methyl dextro-lactate
(2R)-2-hydroxypropanoic acid methyl ester
 
Notes:
None found
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      17392-83-5 (+)-Methyl D-lactate 95%
       
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      L0136 Methyl D-(+)-Lactate >98.0%(GC)
       
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CAS Number: 17392-83-5Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 241-420-6
FDA UNII: 45MZ1T3TBV
Nikkaji Web: J208.669G
MDL: MFCD00004517
XlogP3-AA: -0.10 (est)
Molecular Weight: 104.10536000
Formula: C4 H8 O3
NMR Predictor: Predict (works with chrome, Edge or firefox)
Category: information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Appearance: colorless clear liquid (est)
Assay: 97.00 to 100.00 % 
Food Chemicals Codex Listed: No
Specific Gravity: 1.09200 to 1.09600 @  20.00 °C.
Pounds per Gallon - (est).: 9.097 to  9.130
Refractive Index: 1.41100 to 1.41500 @  20.00 °C.
Boiling Point: 144.00 to  146.00 °C. @ 760.00 mm Hg
Vapor Pressure: 1.933000 mmHg @ 25.00 °C. (est)
Flash Point: 121.00 °F. TCC ( 49.44 °C. )
logP (o/w): -0.719 (est)
Soluble in:
 alcohol
 water, 1e+006 mg/L @ 25 °C (est)
Similar Items: note
amyl lactate
isoamyl lactate
benzyl lactate
butyl butyryl lactate
butyl lactate
isobutyl lactate
sec-butyl lactate
butyl laevo-lactate
cetyl lactate
dodecyl lactate
ethyl acetyl lactate
ethyl butyryl lactate
ethyl lactate
ethyl phenyl lactate
(Z)-3-hexen-1-yl lactate
hexyl lactate
laevo-menthyl lactate
menthyl methyl lactate
methyl laevo-lactate
phenethyl lactate
propyl lactate
vanillyl lactate
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
BOC Sciences
For experimental / research use only.
(+)-Methyl D-lactate 95%
Santa Cruz Biotechnology
For experimental / research use only.
(+)-Methyl D-lactate
Sigma-Aldrich: Aldrich
For experimental / research use only.
(+)-Methyl D-lactate 98%, optical purity ee: 96% (GLC)
TCI AMERICA
For experimental / research use only.
Methyl D-(+)-Lactate >98.0%(GC)
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Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xi - Irritant
R 10 - Flammable.
R 38 - Irritating to skin.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 37/39 - Wear suitable gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: information only not used for fragrances or flavors
Recommendation for methyl dextro-lactate usage levels up to:
 not for fragrance use.
 
Recommendation for methyl dextro-lactate flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 637514
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 3272
WGK Germany: 1
 methyl (2R)-2-hydroxypropanoate
Chemidplus: 0017392835
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References:
 methyl (2R)-2-hydroxypropanoate
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 637514
Pubchem (sid): 135060642
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
HMDB (The Human Metabolome Database): Search
Export Tariff Code: 2918.11.5100
ChemSpider: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
(2R)-2-hydroxypropanoic acid methyl ester
D-lactic acid methyl ester
 methyl (2R)-2-hydroxypropanoate
 methyl (R)-()-lactate
 methyl (R)-(+)-lactate
 methyl (R)-lactate
(R)-methyl 2-hydroxypropanoate
 methyl D-(+)-lactate
 methyl D-lactate
(+)-methyl D-lactate
 propanoic acid, 2-hydroxy-, methyl ester, (2R)-
 propanoic acid, 2-hydroxy-, methyl ester, (R)-
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Articles:
PubMed: Presence in Lactobacillus plantarum of an esterase active on a broad-range of phenolic esters.
PubMed: Tin-containing Silicates: Alkali Salts Improve Methyl Lactate Yield from Sugars.
PubMed: Protective effects of apigenin against 1-methyl-4-phenylpyridinium ion‑induced neurotoxicity in PC12 cells.
