2-methyl pyrazine
2-methylpyrazine
 
Notes:
Flavouring agent. Present in many foods, e.g. bakery products, dairy products, meats, baked or French fried potato, roasted barley, cocoa, coffee, tea, roasted filbert, roasted pecan, peanut, soy products, rum and whisky
  • Advanced Biotech
    • Advanced Biotech. Inc.
      Inspired by Nature
      A diverse range of products, all meeting our stringent commitment to quality.
      Advanced Biotech is a leading manufacturer and supplier of high-quality Natural flavoring ingredients & botanical extracts for the food/beverage, cosmetic and personal care industries. With over 25 years of experience working with Fermentation processing & botanical extracts, we can help develop new innovative and functional products for today’s competitive marketplace. Our company prides itself in the ability to cater to our customer’s specific needs while maintaining our focus on integrity, honesty and the commitment to high quality product standards. We proudly offer our quality Natural ingredients to companies around the world.
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      Product(s):
      4005 2 METHYL PYRAZINE
      SDS
       
  • Augustus Oils
    • Augustus Oils Ltd
      The Premier Supplier
      Augustus Oils Ltd, in harmony with nature - to present it at its best...
      A wealth of experience, expertise and knowledge has allowed Augustus to bridge the gulf in expectation and trust between growers and users of natural ingredients. The Company works in partnership with customers on the one hand, and growers, farmers and distillers on the other. Both users and producers can then focus on exactly what they do best, while skilled Augustus technicians closely monitor and control the delivered product. This ensures users can have the confidence that they will receive the best raw materials suited to their requirements.
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      Product(s):
      2 Methyl Pyrazine
       
  • Beijing Lys Chemicals
    • Beijing Lys Chemicals Co, LTD.
      From Grams to Tons
      Fine chemical high-tech company which contains R&D, production, and sales.
      BEIJING LYS CHEMICALS CO, LTD, established in 2004, is a fine chemical high-tech company which contains R&D, production, and sales. We mainly engaged in export and technology development of flavor and fragrance materials and pharmaceutical intermediates. We have nearly 500 kinds of products, from grams to tons, exported to USA, Europe, South Asia and etc. And we custom manufacture new products according to customers’ needs, and serve good quality products and service. Our goal is to become a fine chemical enterprise which could provide special products and services.
      Email: Mr. Jia
      Email: Mr. Guo
      Voice: 86-10-68418738
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      Mr. Guo86-10-68483445
      Mr. Guo86-10-68418739
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      Product(s):
      10108 2-Methyl pyrazine
       
  • Berjé
    • Berje Inc.
      Where the world comes to its senses
      Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.
      Berjé is a family-owned business that has been in operation for six decades. The company's origins and strength lie in a profound understanding of the supply and the quality of the diverse raw materials consumed by the flavor and fragrance industries. This base was expanded upon more than two decades ago to include fragrance production. The company's unparalleled raw material expertise is focused on the supply of essential oils and aromatic chemicals. This is supported by our long-standing relationships with a worldwide fabric of producers ensuring the greatest prospects for uninterrupted supply in markets that are often volatile and unpredictable.
      Email: For Information
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      Product(s):
      2-Methyl Pyrazine
       
  • BOC Sciences
    • BOC Sciences
      Best of Chemicals Supplier
      Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds.
      BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services.
      BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies.
      Email: Marketing
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      Voice: 1-631-485-4226
      Fax: 1-631-614-7828
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      Europe44-203-286-1088
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      Product(s):
      109-08-0 2-Methylpyrazine 95%
       
  • Charkit Chemical
    • Charkit Chemical Corporation
      The Specialty Chemical Specialists
      Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.
      about: Since 1982, Charkit has been committed to expanding the markets we serve as our roster of products and services continues to grow with us. Our substantial portfolio of personal care ingredients now include a wide array of luxury and exotic components to compliment the key products we have always offered. We have expanded our offerings to the nutraceutical, industrial, and resin markets with a growing roster of versatile and unique ingredients. We continue to lead the way in our traditional markets such as Metal and Water Treatment, Imaging, Flavor & Fragrance, Aroma and Food. Our Pharmaceutical offerings continue to expand, still anchored by the Boronic Derivatives that meet the demands of Suzuki coupling reactions. Please contact us to learn how we can help you reach your goals.
      Email: Sales
      Voice: 203-299-3220
      Fax: 203-299-1355
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      Products List: View
      Product(s):
      METHYL PYRAZINE, 2- FEMA 3309
       
  • Endeavour Specialty Chemicals
    • Endeavour Specialty Chemicals Ltd
      Expertise in high impact aroma chemicals
      Endeavour Speciality Chemicals offers high-impact aroma chemicals, at small to medium scale.
      Speciality Chemical has more than 25 years experience of manufacturing high-impact aroma chemicals. With our core expertise in sulfur and heterocyclic chemistries, Endeavours products have applications in a range of industry sectors including flavours and fragrances, pharmaceutical research and material sciences. Endeavour also offer custom synthesis and contract manufacturing services at their UK manufacturing site.
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      Product(s):
      PZ0120 2-Methylpyrazine 99% F&F
       
