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Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear liquid (est) |
| Assay: | 98.00 to 100.00 %
|
| Food Chemicals Codex Listed: | Yes |
| Specific Gravity: | 0.86200 to 0.86800 @ 25.00 °C.
|
| Pounds per Gallon - (est).: | 7.173 to 7.223
|
| Refractive Index: | 1.38500 to 1.39100 @ 20.00 °C.
|
| Melting Point: | -88.00 to -87.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 112.00 to 113.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 40.00 to 41.00 °C. @ 50.00 mm Hg
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| Acid Value: | 1.00 max. KOH/g
|
| Vapor Pressure: | 25.400000 mmHg @ 25.00 °C. |
| Vapor Density: | 4.01 ( Air = 1 ) |
| Flash Point: | 57.00 °F. TCC ( 13.89 °C. )
|
| logP (o/w): | 1.648 (est) |
| Shelf Life: | 12.00 month(s) or longer if stored properly. |
| Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Soluble in: |
| | alcohol | | | water, 3172 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
| |
| Odor Type: fruity |
| |
| Odor Strength: | high , recommend smelling in a 10.00 % solution or less |
| |
| Substantivity: | 4 hour(s) at 100.00 % |
| |
| | sweet ethereal fruity alcoholic fusel rummy |
Odor Description: at 10.00 % in dipropylene glycol. | sweet ethereal fruity alcoholic fusel rummy |
| |
| | sweet ethereal fruity pungent alcoholic fusel rummy |
Odor Description:
| Sweet, etherial and fruity with pungent, alcoholic, fusel and rummy nuances Mosciano, Gerard P&F 22, No. 2, 69, (1997) |
| |
| |
| Flavor Type: ethereal |
| |
| | pungent ethereal fruity alliaceous egg nog |
Taste Description: at 12.50 ppm. | Pungent, etherial and fruity with a rum-and egg nog-like nuance Mosciano, Gerard P&F 22, No. 2, 69, (1997) |
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| Odor and/or flavor descriptions from others (if found). |
| |
| Alfrebro |
| ETHYL ISOBUTYRATE NATURAL |
| Odor Description: | Citrus, Buttery, Cherry, Strawberry |
| |
| Moellhausen |
| ETHYL ISOBUTYRATE |
| Odor Description: | sweet, fruity, ethereal, with a rum like nuance |
| Taste Description: | fruity, sweet |
| |
| Blue Marble Biomaterials |
| Ethyl Isobutyrate - Natural ≥98% |
| Odor Description: | Fruity, sweet: Alcoholic: rum |
| Taste Description: | Fruity, pungent: rum |
| |
| |
Cosmetic Information:
Suppliers:
| Advanced Biotech |
| ETHYL ISOBUTYRATE NATURAL
98% min. Odor: Fruity |
| Alfrebro |
| ETHYL ISOBUTYRATE NATURAL
Odor: Citrus, Buttery, Cherry, Strawberry |
| Ambles Nature et Chimie |
| ISOBUTYRATE ETHYLE NAT
|
| Apple Flavor & Fragrance |
| Ethyl isobutyrate
|
| Astral Extracts |
| Ethyl Isobutyrate
|
| Augustus Oils |
| Ethyl Iso Butyrate
|
| Services |
| Aurochemicals |
| ETHYL ISOBUTYRATE, Natural
|
| Axxence Aromatic |
| ETHYL ISOBUTYRATE Natural
Kosher |
| Sustainability |
| Beijing Lys Chemicals |
| Ethyl isobutyrate
|
| Berjé |
| Ethyl Iso Butyrate
|
| Media |
| Charkit Chemical |
| ETHYL ISOBUTYRATE FEMA 2428
|
| Elan Inc. |
| ETHYL ISO BUTYRATE
(natural), Kosher |
| EMD Millipore |
| For experimental / research use only. |
| Ethyl Isobutyrate
|
| Ernesto Ventós |