PubMed: Integration of rigid and flexible organic parts for the construction of a homochiral metal-organic framework with high porosity.
PubMed: Inhibition of Glycogen Synthase Kinase-3β Attenuates Organ Injury and Dysfunction Associated With Liver Ischemia-Reperfusion and Thermal Injury in the Rat.
PubMed: Protective effects of the p38 MAPK inhibitor SB203580 on NMDA‑induced injury in primary cerebral cortical neurons.
PubMed: Enhanced degradation of five organophosphorus pesticides in skimmed milk by lactic acid bacteria and its potential relationship with phosphatase production.
PubMed: Involvement of the ERK pathway in the protective effects of glycyrrhizic acid against the MPP+-induced apoptosis of dopaminergic neuronal cells.
PubMed: Activation of mGluR5 attenuates NMDA-induced neurotoxicity through disruption of the NMDAR-PSD-95 complex and preservation of mitochondrial function in differentiated PC12 cells.
PubMed: Resveratrol attenuates the inflammatory reaction induced by ischemia/reperfusion in the rat heart.
PubMed: [The use of succinates for the correction of metabolic disorders in the penumbra in patients with stroke].
PubMed: Enantioselectivity of (321) chiral noble metal surfaces: a density functional theory study of lactate adsorption.
PubMed: Cardioprotection of 17β-estradiol against hypoxia/reoxygenation in cardiomyocytes is partly through up-regulation of CRH receptor type 2.
PubMed: Dioscin prevents the mitochondrial apoptosis and attenuates oxidative stress in cardiac H9c2 cells.
PubMed: New steroidal 17β-carboxy derivatives present anti-5α-reductase activity and anti-proliferative effects in a human androgen-responsive prostate cancer cell line.
PubMed: Chiral recognition mechanism of acyloin-containing chiral solutes by amylose tris[(S)-α-methylbenzylcarbamate].
PubMed: Lipase-catalyzed enantioselective synthesis of (R,R)-lactide from alkyl lactate to produce PDLA (poly D-lactic acid) and stereocomplex PLA (poly lactic acid).
PubMed: A novel axial-stress bioreactor system combined with a substance exchanger for tissue engineering of 3D constructs.
PubMed: The molecular mechanisms and gene expression profiling for shikonin-induced apoptotic and necroptotic cell death in U937 cells.
PubMed: Uptake mechanism of furosemide-loaded pegylated nanoparticles by cochlear cell lines.
PubMed: Dual effects of neuroprotection and neurotoxicity by general anesthetics: role of intracellular calcium homeostasis.
PubMed: Up-regulated expression of indoleamine 2,3-dioxygenase 1 in non-Hodgkin lymphoma correlates with increased regulatory T-cell infiltration.
PubMed: Glutathione metabolism and Parkinson's disease.
PubMed: Ischemic postconditioning attenuate reperfusion injury of small intestine: impact of mitochondrial permeability transition.
PubMed: Different protocols to produce artificial dentine carious lesions in vitro and in situ: hardness and mineral content correlation.
PubMed: Noninvasive characterization of the effect of varying PLGA molecular weight blends on in situ forming implant behavior using ultrasound imaging.
PubMed: Mitochondrial peroxiredoxin-5 as potential modulator of mitochondria-ER crosstalk in MPP+-induced cell death.
PubMed: Characterization of a membrane-active anti-tumor agent, UA8967.
PubMed: Lactate and acrylate metabolism by Megasphaera elsdenii under batch and steady-state conditions.
PubMed: A new biosensor for chiral recognition using goat and rabbit serum albumin self-assembled quartz crystal microbalance.
PubMed: Edaravone inhibits apoptosis caused by ischemia/reperfusion injury in a porcine hepatectomy model.
PubMed: [Neuroprotective effects of combined pretreatment with edaravone and propofol on neonatal rat cerebral cortical neurons with ischemia/reperfusion injury in vitro].
PubMed: The protective effect of curcumin on ischemia-reperfusion-induced liver injury.
