eucalyptus globulus leaf/twig oil
volatile oil obtained from the leaves and twigs of eucalyptus globulus, myrtaceae
 
Notes:
combination aerosol antiseptic containing eucalyptus oil. tsca definition 2008: extractives and their physically modified derivatives. eucalyptus, myrtaceae.
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Name: eucalyptus globulus labille leaf/twig oil
CAS Number: 8000-48-4 
MDL: MFCD00146880
Also Contains: eucalyptus globulus leaf extract
Category: cosmetic, flavor and fragrance agents
 
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FEMA Number: 2466 eucalyptus globulus leaf/twig oil
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):8000-48-4 ; EUCALYPTUS, OIL (EUCALYPTUS GLOBULUS LABILLE)
FDA Regulation:
FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart F--Flavoring Agents and Related Substances
Sec. 172.510 Natural flavoring substances and natural substances used in conjunction with flavors.
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Physical Properties:
Appearance: colorless to pale yellow clear liquid (est)
Food Chemicals Codex Listed: No
Soluble in:
 alcohol
 water, 332.1 mg/L @ 25 °C (est)
Insoluble in:
 water
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Organoleptic Properties:
 
Odor Type: herbal
 
Odor Strength: medium
 
 eucalyptus  
Odor Description:
at 100.00 %. 
eucalyptus
 
 
Flavor Type: herbal
 
 eucalyptus  
Taste Description:
eucalyptus
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: masking agents
perfuming agents
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  2480 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 107, 1975.

oral-child TDLo  2 mL/kg
BEHAVIORAL: ATAXIA
Medical Journal of Australia. Vol. 154, Pg. 430, 1991.

oral-child TDLo  218 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SENSE ORGANS AND SPECIAL SENSES: CILIARY SPASM: EYE
Archives of Disease in Childhood. Vol. 28, Pg. 475, 1953.

oral-man LDLo  375 mg/kg
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SKIN AND APPENDAGES (SKIN): SWEATING: OTHER GASTROINTESTINAL: NAUSEA OR VOMITING
Archives of Disease in Childhood. Vol. 28, Pg. 475, 1953.

Dermal Toxicity:
skin-rabbit LD50 2480 mg/kg
Food and Cosmetics Toxicology. Vol. 13, Pg. 107, 1975.

skin-rabbit LD50 2480 mg/kg
Food and Chemical Toxicology. Vol. 26, Pg. 323, 1988.

Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic, flavor and fragrance agents
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 3
Click here to view publication 3
 average usual ppmaverage maximum ppm
baked goods: -76.00000
beverages(nonalcoholic): -1.70000
beverages(alcoholic): -1.00000
breakfast cereal: --
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: 0.5000050.00000
fruit ices: 0.5000050.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: -130.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: --
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
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Safety References:
EPI System: View
ClinicalTrials.gov: search
Daily Med: search
Cancer Citations: Search
Toxicology Citations: Search
EPA Substance Registry Services (TSCA): 8000-48-4
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 eucalyptus globulus labille leaf/twig oil
Chemidplus: 0008000484
RTECS: LE2530000 for cas# 8000-48-4
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References:
 eucalyptus globulus labille leaf/twig oil
Canada Domestic Sub. List: 8000-48-4
Pubchem (sid): 135264270
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Other Information:
FDA Substances Added to Food (formerly EAFUS): View
MedlinePlusSupp: View
Wikipedia: View
FAO: BASIC PRINCIPLES OF STEAM DISTILLATION
FAO: EUCALYPTUS OIL
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Potential Blenders and core components note
 
