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Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear viscous liquid (est) |
| Assay: | 97.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.92110 @ 25.00 °C.
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| Refractive Index: | 1.49630 @ 20.00 °C.
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| Boiling Point: | 305.00 to 307.00 °C. @ 760.00 mm Hg
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| Flash Point: | 267.00 °F. TCC ( 130.56 °C. )
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| logP (o/w): | 4.639 (est) |
| Soluble in: |
| | alcohol | | | water, 1.688 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
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| Odor Type: citrus |
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| Odor Strength: | medium |
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| | citrus floral tart lemon fresh sweet herbal |
Odor Description: at 100.00 %. | citrus floral tangy lemon fresh sweet herbal |
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| Flavor Type: citrus |
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| | citrus lemon grapefruit |
Taste Description:
| citrus lemon grapefruit |
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| beta-Bisabolol > 95%
Odor: characteristic Use: beta-Bisabolol is a natural monocyclic sesquiterpene alcohol. It has a weak sweet floral aroma and is used in various fragrances. It has also been used for hundreds of years in cosmetics because of its perceived skin healing properties. |
Safety Information:
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| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
Safety References:
References:
Other Information:
Potential Blenders and core components note
| |
| For Odor |
| No odor group found for these |
| | lemon leaf flavor | |
| aldehydic |
| | decanal (aldehyde C-10) | FL/FR |
| | mandarine undecenal | FL/FR |
| | TMH aldehyde | FR |
| aromatic |
| | aromatic woody citrus floral fragrance | FR |
| balsamic |
| iso | bornyl acetate | FL/FR |
| iso | bornyl phenyl acetate | FL/FR |
| | fenchyl acetate | FL/FR |
| citronella |
| 4,8- | dimethyl-7-nonen-2-ol | FR |
| citrus |
| | acetaldehyde citronellyl methyl acetal | FR |
| | agrestic specialty | FR |
| | bergamot fragrance | FR |
| | bergamot oil | FL/FR |
| | bergamot oil bergaptene reduced italy | FL/FR |
| | bergamot oil replacer | FR |
| | bergamot oil turkey | FL/FR |
| | bergamot specialty | FR |
| | bergamot vanilla specialty | FR |
| | citral diethyl acetal | FL/FR |
| | citral dimethyl acetal | FL/FR |
| | citronella fragrance | FR |
| | citronella oil ceylon | FL/FR |
| | citrus floral green fragrance | FR |
| | citrus ocimenol | FR |
| | citrus specialty | FR |
| | dihydromyrcenol | FL/FR |
| 2,4- | dimethyl-3-cyclohexene-1-methanyl acetate | FR |
| 2- | dodecanone | FL/FR |
| 2- | ethyl-1-hexanol | FL/FR |
| citrus | floral fragrance | FR |
| | grapefruit oil terpenes | FL/FR |
| 2- | heptanol | FL/FR |
| | lemon oil terpenes | FL/FR |
| | lemongrass oil | FL/FR |
| | lemongrass oil terpenes | FL/FR |
| | lime fragrance | FR |
| | lime octadienal | FR |
| | lime oil distilled mexico | FL/FR |
| | lime oil replacer | FR |
