butyl methyl ketone
methyl butyl ketone
an industrial solvent which causes nervous system degeneration. mbk is an acronym often used to refer to it. Present in hop oil (Humulus lupulus), potato (Solanum tuberosum) and groundnuts (Arachis hypogaea) 2-Oxohexane is a volatile organic compound. 2-Oxohexane is occasionally found as a volatile component of normal human biofluids. 2-Oxohexane is an hexacarbon solvent; Hexan-2-one is the organic compound with the formula C4H9COCH3. This colorless to pale yellow liquid has a sharp odor. It is a ketone and often known either as MBK (methyl butyl ketone) or 2-hexanone. It dissolves very easily in water, and can evaporate easily into the air as a vapor. Hexan-2-one was used in the past in paint and paint thinner, to make other chemical substances, and to dissolve oils and waxes.; the neurotoxicity of hexacarbon solvents has become apparent and an extensive literature has already developed as a result of the clinical and epidemiological implications of the human disease. The main neurological disorders associated with chronic volatile substance are peripheral neuropathy, cerebellar disease, chronic encephalopathy and dementia. Apart from peripheral neuropathy, the clinical features are non-specific, evidence for solvent-related toxicity is in most cases circumstantial and there is no clear dose/response relationship. (PMID: 5556886, 6278344, 2550357)
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
      Email: Mr. Jia
      Email: Mr. Guo
      Voice: 86-10-68418738
      Fax: 86-10-68418739
      Mr. Guo86-10-68483445
      Mr. Guo86-10-68418739
      10087 2-Hexanone
  • CJ Latta & Associates
    • CJ Latta & Associates, LLC
      Extensive Line
      Aromatic Chemicals and Organic Acids.
      CJ Latta & Associates is a distributor of specialty aromatics and organic acids used in the formulation of flavors and fragrance manufactured worldwide. We pride ourselves on our reputation for, fair pricing, quality and reliability. We’ve built our business on successfully sourcing and developing many challenging specialty chemicals and fine ingredients for our clients.
      Email: Info
      US Email: Chip Latta
      Email: Sales
      US Email: Chip Latta
      Voice: (630) 240-8079
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
      US Email: Sales
      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      08-25300 2-HEXANONE
  • Synerzine
    • Synerzine, Inc.
      Innovation. Customization. Aroma Ingredients.
      Synerzine is a leading supplier of flavor and fragrance ingredients.
      Synerzine expresses what we have grown to embody as an organization - the synergy and connection between raw ingredients, science, technology, and the final product. Our experienced team is passionate about bringing our customers high-quality innovative ingredients that they can trust.
      Building upon our 44 year history, the Synerzine team provides customers around the globe with convenient access to over 1200 high-quality aroma ingredients. We actively engage with customers to add a wide array of new products and services on a regular basis. Our aim is to delight every customer with our exceptional services, large product selection, customization and the highest quality and safety standards. We provide our customers with true value designed to help them bring their products to market faster.
      US Email: Customer Service
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      Products List: View
      W08152 2-Hexanone
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping!
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis.
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      Voice: 1-800-423-8616
      Fax: 1- 888-520-1075
      H0114 Butyl Methyl Ketone >98.0%(GC)
  • WholeChem
    • WholeChem, LLC
      Connecting Innovators To the Building Blocks Of the Universe
      Custom manufacturer and distributor of specialty ingredients. We make global local.
      SQF-Certified Supplier
      We owe our success to our integrity, our dedication to the industry, and our commitment to our clients. We invite your inquiries regarding our current product list and any other products you may be having trouble sourcing.
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Synonyms   Articles   Notes   Search
CAS Number: 591-78-6Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 209-731-1
Nikkaji Web: J3.303K
Beilstein Number: 1737676
MDL: MFCD00009482
CoE Number: 11776
XlogP3: 1.40 (est)
Molecular Weight: 100.16084000
Formula: C6 H12 O
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: colorless clear liquid (est)
Assay: 97.00 to 100.00 % 
Food Chemicals Codex Listed: No
Melting Point: -55.50 °C. @ 760.00 mm Hg
Boiling Point: 127.60 °C. @ 760.00 mm Hg
Vapor Pressure: 11.600000 mmHg @ 25.00 °C.
Flash Point: 95.00 °F. TCC ( 35.00 °C. )
logP (o/w): 1.380
Soluble in:
 water, 17500 mg/L @ 20 °C (exp)
Insoluble in:
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
Odor Type: fruity
 fruity  fungal  meaty  buttery  
Odor Description:
at 1.00 % in dipropylene glycol. 
fruity fungal meaty buttery
Odor and/or flavor descriptions from others (if found).
