advantame
N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl-alpha-L-phenylalanine methyl ester, monohydrate
 
Notes:
Chemical Nomenclature provided by BARK Information Services.
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CAS Number: 714229-20-6Picture of molecule3D/inchi
FDA UNII: 3ZA6810AWX
Molecular Weight: 476.52664000
Formula: C24 H32 N2 O8
NMR Predictor: Predict (works with chrome or firefox)
Category: sweeteners, flavor enhancers
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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NCBI: Search
 FDA/DG SANTE Petitions, Reviews, Notices:
FR DOC # 2012-26315 Ajinomoto Co., Inc.; Filing of Food Additive Petition; Amendment Pages 65340 - 65341 View - petition PDF
JECFA Food Additive: Advantame
GSFA Codex: Advantame (969)
DG SANTE Food Additives: advantame
FEMA Number: 4716 N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl-alpha-L-phenylalanine methyl ester, monohydrate
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):714229-20-6 ; ADVANTAME
FDA Regulation:
FDA PART 172—FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION
Subpart I—Multipurpose Additives
Sec. 172.803 Advantame.
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
Soluble in:
 alcohol
 water, 12.48 mg/L @ 25 °C (est)
Insoluble in:
 water
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Organoleptic Properties:
 
 
Flavor Type: sweet
 
 sweet  sugar  
Taste Description:
sweet sugar
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: sweeteners, flavor enhancers
Recommendation for advantame usage levels up to:
 not for fragrance use.
 
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 25. Update in publication number(s): 29
Click here to view publication 25
 average usual ppmaverage maximum ppm
baked goods: 20.0000020.00000
beverages(nonalcoholic): 1.350001.50000
beverages(alcoholic): 3.000003.00000
breakfast cereal: --
cheese: --
chewing gum: 40.0000050.00000
condiments / relishes: 3.000003.00000
confectionery froastings: 3.750003.75000
egg products: --
fats / oils: 3.000003.00000
fish products: --
frozen dairy: 0.900001.00000
fruit ices: --
gelatins / puddings: 3.750003.75000
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: 0.750000.75000
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: 0.900001.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: 3.750003.75000
soups: --
sugar substitutes: --
sweet sauces: --
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the safety of advantame for the proposed uses as a food additive
View page or View pdf
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 56843846
National Institute of Allergy and Infectious Diseases: Data
 (3R)-4-[[(1S)-1-benzyl-2-methoxy-2-oxo-ethyl]amino]-3-[3-(3-hydroxy-4-methoxy-phenyl)propylamino]-4-oxo-butanoic acid hydrate
Chemidplus: 0714229206
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References:
 (3R)-4-[[(1S)-1-benzyl-2-methoxy-2-oxo-ethyl]amino]-3-[3-(3-hydroxy-4-methoxy-phenyl)propylamino]-4-oxo-butanoic acid hydrate
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 56843846
Pubchem (sid): 135268538
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
HMDB (The Human Metabolome Database): Search
FDA Listing of Food Additive Status: View
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
For Odor
caramellic
 caramel pentadioneFL/FR
 strawberry furanoneFL/FR
floral
 orris rhizome absolute (iris germanica)FL/FR
 orris rhizome absolute (iris pallida)FL/FR
 
For Flavor
 
caramellic
 caramel pentadioneFL/FR
 strawberry furanoneFL/FR
cookie
cinnamon sugar cookie flavorFL
sugar cookie flavorFL
malty
 malt distillatesFL
sugar
 marzipan flavorFL
sweet
 acesulfame potassiumFL
 alitame anhydrousFL
 aspartameFL
 aspartame-acesulfame saltFL
 caramel dioneFL
 corn syrup high fructoseFL
 corn syrupsFL
 glucosyl steviol glycosidesFL
 orris rhizome absolute (iris germanica)FL/FR
 orris rhizome absolute (iris pallida)FL/FR
 rebaudioside CFL
glucosylated rubus suavissimus extract, 60% glucosylated rubusoside glycosidesFL
 stevia rebaudiana extract, rebaudioside A 22%FL
 stevia rebaudiana extract, rebaudioside A 60%FL
 steviol glycoside extract, rebaudioside C 22%FL
enzyme modified steviol glycosidesFL
 sugarFL
maple sugarFL
 sugar cane distillateFL
 sugar extendersFL
 sugar flavorFL
 sugar replacersFL
 sweet flavorFL
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
 aminosweet
(3R)-4-[[(1S)-1-benzyl-2-methoxy-2-oxo-ethyl]amino]-3-[3-(3-hydroxy-4-methoxy-phenyl)propylamino]-4-oxo-butanoic acid hydrate
N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl-alpha-L-phenylalanine methyl ester, monohydrate
N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl-alpha-laevo-phenylalanine methyl ester monohydrate
(N-[N-[3-(3-hydroxy-4-methoxyphenyl)propyl]-L-a-aspartyl]-L-phenylalanine 1-methyl ester) monohydrate
(R)-3-[3-(3-hydroxy-4-methoxyphenyl)propylamino]-4-[(S)-1-methoxy-1-oxo-3-phenylpropan-2-ylamino]-4-oxobutanoic acid hydrate
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