| | lime oil terpenes | FL/FR |
| | lime specialty | FR |
| | mandarin fragrance | FR |
| | mandarin oil | FL/FR |
| | mandarin oil (citrus reticulata nova var. mandarin) uruguay | FL/FR |
| | mandarin oil italy | FL/FR |
| | mandarin oil replacer | FR |
| | mandarin specialty | FR |
| | melissa oil slovak republic | |
| 3- | methyl-4-(2-methyl butyl oxy) butyraldehyde | FR |
| | nonanal dimethyl acetal | FL/FR |
| (+)- | nootkatone | FL/FR |
| | petitgrain bergamot oil | FL/FR |
| | petitgrain combava oil | FR |
| (±)-2,4,8- | trimethyl-7-nonen-2-ol | FL/FR |
| 10- | undecen-1-ol | FL/FR |
| | verbena absolute france | FL/FR |
| | verbena fragrance | FR |
| | verbena oil terpeneless | FL/FR |
| earthy |
| (Z)-4- | octen-1-ol | FL/FR |
| floral |
| iso | amyl salicylate | FL/FR |
| | bergamot blossom fragrance | FR |
| | bois de rose oil brazil | FL/FR |
| | butyl tiglate | FR |
| | citronellal | FL/FR |
| 2,4- | dimethyl-3-cyclohexene-1-methanol | FR |
| | ethyl linalool | FR |
| | ethyl linalyl acetal | FR |
| | gardenia acetal | FR |
| | herbal pyran | FR |
| | karo karounde absolute | FR |
| | lavandula angustifolia flower oil | FL/FR |
| | lavender oil | FL/FR |
| | lavender oil france | FL/FR |
| | lavender oil greece | FL/FR |
| | linalool | FL/FR |
| para- | methyl benzyl acetate | FL/FR |
| | methyl benzyl acetate (mixed ortho-,meta-,para-) | FL/FR |
| (Z)- | methyl epi-jasmonate | FL/FR |
| | muguet nitrile | FR |
| | muguet octadienol | FR |
| | nerol | FL/FR |
| | neroli oil tunisia | FL/FR |
| | nerolidyl acetate | FL/FR |
| (R)- | ocean propanal | |
| (Z)-beta- | ocimene | FL/FR |
| | palmarosa oil | FL/FR |
| | palmarosa oil replacer | FR |
| | peony acetonitrile | FR |
| | petitgrain concrete | FR |
| | petitgrain grapefruit oil | FL/FR |
| | petitgrain lemon oil | FL/FR |
| | petitgrain oil morocco | FL/FR |
| | petitgrain oil terpeneless | FL/FR |
| iso | phytol | FL/FR |
| | prenyl salicylate | FL/FR |
| | rose undecene | FR |
| | terpinyl isobutyrate | FL/FR |
| | tetrahydrolinalyl acetate | FR |
| (S)-2,5,6- | trimethyl-2-heptanol | |
| | undecanal dimethyl acetal | FR |
| fresh |
| | fresh & clean fragrance | FR |
| fruity |
| | ethyl 3-hydroxyhexanoate | FL/FR |
| | eucalyptus staigeriana oil | FR |
| sesqui | phellandrene | |
| fungal |
| | hydroxymethyl hexyl ethyl ketone | FL/FR |
| green |
| iso | butyl benzyl carbinol | FL/FR |
| | cucumber fragrance | FR |
| | heptyl formate | FL/FR |
| herbal |
| | arnica flower oil | FR |
| | carrot seed oil (daucus carota ssp. gummifer hook. fil.) spain | FR |
| | chamomile isobutyrate | FR |
| | chrysanthemum ketone | FR |
| | freesia heptanol | FL/FR |
| abrialis | lavandin oil | FL/FR |
| | lavender absolute bulgaria | FL/FR |
| | lavender absolute france | FL/FR |
| | lavender concrete | FL/FR |
| | lavender oil terpeneless | FL/FR |
| | lavender oil terpenes | |
| | lavender stem oil lithuania | FR |
| | matricaria chamomilla flower oil | FL/FR |
| | myrtle oil | FL/FR |
| | tea leaf absolute | FL/FR |
| alpha- | terpinyl acetate | FL/FR |
| pine |
| | dihydroterpineol | FR |
| | caraway seed oleoresin | FL/FR |
| | gingergrass oil | FR |
| sulfurous |
| 4- | tropical oxathiane | FL/FR |
| terpenic |
| (E,E)-2,6-allo | ocimene | FL/FR |
| alpha- | terpineol | FL/FR |