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: not used anymore
Synonyms   Articles   Notes   Search   Top
Beijing Lys Chemicals
CJ Latta & Associates
Inoue Perfumery
Penta International
For experimental / research use only.
2-Hexanone purum, ≥96.0% (GC)
For experimental / research use only.
Butyl Methyl Ketone >98.0%(GC)
Synonyms   Articles   Notes   Search   Top
Safety Information:
European information :
Most important hazard(s):
T - Toxic.
R 10 - Flammable.
R 48/23 - Toxic: danger of serious damage to health by prolonged exposure through inhalation.
R 62 - Possible risk of impaired fertility.
R 67 - Vapours may cause frowsiness and dizziness.
S 02 - Keep out of the reach of children.
S 07/09 - Keep container tightly closed and in well-ventilated place.
S 16 - Keep away from sources of ignition - No Smoking.
S 20/21 - When using do not eat, drink or smoke.
S 23 - Do not breath vapour.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
Hazards identification
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  2590 mg/kg
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954.

oral-mouse LD50  2430 mg/kg
Toxicology Letters. Vol. 30, Pg. 13, 1986.

unreported-guinea pig LD50  914 mg/kg
Personnal Communication from R.L. Raleigh, Assistant Director of Health and Safety Lab., Eastman Kodak Co., Rochester, NY, Mar. 6, 1974Vol. 01MAR1974

oral-guinea pig LDLo  914 mg/kg
Personnal Communication from R.L. Raleigh, Assistant Director of Health and Safety Lab., Eastman Kodak Co., Rochester, NY, Mar. 6, 1974Vol. 01MAR1974

unreported-rat LD50  914 mg/kg
Personnal Communication from R.L. Raleigh, Assistant Director of Health and Safety Lab., Eastman Kodak Co., Rochester, NY, Mar. 6, 1974Vol. 01MAR1974

intraperitoneal-rat LDLo  914 mg/kg
Personnal Communication from R.L. Raleigh, Assistant Director of Health and Safety Lab., Eastman Kodak Co., Rochester, NY, Mar. 6, 1974Vol. 01MAR1974

Dermal Toxicity:
skin-rabbit LD50 4800 mg/kg
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 78, 1974.

Inhalation Toxicity:
inhalation-rat LC50 8000 ppm/4H
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 78, 1974.

inhalation-human TCLo 1000 ppm
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 78, 1974.

Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: flavoring agents
Recommendation for butyl methyl ketone usage levels up to:
 not for fragrance use.
Synonyms   Articles   Notes   Search   Top
Safety References:
EPI System: View
NIOSH International Chemical Safety Cards: search
NIOSH Pocket Guide: search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 591-78-6
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 11583
National Institute of Allergy and Infectious Diseases: Data
SCCNFP: opinion
WISER: UN 1224
WGK Germany: 1
Chemidplus: 0000591786
EPA/NOAA CAMEO: hazardous materials
RTECS: 591-78-6
Synonyms   Articles   Notes   Search   Top
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 591-78-6
Pubchem (cid): 11583
Pubchem (sid): 134977464
Flavornet: 591-78-6
Pherobase: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): HMDB05842
FooDB: FDB008079
Export Tariff Code: 2914.19.0000
Typical G.C.
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
•grade: technical •commercial grades of mnbk vary in purity from 70 to 96%; the more dilute grades include predominantly methyl isobutyl ketone (mibk).
