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L-a-aspartyl-N-(2,2,4,4-tetramethylthietan-3-yl)-D-alaninamide
Notes:
2000 times sweeter than sucrose; formed from aspartic acid, alanine & an amide. nonnutritive sweetener; 2000 times sweeter than sucrose; formed from aspartic acid, alanine & an amide. Sweetening agent. Intensely sweet, approx. 2000 x sucrose. Use currently (1999) permitted in Australia, New Zealand, Indonesia and China
Alitame is an artificial sweetener developed by Pfizer in the early 1980s and currently marketed in some countries under the brand name Aclame. Like aspartame, alitame is an aspartic acid-containing dipeptide. Most dipeptides are not sweet, but the unexpected discovery of aspartame in 1965 led to a search for similar compounds that shared its sweetness. Alitame is one such second-generation dipeptide sweetener. Neotame, developed by the owners of the NutraSweet brand, is another.
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| CAS Number: | 80863-62-3 |  3D/inchi
|
| Other(deleted CASRN): | 126121-34-4 | |
| FDA UNII: | PCE8DAE750 | |
| Nikkaji Web: | J997.311G | |
| XlogP3-AA: | -2.60 (est) | |
| Molecular Weight: | 331.43605000 | |
| Formula: | C14 H25 N3 O4 S | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: sweeteners, flavor enhancers
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Additive: | Alitame |
| GSFA Codex: | Alitame (956) |
Physical Properties:
| Appearance: | white crystalline powder (est) |
| Assay: | 98.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 607.00 to 609.00 °C. @ 760.00 mm Hg (est) |
| Flash Point: | 611.00 °F. TCC ( 321.67 °C. ) |
| logP (o/w): | 1.508 (est) |
| Soluble in: | |
| water, 815.8 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor Type: odorless | |
| Odor Strength: | none |
| Odor Description: | odorless |
| Flavor Type: sweet | |
| sweet sugar | |
| Taste Description: | sweet |
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| Anhui Haibei |
| Alitame |
| BOC Sciences |
| For experimental / research use only. |
| Aclame 95% |
| Carbosynth |
| For experimental / research use only. |
| Alitame |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Alitame |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| Not determined | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | sweeteners, flavor enhancers | ||
| Recommendation for alitame anhydrous usage levels up to: | |||
| not for fragrance use. | |||
Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 64763 |
| National Institute of Allergy and Infectious Diseases: | Data |
| (3S)-3-amino-4-oxo-4-[[(2R)-1-oxo-1-[(2,2,4,4-tetramethylthietan-3-yl)amino]propan-2-yl]amino]butanoic acid | |
| Chemidplus: | 0080863623 |
References:
| (3S)-3-amino-4-oxo-4-[[(2R)-1-oxo-1-[(2,2,4,4-tetramethylthietan-3-yl)amino]propan-2-yl]amino]butanoic acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 64763 |
| Pubchem (sid): | 135022743 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEMBL: | View |
| HMDB (The Human Metabolome Database): | HMDB37324 |
| FooDB: | FDB016344 |
| FDA Listing of Food Additive Status: | View |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| For Odor | ||
| caramellic | ||
| caramel pentadione | FL/FR | |
| strawberry furanone | FL/FR | |
| floral | ||
| orris rhizome absolute (iris germanica) | FL/FR | |
| orris rhizome absolute (iris pallida) | FL/FR | |
| For Flavor | ||
| caramellic | ||
| caramel pentadione | FL/FR | |
| strawberry furanone | FL/FR | |
| cookie | ||
| cinnamon sugar | cookie flavor | FL |
| sugar | cookie flavor | FL |
| malty | ||
| malt distillates | FL | |
| sugar | ||
| marzipan flavor | FL | |
| sweet | ||
| acesulfame potassium | FL | |
| advantame | FL | |
| aspartame | FL | |
| aspartame-acesulfame salt | FL | |
| caramel dione | FL | |
| corn syrup high fructose | FL | |
| corn syrups | FL | |
| glucosyl steviol glycosides | FL | |
| orris rhizome absolute (iris germanica) | FL/FR | |
| orris rhizome absolute (iris pallida) | FL/FR | |
| rebaudioside C | FL | |
| glucosylated | rubus suavissimus extract, 60% glucosylated rubusoside glycosides | FL |
| stevia rebaudiana extract, rebaudioside A 22% | FL | |
| stevia rebaudiana extract, rebaudioside A 60% | FL | |
| steviol glycoside extract, rebaudioside C 22% | FL | |
| enzyme modified | steviol glycosides | FL |
| maple | sugar | FL |
| sugar | FL | |
| sugar cane distillate | FL | |
| sugar extenders | FL | |
| sugar flavor | FL | |
| sugar replacers | FL | |
| sweet flavor | FL | |
Potential Uses:
| sweetener |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| D- | alaninamide, L-a-aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)- |
| (S)-3- | amino-4-oxo-4-(((R)-1-oxo-1-((2,2,4,4-tetramethylthietan-3-yl)amino)propan-2-yl)amino)butanoic acid |
| (3S)-3- | amino-4-oxo-4-[[(2R)-1-oxo-1-[(2,2,4,4-tetramethylthietan-3-yl)amino]propan-2-yl]amino]butanoic acid |
| 3-(L- | aspartyl-D-alaninamido)-2,2,4,4-tetramethylthietane |
| L- | aspartyl-D-alanine-N-(2,2,4,4-tetramethylthietan-3-yl)amide |
| L-a- | aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)-D-alaninamide |
| L-alpha- | aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)-D-alaninamide |
| L-a- | aspartyl-N-(2,2,4,4-tetramethylthietan-3-yl)-D-alaninamide |