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Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Food Chemicals Codex Listed: | No |
Organoleptic Properties:
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
|
Not determined
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Safety in Use Information:
| Category: | flavoring agents |
| Wisconsin Invasive Non-native plant species |
| Recommendation for clover herb distillate (melilotus officinalis) usage levels up to: | | | not for fragrance use.
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| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). |
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library |
| publication number: 25 |
| Click here to view publication 25 |
| | average usual ppm | average maximum ppm |
| baked goods: | 0.50000 | 2.00000 |
| beverages(nonalcoholic): | 0.30000 | 0.80000 |
| beverages(alcoholic): | 0.50000 | 2.00000 |
| breakfast cereal: | 0.50000 | 2.00000 |
| cheese: | - | - |
| chewing gum: | - | - |
| condiments / relishes: | - | - |
| confectionery froastings: | 0.50000 | 2.00000 |
| egg products: | - | - |
| fats / oils: | - | - |
| fish products: | - | - |
| frozen dairy: | 0.40000 | 2.00000 |
| fruit ices: | - | - |
| gelatins / puddings: | 0.40000 | 2.00000 |
| granulated sugar: | - | - |
| gravies: | - | - |
| hard candy: | - | - |
| imitation dairy: | 0.40000 | 1.60000 |
| instant coffee / tea: | 0.30000 | 1.00000 |
| jams / jellies: | 0.40000 | 3.00000 |
| meat products: | - | - |
| milk products: | 0.40000 | 1.60000 |
| nut products: | 0.40000 | 1.60000 |
| other grains: | - | - |
| poultry: | - | - |
| processed fruits: | - | - |
| processed vegetables: | - | - |
| reconstituted vegetables: | - | - |
| seasonings / flavors: | 0.20000 | 1.00000 |
| snack foods: | 0.50000 | 2.00000 |
| soft candy: | 0.60000 | 2.00000 |
| soups: | - | - |
| sugar substitutes: | - | - |
| sweet sauces: | 0.30000 | 0.80000 |
Safety References:
References:
| | melilotus officinalis distillate |
| Pubchem (sid): | 135330290 |
Other Information:
| FDA Substances Added to Food (formerly EAFUS): | View |
| Wikipedia: | View |
Potential Blenders and core components note
| |
| For Odor |
| aldehydic |
| aldehydic |
| iso | butyraldehyde | FL/FR |
| amber |
| | angelica root oil | FL/FR |
| anise |
| sweet | fennel seed oil | FL/FR |
| anisic |
| | ocimum basilicum herb oil | FL/FR |
| | ocimum basilicum leaf oil america | FL/FR |
| | ocimum basilicum leaf oil CO2 extract | FL/FR |
| coconut |
| delta- | heptalactone | FL/FR |
| fatty |
| (E,Z)-2,6- | dodecadienal | FL/FR |
| floral |
| iso | amyl salicylate | FL/FR |
| beta- | damascenone | FL/FR |
| | dihydrojasmone | FL/FR |
| | prenyl salicylate | FL/FR |
| green |
| | heptanal (aldehyde C-7) | FL/FR |
| 3,6- | ivy carbaldehyde | FL/FR |
| | melon acetal | FL/FR |
| (E,E)- | sorbyl acetate | |
| herbal |
| | anthemis nobilis flower extract | FL/FR |
| | anthemis nobilis flower oil roman | FL/FR |
| sweet | basil absolute | FL/FR |
| | celery ketone | FL/FR |
| 1,4- | cineole | FL/FR |
| | clary sage oil france | FL/FR |
| | hexyl salicylate | FL/FR |
| | hyssop oil | FL/FR |
| | linalyl octanoate | FL/FR |
| curled | parsley seed oil | FL/FR |
| | rosmarinus officinalis extract | FL/FR |
| | rosmarinus officinalis tincture | FL/FR |
| | salvia sclarea oil | FL/FR |
| gamma- | valerolactone | FL/FR |
| minty |
| (-)- | menthone | FL/FR |
| homo | menthyl acetate | FL/FR |
| mossy |
| | oakmoss absolute | FL/FR |
| phenolic |
| 2,3- | dimethyl benzofuran | FL/FR |
| para-alpha- | dimethyl styrene | FL/FR |
| spicy |
| | allspice berry absolute | FL/FR |
| | allspice berry oil | FL/FR |
| | allspice berry oil terpeneless | FL/FR |
