| Name: | humulus lupulus l. extract |
| CAS Number: | 8060-28-4 |
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| ECHA EC Number: | 232-504-3 |
Category: cosmetic, flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| FEMA Number: | 2578 hop extract |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 8060-28-4 ; HOPS, EXTRACT (HUMULUS LUPULUS L.) |
| FDA Regulation: | FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION Subpart C--Solvents, Lubricants, Release Agents and Related Substances Sec. 173.240 Isopropyl alcohol.
FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION Subpart C--Solvents, Lubricants, Release Agents and Related Substances Sec. 173.250 Methyl alcohol residues.
FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION Subpart C--Solvents, Lubricants, Release Agents and Related Substances Sec. 173.255 Methylene chloride.
FDA PART 173 -- SECONDARY DIRECT FOOD ADDITIVES PERMITTED IN FOOD FOR HUMAN CONSUMPTION Subpart C--Solvents, Lubricants, Release Agents and Related Substances Sec. 173.270 Hexane.
FDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE Subpart A--General Provisions Sec. 182.20 Essential oils, oleoresins (solvent-free), and natural extractives (including distillates).
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Physical Properties:
| Appearance: | pale brown to dark brown liquid (est) |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.97180 to 1.04180 @ 25.00 °C.
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| Pounds per Gallon - (est).: | 8.086 to 8.669
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| Refractive Index: | 1.35540 to 1.37140 @ 20.00 °C.
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| Shelf Life: | 6.00 month(s) or longer if stored properly. |
| Storage: | store in cool, dry place in tightly sealed containers, protected from heat and light. |
Organoleptic Properties:
| |
| Odor Type: woody |
| |
| | woody green citrus malty tagette |
Odor Description:
| woody green citrus malt tagette |
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| |
| Flavor Type: woody |
| |
| | hops |
Taste Description:
| hops |
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| Odor and/or flavor descriptions from others (if found). |
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| |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | cosmetic, flavor and fragrance agents |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| |
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 3 |
| Click here to view publication 3 |
| | average usual ppm | average maximum ppm |
| baked goods: | - | - |
| beverages(nonalcoholic): | - | 160.00000 |
| beverages(alcoholic): | - | - |
| breakfast cereal: | - | - |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | - | - |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | - | - |
| fruit ices: | - | - |
| gelatins / puddings: | - | - |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | - |
| imitation dairy: | - | - |
| instant coffee / tea: | - | - |
| jams / jellies: | - | - |
| meat products: | - | - |
| milk products: | - | - |
| nut products: | - | - |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | - | - |
| snack foods: | - | - |
| soft candy: | - | - |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | - | - |
Safety References:
References:
| | humulus lupulus l. extract |
| Pubchem (sid): | 135325910 |
Other Information:
| FDA Substances Added to Food (formerly EAFUS): | View |
| Export Tariff Code: | 1302.13.0000 |
| Wikipedia: | View |
Potential Blenders and core components note
| |
| For Odor |
| No odor group found for these |
| (-)-gamma- | elemene | |
| | humulus lupulus distillates | FL/FR |
| aldehydic |
| | dodecanal (aldehyde C-12 lauric) | FL/FR |
| | green hexanal | FL/FR |
| | undecanal | FL/FR |
| balsamic |
| | betula pubescens bud oil | FL/FR |
| | fir balsam absolute | FR |
| | fir balsam concrete | FR |
| citrus |
| | citral diethyl acetal | FL/FR |
| | citral dimethyl acetal | FL/FR |
| (R)- | citronellyl nitrile | FR |
| iso | decyl acetate | FR |
| | lime oil fractions | FR |
| | limonene aldehyde | FR |
