6-tert-butyl-meta-cresol
5-methyl-2-(tert-butyl)phenol
 
Notes:
Blends better than the birch tar.
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      Product(s):
      88-60-8 2-tert-Butyl-5-methylphenol 95%
       
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      Product(s):
      13-31800 5-METHYL-2-TERT-BUTYLPHENOL
       
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      Product(s):
      B0718 6-tert-Butyl-m-cresol >97.0%(GC)
       
Synonyms   Articles   Notes   Search
CAS Number: 88-60-8Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 201-842-3
FDA UNII: UXV32MJ2CA
Nikkaji Web: J101.497H
Beilstein Number: 1908225
MDL: MFCD00002308
XlogP3: 3.60 (est)
Molecular Weight: 164.24772000
Formula: C11 H16 O
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
DG SANTE Food Flavourings: 04.078  5-methyl-2-(tert-butyl)phenol
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Physical Properties:
Appearance: pale yellow clear oily liquid to solid (est)
Assay: 98.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 0.96500 to 0.96900 @  20.00 °C.
Pounds per Gallon - (est).: 8.039 to  8.072
Refractive Index: 1.51700 to 1.52100 @  20.00 °C.
Melting Point: 23.00 to  28.00 °C. @ 760.00 mm Hg
Boiling Point: 117.00 to  118.00 °C. @ 12.00 mm Hg
Boiling Point: 242.00 to  244.00 °C. @ 760.00 mm Hg
Vapor Pressure: 0.063000 mmHg @ 25.00 °C. (est)
Flash Point: 222.00 °F. TCC ( 105.56 °C. )
logP (o/w): 3.970
Soluble in:
 alcohol
 water, 101.3 mg/L @ 25 °C (est)
Insoluble in:
 water
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Organoleptic Properties:
 
Odor Type: animal
 
 leathery  animal  
Odor Description:
at 0.10 % in dipropylene glycol. 
russian leather
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
BOC Sciences
For experimental / research use only.
2-tert-Butyl-5-methylphenol 95%
Frinton Laboratories
For experimental / research use only.
2-tert-Butyl-5-methylphenol
Penta International
5-METHYL-2-TERT-BUTYLPHENOL
Santa Cruz Biotechnology
For experimental / research use only.
2-tert-Butyl-5-methylphenol
Sigma-Aldrich: Aldrich
For experimental / research use only.
6-tert-Butyl-meta-cresol
TCI AMERICA
For experimental / research use only.
6-tert-Butyl-m-cresol >97.0%(GC)
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Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 23 - Do not breath vapour.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Acute toxicity, Oral (Category 4), H302
Skin irritation (Category 2), H315
Eye irritation (Category 2A), H319
Specific target organ toxicity - single exposure (Category 3), Respiratory system, H335
GHS Label elements, including precautionary statements
 
Pictogramexclamation-mark.jpg
 
Signal word Warning
Hazard statement(s)
H302 - Harmful if swallowed
H315 - Causes skin irritation
H319 - Causes serious eye irritation
H335 - May cause respiratory irritation
Precautionary statement(s)
P261 - Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 - Wash skin thouroughly after handling.
P270 - Do not eat, drink or smoke when using this product.
P271 - Use only outdoors or in a well-ventilated area.
P280 - Wear protective gloves/protective clothing/eye protection/face protection.
P301 + P312 - IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302 + P352 - IF ON SKIN: wash with plenty of soap and water.
P304 + P340 - IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 - Call a POISON CENTER or doctor/physician if you feel unwell.
P330 - Rinse mouth.
P332 + P313 - IF SKIN irritation occurs: Get medical advice/attention.
P337 + P313 - IF eye irritation persists: Get medical advice/attention.
P362 - Take off contaminated clothing and wash before reuse.
P403 + P233 - Store in a well-ventilated place. Keep container tightly closed.
P405 - Store locked up.
P501 - Dispose of contents/ container to an approved waste disposal plant.
Oral/Parenteral Toxicity:
gavage-mouse LD50  [sex: M] 1080 mg/kg
(McOmie et al., 1949)

oral-mouse LD50  1080 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 38, Pg. 366, 1949.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: flavor and fragrance agents
RIFM Fragrance Material Safety Assessment: Search
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for 6-tert-butyl-meta-cresol usage levels up to:
  0.0200 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.061 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI): 420 (μg/person/day)
Threshold of Concern:1800 (μg/person/day)
Structure Class: I
 