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
For Odor
 fusel oilFL/FR
isobutyl formateFL/FR
 butyl acetateFL/FR
 ethyl acetateFL/FR
 ethyl pyruvateFL/FR
isopropyl acetateFL/FR
 propyl valerateFL/FR
isovaleraldehyde propylene glycol acetalFL/FR
 nonan-3-yl acetateFL/FR
 acetaldehyde diisoamyl acetalFL/FR
 amyl acetateFL/FR
 amyl formateFL/FR
 amyl heptanoateFL/FR
 benzyl methyl etherFL/FR
isobutyl acetateFL/FR
isobutyl isobutyrateFL/FR
isobutyl valerateFL/FR
2-ethyl butyl acetateFL/FR
 ethyl propionateFL/FR
 geranyl ethyl etherFL/FR
 methyl 2-methyl butyrateFL/FR
 methyl butyrateFL/FR
 methyl hexanoateFL/FR
 methyl isobutyrateFL/FR
isopropyl propionateFL/FR
 strawberry furanone butyrateFL/FR
 cognac heptanoneFL/FR
For Flavor
No flavor group found for these
 acetaldehyde diisoamyl acetalFL/FR
 ethyl 2-methyl-2-(methyl thio) propionateFL
 geranyl ethyl etherFL/FR
2-heptenoic acidFL
2-methyl butyl isobutyrateFL
2-methyl butyl propionateFL
S-(methyl thio) hexanoateFL
 nonan-3-yl acetateFL/FR
 propyl valerateFL/FR
 cognac heptanoneFL/FR
 butyl acetateFL/FR
 ethyl acetateFL/FR
 methyl isobutyrateFL/FR
isopropyl acetateFL/FR
 amyl acetateFL/FR
 amyl formateFL/FR
 amyl heptanoateFL/FR
 benzyl methyl etherFL/FR
isobutyl acetateFL/FR
isobutyl isobutyrateFL/FR
isobutyl valerateFL/FR
2-ethyl butyl acetateFL/FR
 ethyl propionateFL/FR
2-furyl pentyl ketoneFL
 fusel oilFL/FR
 methyl 2-methyl butyrateFL/FR
2-methyl allyl butyrateFL
 methyl hexanoateFL/FR
isopropyl propionateFL/FR
 strawberry furanone butyrateFL/FR
isovaleraldehyde propylene glycol acetalFL/FR
 methyl butyrateFL/FR
2-ethyl butyraldehydeFL
isobutyl formateFL/FR
 ethyl pyruvateFL/FR
Synonyms   Articles   Notes   Search   Top
Potential Uses:
None Found
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 clove bud oil @ 0.05%
Data  GC  Search Trop  Picture
 clove fruit
Search Trop  Picture
 clove leaf oil @ 0.03%
Data  GC  Search Trop  Picture
 clove oil
Search Trop  Picture
 clove stem oil india @ 0.05%
Data  GC  Search Trop  Picture
 corn husk oil
Search Trop  Picture
 corn seed oil
Search Trop  Picture
 hyssop shoot
Search Trop  Picture
 pepper bell pepper fruit
Search Trop  Picture
 plumcot fruit
Search  PMC Picture
Synonyms   Articles   Notes   Search   Top
N-butyl methyl ketone
 butylmethyl ketone
 ketone, butyl methyl
 methyl butyl ketone
 methyl N-butyl ketone
 methylbutyl ketone
 propyl acetone
Synonyms   Articles   Notes   Search   Top
PubMed: Volatile Organic Compounds during Inflammation and Sepsis in Rats: A Potential Breath Test Using Ion-mobility Spectrometry.
PubMed: Reaction rate constants of H-abstraction by OH from large ketones: measurements and site-specific rate rules.
PubMed: Binding of carbonyl flavours to canola, pea and wheat proteins using GC/MS approach.
PubMed: Salivary microbiota and metabolome associated with celiac disease.
PubMed: Combined IR/NIR and density functional theory calculations analysis of the solvent effects on frequencies and intensities of the fundamental and overtones of the C ═ O stretching vibrations of acetone and 2-hexanone.
PubMed: Development of an electrospray-(63)Ni-differential ion mobility spectrometer for the analysis of aqueous samples.
PubMed: [Biomonitoring of exposure to chemical products in environmental and workplace toxicology].
PubMed: Furry pet allergens, fungal DNA and microbial volatile organic compounds (MVOCs) in the commercial aircraft cabin environment.
PubMed: Brushed block copolymer micelles with pH-sensitive pendant groups for controlled drug delivery.
PubMed: Can volatile organic metabolites be used to simultaneously assess microbial and mite contamination level in cereal grains and coffee beans?
PubMed: Mass and Ion Transport in Ketones and Ketone Electrolytes: Comparison with Acetate Systems.
PubMed: An endophytic Nodulisporium sp. from Central America producing volatile organic compounds with both biological and fuel potential.
PubMed: Airborne molds and bacteria, microbial volatile organic compounds (MVOC), plasticizers and formaldehyde in dwellings in three North European cities in relation to sick building syndrome (SBS).
PubMed: Blending synthetic pheromones of cerambycid beetles to develop trap lures that simultaneously attract multiple species.
PubMed: Analysis of volatile organic compounds released from human lung cancer cells and from the urine of tumor-bearing mice.
PubMed: Bioactivity of short-chain aliphatic ketones against adults of the granary weevil, Sitophilus granarius (L.).