| | allspice leaf oil | FL/FR |
| | allspice leaf oil terpeneless | FL/FR |
| | allspice oil | FL/FR |
| | allspice oleoresin | FL/FR |
| 4- | carvomenthenol | FL/FR |
| beta- | caryophyllene | FL/FR |
| | cascarilla oil replacer | FL/FR |
| | cinnamon leaf oil | FL/FR |
| terpeneless | cinnamon leaf oil | FL/FR |
| | cinnamon leaf oil ceylon | FL/FR |
| | clove bud absolute | FL/FR |
| | clove bud essence | FL/FR |
| | clove bud oil | FL/FR |
| terpeneless | clove bud oil | FL/FR |
| | clove bud oil CO2 extract | FL/FR |
| | clove bud oleoresin | FL/FR |
| | clove bud resinoid | FL/FR |
| | clove leaf oil | FL/FR |
| | clove leaf oil terpeneless | FL/FR |
| | clove stem oil | FL/FR |
| | croton eluteria bark oil | FL/FR |
| | cuminaldehyde | FL/FR |
| | dihydroeugenol | FL/FR |
| | ethyl isoeugenol | FL/FR |
| | eugenol | FL/FR |
| iso | eugenol | FL/FR |
| | eugenyl acetate | FL/FR |
| | methyl eugenol | FR |
| 4- | methyl guaiacol | FL/FR |
| | methyl isoeugenol | FL/FR |
| | syzygium aromaticum bud extract | FL/FR |
| | syzygium aromaticum tincture | FL/FR |
| woody |
| 2- | methoxy-4-vinyl phenol | FL/FR |
| |
| For Flavor |
| |
| absinthe |
| | absinthe flavor | FL |
| aldehydic |
| iso | butyraldehyde | FL/FR |
| anise |
| sweet | fennel seed oil | FL/FR |
| chemical |
| 2,3- | dimethyl benzofuran | FL/FR |
| cooling |
| 4- | carvomenthenol | FL/FR |
| 1,4- | cineole | FL/FR |
| homo | menthyl acetate | FL/FR |
| coumarinic |
| | coumarin flavor | FL |
| floral |
| | dihydrojasmone | FL/FR |
| fruity |
| | linalyl octanoate | FL/FR |
| green |
| | aloe vera flavor | FL |
| iso | amyl salicylate | FL/FR |
| | angelica root oil | FL/FR |
| | celery ketone | FL/FR |
| (E,Z)-2,6- | dodecadienal | FL/FR |
| | heptanal (aldehyde C-7) | FL/FR |
| 3,6- | ivy carbaldehyde | FL/FR |
| | melon acetal | FL/FR |
| | oakmoss absolute | FL/FR |
| | sorbyl acetate | FL |
| (E,E)- | sorbyl acetate | |
| herbal |
| | anthemis nobilis flower extract | FL/FR |
| | anthemis nobilis flower oil roman | FL/FR |
| sweet | basil absolute | FL/FR |
| | celery flavor | FL |
| | celery seed oil distillates | FL |
| | clary sage oil france | FL/FR |
| | hexyl salicylate | FL/FR |
| | hyssop oil | FL/FR |
| | ocimum basilicum herb oil | FL/FR |
| | ocimum basilicum leaf oil america | FL/FR |
| | ocimum basilicum leaf oil CO2 extract | FL/FR |
| curled | parsley seed oil | FL/FR |
| | prenyl salicylate | FL/FR |
| | rosmarinus officinalis extract | FL/FR |
| | rosmarinus officinalis tincture | FL/FR |
| | salvia sclarea oil | FL/FR |
| lactonic |
| delta- | heptalactone | FL/FR |
| minty |
| (-)- | menthone | FL/FR |
| smoky |
| 2- | methoxy-4-vinyl phenol | FL/FR |
| spicy |
| | allspice berry absolute | FL/FR |
| | allspice berry oil | FL/FR |
| | allspice berry oil terpeneless | FL/FR |
| | allspice flavor | FL |
| | allspice leaf oil | FL/FR |
| | allspice leaf oil terpeneless | FL/FR |
| | allspice oil | FL/FR |
| | allspice oleoresin | FL/FR |
| beta- | caryophyllene | FL/FR |
| | cascarilla oil replacer | FL/FR |
| | cinnamon leaf oil | FL/FR |
| terpeneless | cinnamon leaf oil | FL/FR |
| | cinnamon leaf oil ceylon | FL/FR |
| | clove bud absolute | FL/FR |
| | clove bud essence | FL/FR |
| terpeneless | clove bud oil | FL/FR |
| | clove bud oil | FL/FR |
| | clove bud oil CO2 extract | FL/FR |
| | clove bud oleoresin | FL/FR |
| | clove bud resinoid | FL/FR |
| | clove buds | FL |
| | clove flavor | FL |
| | clove leaf oil | FL/FR |
| | clove leaf oil terpeneless | FL/FR |
| | clove stem oil | FL/FR |
| | croton eluteria bark oil | FL/FR |
| | cuminaldehyde | FL/FR |
| | dihydroeugenol | FL/FR |
| para-alpha- | dimethyl styrene | FL/FR |