| tobacco |
| 2,6,6- | trimethyl-2-hydroxycyclohexanone | FL/FR |
| waxy |
| | decanal dimethyl acetal | FL/FR |
| 1,8- | octane dinitrile | |
| 1- | undecanol | FL/FR |
| woody |
| cis-3-tert- | butyl cyclohexyl acetate | |
| 2- | decalinyl acetate | FR |
| alpha- | terpinene | FL/FR |
| | zdravetz oil | FL/FR |
| |
| For Flavor |
| |
| No flavor group found for these |
| iso | bornyl phenyl acetate | FL/FR |
| cis-3-tert- | butyl cyclohexyl acetate | |
| | capsicum oleoresin CO2 extract | FL |
| | decanal dimethyl acetal | FL/FR |
| 8,9- | dehydrotheaspirone | FL |
| | hydroxymethyl hexyl ethyl ketone | FL/FR |
| | lavender oil terpenes | |
| | mandarine undecenal | FL/FR |
| | melissa oil slovak republic | |
| | methyl benzyl acetate (mixed ortho-,meta-,para-) | FL/FR |
| | nerolidyl acetate | FL/FR |
| (R)- | ocean propanal | |
| (E,E)-2,6-allo | ocimene | FL/FR |
| 1,8- | octane dinitrile | |
| (Z)-4- | octen-1-ol | FL/FR |
| sesqui | phellandrene | |
| | terpinyl isobutyrate | FL/FR |
| (S)-2,5,6- | trimethyl-2-heptanol | |
| 2,6,6- | trimethyl-2-hydroxycyclohexanone | FL/FR |
| 10- | undecen-1-ol | FL/FR |
| | zdravetz oil | FL/FR |
| acidic |
| (E)-2- | hexenoic acid | FL |
| aldehydic |
| 1- | undecanol | FL/FR |
| amber |
| iso | butyl benzyl carbinol | FL/FR |
| berry |
| | berry lemon flavor | FL |
| buttery |
| | butter lemon flavor | FL |
| citrus |
| | bergamot oil | FL/FR |
| | bergamot oil bergaptene reduced italy | FL/FR |
| | bergamot oil turkey | FL/FR |
| | citral diethyl acetal | FL/FR |
| | citral dimethyl acetal | FL/FR |
| | citron flavor | FL |
| | citronella oil ceylon | FL/FR |
| | freesia heptanol | FL/FR |
| | grapefruit oil terpenes | FL/FR |
| | lemon berry flavor | FL |
| | lemon oil terpenes | FL/FR |
| | lemon tarragon flavor | FL |
| | lemongrass flavor | FL |
| | lemongrass oil | FL/FR |
| | lemongrass oil terpenes | FL/FR |
| | lime oil distilled mexico | FL/FR |
| | lime oil terpenes | FL/FR |
| | linalool | FL/FR |
| | mandarin oil | FL/FR |
| | mandarin oil (citrus reticulata nova var. mandarin) uruguay | FL/FR |
| | mandarin oil italy | FL/FR |
| | nerol | FL/FR |
| | neroli oil tunisia | FL/FR |
| (+)- | nootkatone | FL/FR |
| | petitgrain bergamot oil | FL/FR |
| | petitgrain grapefruit oil | FL/FR |
| | petitgrain lemon oil | FL/FR |
| | petitgrain oil morocco | FL/FR |
| | petitgrain oil terpeneless | FL/FR |
| alpha- | terpineol | FL/FR |
| (±)-2,4,8- | trimethyl-7-nonen-2-ol | FL/FR |
| | verbena absolute france | FL/FR |
| | verbena oil terpeneless | FL/FR |
| fatty |
| 2- | dodecanone | FL/FR |
| 2- | ethyl-1-hexanol | FL/FR |
| | heptyl formate | FL/FR |
| floral |
| | bois de rose oil brazil | FL/FR |
| | citronellal | FL/FR |
| pseudo | ionone | FL |
| (Z)- | methyl epi-jasmonate | FL/FR |
| fruity |
| | blueberry lemon flavor | FL |
| | ethyl 3-hydroxyhexanoate | FL/FR |
| 2- | heptanol | FL/FR |
| para- | methyl benzyl acetate | FL/FR |
| 4- | tropical oxathiane | FL/FR |
| grassy |
| | palmarosa oil | FL/FR |
| green |
| iso | amyl salicylate | FL/FR |
| | dihydromyrcenol | FL/FR |
| (E,E)-2,4- | hexadienal | FL |
| | lemon leaf flavor | |
| | nonanal dimethyl acetal | FL/FR |
| (Z)-beta- | ocimene | FL/FR |
| herbal |
| abrialis | lavandin oil | FL/FR |