For Odor
No odor group found for these
 eucalyptus deaneti maiden leaf oil ethiopia 
 eucalyptus grandis w. hill ex maiden leaf oil ethiopiaFR
 eucalyptus smithii leaf oilFR
camphoreous
 bornyl ethyl ether 
 melaleuca viridiflora leaf oilFR
citrus
 rhubafuranFR
earthy
(-)-alpha-fencholFL/FR
floral
 lavender oilFL/FR
fruity
2-tert-butyl-5-methyl-2-propyl tetrahydrofuranFR
 cassyraneFL/FR
1,8-cineoleFL/FR
1,4-cineoleFL/FR
 eucalyptus absoluteFL/FR
 eucalyptus absolute replacerFR
 eucalyptus australiana type oil 
 eucalyptus globulus bicostata oilFR
 eucalyptus globulus leaf extractFL/FR
 eucalyptus globulus leaf tinctureFL/FR
 eucalyptus globulus leaf waterFR
 eucalyptus globulus maidenii f. muell oilFR
 eucalyptus globulus oilFL/FR
 eucalyptus globulus oil burundiaFL/FR
 eucalyptus globulus oil pakistanFL/FR
 eucalyptus globulus oil rwandaFL/FR
 eucalyptus globulus oil zambiaFL/FR
 eucalyptus globulus pseudoglobulus oilFR
 eucalyptus oil replacerFR
 eucalyptus radiata leaf/stem oilFR
 herbal undecaneFR
spike lavender oilFL/FR
spike lavender oil spainFL/FR
 melaleuca leucadendron cajaputi oilFL/FR
 melaleuca leucadendron var. cajuputi leaf oilFL/FR
 melaleuca linariifolia oilFR
 melaleuca quinquenervia waterFR
trans-para-menthane-3,8-diol 
para-menthane-3,8-diolFL/FR
 niaouli oilFR
beta-pineneFL/FR
 rosemary specialtyFR
 sabinene hydrateFL/FR
white thyme oilFL/FR
mentholic
laevo-mentholFL/FR
spicy
 elettaria cardamomum seed oilFL/FR
 elettaria cardamomum seed oil guatemalaFL/FR
 marjoram oil (thymus mastichina) spainFL/FR
 piper longum fruit oilFL/FR
 piper longum fruit oil CO2 extractFL/FR
thujonic
 sage oil (salvia lavandulifolia vahl.) spainFL/FR
 sage oil cubaFL/FR
 sage oil dalmatianFL/FR
 sage oil englandFL/FR
 sage oil franceFL/FR
 sage oil germanyFL/FR
 sage oil hydrodistillation franceFL/FR
 sage oil reunionFL/FR
 sage oil sardiniaFL/FR
woody
(+)-campheneFL/FR
 zedoary bark oilFL/FR
 