| ETHYL ISOBUTYRATE
Odor: FRUITY AND AROMATIC |
| Excellentia International |
| Ethyl Isobutyrate Natural
|
| Fleurchem |
| ethyl isobutyrate natural
|
| Frutarom |
| ETHYL ISOBUTYRATE
KOSHER Flavor: Sweet, Ethereal, Fruity, Alcoholic, Rummy |
| CBD Offering |
| Global Essence |
| Ethyl Isobutyrate
|
| Grau Aromatics |
| ETHYL-iso-BUTYRATE FCC
NI, Kosher |
| H. Interdonati, Inc. |
| Ethyl isobutyrate Natural, Kosher
|
| Featured Products |
| IFF |
| ETHYL ISOBUTYRATE
KOSHER Flavor: Sweet, Ethereal, Fruity, Alcoholic, Rummy |
| Indenta Group |
| Ethyl Isobutyrate
|
| Indukern F&F |
| ETHYL ISOBUTYRATE
Odor: SWEET, FRUITY, ETHEREAL |
| Jiangyin Healthway |
| Ethyl Isobutyrate
|
| New functional food ingredients |
| K.L. Koh Enterprise |
| ETHYL ISOBUTYRATE
|
| Lluch Essence |
| ETHYL ISOBUTYRATE NATURAL
|
| Lluch Essence |
| ETHYL ISOBUTYRATE
|
| M&U International |
| ETHYL ISOBUTYRATE
|
| M&U International |
| NAT.ETHYL ISOBUTYRATE, Kosher
|
| Mane |
| Ethyl Isobutyrate
Odor: Fermented Wine lees Apple |
| Moellhausen |
| ETHYL ISOBUTYRATE
Odor: sweet, fruity, ethereal, with a rum like nuance Flavor: fruity, sweet |
| Pearlchem Corporation |
| Natural Ethyl Isobutyrate
|
| Penta International |
| ETHYL ISOBUTYRATE NATURAL
|
| Penta International |
| ETHYL ISOBUTYRATE
|
| R C Treatt & Co Ltd |
| Ethyl Isobutyrate
|
| Reincke & Fichtner |
| Ethyl Iso Butyrate natural
|
| Reincke & Fichtner |
| Ethyl Isobutyrate
|
| Robertet |
| ETHYL ISOBUTYRATE
Pure & Nat (EU) |
| Seasons and Harvest / Crop calendar |
| Seqens |
| Ethyl Iso-butyrate, Kosher
|
| Sigma-Aldrich |
| Ethyl isobutyrate, ≥98%, FCC, FG
Odor: citrus; strawberry |
| Certified Food Grade Products |
| Sigma-Aldrich |
| Ethyl isobutyrate, natural, ≥98%, FCC, FG
Odor: citrus; strawberry |
| SRS Aromatics |
| ETHYL ISO BUTYRATE NATURAL
|
| SRS Aromatics |
| ETHYL ISO BUTYRATE
|
| Sunaux International |
| nat.Ethyl Isobutyrate
|
| Taytonn ASCC |
| Ethyl Isobutyrate
|
| TCI AMERICA |
| For experimental / research use only. |
| Ethyl Isobutyrate >99.0%(GC)
|
| Ungerer & Company |
| Ethyl Iso Butyrate
|
| Vigon International |
| Ethyl Isobutyrate FCC
|
| Vigon International |
| Ethyl Isobutyrate Natural FCC
|
| WEN International |
| ETHYL ISOBUTYRATE Natural
|
| WholeChem |
| Ethyl isobutyrate
|
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | Xi - Irritant |
R 10 - Flammable. R 36/37/38 - Irritating to eyes, respiratory system, and skin. S 02 - Keep out of the reach of children. S 16 - Keep away from sources of ignition - No Smoking. S 24/25 - Avoid contact with skin and eyes. S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
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| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Human Experience: |
| 8 % solution: no irritation or sensitization. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 > 5000 mg/kg (Moreno, 1975b)
intraperitoneal-mouse LD50 800 mg/kg Food and Cosmetics Toxicology. Vol. 16, Pg. 741, 1978.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| Recommendation for ethyl isobutyrate usage levels up to: | | | 8.0000 % in the fragrance concentrate.
