7-iodohinokitiol and the syntheses of Schiff bases of hydrazinotropone derivatives and 5-aminohinokitiol]. |
| PubMed: | Calcium-independent release of [3H]dopamine by veratridine in pargyline- and reserpine-treated corpus striatum. |
| PubMed: | Allergic contact dermatitis to pyridoxine ester and hinokitiol. |
| PubMed: | The multifunctional actions of beta-thujaplicin on the oxidative energy transformations as a consequence of its lipophilic and chelating properties. |
| PubMed: | Comparison of the effects of tropolone, beta-thujaplicin and U-0521 on the extraneuronal accumulation of isoprenaline in guinea-pig trachealis smooth muscle cells. A quantitative fluorescence histochemical study. |
| PubMed: | The extraneuronal accumulation of isoprenaline in trachea and atria of guinea-pig and cat: a fluorescence histochemical study. |
| PubMed: | The uptake kinetics and metabolism of extraneuronal noradrenaline in guinea-pig trachea as studied with quantitative fluorescence microphotometry. |
| PubMed: | Antibacterial activity of beta-thujaplicin. |
| PubMed: | The effect of light on the antibacterial activity of beta-thujaplicin. |
| PubMed: | Synethesis of beta-dolabrin from beta-thujaplicin (hinokitiol). |
| PubMed: | Antibiotic substances from the heart wood of Thuja plicata D. Don; the constitution of beta-thujaplicin. |
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