PubMed: Ischemic preconditioning reduces endoplasmic reticulum stress and upregulates hypoxia inducible factor-1α in ischemic kidney: the role of nitric oxide.
PubMed: Identification of Immunopotentiating Lactic Acid Bacteria that Induce Antibody Production by in vitro Stimulated Human Peripheral Blood Mononuclear Cells.
PubMed: Effects of peripherally restricted κ opioid receptor agonists on pain-related stimulation and depression of behavior in rats.
PubMed: [Sevoflurane postconditioning attenuates myocardial apoptosis in isolated rat hearts via a modulation of Bcl-2 family proteins].
PubMed: Conversion of sterically demanding α,α-disubstituted phenylacetonitriles by the arylacetonitrilase from Pseudomonas fluorescens EBC191.
PubMed: Ginsenoside Rb1 preconditioning enhances eNOS expression and attenuates myocardial ischemia/reperfusion injury in diabetic rats.
PubMed: Metabolic and oxidative effects of sevoflurane and propofol in children undergoing surgery for congenital heart disease.
PubMed: The role of weak hydrogen bonds in chiral recognition.
PubMed: Intermittent hypobaric hypoxia improves postischemic recovery of myocardial contractile function via redox signaling during early reperfusion.
PubMed: Hemoglobin vesicle improves recovery of cardiac function after ischemia-reperfusion by attenuating oxidative stress in isolated rat hearts.
PubMed: Toward stereoselective lactide polymerization catalysts: cationic zinc complexes supported by a chiral phosphinimine scaffold.
PubMed: Gender-related difference of sevoflurane postconditioning in isolated rat hearts: focus on phosphatidylinositol-3-kinase/Akt signaling.
PubMed: Ginseng protects rodent hearts from acute myocardial ischemia-reperfusion injury through GR/ER-activated RISK pathway in an endothelial NOS-dependent mechanism.
PubMed: Exploring electronic versus steric effects in stereoselective ring-opening polymerization of lactide and β-butyrolactone with amino-alkoxy-bis(phenolate)-yttrium complexes.
PubMed: Simplification of a complex microbial antilisterial consortium to evaluate the contribution of its flora in uncooked pressed cheese.
PubMed: Macrophage migration inhibitory factor promotes cell death and aggravates neurologic deficits after experimental stroke.
PubMed: Modular, homochiral, porous coordination polymers: rational design, enantioselective guest exchange sorption and ab initio calculations of host-guest interactions.
PubMed: Pharmacological inhibition of N-methyl d-aspartate receptor promotes secretion of vascular endothelial growth factor in müller cells: effects of hyperglycemia and hypoxia.
PubMed: [Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury].
PubMed: A novel, orally active LPA(1) receptor antagonist inhibits lung fibrosis in the mouse bleomycin model.
PubMed: Water-soluble organic solubilizers for in vitro drug delivery studies with respiratory epithelial cells: selection based on various toxicity indicators.
PubMed: [A comparative study on the protection effect of nerve growth factor and edaravone pretreatment against cerebral ischemia/reperfusion injury].
PubMed: Glucagon-like peptide (GLP)-1(9-36)amide-mediated cytoprotection is blocked by exendin(9-39) yet does not require the known GLP-1 receptor.
PubMed: Noninvasive characterization of in situ forming implants using diagnostic ultrasound.
PubMed: Differential diagnosis between radiation necrosis and glioma progression using sequential proton magnetic resonance spectroscopy and methionine positron emission tomography.
PubMed: Cardioprotective effect of 'methylamine irisolidone', a new compound, in hypoxia/reoxygenation injury in cultured rat cardiac myocytes.
PubMed: A novel strategy for rapid real-time chiral discrimination of enantiomers using serum albumin functionalized QCM biosensor.
PubMed: Energy taxis drives Campylobacter jejuni toward the most favorable conditions for growth.
PubMed: Functional significance of brain glycogen in sustaining glutamatergic neurotransmission.
PubMed: Effect of Lianshu preparation on lipopolysaccharide-induced diarrhea in rats.