|
| |
| Maximised Survey-derived Daily Intakes (MSDI-EU): | 640.00 (μg/capita/day) |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 3 |
| Click here to view publication 3 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | 200.00000 |
| beverages(nonalcoholic): | - | 10.00000 |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | 25.00000 |
| fruit ices: | - | 25.00000 |
| gelatins / puddings: | - | 6.00000 |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | 73.00000 |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| iso | butyric acid ethyl ester | | iso | butyric acid ethylester | | iso | butyric acid, ethyl ester | | | ethyl 2-methyl propanoate | | | ethyl 2-methyl propionate | | | ethyl 2-methylpropanoate | | | ethyl 2-methylpropionate | | | ethyl 2,2-dimethyl acetate | | | ethyl 2,2-dimethylacetate | | | ethyl iso butyrate | | | ethyl isobutanoate | | nat. | ethyl isobutyrate | | | ethyl isobutyrate 99%, (naturals) | | | ethyl isobutyrate FCC | | | ethyl isobutyrate FCC natural | | | ethyl isobutyrate natural | | | ethyl isobutyrate, natural | | | ethyl methylpropanoate | | | ethyl-iso-butyrate FCC | | | ethylisobutyrate | | 2- | methyl propanoic acid ethyl ester | | 2- | methyl propionic acid ethyl ester | | 2- | methylpropanoic acid ethyl ester | | | propanoic acid, 2-methyl ethyl ester | | | propanoic acid, 2-methyl-, ethyl ester | | | propionic acid, 2-methyl-, ethyl ester |
Articles:
| Info: | Volatile Flavor Components in Bogyojosaeng and Suhong Cultivars of Strawberry (Fragaria ananassa Duch.) |
| PubMed: | In situ Metabolic Characteristic Analysis Reveals the Key Yeast in the Spontaneous and Solid-state Fermentation Process of Chinese Light-style Liquor. |
| J-Stage: | Comparative Volatile Profiles in Soy Sauce According to Inoculated Microorganisms |
| PubMed: | Comparative volatile profiles in soy sauce according to inoculated microorganisms. |
| J-Stage: | Recyclable Polymeric p-Acid Catalyst Effective on Mannich-Type Reaction in Water |
| PubMed: | Potential aromatic compounds as markers to differentiate between Tuber melanosporum and Tuber indicum truffles. |
| J-Stage: | Odor-Active Constituents in Fresh Pineapple (Ananas comosus [L.] Merr.) by Quantitative and Sensory Evaluation |
| PubMed: | Influence of phenolic compounds on the sensorial perception and volatility of red wine esters in model solution: an insight at the molecular level. |
| PubMed: | Poly[tri(ethylene glycol) ethyl ether methacrylate]-coated surfaces for controlled fibroblasts culturing. |
| PubMed: | Airborne molds and bacteria, microbial volatile organic compounds (MVOC), plasticizers and formaldehyde in dwellings in three North European cities in relation to sick building syndrome (SBS). |
| PubMed: | Characterization of the major odor-active compounds in Thai durian ( Durio zibethinus L. 'Monthong') by aroma extract dilution analysis and headspace gas chromatography-olfactometry. |
| PubMed: | Identification of aroma-active compounds in Jiashi muskmelon juice by GC-O-MS and OAV calculation. |
| PubMed: | Automated ARGET ATRP Accelerates Catalyst Optimization for the Synthesis of Thiol-Functionalized Polymers. |
| PubMed: | Comparative metabolic profiling to investigate the contribution of O. oeni MLF starter cultures to red wine composition. |
| PubMed: | Main odorants in Jura flor-sherry wines. Relative contributions of sotolon, abhexon, and theaspirane-derived compounds. |
| PubMed: | Experience influences elemental and configural perception of certain binary odour mixtures in newborn rabbits. |
| PubMed: | A novel attractant for Anastrepha ludens (Diptera: Tephritidae) from a Concord grape product. |