Food categories according to Commission Regulation EC No. 1565/2000 (EC, 2000) in FGE.06 (EFSA, 2002a). According to the Industry the "normal" use is defined as the average of reported usages and "maximum use" is defined as the 95th percentile of reported usages (EFSA, 2002i).
Note: mg/kg = 0.001/1000 = 0.000001 = 1/1000000 = ppm.
 average usage mg/kgmaximum usage mg/kg
Dairy products, excluding products of category 02.0 (01.0): 0.500002.50000
Fats and oils, and fat emulsions (type water-in-oil) (02.0): 0.200001.00000
Edible ices, including sherbet and sorbet (03.0): 0.500002.50000
Processed fruit (04.1): 0.400002.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2): --
Confectionery (05.0): 1.000005.00000
Chewing gum (05.0): --
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0): 0.200001.00000
Bakery wares (07.0): 2.0000010.00000
Meat and meat products, including poultry and game (08.0): 0.200001.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0): 0.200001.00000
Eggs and egg products (10.0): --
Sweeteners, including honey (11.0): --
Salts, spices, soups, sauces, salads, protein products, etc. (12.0): 0.300001.50000
Foodstuffs intended for particular nutritional uses (13.0): 0.500002.50000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1): 0.200001.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2): 1.000005.00000
Ready-to-eat savouries (15.0): 2.0000010.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0): 0.400002.00000
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Safety References:
European Food Safety Athority(EFSA): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Flavouring Group Evaluation 22 (FGE.22): Ring-substituted phenolic substances from chemical groups 21 and 25 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Flavouring Group Evaluation 58 (FGE.58) Consideration of phenol derivatives evaluated by JECFA (55th meeting) structurally related to ring substituted phenolic substances evaluated by EFSA in FGE.22 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring-substituted phenolic substances from chemical groups 21 and 25
View page or View pdf
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 88-60-8
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 6937
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 3145
WGK Germany: 2
 2-tert-butyl-5-methylphenol
Chemidplus: 0000088608
EPA/NOAA CAMEO: hazardous materials
RTECS: SK1578180 for cas# 88-60-8
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References:
 2-tert-butyl-5-methylphenol
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 88-60-8
Pubchem (cid): 6937
Pubchem (sid): 134972343
Pherobase: View
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2907.19.1000
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
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Potential Blenders and core components note
 
For Odor
animal
isobutyl quinolineFR
2-isobutyl quinolineFR
isobutyl quinolineFR
6-methyl quinolineFL/FR
chocolate
 vanillyl ethyl etherFL/FR
coffee
 furfuryl mercaptanFL/FR
floral
alpha-amyl cinnamyl acetateFL/FR
 cananga oilFL/FR
 cananga oil chinaFL/FR
 citronellolFL/FR
 dimethyl octanolFL/FR
 floral methanolFR
 orris pyridine 25% IPMFR
fruity
 ethyl 3-hydroxyhexanoateFL/FR
 leather propionateFR
 osmanthus flower absoluteFL/FR
green
3,7-dimethyl-6-octenoic acidFL/FR
 oakmoss oilFR
 phenoxyacetaldehyde 50% in benzyl alcoholFR
herbal
 saffron indenoneFL/FR
 thyme undecaneFR
leathery
4-tert-butyl phenolCS
 castoreum absoluteFL/FR
 leather cyclohexanolFR
marine
 marine pyridineFR
nutty
2,3-dimethyl pyrazineFL/FR
phenolic
2,3-dimethyl benzofuranFL/FR
ortho-guaiacolFL/FR
4-methyl-2,6-dimethoxyphenolFL/FR
 piper betle leaf oilFR
2-propyl phenolFL/FR
2,5-xylenolFL/FR
 birch tar oilFL/FR
 cade oilFR
2,6-dimethoxyphenolFL/FR
alpha-ethoxy-ortho-cresolFL/FR
4-ethyl phenolFL/FR
 phoebe oil brazil 
 propyl parabenCS
 pyroligneous acidsFL/FR
 pyroligneous acids hickoryFL/FR
 cubeb oilFL/FR
 cuminyl alcoholFL/FR
4-ethyl guaiacolFL/FR
4-methyl guaiacolFL/FR
 pepper tree berry oilFL/FR
tobacco
3-ethyl pyridineFL/FR
woody
 guaiacyl acetateFL/FR
 methyl cedryl ketoneFL/FR
 