PubMed: Relationship between serum glycolate and falsely elevated lactate in severe ethylene glycol poisoning.
PubMed: Asymmetric synthesis and biological evaluation of Danshensu derivatives as anti-myocardial ischemia drug candidates.
PubMed: Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals.
PubMed: Pivotal role for two electron reduction in 2,3-dimethoxy-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone metabolism and kinetics in vivo that prevents liver redox stress.
PubMed: Acid-base status and hemodynamic stability during propofol and sevoflurane-based anesthesia in patients undergoing uncomplicated intracranial surgery.
PubMed: Liver X receptor agonists with selectivity for LXRbeta; N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropionamides.
PubMed: Antioxidant effects of a Rhodobryum roseum extract and its active components in isoproterenol-induced myocardial injury in rats and cardiac myocytes against oxidative stress-triggered damage.
PubMed: Total synthesis of (+)-neomarinone.
PubMed: Ghrelin antagonized 1-methyl-4-phenylpyridinium (MPP(+))-induced apoptosis in MES23.5 cells.
PubMed: [Protective effects of propofol combined with reserpine on cultured PC12 cells impaired by ischemia and reperfusion].
PubMed: Kappa-opioid receptor agonist protects the microcirculation of skeletal muscle from ischemia reperfusion injury.
PubMed: Effect of exercise intensities on free fatty acid uptake in whole-body organs measured with (123)I-BMIPP-SPECT.
PubMed: Formate excretion in urine of rats fed dimethylaminoazobenzene-rich diets: the possibility of formate formation from D-lactate.
PubMed: Effect of MAO-B inhibition against ischemia-induced oxidative stress in the rat brain. Comparison with a rational antioxidant.
PubMed: [Protective effect of urantide against myocardial ischemia injury].
PubMed: Generation of volatile fatty acids by axillary bacteria.
PubMed: Is the functional interaction between adenosine A(2A) receptors and metabotropic glutamate 5 receptors a general mechanism in the brain? Differences and similarities between the striatum and the hippocampus.
PubMed: Sevoflurane but not propofol increases interstitial glycolysis metabolites availability during tourniquet-induced ischaemia-reperfusion.
PubMed: Cardioprotective and antiarrhythmic effect of U50,488H in ischemia/reperfusion rat heart.
PubMed: Adenosine and TNF-alpha exert similar inotropic effect on heart cultures, suggesting a cardioprotective mechanism against hypoxia.
PubMed: Interaction of L-arginine-methyl ester and Sonic hedgehog in liver ischemia-reperfusion injury in the rats.
PubMed: Cannabinoids inhibit sodium-dependent, high-affinity excitatory amino acid transport in cultured rat cortical astrocytes.
PubMed: Increased vulnerability of hippocampal neurons with age in culture: temporal association with increases in NMDA receptor current, NR2A subunit expression and recruitment of L-type calcium channels.
PubMed: Decreased hepatic ischemia-reperfusion injury by manganese-porphyrin complexes.
PubMed: Monitoring release of ketoprofen enantiomers from biodegradable poly(D,L-lactide-co-glycolide) injectable implants.
PubMed: In situ tracing the process of human enamel demineralization by electrochemical impedance spectroscopy (EIS).
PubMed: The new 2,3-benzodiazepine derivative EGIS-8332 inhibits AMPA/kainate ion channels and cell death.
PubMed: Fluorescence spectroscopy of jet-cooled chiral (+/-)-indan-1-ol and its cluster with (+/-)-methyl- and ethyl-lactate.
PubMed: Streamlined, asymmetric synthesis of 8,4'-oxyneolignans.
PubMed: The cannabinoid agonist WIN 55,212-2 inhibits TNF-alpha-induced neutrophil transmigration across ECV304 cells.
PubMed: Acyl-based anandamide uptake inhibitors cause rapid toxicity to C6 glioma cells at pharmacologically relevant concentrations.
PubMed: Automated no-carrier-added synthesis of [1-11C]-labeled D- and L-enantiomers of lactic acid.
