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Category: cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 239.00 °C. @ 760.00 mm Hg
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| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
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| logP (o/w): | -1.523 (est) |
| Soluble in: |
| | water, 5260 mg/L @ 25 °C (exp) | | | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Allantoin 98%
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| Allan Chemical |
| Allantoin
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| American International Chemical, LLC. |
| ALLANTOIN USP
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| BOC Sciences |
| For experimental / research use only. |
| Allantoin
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| Camden-Grey Essential Oils |
| Allantoin powder
Odor: characteristic Use: Allantoin is used in cosmetic applications such as shaving creams, shampoos, lipsticks, suntan products, hair gels, body powder, lotions and creams.
Usage recommended rate is from .5% to 2%. Make your emulsion, then add Allantoin during the cooling process (the emulsion should be below 90 deg. F). To completely mix and disperse Allantoin, very good mixing is a must. |
| Charkit Chemical |
| ALLANTOIN MEETS USP FOR COSMETIC USE
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| Charkit Chemical |
| ALLANTOIN USP
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| Connect Chemicals |
| Allantoin
Odor: characteristic Use: ALLANTOIN is used as an active ingredient in a lot of cosmetics with several beneficial effects including: a moisturizing and keratolytic effect, increasing the water content of the extracellular matrix and enhancing the desquamation of upper layers of dead skin cells, increasing the smoothness of the skin; promoting cell proliferation and wound healing; and a soothing, anti-irritant, and skin protectant effect by forming complexes with irritant and sensitizing agents.
ALLANTOIN is frequently present in toothpaste, mouthwash, and other oral hygiene products, in shampoos, lipsticks, anti-acne products, sun care products, and clarifying lotions, various cosmetic lotions and creams, and other cosmetic and pharmaceutical products. |
| ECSA Chemicals |
| ALLANTOIN
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| ECSA TRADE THE MOST UPDATED FINANCIAL PUBLICATION ON THE WORLD OF CHEMISTRY |
| Glentham Life Sciences |
| Allantoin
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| Kraft Chemical |
| Allantoin
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| Nanjing Jiancheng Chemical |
| Allantoin
Odor: characteristic Use: Allantoin is widely used as antiseptic for its bactericidal effect. It can constrain the bacterium, yeast, mould, gram-positive bacterium and gram-negative bacterium. Allantoin can be applied in cream, dew liquid, shampoo, hair conditioner, eye cosmetics, liquid cosmetics and other cosmetics. |
| Norman, Fox & Co. |
| ALLANTOIN
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| Penta International |
| ALLANTOIN POWDER USP
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| Penta International |
| ALLANTOIN POWDER
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| Sigma-Aldrich |
| For experimental / research use only. |
| Allantoin ≥98.0% (N)
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| TRI-K Industries |
| Allantoin
Odor: characteristic Use: An exceptional healing, soothing and moisturizing agent, Allantoin enhances the efficacy and appeal of dermatological and cosmetic formulations, leaving skin soft and supple. |
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | cosmetic agents |
| Recommendation for allantoin usage levels up to: | | | not for fragrance use.
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| Recommendation for allantoin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| Golm Metabolome Database: | Search |
| Metabolomics Database: | Search |
| KEGG (GenomeNet): | C01551 |
| HMDB (The Human Metabolome Database): | HMDB00462 |
| FooDB: | FDB001613 |
| YMDB (Yeast Metabolome Database): | YMDB00213 |
| Export Tariff Code: | 2933.21.0000 |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations: mederma, a topical skin gel produced by merz pharmaceuticals, llc, 4215 tudor lane greensboro, nc 27410, contains water (purified), peg-4, allium cepa (onion) bulb extraxt, xanthan gum, allantoin, fragrance, methylparaben and sorbic acid.
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Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (±)- | allantoin | | DL- | allantoin | | | allantoin powder | | | allantoin powder USP | | | allantoin USP | | | brookosome A | | | cordianin | | | cutemol emollient | | 2,5- | dioxo-4-imidazolidinyl-urea | | (2,5- | dioxo-4-imidazolidinyl)-urea | | (2,5- | dioxo-4-imidazolidinyl)urea | | 1-(2,5- | dioxo-4-imidazolidinyl)urea | | N-(2,5- | dioxo-4-imidazolidinyl)urea | | (2,5- | dioxo-imidazolidin-4-yl)-urea | | (2,5- | dioxoimidazolidin-4-yl)urea | | 1-(2,5- | dioxoimidazolidin-4-yl)urea | | | fancol TOIN | | | glyoxyldiureid | | | glyoxylic diureide | | | hemocane | | 4H- | imidazole-2,5-diol, 4-[(hydroxyiminomethyl)amino]- | | | paxyl | | | psoralon | | | sebical | | | septalan | | | uniderm A | | | urea, (2,5-dioxo-4-imidazolidinyl)- | | | urea, N-(2,5-dioxo-4-imidazolidinyl)- | | 5- | ureidohydantoin | | 5- | ureidohydrantoin |
Articles:
| PubMed: | Characterization of imidazoline receptors in blood vessels for the development of antihypertensive agents. |
| PubMed: | Antihypertensive action of allantoin in animals. |
| PubMed: | Effects of allantoin on cognitive function and hippocampal neurogenesis. |
| PubMed: | Biological system responses to zearalenone mycotoxin exposure by integrated metabolomic studies. |