| PubMed: | Proportion of odorants impacts the configural versus elemental perception of a binary blending mixture in newborn rabbits. |
| PubMed: | Comparison of fermented soybean paste (Doenjang) prepared by different methods based on profiling of volatile compounds. |
| PubMed: | Characterization of odor-active compounds in guava wine. |
| PubMed: | Responses of Rhynchophorus ferrugineus adults to selected synthetic palm esters: electroantennographic studies and trap catches in an urban environment. |
| PubMed: | Characterisation of the most odour-active compounds of bone tainted dry-cured Iberian ham. |
| PubMed: | Identification of odor impact compounds of Tagetes minuta L. essential oil: comparison of two GC-olfactometry methods. |
| PubMed: | Nitrogen addition influences formation of aroma compounds, volatile acidity and ethanol in nitrogen deficient media fermented by Saccharomyces cerevisiae wine strains. |
| PubMed: | Examples of perceptive interactions involved in specific "red-" and "black-berry" aromas in red wines. |
| PubMed: | Characterization of volatile compounds contributing to naturally occurring fruity fermented flavor in peanuts. |
| PubMed: | Defining the typical aroma of sherry vinegar: sensory and chemical approach. |
| PubMed: | Characterization of the key aroma compounds in an american bourbon whisky by quantitative measurements, aroma recombination, and omission studies. |
| PubMed: | Synthesis, alpha 1-adrenoceptor antagonist activity, and SAR study of novel arylpiperazine derivatives of phenytoin. |
| PubMed: | Characterization of the key aroma compounds in soy sauce using approaches of molecular sensory science. |
| PubMed: | Comparison of the odor-active compounds in unhopped beer and beers hopped with different hop varieties. |
| PubMed: | Quantification of selected aroma-active compounds in Pinot noir wines from different grape maturities. |
| PubMed: | Recyclable polymeric pi-acid catalyst effective on Mannich-type reaction in water. |
| PubMed: | Identification based on quantitative measurements and aroma recombination of the character impact odorants in a Bavarian Pilsner-type beer. |
| PubMed: | Odor-active constituents in fresh pineapple (Ananas comosus [L.] Merr.) by quantitative and sensory evaluation. |
| PubMed: | Aroma extract dilution analysis of cv. Meeker (Rubus idaeus L.) red raspberries from Oregon and Washington. |
| PubMed: | Identification of fruity/fermented odorants in high-temperature-cured roasted peanuts. |
| PubMed: | A study on volatile organic compounds (VOCs) produced by tropical ascomycetous yeasts. |
| PubMed: | Aroma extract dilution analysis of Cv. Marion (Rubus spp. hyb) and Cv. Evergreen (R. laciniatus L.) blackberries. |
| PubMed: | Chemical and sensorial aroma characterization of freshly distilled Calvados. 2. Identification of volatile compounds and key odorants. |
| PubMed: | Gas-phase reactivity of the O=P(OCH3)2+ phosphonium ion with aliphatic esters in a quadrupole ion trap. Spontaneous elimination of ketenes. |
| PubMed: | Evaluation of aroma differences between hand-squeezed juices from Valencia late and Navel oranges by quantitation of key odorants and flavor reconstitution experiments. |
| PubMed: | Evaluation of key aroma compounds in hand-squeezed grapefruit juice (Citrus paradisi Macfayden) by quantitation and flavor reconstitution experiments. |
| PubMed: | Volatile flavor components in red fermented soybean (Glycine max) curds. |
| PubMed: | Comparison of the most odor-active compounds in fresh and dried hop cones (Humulus lupulus L. variety spalter select) based on GC-olfactometry and odor dilution techniques. |
| PubMed: | Similarities in the aroma chemistry of Gewürztraminer variety wines and lychee (Litchi chinesis sonn.) fruit. |