| | litsea cubeba fruit oil | FL/FR |
| | methyl heptenone | FL/FR |
| 1- | methyl-4-methyl ethenyl cyclohexene sulfurized | FL/FR |
| alpha- | methylene citronellal | FR |
| | neroli ketone | FR |
| | tangerine acetate | FR |
| fatty |
| 6- | methyl-5-hepten-2-one propylene glycol acetal | FL/FR |
| floral |
| | citronellol | FL/FR |
| | dihydrocitronellyl ethyl ether | FR |
| | glycoacetal | FR |
| | karo karounde absolute | FR |
| | linalool | FL/FR |
| | melaleuca ericifolia leaf oil | FR |
| (E)- | nerolidol | FL/FR |
| | orange leaf absolute | FL/FR |
| fruity |
| iso | butyl 2-methyl butyrate | FL/FR |
| | cyclohexyl crotonate | FR |
| 1,4- | dibutyl-6,8-dioxabicyclo(3.2.1)octane | FR |
| 1,4- | diisopropyl-6,8-dioxabicyclo(3.2.1)octane | FR |
| 1,2- | dimethyl propyl 2-butenoate | |
| | grapefruit acetal | FR |
| | methyl acetoacetate | FL/FR |
| green |
| | bergoxane | FR |
| | bicyclogermacrene | |
| | citral / diisotridecyl acetal | FR |
| | citrus carbaldehyde / methyl anthranilate schiff's base | FR |
| | fresh nitrile | FR |
| | galbanum oleoresin | FL/FR |
| | galbanum resinoid | FL/FR |
| | green carboxylate | FR |
| | hop oil CO2 extract | FL/FR |
| dextro- | limonene oxide | FL/FR |
| | octanal diethyl acetal | FL/FR |
| | octanal dimethyl acetal | FL/FR |
| (E)-2- | octen-1-ol | FL/FR |
| | tricyclene-9-butenone | |
| 2,2,4- | trimethyl-1,3-oxathiane | |
| herbal |
| (+)-alpha- | campholenic aldehyde | FL/FR |
| | canarium luzonicum oil | FL/FR |
| iso | dihydrolavandulal | FL/FR |
| 2- | dodecenal | FL/FR |
| | hop absolute | FL/FR |
| | hop cone oil | FL/FR |
| | hop fragrance | FR |
| | hop oil | FL/FR |
| | hop oleoresin | FL/FR |
| | humulus lupulus cone extract | FL/FR |
| | linalyl formate | FL/FR |
| | nonisyl formate | FR |
| | tricyclo(5.2.1.02,6)dec-3-enyl acetate | FR |
| minty |
| (-)-iso | pulegol | FL/FR |
| iso | pulegol | FL/FR |
| 2,4,4,6- | tetramethyl cyclohexa-2,5-diene-1-one | FR |
| pine |
| | pine oil 85 | FR |
| spicy |
| 2,5- | dimethyl bicyclo(3.2.1)-2-octen-3-yl acetate + 1,4-dimethyl bicyclo(3.2.1)-2-octen-3-yl acetate | FR |
| 2- | octanol | FL/FR |
| black | pepper oil CO2 extract | FL/FR |
| terpenic |
| | juniper branch oil | FR |
| alpha- | phellandrene | FL/FR |
| waxy |
| | decanal dimethyl acetal | FL/FR |
| woody |
| | bruyere root absolute | FR |
| alpha- | farnesene | FL/FR |
| alpha- | farnesene isomer | FL/FR |
| | furfuryl thenyl ether | |
| | humulus lupulus tincture | FL/FR |
| | moss naphthaleneol | FR |
| (±)- | tetrahydronootkatone | FL/FR |
| alpha- | thujene | |
| | xanthoxylum alatum roxb. oil | FR |
| yeasty |
| | beer CO2 extract | FL/FR |
| | beer extract | CS |
| |
| For Flavor |
| |
| No flavor group found for these |
| | betula pubescens bud oil | FL/FR |
| | bicyclogermacrene | |
| | decanal dimethyl acetal | FL/FR |
| 1,2- | dimethyl propyl 2-butenoate | |
| (-)-gamma- | elemene | |
| | furfuryl thenyl ether | |
| | linalyl formate | FL/FR |
| | methyl acetoacetate | FL/FR |
| 6- | methyl-5-hepten-2-one propylene glycol acetal | FL/FR |
| (±)- | tetrahydronootkatone | FL/FR |
| alpha- | thujene | |
| | tricyclene-9-butenone | |
| 2,4,4- | trimethyl-1,3-oxathiane | FL |
| 2,2,4- | trimethyl-1,3-oxathiane | |
| dextro- | limonene oxide | FL/FR |
| citrus |
| | citral diethyl acetal | FL/FR |
| | citral dimethyl acetal | FL/FR |
| | linalool | FL/FR |
| | litsea cubeba fruit oil | FL/FR |
| 1- | methyl-4-methyl ethenyl cyclohexene sulfurized | FL/FR |
| fatty |
| 2- | dodecenal | FL/FR |
| (E)-2- | octen-1-ol | FL/FR |
| floral |
| | citronellol | FL/FR |
| | orange leaf absolute | FL/FR |
| fruity |
| iso | butyl 2-methyl butyrate | FL/FR |
| green |
| (+)-alpha- | campholenic aldehyde | FL/FR |
| | canarium luzonicum oil | FL/FR |
| alpha- | farnesene | FL/FR |
| alpha- | farnesene isomer | FL/FR |
| | galbanum oleoresin | FL/FR |
| | galbanum resinoid | FL/FR |
| | methyl heptenone | FL/FR |
| (E)- | nerolidol | FL/FR |
| (E,E)-2,6- | nonadienal | FL |
| 2,4- | octadienal | FL |
| | octanal diethyl acetal | FL/FR |
| | octanal dimethyl acetal | FL/FR |
| herbal |
| | beer flavor | FL |