For Flavor
 
No flavor group found for these
(+)-campheneFL/FR
 eucalyptus australiana type oil 
 eucalyptus deaneti maiden leaf oil ethiopia 
 melaleuca leucadendron var. cajuputi leaf oilFL/FR
para-menthane-3,8-diolFL/FR
trans-para-menthane-3,8-diol 
 piper longum fruit oil CO2 extractFL/FR
camphoreous
 bornyl ethyl ether 
(-)-alpha-fencholFL/FR
cooling
1,4-cineoleFL/FR
spike lavender oilFL/FR
laevo-mentholFL/FR
 sabinene hydrateFL/FR
fruity
 cassyraneFL/FR
herbal
2-acetoxy-1,8-cineoleFL
 eucalyptus absoluteFL/FR
 eucalyptus flavorFL
 eucalyptus globulus leaf extractFL/FR
 eucalyptus globulus leaf tinctureFL/FR
 eucalyptus globulus oilFL/FR
 eucalyptus globulus oil burundiaFL/FR
 eucalyptus globulus oil pakistanFL/FR
 eucalyptus globulus oil rwandaFL/FR
 eucalyptus globulus oil zambiaFL/FR
 lavender oilFL/FR
spike lavender oil spainFL/FR
 melaleuca leucadendron cajaputi oilFL/FR
 sage oil (salvia lavandulifolia vahl.) spainFL/FR
white thyme oilFL/FR
minty
1,8-cineoleFL/FR
pine
beta-pineneFL/FR
spicy
 elettaria cardamomum seed oilFL/FR
 elettaria cardamomum seed oil guatemalaFL/FR
 marjoram oil (thymus mastichina) spainFL/FR
 piper longum fruit oilFL/FR
thujonic
 sage oil cubaFL/FR
 sage oil dalmatianFL/FR
 sage oil englandFL/FR
 sage oil franceFL/FR
 sage oil germanyFL/FR
 sage oil hydrodistillation franceFL/FR
 sage oil reunionFL/FR
 sage oil sardiniaFL/FR
woody
 zedoary bark oilFL/FR
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 eucalyptus globulus labille
Search Trop  Picture
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Synonyms:
 dinkum leaf/twig oil
 eucalyptus globulus labille leaf/twig oil
 volatile oil obtained from the leaves and twigs of eucalyptus globulus, myrtaceae
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Articles:
PubMed: Hormonal dynamics during recovery from drought in two Eucalyptus globulus genotypes: From root to leaf.
PubMed: Molluscicidal and antischistosomal activities of methanol extracts and isolated compounds from Eucalyptus globulus and Melaleuca styphelioides.
PubMed: Co-ordination of growth, gas exchange and hydraulics define the carbon safety margin in tree species with contrasting drought strategies.
PubMed: Localization of polysaccharides in isolated and intact cuticles of eucalypt, poplar and pear leaves by enzyme-gold labelling.
PubMed: Root damage by insects reverses the effects of elevated atmospheric CO2 on Eucalypt seedlings.
PubMed: Carbon dynamics of eucalypt seedlings exposed to progressive drought in elevated [CO2] and elevated temperature.
PubMed: Application of phytogenic zerovalent iron nanoparticles in the adsorption of hexavalent chromium.
PubMed: Effects of essential oils from Eucalyptus globulus leaves on soil organisms involved in leaf degradation.
PubMed: Whole-plant versus leaf-level regulation of photosynthetic responses after partial defoliation in Eucalyptus globulus saplings.
PubMed: A latitudinal cline in disease resistance of a host tree.
PubMed: Qualitative and semi-quantitative analysis of phenolics in Eucalyptus globulus leaves by high-performance liquid chromatography coupled with diode array detection and electrospray ionisation mass spectrometry.
PubMed: Interactive effects of water supply and defoliation on photosynthesis, plant water status and growth of Eucalyptus globulus Labill.
PubMed: Ecophysiological responses of a young blue gum (Eucalyptus globulus) plantation to weed control.
PubMed: Site-specific responses to short-term environmental variation are reflected in leaf and phloem-sap carbon isotopic abundance of field grown Eucalyptus globulus.
PubMed: A controlled test of the dual-isotope approach for the interpretation of stable carbon and oxygen isotope ratio variation in tree rings.
PubMed: Consequences of resource limitation for recovery from repeated defoliation in Eucalyptus globulus Labilladière.
PubMed: Chemical composition and antimicrobial effects of essential oils of Eucalyptus globulus, Myrtus communis and Satureja hortensis against Escherichia coli O157:H7 and Staphylococcus aureus in minced beef.
PubMed: Screening of allelopathic trees for their antifungal potential against Alternaria alternata strains isolated from dying-back Eucalyptus spp.