PubMed: Simplification of a complex microbial antilisterial consortium to evaluate the contribution of its flora in uncooked pressed cheese.
PubMed: Engineering cofactor preference of ketone reducing biocatalysts: A mutagenesis study on a γ-diketone reductase from the yeast Saccharomyces cerevisiae serving as an example.
PubMed: Improved synthesis of three methyl-branched pheromone components produced by the female lichen moth.
PubMed: Thermodynamic properties of hyperbranched polymer, Boltorn U3000, using inverse gas chromatography.
PubMed: Degradation of hexane and other recalcitrant hydrocarbons by a novel isolate, Rhodococcus sp. EH831.
PubMed: Quantification of volatile compounds in goat milk Jack cheese using static headspace gas chromatography.
PubMed: High-pressure ion mobility spectrometry.
PubMed: Biocatalytical production of (5S)-hydroxy-2-hexanone.
PubMed: Extraction and spectrophotometric determination of cobalt(II) with isonitroso-5-methyl-2-hexanone.
PubMed: Headspace solid phase microextraction/gas chromatography-mass spectrometry combined to chemometric analysis for volatile organic compounds determination in canine hair: a new tool to detect dog contamination by visceral leishmaniasis.
PubMed: Airborne concentrations of volatile organic compounds in neonatal incubators.
PubMed: Aroma barrier properties of sodium caseinate-based films.
PubMed: Microbial volatile organic compounds in the air of moldy and mold-free indoor environments.
PubMed: Acid-catalyzed isomerization and decomposition of ketone-2,4-dinitrophenylhydrazones.
PubMed: Evaluation of lipid oxidation and oxidative products as affected by pork meat cut, packaging method, and storage time during frozen storage (-10 degrees C).
PubMed: Kinetic analysis of volatile formation in milk subjected to pressure-assisted thermal treatments.
PubMed: Rate constants for the reaction of cl with a series of C4 to C6 ketones using the relative rate method.
PubMed: [Identification of volatiles from field cotton plant under different induction treatments].
PubMed: Purification and characterization of alcohol dehydrogenase reducing N-benzyl-3-pyrrolidinone from Geotrichum capitatum.
PubMed: Pulsed laser photolysis vacuum UV laser-induced fluorescence kinetic study of the gas-phase reactions of Cl(2P3/2) atoms with C3-C6 ketones.
PubMed: Ozone artifacts and carbonyl measurements using Tenax GR, Tenax TA, Carbopack B, and Carbopack X adsorbents.
PubMed: Solid-phase microextraction: investigation of the metabolism of substances that may be abused by inhalation.
PubMed: Quantitative determination of thermally derived off-flavor compounds in milk using solid-phase microextraction and gas chromatography.
PubMed: Degradation characteristics of methyl ethyl ketone by Pseudomonas sp. KT-3 in liquid culture and biofilter.
PubMed: Capture of female Hylotrupes bajulus as influenced by trap type and pheromone blend.
PubMed: 1,4-hydroxycarbonyl products of the OH radical initiated reactions of C5-C8 n-alkanes in the presence of NO.
PubMed: Enhancement of attraction and trap catches of the old-house borer, Hylotrupes bajulus (Coleoptera: Cerambycidae), by combination of male sex pheromone and monoterpenes.
PubMed: Tropospheric reaction of OH with selected linear ketones: kinetic studies between 228 and 405 K.
PubMed: Microwave-assisted derivatization of 2,5-hexanedione in urine: evaluation using GC-MS and GC-ECD.
PubMed: Synthesis of 3'-fluoro-2',3'-dideoxy-2',3'-didehydro-4'-ethynyl-D- and -L-furanosyl nucleosides.
PubMed: Stereoselective oxidation of aliphatic diols and reduction of hydroxy-ketones with galactitol dehydrogenase from Rhodobacter sphaeroides D.
PubMed: The prodrug activator EtaA from Mycobacterium tuberculosis is a Baeyer-Villiger monooxygenase.
PubMed: Migration of volatile degradation products into ozonated water from plastic packaging materials.
PubMed: Free and total 2,5-hexanedione in biological monitoring of workers exposed to n-hexane in the shoe industry.
PubMed: Synthesis, structural characterization and antimicrobial studies of hydrazone derivatives of 3-hydroxyimino-5-methyl-2-hexanone.
PubMed: Evaluation of 2,5-hexanedione in urine of workers exposed to n-hexane in Brazilian shoe factories.
PubMed: Synthesis and antimicrobial activity of 3-hydroxyimino-5-methyl-2-hexanone(HIMH) and its dioxime derivative.