| PubMed: | Rapid detection of economic adulterants in fresh milk by liquid chromatography-tandem mass spectrometry. |
| PubMed: | Diet-induced hyperinsulinemia differentially affects glucose and protein metabolism: a high-throughput metabolomic approach in rats. |
| PubMed: | Nanoparticulate silver increases uric acid and allantoin excretion in rats, as identified by metabolomics. |
| PubMed: | Pegloticase: a novel agent for treatment-refractory gout. |
| PubMed: | Distribution and function of allantoin (5-ureidohydantoin) in rice grains. |
| PubMed: | Effect of Dioscorea opposita Thunb. (yam) supplementation on physicochemical and sensory characteristics of yogurt. |
| PubMed: | Decrease of plasma glucose by allantoin, an active principle of yam ( Dioscorea spp.), in streptozotocin-induced diabetic rats. |
| PubMed: | Toxicometabolomics approach to urinary biomarkers for mercuric chloride (HgCl₂)-induced nephrotoxicity using proton nuclear magnetic resonance (¹H NMR) in rats. |
| PubMed: | Intake, digestibility and rumen dynamics of neutral detergent fibre in cattle fed low-quality tropical forage and supplemented with nitrogen and/or starch. |
| PubMed: | Pattern recognition analysis for the prediction of adverse effects by nonsteroidal anti-inflammatory drugs using 1H NMR-based metabolomics in rats. |
| PubMed: | Improved high-performance liquid chromatography (HPLC) method for qualitative and quantitative analysis of allantoin in Zea mays. |
| PubMed: | Uric acid recycling in the shield bug, Parastrachia japonensis (Hemiptera: Parastrachiidae), during diapause. |
| PubMed: | Urinary excretion of purine derivatives as an index of microbial protein synthesis in the camel (Camelus dromedarius). |
| PubMed: | Suppressive effect of viscous dietary fiber on elevations of uric acid in serum and urine induced by dietary RNA in rats is associated with strength of viscosity. |
| PubMed: | Rasburicase: potential role in managing tumor lysis in patients with hematological malignancies. |
| PubMed: | Aspects of excretion of antlion larvae (Neuroptera: myrmeleontidae) during feeding and non-feeding periods. |
| PubMed: | Major constituents, leptin, and non-protein nitrogen compounds in mares' colostrum and milk. |
| PubMed: | Ultrastructural localization of xanthine oxidoreductase activity in isolated rat liver cells. |
| PubMed: | High versus low protein diets to mink--postprandial plasma urea and creatinine response, osmotic load and pattern of nitrogen and electrolyte excretion. |
| PubMed: | Effectiveness of a nonrinse, alcohol-free antiseptic hand wash. |
| PubMed: | Identification of allantoin, uric acid, and indoxyl sulfate as biochemical indicators of filth in food packaging by LC. |
| PubMed: | Effects of corn particle size and source on performance of lactating cows fed direct-cut grass-legume forage. |
| PubMed: | A modified HET-CAM assay approach to the assessment of anti-irritant properties of plant extracts. |
| PubMed: | Intraruminal supplementation with increasing levels of exogenous polysaccharide-degrading enzymes: effects on nutrient digestion in cattle fed a barley grain diet. |
| PubMed: | Biosynthesis and catabolism of caffeine in low-caffeine-containing species of Coffea. |
| PubMed: | Xanthine degradation and related enzyme activities in leaves and fruits of two coffea species differing in caffeine catabolism. |
| PubMed: | Synergistic operation of the CAR2 (Ornithine transaminase) promoter elements in Saccharomyces cerevisiae. |
| PubMed: | Effect of dietary or abomasal supplementation of exogenous polysaccharide-degrading enzymes on rumen fermentation and nutrient digestibility. |
| PubMed: | Food intake, nutrient utilization and water turnover in the lesser mouse-deer (Tragulus javanicus) given lundai (Sapium baccatum). |
| PubMed: | Compositional and toxicological evaluation of the diazotrophic cyanobacterium, Cyanothece sp. strain ATCC 51142. |
| PubMed: | Winter evaluation of a postmilking powdered teat dip. |
| PubMed: | [Purine and pyrimidine metabolites for the estimation of rumen metabolism: HPLC analysis in milk and blood plasma]. |
| PubMed: | [The effect of aldioxa on the formation of gastritis induced with sodium hydroxide]. |
| PubMed: | Uricogenic potential of selected cooked foods in rats. |
| PubMed: | Improved reagent for detection of allantoin in thin-layer chromatographic method for urine stains on foods and packaging. |
| PubMed: | Effects of intraruminal sodium chloride infusion on rumen and renal nitrogen and electrolyte dynamics in sheep. |
| PubMed: | [Allantoin excretion of wethers in variations of raw protein and energy administration]. |
| PubMed: | Induction of tumours in rats by feeding nitrosatable amines together with sodium nitrite. |
| PubMed: | Extraction and thin layer chromatographic confirmation of urine residues: new plate development. |
| PubMed: | Food additives. |
| PubMed: | Nitrogen retention in rats fed on diets enriched with arginine and glycine. 1. Improved N retention after trauma. |
| PubMed: | Utilization of dried microbial cells grown on methanol in a semi-purified diet for growing pigs. |
| PubMed: | Long-term feeding study on disodium 5-ribonucleotide in dogs. |
| PubMed: | Extraction and thin layer chromatographic confirmation of urine residues from food packaging materials. |
| PubMed: | Thin layer chromatographic test for mammalian urine on wheat. |
| PubMed: | Observations on the regulation of uricase activity during development of Drosophila melanogaster. |
| PubMed: | Decomposition of nucleic acids and some of their degradation products by microorganisms. |
| PubMed: | PROTEINURIA IN NEW-BORN CALVES FOLLOWING THE FEEDING OF COLOSTRUM. |
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