PubMed: Are gas exchange responses to resource limitation and defoliation linked to source:sink relationships?
PubMed: Compound-specific differences in (13)C of soluble carbohydrates in leaves and phloem of 6-month-old Eucalyptus globulus (Labill).
PubMed: Antibacterial activity of essential oils from Eucalyptus and of selected components against multidrug-resistant bacterial pathogens.
PubMed: miRNA control of vegetative phase change in trees.
PubMed: Seasonal patterns of foliage respiration in dominant and suppressed Eucalyptus globulus canopies.
PubMed: Observed and modelled leaf area index in Eucalyptus globulus plantations: tests of optimality and equilibrium hypotheses.
PubMed: Eucalyptus leaf extract suppresses the postprandial elevation of portal, cardiac and peripheral fructose concentrations after sucrose ingestion in rats.
PubMed: Differences in Rubisco content and its synthesis in leaves at different positions in Eucalyptus globulus seedlings.
PubMed: Phloem sap and leaf delta13C, carbohydrates, and amino acid concentrations in Eucalyptus globulus change systematically according to flooding and water deficit treatment.
PubMed: A geographic mosaic of genetic variation within a foundation tree species and its community-level consequences.
PubMed: Plasticity in maximum stomatal conductance constrained by negative correlation between stomatal size and density: an analysis using Eucalyptus globulus.
PubMed: Comparison of bacteriostatic and bactericidal activity of 13 essential oils against strains with varying sensitivity to antibiotics.
PubMed: Marker constituents of the natural antioxidant Eucalyptus leaf extract for the evaluation of food additives.
PubMed: Role of corticular photosynthesis following defoliation in Eucalyptus globulus.
PubMed: A comparison of growth, photosynthetic capacity and water stress in Eucalyptus globulus coppice regrowth and seedlings during early development.
PubMed: Shifts in biomass and resource allocation patterns following defoliation in Eucalyptus globulus growing with varying water and nutrient supplies.
PubMed: Oxygen and nitrogen reactive species are effectively scavenged by Eucalyptus globulus leaf water extract.
PubMed: Acclimation to short-term low temperatures in two Eucalyptus globulus clones with contrasting drought resistance.
PubMed: Development of Nested Polymerase Chain Reaction Detection of Mycosphaerella spp. and Its Application to the Study of Leaf Disease in Eucalyptus Plantations.
PubMed: Characterization of juvenile and adult leaves of Eucalyptus globulus showing distinct heteroblastic development: photosynthesis and volatile isoprenoids.
PubMed: Few Mendelian genes underlie the quantitative response of a forest tree, Eucalyptus globulus, to a natural fungal epidemic.
PubMed: Retranslocation of foliar nutrients in evergreen tree species planted in a Mediterranean environment.
PubMed: Novel mannose-sequestration technique reveals variation in subcellular orthophosphate pools do not explain the effects of phosphorus nutrition on photosynthesis in Eucalyptus globulus seedlings.
PubMed: Stability of genetic-based defensive chemistry across life stages in a Eucalyptus species.
PubMed: Within-canopy nitrogen and photosynthetic gradients are unaffected by soil fertility in field-grown Eucalyptus globulus.
PubMed: Increased photosynthesis following partial defoliation of field-grown Eucalyptus globulus seedlings is not caused by increased leaf nitrogen.
PubMed: Modelling advection and diffusion of water isotopologues in leaves.
PubMed: Defoliation and nitrogen effects on photosynthesis and growth of Eucalyptus globulus.
PubMed: Internal conductance does not scale with photosynthetic capacity: implications for carbon isotope discrimination and the economics of water and nitrogen use in photosynthesis.
PubMed: Physiology and anatomy of lenticel-like structures on leaves of Eucalyptus nitens and Eucalyptus globulus seedlings.
PubMed: Photosynthesis of Eucalyptus globulus with Mycosphaerella leaf disease.
PubMed: Antibacterial effects of Eucalyptus globulus leaf extract on pathogenic bacteria isolated from specimens of patients with respiratory tract disorders.
PubMed: Precision and accuracy of pest and pathogen damage assessment in young eucalypt plantations.