| | lavandula angustifolia flower oil | FL/FR |
| | lavender absolute bulgaria | FL/FR |
| | lavender absolute france | FL/FR |
| | lavender concrete | FL/FR |
| | lavender oil | FL/FR |
| | lavender oil france | FL/FR |
| | lavender oil greece | FL/FR |
| | lavender oil terpeneless | FL/FR |
| | matricaria chamomilla flower oil | FL/FR |
| | prenyl salicylate | FL/FR |
| oily |
| iso | phytol | FL/FR |
| spicy |
| | caraway seed oleoresin | FL/FR |
| | myrtle oil | FL/FR |
| tea |
| | tea leaf absolute | FL/FR |
| terpenic |
| alpha- | terpinene | FL/FR |
| waxy |
| | decanal (aldehyde C-10) | FL/FR |
| woody |
| iso | bornyl acetate | FL/FR |
| | fenchyl acetate | FL/FR |
| alpha- | terpinyl acetate | FL/FR |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| .beta.- | bisabolol | | 3- | cyclohexen-1-ol, 1-(1,5-dimethyl-4-hexenyl)-4-methyl- | | (1S)-1-((1S)-1,5- | dimethyl-4-hexenyl)-4-methyl-3-cyclohexen-1-ol | | (S-(R*,R*))-1-(1,5- | dimethyl-4-hexenyl)-4-methyl-3-cyclohexen-1-ol | | 4- | methyl-1-(6-methylhept-5-en-2-yl)cyclohex-3-en-1-ol |
Articles:
| PubMed: | Essential oils composition of croton species from the Amazon. |
| PubMed: | Hepatoprotection of sesquiterpenoids: a quantitative structure-activity relationship (QSAR) approach. |
| PubMed: | Hydroxylated bisabolol oxides: evidence for secondary oxidative metabolism in Matricaria chamomilla. |
| PubMed: | Antihyperalgesic and antiedematous activities of bisabolol-oxides-rich matricaria oil in a rat model of inflammation. |
| PubMed: | Chemotaxonomic importance of the essential-oil composition in two subspecies of Teucrium stocksianum Boiss. from Iran. |
| PubMed: | Essential oil of flowers of Anaphalis contorta, an aromatic and medicinal plant from India. |
| PubMed: | α-bisabolol is an effective proapoptotic agent against BCR-ABL(+) cells in synergism with Imatinib and Nilotinib. |
| PubMed: | Fast quality assessment of German chamomile (Matricaria chamomilla L.) by headspace solid-phase microextraction: influence of flower development stage. |
| PubMed: | STAT-3 inhibitory bisabolanes from Carthamus glaucus. |
| PubMed: | Psychopharmacological profile of Chamomile (Matricaria recutita L.) essential oil in mice. |
| PubMed: | Composition and antimicrobial activity of the essential oil of Heracleum thomsonii (Clarke) from the cold desert of the western Himalayas. |
| PubMed: | Inhibitory effects of (-)-α-bisabolol on LPS-induced inflammatory response in RAW264.7 macrophages. |
| PubMed: | Composition and antifungal activity of the essential oil from the rhizome and roots of Ferula hermonis. |
| PubMed: | Pro-apoptotic activity of α-bisabolol in preclinical models of primary human acute leukemia cells. |
| PubMed: | Sandalwood fragrance biosynthesis involves sesquiterpene synthases of both the terpene synthase (TPS)-a and TPS-b subfamilies, including santalene synthases. |
| PubMed: | Effect of topical heparin and levomenol on atopic dermatitis: a randomized four-arm, placebo-controlled, double-blind clinical study. |
| PubMed: | Antiplasmodial volatile extracts from Cleistopholis patens Engler & Diels and Uvariastrum pierreanum Engl. (Engl. & Diels) (Annonaceae) growing in Cameroon. |
| PubMed: | In vivo effect of alpha-bisabolol, a nontoxic sesquiterpene alcohol, on the induction of spontaneous mammary tumors in HER-2/neu transgenic mice. |
