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Category: solvents/deluents for cosmetic and fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless clear liquid (est) |
| Assay: | 97.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.85000 to 0.86000 @ 25.00 °C.
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| Pounds per Gallon - (est).: | 7.073 to 7.156
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| Refractive Index: | 1.44600 to 1.45200 @ 20.00 °C.
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| Boiling Point: | 332.00 to 333.00 °C. @ 760.00 mm Hg
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| Acid Value: | 1.00 max. KOH/g
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| Vapor Pressure: | 0.000120 mmHg @ 25.00 °C. (est) |
| Flash Point: | 317.00 °F. TCC ( 158.33 °C. )
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| logP (o/w): | 7.918 (est) |
| Soluble in: |
| | alcohol | | | water, 0.00371 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
| Similar Items: note |
| isoamyl myristate |
| isobutyl myristate |
| ethyl myristate |
| hexyl myristate |
| 2-methyl butyl myristate |
| methyl myristate |
| isopropyl myristate |
Organoleptic Properties:
| |
| Odor Type: oily |
| |
| Odor Strength: | low |
| |
| | oily fatty |
Odor Description: at 100.00 %. | mild oily fatty |
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| European information : |
| Most important hazard(s): | | None - None found. |
S 02 - Keep out of the reach of children. S 24/25 - Avoid contact with skin and eyes.
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 > 8000 mg/kg Journal of the American College of Toxicology. Vol. 9(2), Pg. 247, 1990.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | solvents/deluents for cosmetic and fragrance agents |
| Recommendation for butyl myristate usage levels up to: | | | not for fragrance use.
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| |
| Recommendation for butyl myristate flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
| | emollients | |
| | skin conditioning | |
Occurrence (nature, food, other): note
Synonyms:
| N- | butyl myristate | | N- | butyl myristate tech. grade | | | butyl N-tetradecanoate | | | butyl tetradecanoate | | | dermol 414 | | | myristic acid butyl ester | | | myristic acid N-butyl ester | | | myristic acid, butyl ester | | | nikkol BM | | | tetradecanoic acid butyl ester | | | tetradecanoic acid, butyl ester | | | wickenol 141 |
Articles:
| PubMed: | Development of Novel Ionic Liquid-Based Microemulsion Formulation for Dermal Delivery of 5-Fluorouracil. |
| PubMed: | Uric acid induces NADPH oxidase-independent neutrophil extracellular trap formation. |
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| PubMed: | Occurrence of fatty acid short-chain-alkyl esters in fruits of Celastraceae plants. |
| PubMed: | Increased expression of CYP4Z1 promotes tumor angiogenesis and growth in human breast cancer. |
| PubMed: | Immunomodulatory properties of novel nucleotide oligomerization domain 2 (nod2) agonistic desmuramyldipeptides. |
| PubMed: | Microstructure, morphology, and ultrafast dynamics of a novel edible microemulsion. |
| PubMed: | Effects of peanut-skin procyanidin A1 on degranulation of RBL-2H3 cells. |
| PubMed: | The nitric oxide-donating pravastatin, NCX 6550, inhibits cytokine release and NF-kB activation while enhancing PPARgamma expression in human monocyte/macrophages. |
| PubMed: | New approach to hydrophobic cyanine-type photosensitizer delivery using polymeric oil-cored nanocarriers: hemolytic activity, in vitro cytotoxicity and localization in cancer cells. |
| PubMed: | Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: potential clinical implications in hypertension. |
| PubMed: | Expression and characterization of CYP4V2 as a fatty acid omega-hydroxylase. |
| PubMed: | Protein delivery using nanoparticles based on microemulsions with different structure-types. |
| PubMed: | Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant. |
| PubMed: | Association of nicotinamide with parabens: effect on solubility, partition and transdermal permeation. |
| PubMed: | Comedogenicity in rabbit: some cosmetic ingredients/vehicles. |
| PubMed: | Microemulsions containing lecithin and sugar-based surfactants: nanoparticle templates for delivery of proteins and peptides. |
| PubMed: | Chemical composition and antifungal activity of volatiles from three Opuntia species growing in Tunisia. |
| PubMed: | Propofol reverses oxidative stress-attenuated glutamate transporter EAAT3 activity: evidence of protein kinase C involvement. |