PubMed: Aromatic as well as aliphatic hydrocarbon solvent axonopathy.
PubMed: Determination of unique microbial volatile organic compounds produced by five Aspergillus species commonly found in problem buildings.
PubMed: Detection and quantification of ochratoxin A and deoxynivalenol in barley grains by GC-MS and electronic nose.
PubMed: The generalization of an olfactory-based conditioned response reveals unique but overlapping odour representations in the moth Manduca sexta.
PubMed: Aroma compounds-proteins interaction using headspace techniques.
PubMed: Evaluation of individual components of plum odor as potential attractants for adult plum curculios.
PubMed: Positional effect of solute functional group among positional isomers in hydroxyl group-solvent and carbonyl group-solvent specific interactions in menthanol--water mixed solvents monitored by high-performance liquid chromatography.
PubMed: Ruthenium complex-catalyzed anti-Markovnikov hydration of terminal alkynes.
PubMed: Regulated workplace ketones and their interference in the PFBHA method for aldehydes.
PubMed: Modular representations of odorants in the glomerular layer of the rat olfactory bulb and the effects of stimulus concentration.
PubMed: Effect of aeration during cell growth on ketone reactions by immobilized yeast.
PubMed: NAD(+)-dependent (S)-specific secondary alcohol dehydrogenase involved in stereoinversion of 3-pentyn-2-ol catalyzed by Nocardia fusca AKU 2123.
PubMed: Determination of free and glucuronated hexane metabolites without prior hydrolysis by liquid- and gas-chromatography coupled with mass spectrometry.
PubMed: Evidence for an inducible nucleotide-dependent acetone carboxylase in Rhodococcus rhodochrous B276.
PubMed: Water activity control: a way to improve the efficiency of continuous lipase esterification.
PubMed: Determination of n-hexane metabolites by liquid chromatography/mass spectrometry. 2. Glucuronide-conjugated metabolites in untreated urine samples by electrospray ionization.
PubMed: Determination of n-hexane metabolites by liquid chromatography/mass spectrometry. 1. 2,5-hexanedione and other phase I metabolites in untreated and hydrolyzed urine samples by atmospheric pressure chemical ionization.
PubMed: Do endogenous volatile organic chemicals measured in breath reflect and maintain CYP2E1 levels in vivo?
PubMed: Method for the simultaneous quantification of n-hexane metabolites: application to n-hexane metabolism determination.
PubMed: Toxic effects of hexane derivatives on cultured rat Schwann cells.
PubMed: In vitro quantitative structure-activity relationship assessment of pyrrole adducts production by gamma-diketone-forming neurotoxic solvents.
PubMed: Different contributions of cytochrome P450 2E1 and P450 2B1/2 to chloroform hepatotoxicity in rat.
PubMed: Structure, stereochemistry, and thermal isomerization of the male sex pheromone of the longhorn beetle Anaglyptus subfasciatus.
PubMed: Induction of chromosome loss in yeast by combined treatment with neurotoxic hexacarbons and monoketones.
PubMed: Sensory irritation and pulmonary irritation of n-methyl ketones: receptor activation mechanisms and relationships with threshold limit values.
PubMed: A markedly diminished pleiotropic response to phenobarbital and structurally-related xenobiotics in Zucker rats in comparison with F344/NCr or DA rats.
PubMed: A pleiotropic response to phenobarbital-type enzyme inducers in the F344/NCr rat. Effects of chemicals of varied structure.
PubMed: Compounds affecting mosquito oviposition: structure-activity relationships and concentration effects.
PubMed: Immunochemical detection of cytochrome P450 isozymes induced in rat liver by n-hexane, 2-hexanone and acetonyl acetone.
PubMed: Gonadotoxic effects of 2-hexanone and 1,2-dibromo-3-chloropropane on the enzymatic activity of rat testicular 17 alpha-hydroxylase/C17,20-lyase.
PubMed: Evidence for the involvement of organelles in the mechanism of ketone-potentiated chloroform-induced hepatotoxicity.
PubMed: The neurotoxic effect of carbon disulphide, N-hexane and its metabolites studied with erythrocyte and synaptosome membranes in vitro.
PubMed: Induction of chromosome loss by mixtures of organic solvents including neurotoxins.
PubMed: Induction of cytochromes P450IIE1 and P450IIB1 by secondary ketones and the role of P450IIE1 in chloroform metabolism.
