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Category: herbicides / pesticides
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless to pale yellow clear liquid (est) |
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 14.00 to 18.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 231.00 to 233.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.122000 mmHg |
| Flash Point: | 194.00 °F. TCC ( 90.00 °C. )
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| logP (o/w): | 2.350 |
| Soluble in: |
| | alcohol | | | water, 755.9 mg/L @ 25 °C (est) |
| Insoluble in: |
| | water |
Organoleptic Properties:
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| Odor Type: floral |
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| Odor Strength: | medium |
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| Substantivity: | 216 hour(s) at 100.00 % |
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| | sweet hawthorn hay floral |
Odor Description: at 100.00 %. | sweet mild acetophenone hay Luebke, William tgsc, (1986) |
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 100 mg/kg National Technical Information Service. Vol. AD277-689
oral-mouse LD50 1207 mg/kg PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
BEHAVIORAL: MUSCLE WEAKNESS
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION Pharmazie. Vol. 31, Pg. 317, 1976.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
inhalation-human TCLo 1 mg/m3/1M SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE "Manual of Pharmacology and Its Applications to Therapeutics and Toxicology," 8th ed., Sollman, T., Philadelphia, W.B. Saunders Co., 1957Vol. 8, Pg. 192, 1957.
inhalation-mouse LC50 1752 mg/m3/15M JAT, Journal of Applied Toxicology. Vol. 14, Pg. 411, 1994.
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Safety in Use Information:
| Category: | herbicides / pesticides |
| Recommendation for para-chloroacetophenone usage levels up to: | | | not for fragrance use.
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| Recommendation for para-chloroacetophenone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | acetophenone, 4-chloro- | | | acetophenone, 4'-chloro- | | 1- | acetyl-4-chlorobenzene | | 4- | acetylchlorobenzene | | p- | acetylchlorobenzene | | p- | chloracetophenone | | 1-(4- | chloro-phenyl)-ethanone | | 4- | chloroacetophenone | | 4'- | chloroacetophenone | | p- | chloroacetophenone | | 4- | chlorophenyl methyl ketone | | p- | chlorophenyl methyl ketone | | 1-(4- | chlorophenyl)-ethanone | | 1-(4- | chlorophenyl)ethan-1-one | | 1-(4- | chlorophenyl)ethanone | | 4- | chlorophenylacetone | | 1-(4- | chlorphenyl)ethanon | | | ethanone, 1-(4-chlorophenyl)- | | | methyl 4-chlorophenyl ketone | | | methyl p-chlorophenyl ketone |
Articles:
| PubMed: | A Novel Carbonyl Reductase with Anti-Prelog Stereospecificity from Acetobacter sp. CCTCC M209061: Purification and Characterization. |
| PubMed: | Synthesis, Characterization, and Bioactivity of Schiff Bases and Their Cd(2+), Zn(2+), Cu(2+), and Ni(2+) Complexes Derived from Chloroacetophenone Isomers with S-Benzyldithiocarbazate and the X-Ray Crystal Structure of S-Benzyl- β -N-(4-chlorophenyl)methylenedithiocarbazate. |
| PubMed: | Synthesis of imine and reduced imine compounds containing aromatic sulfonamide: use as catalyst for in situ generation of ruthenium catalysts in transfer hydrogenation of acetophenone derivatives. |
| PubMed: | Halo-substituted thiosemicarbazones and their copper(II), nickel(II) complexes: detailed spectroscopic characterization and study of antitumour activity against HepG2 human hepatoblastoma cells. |
| PubMed: | Mechanism of ketone allylation with allylboronates as catalyzed by zinc compounds: a DFT study. |
| PubMed: | Immobilization of Acetobacter sp. CCTCC M209061 for efficient asymmetric reduction of ketones and biocatalyst recycling. |
| PubMed: | Synthesis, characterization, photophysical properties of a novel organic photoswitchable dyad in its pristine and hybrid nanocomposite forms. |
| PubMed: | Synthesis and anti-inflammatory evaluation of new substituted 1-(3-chlorophenyl)-3-(4-methoxyphenyl)-1H-pyrazole derivatives. |
| PubMed: | The rates of charge separation and energy destructive charge recombination processes within an organic dyad in presence of metal-semiconductor core shell nanocomposites. |
| PubMed: | Optimization of culture conditions to produce high yields of active Acetobacter sp. CCTCC M209061 cells for anti-Prelog reduction of prochiral ketones. |
| PubMed: | [Broader substrate specifity of Candida parapsilosis SCR II for catalyzing acetophenone derivatives by site-directed mutagenesis]. |
| PubMed: | Development of a nanocomposite system by combining an organic dyad 1-(4-chloro-phenyl)-3-(4-methoxy-naphthalen-1-yl)-Propenone with semiconductor TiO2 nanoparticles. |
| PubMed: | Asymmetric reduction of prochiral ketones to chiral alcohols catalyzed by plants tissue. |
| PubMed: | A new facile approach to the synthesis of 3-methylthio-substituted furans, pyrroles, thiophenes, and related derivatives. |
| PubMed: | Precolumn derivatization of cysteine residues for quantitative analysis of five major cytochrome P450 isoenzymes by liquid chromatography/tandem mass spectrometry. |
| PubMed: | Perfect polar stacking of parallel beloamphiphile layers. Synthesis, structure and solid-state optical properties of the unsymmetrical acetophenone azine DCA. |
| PubMed: | [Preparation of chiral alcohol by stereoselective reduction of acetophenone and chloroacetophenone with yeast cells]. |
| PubMed: | The methoxycarbonylation of aryl chlorides catalysed by palladium complexes of bis(di-tert-butylphosphinomethyl)benzene. |
| PubMed: | Bulky triarylarsines are effective ligands for palladium catalysed Heck olefination. |
| PubMed: | Oxime carbapalladacycle covalently anchored to high surface area inorganic supports or polymers as heterogeneous green catalysts for the Suzuki reaction in water. |
| PubMed: | Ab initio evaluation of intramolecular electron transfer reactions in halobenzenes and stabilized derivatives. |
| PubMed: | An oxime-carbapalladacycle complex covalently anchored to silica as an active and reusable heterogeneous catalyst for Suzuki cross-coupling in water. |
| PubMed: | 4-chloroacetophenone |
| PubMed: | Microbial degradation of chlorinated acetophenones. |
| PubMed: | Novel biotransformations of 4-chlorobiphenyl by a Pseudomonas sp. |
| PubMed: | [Morphological findings in the rabbit cornea after tear gas cauterization (author's transl)]. |
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