PubMed: Degradation of leaf litter phenolics by aquatic and terrestrial isopods.
PubMed: PCR-identification of Mycosphaerella species associated with leaf diseases of Eucalyptus.
PubMed: Eucalyptus leaf extract inhibits intestinal fructose absorption, and suppresses adiposity due to dietary sucrose in rats.
PubMed: A specific primer PCR and RFLP assay for the rapid detection and differentiation in planta of some Mycosphaerella species associated with foliar diseases of Eucalyptus globulus.
PubMed: Growth efficiency increases as relative growth rate increases in shoots and roots of Eucalyptus globulus deprived of nitrogen or treated with salt.
PubMed: Capillary electrophoresis of the major anions and cations in leaf extracts of woody species.
PubMed: Environmental and physiological controls over oxygen and carbon isotope composition of Tasmanian blue gum, Eucalyptus globulus.
PubMed: Responses to water stress in two Eucalyptus globulus clones differing in drought tolerance.
PubMed: Antimicrobial activities of eucalyptus leaf extracts and flavonoids from Eucalyptus maculata.
PubMed: Ovicidal and adulticidal activity of Eucalyptus globulus leaf oil terpenoids against Pediculus humanus capitis (Anoplura: Pediculidae).
PubMed: Effects of Eucalyptus plantations on detritus, decomposers, and detritivores in streams.
PubMed: Leaf orientation, light interception and stomatal conductance of Eucalyptus globulus ssp. globulus leaves.
PubMed: Water deficits are more important in delaying growth than in changing patterns of carbon allocation in Eucalyptus globulus.
PubMed: Movement and regeneration of epicuticular waxes through plant cuticles.
PubMed: Effects of thinning on wood production, leaf area index, transpiration and canopy interception of a plantation subject to drought.
PubMed: Growth, leaf morphology, water use and tissue water relations of Eucalyptus globulus clones in response to water deficit.
PubMed: Influence of light availability on leaf structure and growth of two Eucalyptus globulus ssp. globulus provenances.
PubMed: Foliar nutrient retranslocation in Eucalyptus globulus.
PubMed: Emission of isoprene from salt-stressed Eucalyptus globulus leaves.
PubMed: Strong, independent, quantitative genetic control of the timing of vegetative phase change and first flowering in eucalyptus globulus ssp. globulus (Tasmanian blue gum)
PubMed: Leaf Barriers to Fungal Colonization and Shredders (Tipula lateralis) Consumption of Decomposing Eucalyptus globulus.
PubMed: Ontogenetic differences in mesophyll structure and chlorophyll distribution in Eucalyptus globulus ssp. globulus.
PubMed: Eucalyptus has a functional equivalent of the Arabidopsis floral meristem identity gene LEAFY.
PubMed: Evaluating a simple radiation/dry matter conversion model using data from Eucalyptus globulus plantations in Western Australia.
PubMed: Leaf water relations of Eucalyptus globulus ssp. globulus and E. nitens: seasonal, drought and species effects.
PubMed: In vitro evaluation of medicinal plant extracts against Pestalotiopsis mangiferae.
PubMed: Photosynthetic temperature responses of Eucalyptus globulus and Eucalyptus nitens.
PubMed: Conductimetric analysis of the ion binding properties of three leaf extracts of chestnut (Castanea sativa), Eucalyptus (Eucalyptus globulus) and oak (Quercus robur).
PubMed: Role of nitrogen remobilization from old leaves for new leaf growth of Eucalyptus globulus seedlings.
PubMed: Comparative analysis of allelopathic effects produced by four forestry species during decomposition process in their soils in Galicia (NW Spain).
PubMed: Genotypic differences in water use efficiency and (13)C discrimination in Eucalyptus globulus.
PubMed: Photosynthetic capacity of leaves of Eucalyptus globulus (Labill.) growing in the field with different nutrient and water supplies.
PubMed: Control of growth of juvenile leaves of Eucalyptus globulus: effects of leaf age.
PubMed: Leaf growth of Eucalyptus globulus seedlings under water deficit.
PubMed: Water and nutrient supply regimes and the water relations of juvenile leaves of Eucalyptus globulus.
PubMed: Growth and water relations of seedlings of two subspecies of Eucalyptus globulus.
PubMed: The thermal conductivity of leaves.
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