PubMed: Protective role of 3-nitro-N-methyl-salicylamide on isolated rat heart during 4 hours of cold storage and reperfusion.
PubMed: Impact of in vivo fatty acid oxidation blockade on glucose turnover and muscle glucose metabolism during low-dose AICAR infusion.
PubMed: Modelling neurotransmitter functions: a laser spectroscopic study of (1S,2S)-N-methyl pseudoephedrine and its complexes with achiral and chiral molecules.
PubMed: [D-lactic acidosis in an 11-year-old patient with short bowel syndrome].
PubMed: Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors.
PubMed: Chiral recognition between lactic acid derivatives and an aromatic alcohol in a supersonic expansion: electronic and vibrational spectroscopy.
PubMed: Laser-induced fluorescence and single vibronic level emission spectroscopy of chiral (R)-1-aminoindan and some of its clusters in a supersonic jet.
PubMed: Metalloproteinase inhibitor counters high-energy phosphate depletion and AMP deaminase activity enhancing ventricular diastolic compliance in subacute heart failure.
PubMed: Nitric oxide-cGMP-protein kinase G signaling pathway induces anoxic preconditioning through activation of ATP-sensitive K+ channels in rat hearts.
PubMed: Chiral clusters in a supersonic beam: R2PI-TOF spectroscopy of diastereomeric carboxylic esters/(R)-(+)-1-phenyl-1-propanol complexes.
PubMed: Hepatotoxic effects of tert-butyl hydroperoxide (t-BHP) and protection by antioxidants.
PubMed: Total synthesis of cyclic tetrapeptide FR235222, a potent immunosuppressant that inhibits mammalian histone deacetylases.
PubMed: Involvement of protein kinase A in cannabinoid receptor-mediated protection from oxidative neuronal injury.
PubMed: Ischemia and reperfusion of liver induces eNOS and iNOS expression: effects of a NO donor and NOS inhibitor.
PubMed: Spirocyclic zwitterionic lambda5Si-silicates with two bidentate ligands derived from alpha-amino acids or alpha-hydroxycarboxylic acids: synthesis, structure, and stereodynamics.
PubMed: Altered substrate specificity in flavocytochrome b2: structural insights into the mechanism of L-lactate dehydrogenation.
PubMed: Para-position derivatives of fungal anthelmintic cyclodepsipeptides engineered with Streptomyces venezuelae antibiotic biosynthetic genes.
PubMed: Combined high-field 13C CP MAS NMR and low-field NMR relaxation measurements on post mortem porcine muscles.
PubMed: Resveratrol protects myocardial ischemia-reperfusion injury through both NO-dependent and NO-independent mechanisms.
PubMed: Total synthesis of macrosphelides A, B, and E: first application of ring-closing metathesis for macrosphelide synthesis.
PubMed: A novel series of complexones with bis- or biazole structure as mixed ligands of paramagnetic contrast agents for MRI.
PubMed: Neuroprotective effects of hydroxysafflor yellow A: in vivo and in vitro studies.
PubMed: Apoptosis and necrosis after warm ischemia-reperfusion injury of the pig liver and their inhibition by ONO-1714.
PubMed: Aspirin inhibits p44/42 mitogen-activated protein kinase and is protective against hypoxia/reoxygenation neuronal damage.
PubMed: Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction.
PubMed: Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase.
PubMed: Calcium homeostasis and glucose uptake of murine myotubes exposed to insulin, caffeine and 4-chloro-m-cresol.
PubMed: Study of a glucose-activated anion-selective channel in rat pancreatic beta-cells.
PubMed: [A new oxidase method for analyzing L-lactate].
PubMed: Straightforward synthesis of two pairs of enantiomeric butenolides 3-tetradecyl- and 3-hexadecyl-5-methyl-2(5H)-furanone.
PubMed: Domain closure, substrate specificity and catalysis of D-lactate dehydrogenase from Lactobacillus bulgaricus.
PubMed: Development of a flow cytometric method to analyze subpopulations of bacteria in probiotic products and dairy starters.
