pyrrolidine
tetramethylenimine
 
Notes:
Widely distributed in foodstuffs in trace amts., presumably as bacterial decarboxylation prod. of proline. Present in bread, milk, cheese, carrots, celery stalks, beer, spirits, coffee, caviar and fatty fish. Flavouring agent Pyrrolidine is a clear liquid with an unpleasant odor that is ammoniacal, fishy, shellfish-like and seaweed-like. Pyrrolidine is found naturally in the leaves of tobacco and carrot. The pyrrolidine ring structure is present in numerous natural alkaloids such as nicotine and hygrine. It is found in many pharmaceutical drugs such as procyclidine and bepridil. It also forms the basis for the racetam compounds (e.g. piracetam, aniracetam). A pyrrolidine ring is the central structure of the amino acids proline and hydroxyproline. (Wikipedia)
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
      Email: Mr. Jia
      Email: Mr. Guo
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      Product(s):
      10426 Pyrrolidine
       
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co., Ltd
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
      Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
      Email: Info
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      Product(s):
      HL0187 tetrahydro pyrrole
       
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers.
      Email: Sales
      US Email: Sales
      Voice: +86-21-32515501 60762991 60762992
      Fax: +86-21-32515502 64204960
      US Voice: 908-359-9000
      US Fax: 908-359-9002
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      Product(s):
      H0100 TETRAHYDRO PYRROLE, Kosher
       
  • Penta International
    • Penta International Corporation
      Chemistry innovation
      At Penta, our products and services help businesses do business better.
      For over 30 years, Penta Manufacturing Company has played a growing role in worldwide chemistry innovations and applications. As an industry leader, Penta continues to pioneer chemistry-based solutions for practically every area of commerce. Our products and expertise have helped fuel technical advances in dozens of commercial applications including flavoring, coloring, fragrances and chemical processes.
      US Email: Technical Services
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      US Voice: (973) 740-2300
      US Fax: (973) 740-1839
      Product(s):
      16-92700 PYRROLIDINE
      16-92710 PYRROLIDINE NATURAL 1% IN ETHYL ALCOHOL
       
  • Sigma-Aldrich
  • Sunaux International
    • Sunaux International
      Buy With Confidence
      We have industry leading processes and procedures to ensure nothing but the most reliable product.
      Sunaux International was founded in 2012 by the owner Mr.John Felton after spending 18 years involved in developing global business in the aromatic chemicals, fragrance and flavour compounds business.
      Email: John Felton
      Email: Stephen Zhou (Sales)
      Voice: 0512-57995626
      Fax: 0512-57570299
      Sales0512-57995626
      Sales0512-57570299
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      Product(s):
      H0100 Tetrahydro Pyrrole
       
  • Synerzine
    • Synerzine, Inc.
      Innovation. Customization. Aroma Ingredients.
      Synerzine is a leading supplier of flavor and fragrance ingredients.
      Synerzine expresses what we have grown to embody as an organization - the synergy and connection between raw ingredients, science, technology, and the final product. Our experienced team is passionate about bringing our customers high-quality innovative ingredients that they can trust.
      Building upon our 44 year history, the Synerzine team provides customers around the globe with convenient access to over 1200 high-quality aroma ingredients. We actively engage with customers to add a wide array of new products and services on a regular basis. Our aim is to delight every customer with our exceptional services, large product selection, customization and the highest quality and safety standards. We provide our customers with true value designed to help them bring their products to market faster.
      US Email: Customer Service
      US Email: Sales
      US Voice: (404) 524-6744
      US Fax: (404) 577-1651
      Inquiry
      Products List: View
      Product(s):
      W1650 Pyrrolidine
      P1000N PYRROLIDINE, NATURAL
       
  • TCI AMERICA
    • TCI AMERICA
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping!
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis.
      US Email: Sales
      Email: Technical Support
      Voice: 1-800-423-8616
      Fax: 1- 888-520-1075
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      Product(s):
      P0576 Pyrrolidine >98.0%(GC)
       
  • R C Treatt & Co Ltd
    • R C Treatt and Co Ltd
      Innovative ingredient solutions
      World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.
      We offer innovative and trend-setting product concepts for our customers, collaborating with them to create true value for their products.
      Email: Enquiries
      US Email: Enquiries
      Voice: +44 (0) 1284 702500
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      Product(s):
      Pyrrolidine
       
  • United International
    • Qingdao Free Trade Zone United International Co Ltd
      Quality Products
      A partner in your supply chain solution.
      Qingdao Free Trade Zone United International Trade Co., Ltd.was founded in 1996, specializing in the production and import and export of food additives,flavor raw materials and pharmaceutical and chemical raw materials. The company has experienced R&D and business personnel,product quality, low price, efficient service and fast insight and grasp the latest market information.
      Email: Info
      Email: Sales
      Voice: +86-532-83893699
      Fax: +86-532-83893695
      Product(s):
      7019 Pyrrolidine
       