| PubMed: | Total Synthesis of Bafilomycin A(1). |
| PubMed: | Ethyl propionate: Synergistic kairomone for african palm weevil,Rhynchophorus phoenicis L. (Coleoptera: Curculionidae). |
| PubMed: | Inhibition of lipogenesis in rat brown adipose tissue by clofibrate. |
| PubMed: | [Impact of odor hedonics on sensory odor intensity--physiological intensity and sensory intensity]. |
| PubMed: | Enhanced peroxisomal beta-oxidation of fatty acids and glutathione metabolism in rats exposed to phenoxyacetic acids. |
| PubMed: | Hypolipidemia and peroxisome proliferation induced by phenoxyacetic acid herbicides in rats. |
| PubMed: | Xanthone analogues of clofibrate / Synthesis and biological evaluation as antagonists of lipolysis in vitro. |
| PubMed: | The mouse as a model for evaluation of hypotriglyceridemic drugs effects of nicotinic acid, clofibrate and ethyl 2-(4-dibenzofuranyloxy)-2-methylpropionate on plasma lipoproteins. |
| PubMed: | The spontaneously hyperlipidemic old rat as a model for evaluation of hypolipoproteinemic drugs. Effects of nicotinic acid, clofibrate and ethyl 2-(4-dibenzofuranyloxy)-2-methylpropionate on plasma lipoproteins. |
| PubMed: | Larval osmeterial secretions of the swallowtails (Papilio). |
| PubMed: | [On the uricosuric activity of etofylline clofibrate (author's transl)]. |
| PubMed: | [Therapeutic experiences in the treatment of hyperlipoproteinaemia with etofylline clofibrate (author's transl)]. |
| PubMed: | [Effect of etofylline clofibrate on the composition of lipoproteins in hyperlipidaemia type IIb and IV (author's transl)]. |
| PubMed: | [On the effect of etofylline clofibrate on serum lipids and lipoproteins in patients with hyperlipoproteinemia of various degrees (author's transl)]. |
| PubMed: | [Clinical effects and tolerance of etofylline clofibrate]. |
| PubMed: | [Metabolism and pharmacokinetics of etofylline clofibrate, new antilipemic]. |
| PubMed: | Effect of etofylline clofibrate on experimental thrombosis and platelet function. |
| PubMed: | [Evaluation of the antilipaemic potential of etofylline clofibrate, its metabolites and clofibrate in dietary-induced hyperlipidaemia in the rat (author's transl)]. |
| PubMed: | Evaluation of the hypolipaemic activity of etofylline clofibrate, a new ester of etofylline and clofibric acid, and comparison with effects of known hypolipaemic agents. |
| PubMed: | Hypolipaemic activity of 1-(theophyllin-7-yl)-ethyl-2-[2-(p-chlorophenoxy)-2-methylpropionate] (etofylline clofibrate) and its analogues in normolipaemic rats. |
| PubMed: | [Pharmacology and toxicology of etofylline clofibrate]. |
| PubMed: | Biopharmaceutic evaluation of etofylline clofibrate and its drug formulation. |
| PubMed: | Clofibrate-induced increase in coenzyme A concentration in rat tissues. |
| PubMed: | Potential hypolipidemic agents. XVII. Synthesis and plasma lipid-lowering properties of compounds related to ethyl 2-(4-dibenzofuranyloxy)-2-methylpropionate and ethyl 2-(4-chlorophenoxy)-2-methylpropionate. |
| PubMed: | 1-(Theophyllin-7-yl)-ethyl-2-[2-(p-chlorophenoxy)-2-methylpropionate] (ML 1024), a new hypolipemic agent. |
| PubMed: | Potential hypolipidemic agents. XIV. Synthesis and plasma lipid-lowering properties of substituted biphenyls, diphenyl ethers and benzofurans related to ethyl 2-(4-dibenzofuranyloxy)-2-methylpropionate. |
| PubMed: | Hypolipemic activity of clofibrate-related compounds. |
| PubMed: | Increase in hepatic catalase and glycerol phosphate dehydrogenase activities on administration of clofibrate and clofenapate to the rat. |
| PubMed: | Ethyl-2-(p-chlorophenoxy)-2-methylpropionate (clofibrate) in experimental fat embolism in rats. |
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