| iso | dihydrolavandulal | FL/FR |
| | green hexanal | FL/FR |
| | hop absolute | FL/FR |
| | hop cone oil | FL/FR |
| | hop flavor | FL |
| | hop oil | FL/FR |
| | hop oleoresin | FL/FR |
| | humulus lupulus cone extract | FL/FR |
| | humulus lupulus distillates | FL/FR |
| | humulus lupulus extract modified | FL |
| | humulus lupulus extract solid | FL |
| | humulus lupulus tincture | FL/FR |
| malty |
| | yeast thiazoline | FL |
| minty |
| (-)-iso | pulegol | FL/FR |
| iso | pulegol | FL/FR |
| orris |
| | costus root oil | FL |
| soapy |
| | dodecanal (aldehyde C-12 lauric) | FL/FR |
| spicy |
| | hop oil CO2 extract | FL/FR |
| 2- | octanol | FL/FR |
| black | pepper oil CO2 extract | FL/FR |
| terpenic |
| alpha- | phellandrene | FL/FR |
| waxy |
| | undecanal | FL/FR |
| yeasty |
| | beer | FL |
| | beer CO2 extract | FL/FR |
| |
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | extract of the hops, humulus lupulus l., cannabidaceae | | | hop CL (Symrise) | | | hop extract | | extrapone | hop GW (Symrise) | | | hops extract | | | hops extract HS 2367 G | | | hops extract LS 3473 G | | | hops extract natural | | | hops P.E | | | phytovital hops |
Articles:
| PubMed: | Effects of Xanthohumol-Rich Hop Extract on the Differentiation of Preadipocytes. |
| PubMed: | Comprehensive separation and structural analyses of polyphenols and related compounds from bracts of hops (Humulus lupulus L.). |
| PubMed: | Effects of xanthohumol-rich extract from the hop on fatty acid metabolism in rats fed a high-fat diet. |
| PubMed: | A preliminary investigation of anticholinesterase activity of some Iranian medicinal plants commonly used in traditional medicine. |
| PubMed: | Inhibition of human cytochrome P450 enzymes by hops (Humulus lupulus) and hop prenylphenols. |
| PubMed: | In vitro and in vivo antioxidant and antimutagenic activities of polyphenols extracted from hops (Humulus lupulus L.). |
| PubMed: | Antiadherent and antibiofilm activity of Humulus lupulus L. derived products: new pharmacological properties. |
| PubMed: | Comparative study of antioxidant properties and total phenolic content of the extracts of Humulus lupulus L. and quantification of bioactive components by LC-MS/MS and GC-MS. |
| PubMed: | A semi-automatic microextraction in packed sorbent, using a digitally controlled syringe, combined with ultra-high pressure liquid chromatography as a new and ultra-fast approach for the determination of prenylflavonoids in beers. |
| PubMed: | Differential regulation of detoxification enzymes in hepatic and mammary tissue by hops (Humulus lupulus) in vitro and in vivo. |
| PubMed: | Effects of extracts of Humulus lupulus (hops) and Yucca schidigera applied alone or in combination with monensin on rumen fermentation and microbial populations in vitro. |
| PubMed: | Evaluation of the effect of Humulus lupulus alcoholic extract on rifampin-sensitive and resistant isolates of Mycobacterium tuberculosis. |
| PubMed: | Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from human nasal epithelial cells. |
| PubMed: | Optimized mixture of hops rho iso-alpha acids-rich extract and acacia proanthocyanidins-rich extract reduces insulin resistance in 3T3-L1 adipocytes and improves glucose and insulin control in db/db mice. |
| PubMed: | META060 protects against diet-induced obesity and insulin resistance in a high-fat-diet fed mouse. |
| PubMed: | The sedative effects of hops (Humulus lupulus), a component of beer, on the activity/rest rhythm. |
| PubMed: | Hop bitter acids inhibit tumorigenicity of hepatocellular carcinoma cells in vitro. |
| PubMed: | Hop (Humulus lupulus L.) extract inhibits obesity in mice fed a high-fat diet over the long term. |
| PubMed: | Dose-response relationships for the antifeedant effects of Humulus lupulus extracts against larvae and adults of the Colorado potato beetle. |
| PubMed: | Hop bitter acids exhibit anti-fibrogenic effects on hepatic stellate cells in vitro. |
| PubMed: | Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A). |
| PubMed: | [Effects of ethanol extracts of herbal medicines on dermatitis in an atopic dermatitis mouse model]. |