  • WholeChem
    • WholeChem, LLC
      Connecting Innovators To the Building Blocks Of the Universe
      Custom manufacturer and distributor of specialty ingredients. We make global local.
      SQF-Certified Supplier
      We owe our success to our integrity, our dedication to the industry, and our commitment to our clients. We invite your inquiries regarding our current product list and any other products you may be having trouble sourcing.
      Email: Info
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      Voice: +1 (262) 995.8668
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      Product(s):
      Pyrrolidine
       
Synonyms   Articles   Notes   Search
CAS Number: 123-75-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 204-648-7
FDA UNII: LJU5627FYV
Nikkaji Web: J2.931I
Beilstein Number: 0102395
MDL: MFCD00005249
CoE Number: 10491
XlogP3: 0.50 (est)
Molecular Weight: 71.12273000
Formula: C4 H9 N
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: flavoring agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 1609  pyrrolidine
DG SANTE Food Flavourings: 14.064  pyrrolidine
FEMA Number: 3523 pyrrolidine
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):123-75-1 ; PYRROLIDINE
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: colorless clear liquid (est)
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 0.84700 to 0.85300 @  25.00 °C.
Pounds per Gallon - (est).: 7.048 to  7.098
Refractive Index: 1.44000 to 1.44600 @  20.00 °C.
Melting Point: -57.80 °C. @ 760.00 mm Hg
Boiling Point: 87.00 to  88.00 °C. @ 760.00 mm Hg
Vapor Pressure: 58.582001 mmHg @ 25.00 °C. (est)
Vapor Density: 2.45 ( Air = 1 )
Flash Point: 37.00 °F. TCC ( 2.78 °C. )
logP (o/w): 0.460
Soluble in:
 alcohol
 water, 1.00E+06 mg/L @ 20 °C (exp)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
 
Odor Type: ammoniacal
 
 ammoniacal  animal  eggy  
Odor Description:
at 0.10 % in propylene glycol. 
ammoniacal animal egg amine
 
 ammoniacal  fishy  shellfish  seaweed  
Odor Description:
Ammonia, fishy, shellfish and seaweed-like
Mosciano, Gerard P&F 20, No. 2, 37, (1995)
 
 
Flavor Type: ammoniacal
 
 ammoniacal  fishy  ammoniacal  seaweed  shellfish  
Taste Description:
at 50.00 ppm.  
Ammonia and fishy amine-like with seaweed and shellfish nuances
Mosciano, Gerard P&F 20, No. 2, 37, (1995)
 
Odor and/or flavor descriptions from others (if found).
 
 
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
None found
Synonyms   Articles   Notes   Search   Top
Suppliers:
Ambles Nature et Chimie
TETRAHYDRO-PYRROLE
Anhui Suzhou Jinli Aromatic Chemicals
Tetrahydro-pyrrole
Odor: fish, Amine
BASF
Pyrrolidine pure
Beijing Lys Chemicals
Pyrrolidine
DeLong Chemicals America
Tetrahydro pyrrole, Kosher
EMD Millipore
For experimental / research use only.
Pyrrolidine
Jiangyin Healthway
tetrahydro pyrrole
New functional food ingredients
Jinan Enlighten Chemical Technology(Wutong Aroma )
Tetrahydro pyrrole, Kosherk
M&U International
TETRAHYDRO PYRROLE, Kosher
Penta International
PYRROLIDINE NATURAL 1% IN ETHYL ALCOHOL
Penta International
PYRROLIDINE
R C Treatt & Co Ltd
Pyrrolidine
Sigma-Aldrich
Pyrrolidine, ≥99%, FG
Certified Food Grade Products
Sigma-Aldrich: Aldrich
For experimental / research use only.
Pyrrolidine ≥99%
Sunaux International
Tetrahydro Pyrrole
Synerzine
PYRROLIDINE, NATURAL
Synerzine
Pyrrolidine
TCI AMERICA
For experimental / research use only.
Pyrrolidine >98.0%(GC)
Tengzhou Xiang Yuan Aroma Chemicals
Tetrahydro Pyrrole
United International
Pyrrolidine
WholeChem
Pyrrolidine
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Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
T - Toxic.
R 11 - Highly flammable.
R 20/22 - Harmful by inhalation and if swallowed.
R 35 - Causes severe burns.
S 01/02 - Keep locked up and out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 20/21 - When using do not eat, drink or smoke.
S 23 - Do not breath vapour.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 28 - After contact with skin, wash immediately with plenty of water.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
S 45 - In case of accident or if you feel unwell seek medical advice immediately.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50  300 mg/kg
BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: OTHER CHANGES
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 29, 1974.

oral-guinea pig LDLo  250 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 104, 1982.

oral-mouse LD50  450 mg/kg
Bollettino Chimico Farmaceutico. Vol. 103, Pg. 414, 1964.

intraperitoneal-mouse LD50  420 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 82, 1946.

oral-rabbit LDLo  250 mg/kg
"Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 104, 1982.

oral-mammal (species unspecified) LD50  250 mg/kg
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.

intravenous-mouse LD50  56 mg/kg
U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#06769

Dermal Toxicity:
Not determined
Inhalation Toxicity:
inhalation-mouse LC50 1300 mg/m3/2H
BEHAVIORAL: EXCITEMENT VASCULAR: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 29, 1974.