PubMed: A novel inhibitor of inducible nitric oxide synthase (ONO-1714) prevents critical warm ischemia-reperfusion injury in the pig liver.
PubMed: Hypoxia/reoxygenation induces cell injury via different mechanisms in cultured rat cortical neurons and glial cells.
PubMed: 12-hydroxyeicosatetrenoate (12-HETE) attenuates AMPA receptor-mediated neurotoxicity: evidence for a G-protein-coupled HETE receptor.
PubMed: Nanoscale clustering of RGD peptides at surfaces using comb polymers. 2. Surface segregation of comb polymers in polylactide.
PubMed: Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide.
PubMed: The protective effect of niacinamide on ischemia-reperfusion-induced liver injury.
PubMed: Quantitative gas chromatography-olfactometry carried out at different dilutions of an extract. Key differences in the odor profiles of four high-quality Spanish aged red wines.
PubMed: First total syntheses of aeruginosin 298-A and aeruginosin 298-B, based on a stereocontrolled route to the new amino acid 6-hydroxyoctahydroindole-2-carboxylic acid.
PubMed: [Analysis of MDMA and its metabolites in urine by GC and GC/MS].
PubMed: Contribution of excitatory amino acids to hypoglycemic counter-regulation.
PubMed: Thin layer chromatographic determination of organic acids for rapid identification of bifidobacteria at genus level.
PubMed: Total synthesis of (+)-blastmycinone, (-)-litsenolide C1, and related natural trisubstituted lactones via alkynyltungsten compounds.
PubMed: Hippuryl-alpha-methylphenylalanine and hippuryl-alpha-methylphenyllactic acid as substrates for carboxypeptidase A. Syntheses, kinetic evaluation and mechanistic implication.
PubMed: Limitations of exogenous L-arginine in exerting a cytoprotective effect on hepatic ischemia/reperfusion injury.
PubMed: Enantiomeric separation and discrimination of 2-hydroxy acids as O-trifluoroacetylated (S)-(+)-3-methyl-2-butyl esters by achiral dual-capillary column gas chromatography.
PubMed: Biosynthesis of PF1022A and related cyclooctadepsipeptides.
PubMed: Effect of exercise induced hyperlactatemia on the biodistribution and metabolism of iodine-123-15(p-iodophenyl)-3-R,S-methyl pentadecanoic acid in normal volunteers.
PubMed: Secondary amides of (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase.
PubMed: Nitric oxide mediates capsaicin-induced cytotoxicity in cultured dorsal root ganglion neurons.
PubMed: Histamine H3-receptor stimulation is unable to modulate noradrenaline release by the isolated rat heart during ischaemia-reperfusion.
PubMed: Beneficial and harmful effects of L-arginine on renal ischaemia.
PubMed: Effects of methylglyoxal on rat pancreatic beta-cells.
PubMed: Bacteria used for the production of yogurt inactivate carcinogens and prevent DNA damage in the colon of rats.
PubMed: The 5-HT1A receptor agonist BAY x 3702 prevents staurosporine-induced apoptosis.
PubMed: Induction of neurosteroid synthesis by NMDA receptors in isolated rat retina: a potential early event in excitotoxicity.
PubMed: Reactive oxygen species in reoxygenation injury of rat brain capillary endothelial cells.
PubMed: Adenosine, inosine, and guanosine protect glial cells during glucose deprivation and mitochondrial inhibition: correlation between protection and ATP preservation.
PubMed: [Clinical usefulness of myocardial iodine-123-15-(p-iodophenyl)-3(R,S)-methyl-pentadecanoic acid distribution abnormality in patients with mitochondrial encephalomyopathy based on normal data file in bull's-eye polar map].
PubMed: Evaluation of heart-to-organ ratios of 123I-BMIPP and the dimethyl-substituted 123I-DMIPP fatty acid analogue in humans.
PubMed: Metabolic and antioxidant effects of R(+/-)-N6-(2-phenylisopropyl)-adenosine following regional ischemia and reperfusion in canine myocardium.
