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Category: fragrance agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to pale yellow crystalline solid (est) |
| Assay: | 97.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Refractive Index: | 1.52450 @ 20.00 °C.
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| Melting Point: | 55.00 to 58.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 140.00 °C. @ 8.00 mm Hg
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| Boiling Point: | 287.00 to 288.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.000278 mmHg @ 25.00 °C. (est) |
| Flash Point: | 215.00 °F. TCC ( 101.67 °C. )
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| logP (o/w): | 4.484 (est) |
| Soluble in: |
| | alcohol | | | water, 42.87 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
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| Odor Type: woody |
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| Odor Strength: | low |
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| | patchouli earthy camphoreous powdery |
Odor Description: at 100.00 %. | patchouli earthy camphor powdery |
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Patchouli alcohol 98%
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| Argeville |
| PATCHOULOL
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| Arora Aromatics |
| Patchouli Crystals
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| Augustus Oils |
| Patchoulol
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| Services |
| BOC Sciences |
| For experimental / research use only. |
| Patchouli Alcohol
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| Carbosynth |
| For experimental / research use only. |
| Patchouli Alcohol
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| Ernesto Ventós |
| PATCHOULOL
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| Gem Aromatics |
| Patchouli Alcohol content 27- 30 %
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| Hermitage Oils |
| Patchoulol Natural Isolate
Odor: characteristic Use: Adam Michael has this to say “Patchouli is a material I became aware of when I took charge of Hermitage over 10 years ago and it was instant love. What always fascinated me was how this aroma held my attention, how I would struggle to find any keywords to describe this material and instead found myself talking about feelings, about scenarios and atmospheres I had lived and how this material somehow captured the essence of that moment. Now as I write on 5/3/16 I once more find myself in patchouli heaven as this natural isolate of patchoulol obtained from patchouli fractions is nothing short of utterly exquisite. |
| Lluch Essence |
| PATCHOULOL
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| Matrix Scientific |
| For experimental / research use only. |
| Patchouli alcohol, 95+%
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| Perfumer Supply House |
| Patchoulol Crystals 99+% (Ventos)
Odor: Sweet, woody, powdery, earthy, camphoraceous |
| Perfumery Laboratory |
| PACHULOL natural (crystals) VENTOS (Patchoulol Crystals VENTOS)
Odor: Sweet, woody, powdery, earthy with camphor, dry note of patchouli |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Patchouli Alcohol ≥98%
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| SRS Aromatics |
| HEALINGWOOD
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| Synerzine |
| PATCHOULI ALCOHOL
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| Van Aroma |
| PATCHOULOL NATURAL 99%+
Odor: woody, earthy, camphoraceous |
| maps.vanaroma.com |
| Chemical Sources Association |
| Need This Item for Flavor/Food?: You can contact the CSA |
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | fragrance agents |
| RIFM Fragrance Material Safety Assessment: Search |
| IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice |
| maximum skin levels for fine fragrances: | | | 0.0200 % and are based on the assumption that the fragrance mixture is used at 20% in a consumer product (IFRA Use Level Survey). (IFRA, 2004)
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| Recommendation for patchouli alcohol usage levels up to: | | | 40.0000 % in the fragrance concentrate.