| PubMed: | The extract from hop cones (Humulus lupulus) as a modulator of oxidative stress in blood platelets. |
| PubMed: | Increased sexual motivation in female rats treated with Humulus lupulus L. extract. |
| PubMed: | A dietary supplement to improve the quality of sleep: a randomized placebo controlled trial. |
| PubMed: | Effects of hops (Humulus lupulus L.) extract on volatile fatty acid production by rumen bacteria. |
| PubMed: | Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes. |
| PubMed: | Experimental evidence of the anaphrodisiac activity of Humulus lupulus L. in naïve male rats. |
| PubMed: | The antimicrobial effects of hops (Humulus lupulus L.) on ruminal hyper ammonia-producing bacteria. |
| PubMed: | Oestrogenicity of prenylflavonoids from hops: activation of pro-oestrogens by intestinal bacteria. |
| PubMed: | In vivo estrogenic comparisons of Trifolium pratense (red clover) Humulus lupulus (hops), and the pure compounds isoxanthohumol and 8-prenylnaringenin. |
| PubMed: | Development of a screening assay for ligands to the estrogen receptor based on magnetic microparticles and LC-MS. |
| PubMed: | Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. |
| PubMed: | Antimutagenicity of hops (Humulus lupulus L.): bioassay-directed fractionation and isolation of xanthohumol. |
| PubMed: | Effects of aqueous hop (Humulus Lupulus L.) extract on vascular reactivity in rats: mechanisms and influence of gender and hormonal status. |
| PubMed: | Modulation of breast cancer cell survival by aromatase inhibiting hop (Humulus lupulus L.) flavonoids. |
| PubMed: | NMR assignment of iso-alpha-acids from isomerised extracts of Humulus lupulus L. cones. |
| PubMed: | Hypothermic effects of hops are antagonized with the competitive melatonin receptor antagonist luzindole in mice. |
| PubMed: | Determination of xanthohumol in hops (Humulus lupulus L.) by nonaqueous CE. |
| PubMed: | Flavonoid glycosides extracted from hop (Humulus lupulus L.) as inhibitors of chemical mediator release from human basophilic KU812 cells. |
| PubMed: | Behavioural response of Colorado potato beetle (Leptinotarsa decemlineata) larvae to selected plant extracts. |
| PubMed: | Open, non-controlled clinical studies to assess the efficacy and safety of a medical device in form of gel topically and intravaginally used in postmenopausal women with genital atrophy. |
| PubMed: | Effects of hop extracts on nasal rubbing and sneezing in BALB/c mice. |
| PubMed: | Effects of beer and hop on ionotropic gamma-aminobutyric acid receptors. |
| PubMed: | Selective inhibition of COX-2 by a standardized CO2 extract of Humulus lupulus in vitro and its activity in a mouse model of zymosan-induced arthritis. |
| PubMed: | A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts. |
| PubMed: | Anti-inflammatory acylphloroglucinol derivatives from Hops (Humulus lupulus). |
| PubMed: | Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1. |
| PubMed: | Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase. |
| PubMed: | Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). |
| PubMed: | New insight in the neuropharmacological activity of Humulus lupulus L. |
| PubMed: | Estrogens and congeners from spent hops (Humulus lupulus). |
| PubMed: | The antimycobacterial components of hops (Humulus lupulus) and their dereplication. |
| PubMed: | Direct characterization of bitter acids in a crude hop extract by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. |
| PubMed: | Occupational airborne and hand dermatitis to hop (Humulus lupulus) with non-occupational relapses. |
| PubMed: | Comparison of the most odor-active compounds in fresh and dried hop cones (Humulus lupulus L. variety spalter select) based on GC-olfactometry and odor dilution techniques. |
| PubMed: | Molecular characterization and genome organization of 7SL RNA genes from hop (Humulus lupulus L.). |
| PubMed: | Phlorisovalerophenone synthase, a novel polyketide synthase from hop (Humulus lupulus L.) cones. |
| PubMed: | Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus. |
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