| PubMed: | Variability of the essential oil content and composition of chamomile (Matricaria recutita L.) affected by weather conditions. |
| PubMed: | alpha-Bisabolol induces dose- and time-dependent apoptosis in HepG2 cells via a Fas- and mitochondrial-related pathway, involves p53 and NFkappaB. |
| PubMed: | Content and composition of the essential oil of Chamomilla recutita (L.) Rauschert from some European countries. |
| PubMed: | Validation of a high-performance liquid chromatography method for the determination of (-)-alpha-bisabolol from particulate systems. |
| PubMed: | Chemical composition and antifungal activity of Arnica longifolia, Aster hesperius, and Chrysothamnus nauseosus essential oils. |
| PubMed: | Chemical composition and antimicrobial activity of volatile components from capitula and aerial parts of Rhaponticum acaule DC growing wild in Tunisia. |
| PubMed: | Analysis of leaf volatiles of Zanthoxylum gillettii used in folk medicine of Cameroon. |
| PubMed: | Phytochemical analysis of the essential oil of Achillea millefolium L. from various European Countries. |
| PubMed: | Synthesis of beta-bisabolol by ring-closing olefin metathesis reaction. |
| PubMed: | Evaluation of mutagenic and antimutagenic activities of alpha-bisabolol in the Salmonella/microsome assay. |
| PubMed: | Effect of magnesium on essential oil formation of genetically transformed and non-transformed chamomile cultures. |
| PubMed: | Determination of alpha-bisabolol in human blood by micro-HPLC-ion trap MS and head space-GC-MS methods. |
| PubMed: | New terpenoids in cultivated and wild chamomile (in vivo and in vitro). |
| PubMed: | Sensitization of Staphylococcus aureus and Escherichia coli to antibiotics by the sesquiterpenoids nerolidol, farnesol, bisabolol, and apritone. |
| PubMed: | The ability of Bipolaris sorokiniana to modify geraniol and (-)-alpha-bisabolol as exogenous substrates. |
| PubMed: | Phase solubility studies of pure (-)-alpha-bisabolol and camomile essential oil with beta-cyclodextrin. |
| PubMed: | Anthocyanin, bisabolol and phenylammonialyase activity in cell cultures of Populus deltoides. |
| PubMed: | [Study of tolerance and efficacy of cosmetic preparations with lenitive action in atopic dermatitis in children]. |
| PubMed: | Antennal olfactory responsiveness ofMicroplitis croceipes (Hymenoptera: Braconidae) to cotton plant volatiles. |
| PubMed: | Determination of alpha-bisabolol and d-panthenol in cosmetic products by gas chromatography. |
| PubMed: | Orientation of boll weevil,Anthonomus grandis boh. (Coleoptera: Curculionidae), to pheromone and volatile host compound in the laboratory. |
| PubMed: | Electroantennogram responses ofTrirhabda bacharides (weber) (Coleoptera: Chrysomelidae) to plant volatiles. |
| PubMed: | Olfaction in the boll weevil,Anthonomus grandis Boh. (Coleoptera: Curculionidae): Electroantennogram studies. |
| PubMed: | Isolation and identification of cotton synomones mediating searching behavior by parasitoidCampoletis sonorensis. |
| PubMed: | Identification and quantitative analysis of the volatile substances emitted by maturing cotton in the field. |
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