Articles:
D-neomenthol
Notes:
Constit. of Japanese peppermint oil. Flavouring ingredient
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 2216-52-6 Cyclohexanol,5-methyl-2-(1-methylethyl)-, (1S,2S,5R)-
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M&U International LLC Steady supply & demand Meeting customers increasing demands at home as well as abroad. M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers. Email: Sales US Email: Sales Voice: +86-21-32515501 60762991 60762992 Fax: +86-21-32515502 64204960 US Voice: 908-359-9000 US Fax: 908-359-9002 News Product(s): A0496 neoMENTHOL
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 14-11500 D-NEOMENTHOL
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Synerzine, Inc. Innovation. Customization. Aroma Ingredients. Synerzine is a leading supplier of flavor and fragrance ingredients. Synerzine expresses what we have grown to embody as an organization - the synergy and connection between raw ingredients, science, technology, and the final product. Our experienced team is passionate about bringing our customers high-quality innovative ingredients that they can trust. Building upon our 44 year history, the Synerzine team provides customers around the globe with convenient access to over 1200 high-quality aroma ingredients. We actively engage with customers to add a wide array of new products and services on a regular basis. Our aim is to delight every customer with our exceptional services, large product selection, customization and the highest quality and safety standards. We provide our customers with true value designed to help them bring their products to market faster. US Email: Customer Service US Email: Sales US Voice: (404) 524-6744 US Fax: (404) 577-1651 Inquiry Products List: View Product(s): W1313 d-neo-Menthol
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TCI AMERICA Moving Your Chemistry Forward We continuously strive to advance our technology. With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping! Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis. US Email: Sales Email: Technical Support Voice: 1-800-423-8616 Fax: 1- 888-520-1075 Facebook Twitter Instagram Linkedin Product(s): N0626 (+)-NeoMenthol >96.0%(GC)
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| CAS Number: | 2216-52-6 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 218-691-4 | |
| FDA UNII: | 42RE7MA7PA | |
| Beilstein Number: | 2037488 | |
| MDL: | MFCD00062980 | |
| CoE Number: | 2028 | |
| XlogP3-AA: | 3.00 (est) | |
| Molecular Weight: | 156.26860000 | |
| Formula: | C10 H20 O | |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) | |
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 428 D-neo-menthol |
| DG SANTE Food Flavourings: | 02.063 D-neomenthol |
| FEMA Number: | 2666 D-neomenthol |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 2216-52-6 ; D-NEOMENTHOL |
| FDA Regulation: | |
| FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION Subpart F--Flavoring Agents and Related Substances Sec. 172.515 Synthetic flavoring substances and adjuvants. | |
Physical Properties:
| Appearance: | colorless liquid (est) |
| Assay: | 99.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.90000 to 0.90300 @ 20.00 °C. |
| Pounds per Gallon - (est).: | 7.498 to 7.523 |
| Specific Gravity: | 0.89600 to 0.90300 @ 20.00 °C. |
| Pounds per Gallon - est.: | 7.464 to 7.523 |
| Refractive Index: | 1.45900 to 1.46200 @ 20.00 °C. |
| Refractive Index: | 1.45900 to 1.46000 @ 20.00 °C. |
| Optical Rotation: | +15.0 to +20.0 |
| Melting Point: | -22.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 95.00 °C. @ 12.00 mm Hg |
| Boiling Point: | 107.00 to 108.00 °C. @ 20.00 mm Hg |
| Vapor Pressure: | 0.032000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 180.00 °F. TCC ( 82.22 °C. ) |
| logP (o/w): | 3.216 (est) |
| Soluble in: | |
| alcohol | |
| dipropylene glycol | |
| water, 434.5 mg/L @ 25 °C (est) | |
| Insoluble in: | |
| water | |
Organoleptic Properties:
| Odor Type: mentholic | |
| mentholic minty sweet | |
| Odor Description: at 10.00 % in dipropylene glycol. | mentholic minty sweet |
| Flavor Type: mentholic | |
| cooling mentholic minty peppermint | |
| Taste Description: | cooling mentholic minty peppermint |
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Cyclohexanol,5-methyl-2-(1-methylethyl)-, (1S,2S,5R)- |
| ExtraSynthese |
| For experimental / research use only. |
| (+)-Neomenthol (GC) ≥97% |
| M&U International |