| | ethyl isoeugenol | FL/FR |
| iso | eugenol | FL/FR |
| | eugenol | FL/FR |
| | eugenyl acetate | FL/FR |
| | methyl isoeugenol | FL/FR |
| | syzygium aromaticum bud extract | FL/FR |
| | syzygium aromaticum tincture | FL/FR |
| tonka |
| gamma- | valerolactone | FL/FR |
| vanilla |
| 4- | methyl guaiacol | FL/FR |
| woody |
| beta- | damascenone | FL/FR |
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Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | brachylobus officinalis distillate | | yellow sweet | clover distillate (melilotus officinalis) | | | melilotus arvensis distillate | | | melilotus graveolens distillate | | | melilotus officinalis distillate | | | melilotus officinalis fo. suaveolens distillate | | | melilotus pallidus distillate | | | melilotus suaveolens distillate | | | sertula officinalis distillate | | | trifolium officinale distillate |
Articles:
| PubMed: | [Allelopathic effects of the humus soils from Betula platyphylla and Quercus liaotungensis pure plantations on 9 kinds of common shrubs and herbs]. |
| PubMed: | In vitro screening of forty medicinal plant extracts from the United States Northern Great Plains for anthelmintic activity against Haemonchus contortus. |
| PubMed: | Fatty acids, α-tocopherol, β-carotene, and lutein contents in forage legumes, forbs, and a grass-clover mixture. |
| PubMed: | The diversity of Rhizobia, Sinorhizobia and novel non-Rhizobial Paenibacillus nodulating wild herbaceous legumes. |
| PubMed: | [Soil and water losses and phosphorus output at the places between ridges in sloping peanut land under different planting modes in Yimeng mountainous area of Shandong Province, East China]. |
| PubMed: | Using the pollen viability and morphology for fluoride pollution biomonitoring. |
| PubMed: | Isolation and characterization of pyrene metabolizing microbial consortia from the plant rhizoplane. |
| PubMed: | Pyrene effects on rhizoplane bacterial communities. |
| PubMed: | Rhizobium tibeticum sp. nov., a symbiotic bacterium isolated from Trigonella archiducis-nicolai (Sirj.) Vassilcz. |
| PubMed: | Stable low molecular weight RNA profiling showed variations within Sinorhizobium meliloti and Sinorhizobium medicae nodulating different legumes from the alfalfa cross-inoculation group. |
| PubMed: | De-inking sludge and phosphorus effects on growth and symbiotic dinitrogen fixation in forage legumes. |
| PubMed: | Microwave-assisted extraction of coumarin and related compounds from Melilotus officinalis (L.) Pallas as an alternative to Soxhlet and ultrasound-assisted extraction. |
| PubMed: | The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases. |
| PubMed: | Effect of root death and decay on dissipation of polycyclic aromatic hydrocarbons in the rhizosphere of yellow sweet clover and tall fescue. |
| PubMed: | Effectiveness of phytoremediation as a secondary treatment for polycyclic aromatic hydrocarbons (PAHs) in composted soil. |
| PubMed: | Ability of cold-tolerant plants to grow in hydrocarbon-contaminated soil. |
| PubMed: | [Chronic venous insufficiency: an open trial of FLEBS Crema]. |
| PubMed: | Leghaemoglobin oxygenation gradients in alfalfa and yellow sweetclover nodules. |
| PubMed: | Effects of Melilotus officinalis on acute inflammation. |
| PubMed: | [Effectiveness of the combination of alpha tocopherol, rutin, melilotus, and centella asiatica in the treatment of patients with chronic venous insufficiency]. |
| PubMed: | [Lymphedema of the upper extremity in patients operated for carcinoma of the breast: clinical experience with coumarinic extract from Melilotus officinalis]. |
| PubMed: | A new oleanene glucuronide obtained from the aerial parts of Melilotus officinalis. |