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| use level in formulae for use in cosmetics: | | | 0.1100 %
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| Dermal Systemic Exposure in Cosmetic Products: | | | 0.0028 mg/kg/day (IFRA, 2004)
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| Recommendation for patchouli alcohol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1,6- | methanonaphthalen-1(2H)-ol, octahydro-4,8a,9 | | (1R-(1alpha,4beta, 4aalpha,6beta,8aalpha))- | octahydro-4,8a,9,9-tetramethyl-1,6-methano-1(2H)-naphthol | | | octahydrotetramethyl methano-1-naphthol | | | patchouli alcohol | | | patchouli camphor | | | patchoulol | | (-)- | patchoulol | | 2,2,6,8- | tetramethyltricyclo[5.3.1.03,8]undecan-3-ol |
Articles:
| PubMed: | Prevention of UV radiation-induced cutaneous photoaging in mice by topical administration of patchouli oil. |
| PubMed: | Expression, purification and activity assay of a patchoulol synthase cDNA variant fused to thioredoxin in Escherichia coli. |
| PubMed: | Characterization of solid dispersions of Patchouli alcohol with different polymers: effects on the inhibition of reprecipitation and the improvement of dissolution rate. |
| PubMed: | [Study on constituents of the aerial parts of Pogostemon cablin]. |
| PubMed: | Evaluation of the antibacterial activity of patchouli oil. |
| PubMed: | Identification of repellent and insecticidal constituents of the essential oil of Artemisia rupestris L. aerial parts against Liposcelis bostrychophila Badonnel. |
| PubMed: | Immunologic mechanism of Patchouli alcohol anti-H1N1 influenza virus may through regulation of the RLH signal pathway in vitro. |
| PubMed: | Antifungal effect of Allium tuberosum, Cinnamomum cassia, and Pogostemon cablin essential oils and their components against population of Aspergillus species. |
| PubMed: | Insecticidal and repellence activity of the essential oil of Pogostemon cablin against urban ants species. |
| PubMed: | Patchouli alcohol, an essential oil of Pogostemon cablin, exhibits anti-tumorigenic activity in human colorectal cancer cells. |
| PubMed: | Virtual screening of compounds from the patchouli oil of Pogostemon herba for COX-1 inhibition. |
| PubMed: | Anti-inflammatory activity of patchouli alcohol in RAW264.7 and HT-29 cells. |
| PubMed: | [Quantitative model for patchouli alcohol in Pogostemon cablin by near-infrared spectroscopy]. |
| PubMed: | Quantitative and physical evaluation of patchouli essential oils obtained from different sources of Pogostemon cablin. |
| PubMed: | Technology for efficient and successful delivery of vermicompost colonized bioinoculants in Pogostemon cablin (patchouli) Benth. |
| PubMed: | Enhancing the copy number of episomal plasmids in Saccharomyces cerevisiae for improved protein production. |
| PubMed: | Selective separation of patchouli alcohol from the essential oil of Cablin potchouli by inclusion crystalline method. |
| PubMed: | Acaricidal activity of DHEMH, derived from patchouli oil, against house dust mite, Dermatophagoides farinae. |
| PubMed: | Oral administration of patchouli alcohol isolated from Pogostemonis Herba augments protection against influenza viral infection in mice. |
| PubMed: | Chemical constituents, antioxidant and antimocrobial activity of essential oil of Pogostemon paniculatus (Willd.). |
| PubMed: | Chemical diversity in the essential oil of Indian valerian (Valeriana jatamansi Jones). |
| PubMed: | Enhanced extraction of patchouli alcohol from Pogostemon cablin by microwave radiation-accelerated ionic liquid pretreatment. |
| PubMed: | Anti-inflammatory activity of patchouli alcohol isolated from Pogostemonis Herba in animal models. |
| PubMed: | Inhibitory effect and possible mechanism of action of patchouli alcohol against influenza A (H2N2) virus. |
| PubMed: | Involvement of nitric oxide (NO) signalling pathway in the antidepressant activity of essential oil of Valeriana wallichii Patchouli alcohol chemotype. |
| PubMed: | Patchouli alcohol: in vitro direct anti-influenza virus sesquiterpene in Pogostemon cablin Benth. |
| PubMed: | Anti-inflammatory effect of patchouli alcohol isolated from Pogostemonis Herba in LPS-stimulated RAW264.7 macrophages. |
| PubMed: | Terpenoid compositions and antioxidant activities of two Indian valerian oils from the Khasi Hills of north-east India. |
| PubMed: | Antidepressant effect of Valeriana wallichii patchouli alcohol chemotype in mice: Behavioural and biochemical evidence. |
| PubMed: | Volatile oil composition of Pogostemon heyneanus and comparison of its composition with patchouli oil. |
| PubMed: | Sedative effects of vapor inhalation of the essential oil of Microtoena patchoulii and its related compounds. |
| PubMed: | Diversion of flux toward sesquiterpene production in Saccharomyces cerevisiae by fusion of host and heterologous enzymes. |
| PubMed: | [Analysis of the chemical constituents of volatile oil from Asarum insigne by GC-MS]. |