| PubMed: | Mechanisms of the antispasmodic activity of 3,5-di-t-butyl catechol (DTCAT) on rat vascular smooth muscles. |
| PubMed: | Raf-1 kinase activation is uncoupled from downstream MEK/ERK pathway in cells treated with Src tyrosine kinase inhibitor PP2. |
| PubMed: | The nitric oxide-donating pravastatin derivative, NCX 6550 [(1S-[1alpha(betaS*, deltaS*), 2alpha, 6alpha, 8beta-(R*), 8a alpha]]-1,2,6,7,8,8a-Hexahydro-beta, delta, 6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphtalene-heptanoic acid 4-(nitrooxy)butyl ester)], reduces splenocyte adhesion and reactive oxygen species generation in normal and atherosclerotic mice. |
| PubMed: | Purification and characterization of C-terminal truncated forms of histone H2A in monocytic THP-1 cells. |
| PubMed: | On the incorporation of the non-steroidal anti-inflammatory naproxen into cationic O/W microemulsions. |
| PubMed: | Chronic oxidative stress reduces the respiratory burst response of neutrophils from beta-thalassaemia patients. |
| PubMed: | A role for ERK1/2 in EGF- and ATP-dependent regulation of amiloride-sensitive sodium absorption. |
| PubMed: | Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells. |
| PubMed: | [Research on components of Cornus officinalis extracted by supercritical carbon dioxide]. |
| PubMed: | Src tyrosine kinase inhibitor PP2 markedly enhances Ras-independent activation of Raf-1 protein kinase by phorbol myristate acetate and H2O2. |
| PubMed: | Qualitative investigation on hydrothermal treatment of Hinoki (Chamaecyparis obtusa) bark for production of useful chemicals. |
| PubMed: | Proteasome-mediated degradation of RNase L in response to phorbol-12-myristate-13-acetate (PMA) treatment of mouse L929 cells. |
| PubMed: | Endogenous oxidoreductase expression is induced by aminoglycosides. |
| PubMed: | Effect of butylated hydroxyanisole and some of its derivatives on human neutrophil oxidative burst: chemiluminescence evaluation. |
| PubMed: | Formulation study and anti-inflammatory efficacy of topical semi-solids containing a nitro ester of flurbiprofen. |
| PubMed: | Regulation of the very late antigen-4-mediated adhesive activity of normal and nonreleaser basophils: roles for Src, Syk, and phosphatidylinositol 3-kinase. |
| PubMed: | NF-kappaB is involved in the regulation of CD154 (CD40 ligand) expression in primary human T cells. |
| PubMed: | Phosphorylation of protein kinase Cdelta on distinct tyrosine residues regulates specific cellular functions. |
| PubMed: | A novel fluorescent probe diphenyl-1-pyrenylphosphine to follow lipid peroxidation in cell membranes. |
| PubMed: | Epidermal growth factor-stimulated tyrosine phosphorylation of caveolin-1. Enhanced caveolin-1 tyrosine phosphorylation following aberrant epidermal growth factor receptor status. |
| PubMed: | Activation of antioxidant/electrophile-responsive elements in IMR-32 human neuroblastoma cells. |
| PubMed: | Bradykinin-evoked Ca2+ mobilization in Madin Darby canine kidney cells. |
| PubMed: | Further characterization of hydrogen peroxide-dependent fatty acid alpha-hydroxylase from Sphingomonas paucimobilis. |
| PubMed: | Genetic and biochemical studies establish that the fungicidal effect of a fully depeptidized inhibitor of Cryptococcus neoformans myristoyl-CoA:protein N-myristoyltransferase (Nmt) is Nmt-dependent. |
| PubMed: | [Assay for oxidative stress injury by detection of luminol-enhanced chemiluminescence in a freshly obtained blood sample: a study to follow the time course of oxidative injury]. |
| PubMed: | Antioxidative properties of organotellurium compounds in cell systems. |
| PubMed: | Neuroprotective effects of pterin-6-aldehyde in gerbil global brain ischemia: comparison with those of alpha-phenyl-N-tert-butyl nitrone. |
| PubMed: | Ca(2+)-dependent p47phox translocation in hydroperoxide modulation of the alveolar macrophage respiratory burst. |
| PubMed: | Inhibitory effects of N-acetylcysteine on superoxide anion generation in human polymorphonuclear leukocytes. |
| PubMed: | Augmentation of oxidant injury to human pulmonary epithelial cells by the Pseudomonas aeruginosa siderophore pyochelin. |
| PubMed: | Distinct mechanisms of neurotransmitter release from PC 12 cells exposed to lead. |
| PubMed: | Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1. |
| PubMed: | Synthesis of racemic 2,4-dimethyltetradecanoic acid from Mycobacterium kansasii. |
| PubMed: | Effects of hydroquinone-type and phenolic antioxidants on calcium signals and degranulation of RBL-2H3 cells. |