PubMed: Antioxidants and cataract: (cataract induction in space environment and application to terrestrial aging cataract).
PubMed: Membrane potential-generating malate (MleP) and citrate (CitP) transporters of lactic acid bacteria are homologous proteins. Substrate specificity of the 2-hydroxycarboxylate transporter family.
PubMed: [Studies on the mechanism of protection of cultured neurous by ketamine anoxia/reoxygenation-induced injury].
PubMed: Crystal structure of a ternary complex of D-2-hydroxyisocaproate dehydrogenase from Lactobacillus casei, NAD+ and 2-oxoisocaproate at 1.9 A resolution.
PubMed: Correlation between hydrophobicity of short-chain aliphatic alcohols and their ability to alter plasma membrane integrity.
PubMed: NAD-independent lactate and butyryl-CoA dehydrogenases of Clostridium acetobutylicum P262.
PubMed: Isoproterenol mimics calcium preconditioning-induced protection against ischemia.
PubMed: Substitution of amino acids 1 and 3 in teicoplanin aglycon: synthesis and antibacterial activity of three first non-natural dalbaheptides.
PubMed: Pharmacokinetics of radioiodinated fatty acid myocardial imaging agents in animal models and human studies.
PubMed: Optically active antifungal azoles. VI. Synthesis and antifungal activity of N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazo l-1- yl)propyl]-N'-(4-substituted phenyl)-3(2H,4H)-1,2,4-triazolones and 5(1H,4H)-tetrazolones.
PubMed: Changes in concentrations of methylglyoxal, D-lactate and glyoxalase activities in liver and plasma of rats fed a 3'-methyl-4-dimethylaminoazobenzene-rich diet.
PubMed: VA-045, a novel apovincamic acid derivative attenuates neuronal injury induced by hypoxia or by excitatory amino acids in cultures of rat cortices.
PubMed: Tricyclic CNS active agents by intramolecular Oxa-Pictet-Spengler reaction.
PubMed: Oxygen-derived free radical (ODFR) action on hyaluronan (HA), on two HA ester derivatives, and on the metabolism of articular chondrocytes.
PubMed: Knowledge-based modeling of the D-lactate dehydrogenase three-dimensional structure.
PubMed: Inhibition of nitric oxide synthesis reduces infarct size by an adenosine-dependent mechanism.
PubMed: Degradation of hyaluronate by Streptococcus intermedius strain UNS 35.
PubMed: In vitro neuroprotection by substituted guanidines with varying affinities for the N-methyl-D-aspartate receptor ionophore and for sigma sites.
PubMed: NAD(+)-dependent D-2-hydroxyisocaproate dehydrogenase of Lactobacillus delbrueckii subsp. bulgaricus. Gene cloning and enzyme characterization.
PubMed: Reconstitution of the lactate carrier from rat skeletal-muscle sarcolemma.
PubMed: Nitric oxide: a mediator in rat tubular hypoxia/reoxygenation injury.
PubMed: Metabolic response of preterm infants to variable degrees of respiratory illness.
PubMed: Perioperative TNF alpha and IL-6 concentrations correlate with septic state, organ function, and APACHE II scores in intra-abdominal infection.
PubMed: Antagonism by NG-nitro-L-arginine of L-glutamate-induced neurotoxicity in cultured neonatal rat cortical neurons. Prolonged application enhances neuroprotective efficacy.
PubMed: Intrinsic properties of the nonpeptide angiotensin II antagonist losartan in glomeruli and mesangial cells at high concentrations.
PubMed: Optically active antifungal azoles. I. Synthesis and antifungal activity of (2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-b utanol and its stereoisomers.
PubMed: Iodine 125-phenylpentadecanoic acid and its beta-methyl substitute metabolism in cultured mouse embryonal myocytes--iodine-labelled fatty acids as tracers of myocardial high energy phosphate.
PubMed: [Separation and quantitative determination of seven aqueous depsides in Salvia miltiorrhiza by HPTLC scanning].