PubMed: Synthesis and pheromonal activity of 6,10,13-trimethyl-1-tetradecanol for predatory stink bug,Stiretrus anchorago (Heteroptera: Pentatomidae).
PubMed: Cytoskeletal changes induced in vitro by 2,5-hexanedione: an immunocytochemical study.
PubMed: Volatile methyl ketone seed-germination inhibitors fromAmaranthus palmeri S. Wats. Residues.
PubMed: The relevance of 4,5-dihydroxy-2-hexanone in the excretion kinetics of n-hexane metabolites in rat and man.
PubMed: The role of biotransformation-detoxication in acetone-, 2-butanone-, and 2-hexanone-potentiated chloroform-induced hepatotoxicity.
PubMed: Disposition, pharmacokinetics, and metabolism of a dermal dose of [14C]2,5-hexanedione in hens.
PubMed: 4,5-Dihydroxy-2-hexanone: a new metabolite of N-hexane and of 2,5-hexanedione in rat urine.
PubMed: Modifications in rat hepatobiliary function following treatment with acetone, 2-butanone, 2-hexanone, mirex, or chlordecone and subsequently exposed to chloroform.
PubMed: Renal and hepatic interactions between 2-hexanone and carbon tetrachloride in F-344 rats.
PubMed: Impairment of human polymorphonuclear leukocyte chemotaxis by 2,5-hexanedione.
PubMed: Methodological investigations on the determination of n-hexane metabolites in urine.
PubMed: Analysis of n-hexane, 2-hexanone, 2,5-hexanedione, and related chemicals by capillary gas chromatography and high-performance liquid chromatography.
PubMed: The joint neurotoxic action of inhaled methyl butyl ketone vapor and dermally applied O-ethyl O-4-nitrophenyl phenylphosphonothioate in hens: potentiating effect.
PubMed: Role of intrarenal biotransformation in chloroform-induced nephrotoxicity in rats.
PubMed: Temporal analysis of rat liver injury following potentiation of carbon tetrachloride hepatotoxicity with ketonic or ketogenic compounds.
PubMed: Dose-response relationships in ketone-induced potentiation of chloroform hepato- and nephrotoxicity.
PubMed: Nephrotoxic interactions between ketonic solvents and halogenated aliphatic chemicals.
PubMed: An electrophysiological study of 2-hexanone and 2,5-hexanedione neurotoxicity in rats.
PubMed: Mechanisms in 2-hexanone potentiation of chloroform hepatotoxicity.
PubMed: Anaesthetic action of esters and ketones: evidence for an interaction with the sodium channel protein in squid axons.
PubMed: 2-hexanone potentiation of [14C]chloroform hepatotoxicity: covalent interaction of a reactive intermediate with rat liver phospholipid.
PubMed: In vitro effect of n-hexane and its metabolites on selected enzymes in glycolysis, pentose phosphate pathway and citric acid cycle.
PubMed: Relationship between the carbon skeleton length of ketonic solvents and potentiation of chloroform-induced hepatotoxicity in rats.
PubMed: Ultrastructural studies of the dying-back process. VI. Examination of nerve fibers undergoing giant axonal degeneration in organotypic culture.
PubMed: [An experimental study on the neurotoxicity of 2-octanone and 2-hexanol, a metabolite of n-hexane].
PubMed: Neurotoxicity of continuous (90 days) inhalation of technical grade methyl butyl ketone in hens.
PubMed: Toxicity and metabolism of the neurotoxic hexacarbons n-hexane, 2-hexanone, and 2,5-hexanedione.
PubMed: Microbial Oxidation of Gaseous Hydrocarbons: Production of Methylketones from Corresponding n-Alkanes by Methane-Utilizing Bacteria.
PubMed: Clinical epidemiology of occupational neurotoxic disease.
PubMed: Microbial production of methyl ketones. Purification and properties of a secondary alcohol dehydrogenase from yeast.
PubMed: Oxidation of secondary alcohols to methyl ketones by yeasts.
PubMed: Simultaneous determination of n-hexane, 2-hexanone and 2,5-hexanedione in biological tissues by gas chromatography mass spectrometry.
PubMed: Peripheral nervous system in a case of canine giant axonal neuropathy.
PubMed: The effect of 2-hexanone and 2-hexanone metabolites on pupillomotor activity and growth.
PubMed: Toxicity and metabolism of methyl n-butyl ketone.
PubMed: 2-hexanone. (Methylbutyl ketone, MBK).
PubMed: 2-Hexanone (methyl-n-butyl ketone, n-butyl methyl ketone, propyl acetone).
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