| PubMed: | Effects of extracellular ATP on hepatic fatty acid metabolism. |
| PubMed: | Comparison of tBuBHQ with chemotactic peptide and phorbol ester in O2- production in HL-60 cells. |
| PubMed: | Role of intracellular calcium as a priming signal for the induction of nitric oxide synthesis in murine peritoneal macrophages. |
| PubMed: | Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. |
| PubMed: | A role for protein phosphorylation in modulating Ca2+ elevation in rabbit platelets treated with thapsigargin. |
| PubMed: | Granulation in livers of mice infected with Salmonella typhimurium is caused by superoxide released from host phagocytes. |
| PubMed: | Effects of 2,5-di(tert-butyl)-1,4-hydroquinone on intracellular free Ca2+ levels and histamine secretion in RBL-2H3 cells. |
| PubMed: | Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli. |
| PubMed: | Activation of protein kinase C inhibits potassium currents in cultured endothelial cells. |
| PubMed: | Eosinophil peroxidase-dependent hydroxyl radical generation by human eosinophils. |
| PubMed: | Contrasting effects of two arachidonate 5-lipoxygenase inhibitors on formyl-methionyl-leucyl-phenylalanine (fMLP) and complement fragment 5a induced human neutrophil superoxide generation. |
| PubMed: | Differentiation of HL60 promyelocytic cells is promoted by a 'differentiation enhancing factor' produced by erythroleukemia cells. |
| PubMed: | Activated polymorphonuclear leukocytes increase low-level chemiluminescence of isolated perfused rat lungs. |
| PubMed: | Single-channel properties and regulation of pinacidil/glibenclamide-sensitive K+ channels in follicular cells from Xenopus oocyte. |
| PubMed: | Augmented glucose use and pentose cycle activity in hepatic endothelial cells after in vivo endotoxemia. |
| PubMed: | Protein and amino acid oxidation is associated with increased chemiluminescence. |
| PubMed: | High correlation between lipid peroxide radical and tumor-promoter effect: suppression of tumor promotion in the Epstein-Barr virus/B-lymphocyte system and scavenging of alkyl peroxide radicals by various vegetable extracts. |
| PubMed: | Synthesis and biological studies of new lipid-soluble cisplatin analogues entrapped in liposomes. |
| PubMed: | Inhibitory effects of bis(2-aminohexyl)disulfide and its analogues on polymorphonuclear leukocyte functions in vitro. |
| PubMed: | Spin trapping evidence for the lack of significant hydroxyl radical production during the respiration burst of human phagocytes using a spin adduct resistant to superoxide-mediated destruction. |
| PubMed: | Inhibition by linoleic acid hydroperoxide of alveolar macrophage superoxide production: effects upon mitochondrial and plasma membrane potentials. |
| PubMed: | Protein kinase C involvement in lipid peroxidation and cell membrane damage induced by oxygen-based radicals in hepatocytes. |
| PubMed: | Phorbol esters modulate cyclic AMP accumulation in porcine thyroid cells. |
| PubMed: | In vitro effect of N-methoxy-3-(3,5-ditert-butyl-4-hydroxybenzylidene)-2-pyrrolidon e (E-5110), a novel nonsteroidal antiinflammatory agent, on generation of some inflammatory mediators. |
| PubMed: | Effect of the novel non-steroidal antiinflammatory agent N-methoxy-3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-one on in vitro generation of some inflammatory mediators. |
| PubMed: | Vapour and liquid diffusion of model penetrants through human skin; correlation with thermodynamic activity. |
| PubMed: | Correlation of thermodynamic activity and vapour diffusion through human skin for the model compound, benzyl alcohol. |
| PubMed: | Identification of hydrogen peroxide and hydroxyl radicals as mediators of leukocyte-induced myocardial dysfunction. Limitation of infarct size with neutrophil inhibition and depletion. |
| PubMed: | The superoxide-generating oxidase of leucocytes. NADPH-dependent reduction of flavin and cytochrome b in solubilized preparations. |
| PubMed: | [Failure to activate Epstein-Barr virus genome in a latently-infected human lymphoblastoid cell line with urine containing a bladder carcinogenesis promoter]. |
| PubMed: | Comedogenicity of current therapeutic products, cosmetics, and ingredients in the rabbit ear. |
| PubMed: | Hydrogen peroxide and hydroxyl radical mediation of activated leukocyte depression of cardiac sarcoplasmic reticulum. Participation of the cyclooxygenase pathway. |
| PubMed: | Mutation assay at the thymidine kinase locus in diploid human lymphoblasts. |
| PubMed: | Non-comedogenic cosmetics. |
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