Articles:
D-menthol
Notes:
None found
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 15356-60-2 Cyclohexanol,5-methyl-2-(1-methylethyl)-, (1S,2R,5S)-
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Penta International Corporation Chemistry innovation At Penta, our products and services help businesses do business better. For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes. US Email: Technical Services US Email: Sales US Voice: (973) 740-2300 US Fax: (973) 740-1839 Product(s): 13-11800 MENTHOL LIQUID 13-12500 D-MENTHOL
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TCI AMERICA Moving Your Chemistry Forward We continuously strive to advance our technology. With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping! Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis. US Email: Sales Email: Technical Support Voice: 1-800-423-8616 Fax: 1- 888-520-1075 Facebook Twitter Instagram Linkedin Product(s): M0826 (+)-Menthol >99.0%(GC)
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| CAS Number: | 15356-60-2 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 239-387-8 | |
| FDA UNII: | C6B1OE8P3W | |
| Beilstein Number: | 1902292 | |
| MDL: | MFCD00062983 | |
| CoE Number: | 63 | |
| XlogP3-AA: | 3.00 (est) | |
| Molecular Weight: | 156.26860000 | |
| Formula: | C10 H20 O | |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) | |
Category: flavor and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| FEMA Number: | 2665 D-menthol |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 43.00 to 44.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 103.00 to 104.00 °C. @ 9.00 mm Hg |
| Vapor Pressure: | 0.032000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 196.00 °F. TCC ( 91.11 °C. ) |
| logP (o/w): | 3.216 (est) |
| Soluble in: | |
| alcohol | |
| water, 434.5 mg/L @ 25 °C (est) | |
| Insoluble in: | |
| paraffin oil | |
Organoleptic Properties:
| Odor Description: | mentholic |
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
perfuming agents |
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| D-Menthol 98% |
| BOC Sciences |
| For experimental / research use only. |
| Cyclohexanol,5-methyl-2-(1-methylethyl)-, (1S,2R,5S)- |
| Coompo |
| For experimental / research use only. |
| D-Menthol from Plants ≥98%
Odor: characteristic Use: The distinct effects of optically active menthols on lipid bilayers were clarified: l-menthol acts on orthorhombic hydrocarbon chain packing with high selectivity, whereas d-menthol has no such specific effect. These findings extend our understanding of the mechanisms by which menthols affect the intercellular lipids in the stratum corneum.
Menthol's ability to chemically trigger the cold-sensitive TRPM8 receptors in the skin is responsible for the well-known cooling sensation it provokes when inhaled, eaten, or applied to the skin. Menthol's analgesic properties are mediated through a selective activation of ?-opioid receptors. Menthol also blocks voltage-sensitive sodium channels, reducing neural activity that may stimulate muscles. Menthol also enhances the efficacy of ibuprofen in topical applications via vasodilation, which reduces skin barrier function. |
| ExtraSynthese |
| For experimental / research use only. |
| (+)-Menthol (GC) ≥98% |
| Penta International |
| D-MENTHOL |
| Penta International |
| MENTHOL LIQUID |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| (+)-Menthol |
| Sigma-Aldrich: Aldrich |
| For experimental / research use only. |
| (1S,2R,5S)-(+)-Menthol 99% |
| TCI AMERICA |
| For experimental / research use only. |
| (+)-Menthol >99.0%(GC) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| Not determined | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavor and fragrance agents | ||
| RIFM Fragrance Material Safety Assessment: Search | |||
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice | |||
| maximum skin levels for fine fragrances: | |||
| 0.2000 % and are based on the assumption that the fragrance mixture is used at 20% in a consumer product (IFRA Use Level Survey). (IFRA, 2006) | |||
| use level in formulae for use in cosmetics: | |||
| 2.2500 % | |||
| Dermal Systemic Exposure in Cosmetic Products: | |||
| 0.0573 mg/kg/day (IFRA, 2006) | |||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 3 | |||
| Click here to view publication 3 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | 130.00000 | |
| beverages(nonalcoholic): | - | 35.00000 | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | - | 1100.00000 | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | 68.00000 | |
| fruit ices: | - | 68.00000 | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | - | 400.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 15356-60-2 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 165675 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 1 |
| (1S,2R,5S)-5-methyl-2-propan-2-ylcyclohexan-1-ol | |
| Chemidplus: | 0015356602 |
| RTECS: | OT0700000 for cas# 15356-60-2 |
References:
| Leffingwell: | Chirality or Article |
| (1S,2R,5S)-5-methyl-2-propan-2-ylcyclohexan-1-ol | |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 15356-60-2 |
| Pubchem (cid): | 165675 |
| Pubchem (sid): | 135043092 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| HMDB (The Human Metabolome Database): | Search |
| Export Tariff Code: | 2906.11.0000 |
| ChemSpider: | View |
| Wikipedia: | View |
| Formulations/Preparations: •some synthetic menthols are not chemical individuals but...mixtures of various isomers...these are designated...l-menthol, dl-menthol, l-isomenthol, d-isomenthol, dl-isomenthol, l-neomenthol, d-neomenthol, l-neoisomenthol, d-neoisomenthol and dl-neoisomenthol. •when mixed with about equal wt of camphor, chloral hydrate, phenol, or thymol, menthol forms "eutectic" mixt liquifying @ room temp. •menthol, usp drug marketed under generic name. •grades: technical; usp; fcc •synthetic menthol is available as the optically active levo-menthol with a purity of 99.9%. synthetic menthol is also commercially available as the racemic mixture •present in cigarettes and pipe tobacco (0.1-0.45%) shaving creams, pre- and aftershave lotions (0.2-0.3%); toothpastes (0.5%); mouthwashes (1-2%); chewing gums (0.5%); cough drops (0.1%); refreshing towels (1%); rubbing alcohol (1-1.2%); and shampoos (2-0.5%) •mentholatum deep heating rub contains 5.9% menthol; mentholatum ointment, 1.35%; mentholatum deep heating lotion, 6% | |
Potential Blenders and core components note
Potential Uses:
| mint | FR |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| cyclohexanol, 5-methyl-2-(1-methylethyl)-, (1S,2R,5S)- | |
| (+)- | menthol |
| (1S,2R,5S)-(+)- | menthol |
| D- | menthol |
| menthol, (1S,3S,4R)-(+)- | |
| menthol-d dist. | |
| (1S,2R,5S)-5- | methyl-2-propan-2-ylcyclohexan-1-ol |