| neoMENTHOL |
| Penta International |
| D-NEOMENTHOL |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| (+)-NeoMenthol |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| (1S,2S,5R)-(+)-Neomenthol ≥95% |
| Synerzine |
| d-neo-Menthol |
| TCI AMERICA |
| For experimental / research use only. |
| (+)-NeoMenthol >96.0%(GC) |
Safety Information:
| Preferred SDS: View | |
| European information : | |
| Most important hazard(s): | |
| Xi - Irritant | |
|
R 37/38 - Irritating to respiratory system and skin. R 41 - Risk of serious damage to eyes. S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes. S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 36 - Wear suitable protective clothing. | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| Not determined | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavor and fragrance agents | ||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| Recommendation for dextro-neomenthol usage levels up to: | |||
| 3.0000 % in the fragrance concentrate. | |||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 48.00000 | |
| beverages(nonalcoholic): | - | 10.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | - | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 31.00000 | |
| fruit ices: | - | 31.00000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 50.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| Flavor & Extract Manufacturers Association (FEMA) reference(s): | |
| The FEMA GRAS assessment of alicyclic substances used as flavor ingredients. View pdf | |
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 2216-52-6 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 439263 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| (1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol | |
| Chemidplus: | 0002216526 |
| RTECS: | OT0450000 for cas# 2216-52-6 |
References:
| Leffingwell: | Chirality or Article |
| (1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 2216-52-6 |
| Pubchem (cid): | 439263 |
| Pubchem (sid): | 135335014 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| CHEBI: | View |
| Metabolomics Database: | Search |
| KEGG (GenomeNet): | C00553 |
| HMDB (The Human Metabolome Database): | HMDB35763 |
| FooDB: | FDB014500 |
| Export Tariff Code: | 2906.19.5000 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •some synthetic menthols are not chemical individuals but...mixtures of various isomers...these are designated...l-menthol, dl-menthol, l-isomenthol, d-isomenthol, dl-isomenthol, l-neomenthol, d-neomenthol, l-neoisomenthol, d-neoisomenthol and dl-neoisomenthol. •when mixed with about equal wt of camphor, chloral hydrate, phenol, or thymol, menthol forms "eutectic" mixt liquifying @ room temp. •menthol, usp drug marketed under generic name. •grades: technical; usp; fcc •synthetic menthol is available as the optically active levo-menthol with a purity of 99.9%. synthetic menthol is also commercially available as the racemic mixture •present in cigarettes and pipe tobacco (0.1-0.45%) shaving creams, pre- and aftershave lotions (0.2-0.3%); toothpastes (0.5%); mouthwashes (1-2%); chewing gums (0.5%); cough drops (0.1%); refreshing towels (1%); rubbing alcohol (1-1.2%); and shampoos (2-0.5%) •mentholatum deep heating rub contains 5.9% menthol; mentholatum ointment, 1.35%; mentholatum deep heating lotion, 6% | |
Potential Blenders and core components note
Potential Uses:
| mint | FR | |
| peppermint | FR | |
| spearmint | FR | |
| wintergreen | FR |
Occurrence (nature, food, other): note
| buchu leaf Search Trop Picture | |
| cabbage leaf Search Trop Picture | |
| cornmint Search Trop Picture | |
| cornmint leaf Search Trop Picture | |
| peppermint leaf Search Trop Picture | |
| spearmint leaf Search Trop Picture | |
| spearmint leaf oil Search Trop Picture | |
| spearmint oil Search Trop Picture | |
| water mint leaf Search Trop Picture |
Synonyms:
| cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1S,2S,5R)- | |
| (+)-neo | menthol |
| (1R,3S,4S)-(+)- | menthol |
| (1S,2S,5R)-(+)-neo | menthol |
| D-neo | menthol |
| D-neo- | menthol |
| (1S,2S,5R)-5- | methyl-2-(1-methyl ethyl) cyclohexanol |
| (1S-(1alpha, 2alpha,5beta))-5- | methyl-2-(1-methyl ethyl) cyclohexanol |
| (1S-(1beta, 2beta,5alpha))-5- | methyl-2-(1-methyl ethyl) cyclohexanol |
| (1S,2S,5R)-5- | methyl-2-propan-2-ylcyclohexan-1-ol |
| 2-iso | propyl-5-methyl cyclohexanol stereoisomer |
| D-beta- | pulegomenthol |
| dextro-beta- | pulegomenthol |