| PubMed: | Expression of beta-amylase from alfalfa taproots. |
| PubMed: | A new oleanene glucuronide having a branched-chain sugar from Melilotus officinalis. |
| PubMed: | Importance of Temperature in the Pathology of Meloidogyne hapla and M. chitwoodi on Legumes. |
| PubMed: | [Contribution of a combination of alpha and beta benzopyrones, flavonoids and natural terpenes in the treatment of lymphedema of the lower limbs at the 2d stage of the surgical classification]. |
| PubMed: | [Immunocorrecting, antianemia, and adaptogenic effects of polysaccharides from Melilotus officinalis]. |
| PubMed: | Impact of Multi-year Cropping Regimes on Solanum tuberosum Tuber Yields in the Presence of Pratylenchus penetrans and Verticillium dahliae. |
| PubMed: | Ferric Leghemoglobin in Plant-Attached Leguminous Nodules. |
| PubMed: | Forage intake and digestion by cattle grazing midgrass prairie rangeland or sideoats grama/sweetclover pasture. |
| PubMed: | A PCR-based method of identifying species-specific repeated DNAs. |
| PubMed: | Ultrastructure of fusion products from soybean cell culture and sweet clover leaf protoplasts. |
| PubMed: | Multielement residues in tissues of guinea pigs fed sweet clover grown on fly ash. |
| PubMed: | [Extraction of Melilotus officinalis]. |
| PubMed: | [The anti-inflammatory and anti-edematous effects of coumarins from Melilotus officinalis]. |
| PubMed: | [Effect of coumarin from Melilotus officinalis on the function of the lymphatic vessel]. |
| PubMed: | [Effect of coumarin from Melilotus officinalis on the blood circulation of the dog]. |
| PubMed: | [Experimental lymphostatic encephalopathy as a consequence of cervical lymphangiothrombophlebitis and its therapy by coumarin from Melilotus officinalis]. |
| PubMed: | [Effect of coumarin from Melilotus officinalis on the convulsion threshold of the central nervous system in rats and guinea pigs]. |
| PubMed: | [Effect of pantothenic acid and pyridoxine deficiency on unconditioned reflex activity and its influencing by coumarin from Melilotus officinalis in rats]. |
| PubMed: | [Unconditioned reflex activity in experimental lymphogenic encephalopathy and therapeutic effects thereon by coumarin from Melilotus officinalis]. |
| PubMed: | [Influence of isoniazid (INH) on the central nervous system and the antagonism between isoniazid and pyridoxine as well as pantothenic acid and coumarin from Melilotus officinalis in rats]. |
| PubMed: | [Effect of chlorpromazine on conditioned reflexes and antagonistic activity of coumarin from Melilotus officinalis]. |
| PubMed: | [Effect of deficiency of pantothenic acid and pyridoxine on the function of the central nervous system and its response to coumarin from Melilotus officinalis]. |
| PubMed: | [Decrease of spontaneous motility in experimental lymphogenic encephalopathy and the prophylactic activity of coumarin from Melilotus officinalis]. |
| PubMed: | [Learning ability in experimental lymphogenic encephalopathy, under the influence of coumarin from Melilotus officinalis]. |
| PubMed: | [Conditioned reflex function in experimental lymphogenic encephalopathy and its therapeutic modification by coumarin from Melilotus officinalis]. |
| PubMed: | [LOCAL TREATMENT OF DISEASES OF VARICOSE ORIGIN. CLINICAL EXPERIENCES WITH ESBERIVEN, A MELILOTUS OFFICINALIS PREPARATION]. |
| PubMed: | [Effect of aqueous extracts of Melilotus officinalis on the regenerating liver]. |
| PubMed: | Biosynthesis of the coumarins. Tracer studies on coumarin formation in Hierochloe odorata and Melilotus officinalis. |
| PubMed: | [Effect of Melilotus officinalis tea and its comparison with pelentan]. |
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