PubMed: Effects of R 56865 and phenytoin on mechanical, biochemical, and morphologic changes during ouabain intoxication in isolated perfused rabbit heart.
PubMed: 1H NMR study of lithium D-lactate.
PubMed: Metabolic oxidation and toxification of N-methylformamide catalyzed by the cytochrome P450 isoenzyme CYP2E1.
PubMed: Carbohydrate supplementation, glycogen depletion, and amino acid metabolism during exercise.
PubMed: Effects of dextromethorphan on rat brain during ischemia and reperfusion assessed by magnetic resonance spectroscopy.
PubMed: Kinetic mechanism of the endogenous lactate dehydrogenase activity of duck epsilon-crystallin.
PubMed: Spectrophotometric enzymatic assay for S-3-hydroxyisobutyrate.
PubMed: Synthesis of some 3-(1-azabicyclo[2.2.2]octyl) 3-amino-2-hydroxy-2-phenylpropionates: profile of antimuscarinic efficacy and selectivity.
PubMed: The absolute configuration of benproperinium dihydrogen phosphate, an antitussive drug.
PubMed: Metabolic acidosis induced by N-methyl-D-aspartate in brain slices of the neonatal rat: 31P- and 1H-magnetic resonance spectroscopy.
PubMed: Optimization of efficiency in the glyoxalase pathway.
PubMed: Biotransformation of muroctasin in mice.
PubMed: Stereochemistry and accessibility of prosthetic groups in flavoproteins.
PubMed: Synthesis and identification of 3-(4-hydroxy-1-naphthoxy)lactic acid as a metabolite of propranolol in the rat, in man, and in the rat liver 9000 g supernatant fraction.
PubMed: Synthesis and biological activity of derivatives of ubiquinone: photoaffinity analogues containing the 4-azido-2-nitroanilino group.
PubMed: Laminin increases both levels and activity of tyrosine hydroxylase in calf adrenal chromaffin cells.
PubMed: Lactate reduction in Clostridium propionicum. Purification and properties of lactyl-CoA dehydratase.
PubMed: Regional coronary hemodynamics during isoflurane-nitrous oxide anesthesia in patients with ischemic heart disease.
PubMed: A model for L-lactate binding to Cancer magister hemocyanin.
PubMed: Host-Pathogen Interactions : XXIII. The Mechanism of the Antibacterial Action of Glycinol, a Pterocarpan Phytoalexin Synthesized by Soybeans.
PubMed: Analysis of cell wall and membrane contamination of ribosomal preparations from Streptococcus mutans.
PubMed: Regulation of lactose transport by the phosphoenolpyruvate-sugar phosphotransferase system in membrane vesicles of Escherichia coli.
PubMed: Characterization of a respiratory mutant of Escherichia coli with reduced uptake of aminoglycoside antibiotics.
PubMed: D-lactate dehydrogenase of Desulfovibrio vulgaris.
PubMed: Combined coenzyme-substrate analogues of various dehydrogenases. Synthesis of (3S)- and (3R)-5-(3-carboxy-3-hydroxypropyl)nicotinamide adenine dinucleotide and their interaction with (S)- and (R)-lactate-specific dehydrogenases.
PubMed: Aerobic respiration in mutants of Escherichia coli accumulating quinone analogues of ubiquinone.
PubMed: Sodium-dependent methyl 1-thio-beta-D-galactopyranoside transport in membrane vesicles isolated from Salmonella typhimurium.
PubMed: Metabolism of 1-3H-ethanol by isolated liver cells. Time-course of the transfer of tritium from R,S-1-3H-ethanol to lactate and beta-hydroxybutyrate.
PubMed: Methionine transport in Yersinia pestis.
PubMed: Effect of the systemic fungicide carboxin on electron transport function in membranes of Micrococcus denitrificans.
PubMed: Absolute configuration of a metabolite in the m-fission pathway of protocatechuate.
PubMed: Mercapturic acid formation during the metabolism of arecoline and arecaidine in the rat.
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