For Flavor
 
No flavor group found for these
 benzyl disulfideFL
 birch tar oilFL/FR
2,6-dimethoxy-4-vinyl phenolFL
alpha-ethoxy-ortho-cresolFL/FR
2-furfurylidene butyraldehydeFL
1-methyl pyrroleFL
 phoebe oil brazil 
 prenyl mercaptanFL
2-propyl phenolFL/FR
animal
6-methyl quinolineFL/FR
caramellic
3-ethyl pyridineFL/FR
chemical
2,3-dimethyl benzofuranFL/FR
coffee
 furfuryl mercaptanFL/FR
earthy
alpha-amyl cinnamyl acetateFL/FR
fatty
 dimethyl octanolFL/FR
floral
 cananga oilFL/FR
 cananga oil chinaFL/FR
 citronellolFL/FR
3,7-dimethyl-6-octenoic acidFL/FR
fruity
 ethyl 3-hydroxyhexanoateFL/FR
 osmanthus flower absoluteFL/FR
herbal
 saffron indenoneFL/FR
leathery
 castoreum absoluteFL/FR
meaty
4-allyl-2,6-dimethoxyphenolFL
medicinal
2,6-dimethoxyphenolFL/FR
musty
2,5-xylenolFL/FR
nutty
2,3-dimethyl pyrazineFL/FR
onion
2-methyl-1,3-dithiolaneFL
phenolic
4-methyl-2,6-dimethoxyphenolFL/FR
rummy
 vanillyl ethyl etherFL/FR
smoky
4-ethyl phenolFL/FR
 pyroligneous acidsFL/FR
 pyroligneous acids hickoryFL/FR
dextro-xyloseFL
spicy
 chipotle chili oleoresinFL
 cubeb oilFL/FR
 cuminyl alcoholFL/FR
4-methyl guaiacolFL/FR
 pepper tree berry oilFL/FR
woody
4-ethyl guaiacolFL/FR
ortho-guaiacolFL/FR
 guaiacyl acetateFL/FR
 methyl cedryl ketoneFL/FR
 
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Potential Uses:
 leather russian leatherFR
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 milk powder - 0.0051 mg/kg
Search  PMC Picture
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Synonyms:
 benzene, 1-tert-butyl-2-hydroxy-4-methyl-
6-tert-butyl-3-cresol
4-tert-butyl-3-methyl phenol
4-tert-butyl-3-methylphenol
6-tert-butyl-3-methylphenol
2-tert-butyl-5-methyl phenol
2-tert-butyl-5-methylphenol
6-tert-butyl-m-cresol
p-tert-butyl-m-cresol
para-tert-butyl-meta-cresol
2-(tert-butyl)-5-methylphenol
m-cresol, 6-tert-butyl-
2-(1,1-dimethylethyl)-5-methylphenol
5-methyl-2-(2-methyl-2-propanyl)phenol
5-methyl-2-(tert-butyl) phenol
5-methyl-2-(tert-butyl)phenol
5-methyl-2-tert-butylphenol
3-methyl-6-tert-butylphenol
 phenol, 2- (1, 1-dimethylethyl)-5-methyl-
 phenol, 2-(1,1-dimethylethyl)-5-methyl-
 phenol, 2-tert-butyl-5-methyl-
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Articles:
PubMed: Synthesis and properties of optically active nanostructured polymers bearing amino acid moieties by direct polycondensation of 4,4'-thiobis(2-tert-butyl-5-methylphenol) with chiral diacids.
PubMed: Isolation and characterization of a novel 2-sec-butylphenol-degrading bacterium Pseudomonas sp. strain MS-1.
PubMed: Identification of phenolic dermal sensitizers in a wound closure tape.
PubMed: Thymol and related alkyl phenols activate the hTRPA1 channel.
PubMed: Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 4,4'-butylidenebis(2-tert-butyl-5-methylphenol) and 3-(dibutylamino)phenol, based on the OECD draft protocols.
PubMed: Monoterpenoid agonists of TRPV3.
PubMed: [Identification of migrants from nitrile-butadiene rubber gloves].
PubMed: Glucuronidation of propofol and its analogs by human and rat liver microsomes.
PubMed: Evaluation of leukocyte adhesion on polyurethanes: the effects of shear stress and blood proteins.
PubMed: Allergic contact dermatitis to two antioxidants in latex gloves: 4,4'-thiobis(6-tert-butyl-meta-cresol) (Lowinox 44S36) and butylhydroxyanisole. Allergen alternatives for glove-allergic patients.
PubMed: Dermal absorption of the antioxidant 4,4'-thiobis(6-tert-butyl-m-cresol) in Sencar mice and Fischer rats.
PubMed: A lipid-soluble antioxidant from polyallomer centrifuge tubes.
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