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Safety in Use Information:
Category: flavoring agents
Recommendation for pyrrolidine usage levels up to:
 not for fragrance use.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 0.12 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 2.00 (μg/capita/day)
Threshold of Concern:540 (μg/person/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 10
Click here to view publication 10
 average usual ppmaverage maximum ppm
baked goods: -2.00000
beverages(nonalcoholic): -0.50000
beverages(alcoholic): --
breakfast cereal: -1.50000
cheese: --
chewing gum: -6.00000
condiments / relishes: --
confectionery froastings: -3.00000
egg products: --
fats / oils: --
fish products: --
frozen dairy: -1.00000
fruit ices: -1.00000
gelatins / puddings: --
granulated sugar: --
gravies: --
hard candy: --
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: --
milk products: -0.50000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: --
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
European Food Safety Athority(EFSA): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Flavouring Group Evaluation 86, (FGE.86)[1] - Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) - Scientific Opinion of the Panel on Food Additives - Flavourings, Processing Aids and Materials in Contact with Food
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 86, Revision 1 (FGE.86Rev1): Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting)
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting)
View page or View pdf
Safety and efficacy of pyridine and pyrrole derivatives belonging to chemical group 28 when used as flavourings for all animal species
View page or View pdf
EPI System: View
NIOSH International Chemical Safety Cards: search
Chemical Carcinogenesis Research Information System: Search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA GENetic TOXicology: Search
EPA Substance Registry Services (TSCA): 123-75-1
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 31268
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 1922
WGK Germany: 2
 pyrrolidine
Chemidplus: 0000123751
EPA/NOAA CAMEO: hazardous materials
RTECS: 123-75-1
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References:
 pyrrolidine
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 123-75-1
Pubchem (cid): 31268
Pubchem (sid): 134974741
Flavornet: 123-75-1
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
CHEBI: View
CHEMBL: View
HMDB (The Human Metabolome Database): HMDB31641
FooDB: FDB008290
Export Tariff Code: 2933.99.9700
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
Formulations/Preparations:
grades: 95% min purity
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
For Odor
citrus
citrus
 tangerine acetateFR
floral
grosso lavandin oilFL/FR
green
 seaweed absolute (fucus vesiculosus et serratus)FL/FR
mossy
 treemoss absoluteFR
spicy
para-anisyl formateFL/FR
 
For Flavor
 
No flavor group found for these
2-acetyl-1-pyrrolineFL
 amyl amineFL
(±)-sec-butyl amineFL
 butyl amineFL
isobutyl amineFL
 ethyl amineFL
 hexyl amineFL
2-methyl butyl amineFL
isopentylidene isopentyl amineFL
 phenethyl amineFL
 propionyl pyrroline 1% in vegatable oil triglycerideFL
isopropyl amineFL
 seaweed absolute (fucus vesiculosus et serratus)FL/FR
(R)-N,N,alpha-trimethyl benzyl amineFL
 tripropyl amineFL
ammoniacal
2-methyl piperidineFL
fishy
4,5-dimethyl thiazoleFL
3-penten-2-oneFL
herbal
grosso lavandin oilFL/FR
spicy
para-anisyl formateFL/FR
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 algaeFR
 animalFR
 eggFL
 seafoodFL
 seaweed absolute replacerFR
 shellfishFL
 prawnFL
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 apple pericarp
Search Trop  Picture
 barley seed
Search Trop  Picture
 beer
Search  PMC Picture
 carrot plant
Search Trop  Picture
 caviar
Search  PMC Picture
 celery plant
Search Trop  Picture
 celery stem
Search Trop  Picture
 cheese camembert cheese
Search  PMC Picture
 cheese limburger cheese
Search  PMC Picture
 cheese tilsit cheese
Search  PMC Picture
 coffee
Search  PMC Picture
 corn seed
Search Trop  Picture
 grape fruit juice
Search Trop  Picture
 peanut roasted peanut
Search Trop  Picture
 pepper bell pepper fruit
Search Trop  Picture
 pepper black pepper seed
Search Trop  Picture
 poppy opium poppy latex
Search Trop  Picture
 radish
Search Trop  Picture
 spinach leaf
Search Trop  Picture
 whiskey
Search  Picture
 wine red wine
Search  Picture
 wine white wine
Search  Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
 azolan
 butylenimine
1-azacyclopentane
perhydropyrrole
 pyrrole, tetrahydro-
 pyrrolidin
 pyrrolidine pure
 tetrahydro pyrrole
 tetrahydropyrrole
 tetramethylenimine
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Synonyms   Articles   Notes   Search   Top
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