Articles:
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(5-methyl-2-propan-2-ylcyclohexyl) 5-oxopyrrolidine-2-carboxylate
Notes:
Used as a food additive [EAFUS]
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 68127-22-0 [1R-(1alpha,2Beta,5alpha)]-2-isopropyl-5-methylcyclohexyl 5-oxo-D-prolinate
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Jiangyin Healthway International Trade Co., Ltd Independent Ingredients Supplier We provide custom synthesis and contract manufacturing from milligrams to metric tonnes. Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals. Email: Info Email: Sales Voice: 86-510-86023169 Fax: 86-510-86023170 Mobile 0086-13093133011 Services Biochemical Natural Food Colour New functional food ingredients Product(s): 159410 Menthyl PCA HLC-410 Menthyl PCA
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| CAS Number: | 68127-22-0 |  3D/inchi
|
| Other(deleted CASRN): | 52528-10-6 | |
| ECHA EINECS - REACH Pre-Reg: | 268-568-4 | |
| FDA UNII: | Y27B4585KO | |
| XlogP3-AA: | 3.00 (est) | |
| Molecular Weight: | 267.36885000 | |
| Formula: | C15 H25 N O3 | |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) | |
| CAS Number: | 64519-44-4 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 264-935-8 | |
| FDA UNII: | C7ZIB25BE7 | |
| Nikkaji Web: | J307.247I | |
| XlogP3-AA: | 3.00 (est) | |
| Molecular Weight: | 267.36885000 | |
| Formula: | C15 H25 N O3 | |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) | |
Category: flavoring agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Perfumer and Flavorist: | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| JECFA Food Flavoring: | 1858 menthyl pyrrolidone carboxylate |
| FEMA Number: | 4155 menthyl pyrrolidone carboxylate |
| FDA: | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF): | 52528-10-6 ; MENTHYL PYRROLIDONECARBOXYLATE |
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Melting Point: | 68.00 to 72.00 °C. @ 760.00 mm Hg |
| Boiling Point: | 409.00 to 410.00 °C. @ 760.00 mm Hg |
| Flash Point: | 394.00 °F. TCC ( 201.11 °C. ) |
| logP (o/w): | 3.195 (est) |
| Soluble in: | |
| alcohol | |
| water, slightly | |
| water, 14.07 mg/L @ 25 °C (est) | |
| Insoluble in: | |
| water | |
Organoleptic Properties:
| Odor Description: | cooling |
| Flavor Type: cooling | |
| cooling mentholic minty | |
| Taste Description: | cooling mentholic minty |
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
humectants skin conditioning |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| [1R-(1alpha,2Beta,5alpha)]-2-isopropyl-5-methylcyclohexyl 5-oxo-D-prolinate |
| Givaudan |
| Questice®
Odor: characteristic Use: Questice® long-lasting cooling active releasing Menthol over several hours. It also releases a natural moisturizing factor to condition the skin. It can be used as a perception trigger for other actives. Ecocert® approved. |
| Jiangyin Healthway |
| Menthyl PCA |
| New functional food ingredients |
| Jiangyin Healthway |
| Menthyl PCA |
| Parchem |
| menthyl pyrrolidone carboxylate |
Safety Information:
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
| Not determined | |
| Dermal Toxicity: | |
| Not determined | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | flavoring agents | ||
| Recommendation for menthyl pyrrolidone carboxylate usage levels up to: | |||
| not for fragrance use. | |||
| Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS). | |||
| The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library | |||
| publication number: 22 | |||
| Click here to view publication 22 | |||
| average usual ppm | average maximum ppm | ||
| baked goods: | - | - | |
| beverages(nonalcoholic): | - | - | |
| beverages(alcoholic): | - | - | |
| breakfast cereal: | - | - | |
| cheese: | - | - | |
| chewing gum: | 3000.00000 | 3000.00000 | |
| condiments / relishes: | - | - | |
| confectionery froastings: | - | - | |
| egg products: | - | - | |
| fats / oils: | - | - | |
| fish products: | - | - | |
| frozen dairy: | - | - | |
| fruit ices: | - | - | |
| gelatins / puddings: | - | - | |
| granulated sugar: | - | - | |
| gravies: | - | - | |
| hard candy: | 500.00000 | 500.00000 | |
| imitation dairy: | - | - | |
| instant coffee / tea: | - | - | |
| jams / jellies: | - | - | |
| meat products: | - | - | |
| milk products: | - | - | |
| nut products: | - | - | |
| other grains: | - | - | |
| poultry: | - | - | |
| processed fruits: | - | - | |
| processed vegetables: | - | - | |
| reconstituted vegetables: | - | - | |
| seasonings / flavors: | - | - | |
| snack foods: | - | - | |
| soft candy: | - | - | |
| soups: | - | - | |
| sugar substitutes: | - | - | |
| sweet sauces: | - | - | |
Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 68127-22-0 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 109140 |
| National Institute of Allergy and Infectious Diseases: | Data |
| (5-methyl-2-propan-2-ylcyclohexyl) 5-oxopyrrolidine-2-carboxylate | |
| Chemidplus: | 0068127220 |
| [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] (2S)-5-oxopyrrolidine-2-carboxylate | |
| Chemidplus: | 0064519444 |
References:
| Leffingwell: | Chirality or Article |
| (5-methyl-2-propan-2-ylcyclohexyl) 5-oxopyrrolidine-2-carboxylate | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 109140 |
| Pubchem (sid): | 135066234 |
| [(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] (2S)-5-oxopyrrolidine-2-carboxylate | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 115834 |
| Pubchem (sid): | 135071737 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Substances Added to Food (formerly EAFUS): | View |
| KEGG (GenomeNet): | C03962 |
| HMDB (The Human Metabolome Database): | HMDB32368 |
| FooDB: | FDB009781 |
| ChemSpider: | View |
Potential Blenders and core components note
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| (-)- | menthyl (+)-2-pyrrolidone-5-carboxylate |
| menthyl PCA | |
| (5- | methyl-2-propan-2-ylcyclohexyl) 5-oxopyrrolidine-2-carboxylate |
| [(1R,2S,5R)-5- | methyl-2-propan-2-ylcyclohexyl] (2S)-5-oxopyrrolidine-2-carboxylate |
| (1R-(1alpha,2beta,5alpha))-2-iso | propyl-5-methyl cyclohexyl 5-oxo-dextro-prolinate |
| (1R-(1alpha,2beta,5alpha))-2-iso | propyl-5-methylcyclohexyl 5-oxo-D-prolinate |
| questice (Givaudan) |