| PubMed: | [Identification method with significant specificity of volatile oil of Pogostemon cablin]. |
| PubMed: | Elucidation of possible mechanism of analgesic action of Valeriana wallichii DC chemotype (patchouli alcohol) in experimental animal models. |
| PubMed: | Chemical analysis and biological activity of the essential oils of two valerianaceous species from China: Nardostachys chinensis and Valeriana officinalis. |
| PubMed: | Qualitative analysis of the smoke-stream of different kinds of incense by SPME/GC-MS. |
| PubMed: | Novel silicon-based patchouli odorants of the trialkyl(1-hydroxy-1-methylethyl)silane type: design, synthesis, and olfactory properties. |
| PubMed: | [Self-microemulsifying drug delivery system of patchoulic alcohol to improve oral bioavailability in rats]. |
| PubMed: | [Studies on characteristics of volatile oil and micro-identification between Herba Pogostemonis and Herba Agastachis rugosae]. |
| PubMed: | Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-(2)H(1)]farnesyl diphosphate catalyzed by recombinant patchoulol synthase. |
| PubMed: | Kanokonyl acetate-rich Indian valerian from northwestern Himalaya. |
| PubMed: | Chemical composition, oviposition deterrent and larvicidal activities against Aedes aegypti of essential oils from Piper marginatum Jacq. (Piperaceae). |
| PubMed: | Convenient TLC-based Identification Test for the Crude Drug "Pogostemoni Herba". |
| PubMed: | Insecticidal activity of Valeriana jatamansi (Valerianaceae) against mosquitoes. |
| PubMed: | Fragrance material review on patchouli alcohol. |
| PubMed: | Woody pretzels: spirocycles from vetiver to patchouli and Georgywood. |
| PubMed: | Comparative study on volatile components of Nardostachys rhizome. |
| PubMed: | Production of plant sesquiterpenes in Saccharomyces cerevisiae: effect of ERG9 repression on sesquiterpene biosynthesis. |
| PubMed: | Antioxidant activities and volatile constituents of various essential oils. |
| PubMed: | Solubility of the sesquiterpene alcohol patchoulol in supercritical carbon dioxide. |
| PubMed: | Compositional diversity of terpenoids in the Himalayan Valeriana genera. |
| PubMed: | Biotransformation of terpenoids by mammals, microorganisms, and plant-cultured cells. |
| PubMed: | Engineering the essence of plants. |
| PubMed: | Redirection of cytosolic or plastidic isoprenoid precursors elevates terpene production in plants. |
| PubMed: | The diverse sesquiterpene profile of patchouli, Pogostemon cablin, is correlated with a limited number of sesquiterpene synthases. |
| PubMed: | GC-MS fingerprint of Pogostemon cablin in China. |
| PubMed: | Determination of patchoulic alcohol in Herba Pogostemonis by GC-MS-MS. |
| PubMed: | [Re-study on characteristic fingerprint of volatile oil from Herba Pogostemonis by GC]. |
| PubMed: | [Investigation on the influential factors of the volatile oil and main constituent content in Pogostemon cablin]. |
| PubMed: | [Study on purification technology of patchouly oil with molecular distillation]. |
| PubMed: | [Pharmacokinetics of patchouli alcohol and patchouli alcohol in patchouli oil after iv administrated to rats]. |
| PubMed: | New sesquiterpene hydroperoxides with trypanocidal activity from Pogostemon cablin. |
| PubMed: | The effect of essential oils on methicillin-resistant Staphylococcus aureus using a dressing model. |
| PubMed: | Toxicity and repellency of patchouli oil and patchouli alcohol against Formosan subterranean termites Coptotermes formosanus Shiraki (Isoptera: Rhinotermitidae). |
| PubMed: | [Constituents analysis on volatile oil of Pogostemon cablin from different collection time cultivated in Hainan]. |
| PubMed: | [GC-MS analysis of volatile oil of Herba Pogostemonis collected from Leizhou county]. |
| PubMed: | [GC-MS analysis of volatile oil of herba Pogostemonis collected from Gaoyao county]. |
| PubMed: | [Study on the chemical constituents of the volatile oil from Lysimachia trientaloides Hemsl]. |
| PubMed: | Anti-emetic principles of Pogostemon cablin (Blanco) Benth. |
| PubMed: | Biotransformation of the fungistatic sesquiterpenoid patchoulol by botrytis cinerea |
| PubMed: | [Chemical constituents of Pogostemon cablin (Blanco) Benth]. |
| PubMed: | Purification and characterization of the sesquiterpene cyclase patchoulol synthase from Pogostemon cablin. |
| PubMed: | The screening of Chinese crude drugs for Ca2+ antagonist activity: identification of active principles from the aerial part of Pogostemon cablin and the fruits of Prunus mume. |
| PubMed: | Biosynthesis of the sesquiterpene patchoulol from farnesyl pyrophosphate in leaf extracts of Pogostemon cablin (patchouli): mechanistic considerations. |
| PubMed: | Regio-selective 10-hydroxylation of patchoulol, a sesquiterpene, by pithomyces species. |
| PubMed: | [Patchouli alcohol and beta patchoulene from Nardostachys chinensis]. |
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