  • FCI SAS
    • FCI SAS
      Inspired by Nature
      At FCI customer service is not a department it’s an attitude.
      Our team is composed of motivated professionals with great experience in the flavours and fragrances market. Our company has been serving this industry for more than 40 years and is ISO 9001 certified since 2009 . Whatever your question on flavour and fragrance ingredients: commercial, technical or regulatory – we will answer it very quickly.
      Email: Info
      Email: Philippe Faucher
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      Voice: +33 (0)1 34 25 58 10
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      About Us
      Product(s):
      50023 2-METHYL PYRAZINE
       
  • Fleurchem
    • Fleurchem, Inc.
      Have A Flavorful Day
      A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.
      Operating out of the 200,000 sq. ft., former Hercules/PFW facility in Middletown, NY; Fleurchem produces a full range of natural isolates, synthetic chemicals & specialities, essential oils and flavors. Additionally, the company performs toll manufacturing, as well as custom chemical synthesis for a wide range of clients.
      Email: Information
      US Voice: 845-341-2100
      US Fax: 845-341-2121
      Product(s):
      2-methyl pyrazine
       
  • Frutarom
    • FRUTAROM USA INC,
      Flavor & Specialty Ingredients
      Your preferred partner for flavour and fragrance success.
      Our broad and diverse product portfolio is designed to provide and cater for every flavor and taste profile required by our customer base and incorporates historic, and iconic, market leading products.
      Email: Info
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      Email: Sales
      Voice: +44 (0) 1429 863 222
      Products List: View
      Product(s):
      441M2400 2-METHYL PYRAZINE KOSHER
       
  • Indukern F&F
  • Jiangyin Healthway
    • Jiangyin Healthway International Trade Co., Ltd
      Independent Ingredients Supplier
      We provide custom synthesis and contract manufacturing from milligrams to metric tonnes.
      Jiangyin Healthway International Trade Co., Ltd is a professional company, main engaged in manufacturing and exporting aroma chemicals ,food additives , cosmetic ingredient ,pharmaceutical intermediates & other fine chemicals; especially on aroma chemicals , as the major manufacturer of heterocyclic and sulphur aroma compounds , we are the leading independent ingredients supplier to the flavour and fragrance industries in China, can offer hundreds of different high quality aroma chemicals.
      Email: Info
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      Voice: 86-510-86023169
      Fax: 86-510-86023170
      Mobile0086-13093133011
      Services
      Biochemical
      Natural Food Colour
      New functional food ingredients
      Product(s):
      HL0101 2-Methyl Pyrazine
       
  • Lluch Essence
    • Lluch Essence S.L.
      A family company dedicated to sales and distribution
      Flexibility, availability, price and quality.
      Flexibility, availability, price and quality make LLUCH ESSENCE S.L. one of Europe’s references when it comes to essential oils and aroma chemicals, and it is now well known all around the world.
      Email: Info
      Voice: 34 93 379 38 49
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      Product(s):
      PYRAZINE 2-METHYL
       
  • M&U International
    • M&U International LLC
      Steady supply & demand
      Meeting customers increasing demands at home as well as abroad.
      M&U dedicates itself to the development and production of new products as well as continuously promoting those new products. We’ve maintained a steady supply&demand relationship with a large number of manufacturers at home and abroad. We’ve developed an extensive network and because of our relationships with these manufacturers, we’re able to provide a stable supply of great quality materials. We’re located in China’s largest communications hub, Shanghai and in the U.S. near one of the largest sea ports on the East Coast. The strategic locations of our facilities ensure convenient, prompt and secure delivery of our products to our customers.
      Email: Sales
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      Voice: +86-21-32515501 60762991 60762992
      Fax: +86-21-32515502 64204960
      US Voice: 908-359-9000
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      News
      Product(s):
      H0002 2-METHYL PYRAZINE, Kosher
      N0292 Nat. 2-Methyl Pyrazine
       
  • Moellhausen
  • Pell Wall Perfumes
    • Pell Wall Perfumes
      Hand-made fragrances
      Pell Wall maintains a broad palette of ingredients & in order to keep stocks fresh & the options wide we also sell from our own stock.
      Pell Wall was founded by perfumer Chris Bartlett to provide exclusive hand-made fragrances to a select few people who love them. All our products are created using fine quality ingredients, many of which we also offer for sale to other perfumers and enthusiasts. Pell Wall make fragrances for men, for women and for the home.
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      Product(s):
      Methyl Pyrazine
      As with all pyrazines this is used in traces – Methyl Pyrazine at 0.1% in Ethanol has a nutty-chocolate odour (reminiscent of hazelnut chocolate spread) but also has a distinctive green-vegetable aspect. Very useful as part of an authentic chocolate or coffee accord, and can also contribute a nutty note to any gourmand fragrance or form part of a natural-smelling green complex.
       
       
  • Penta International
  • Robinson Brothers
  • Sigma-Aldrich
  • Sunaux International
    • Sunaux International
      Buy With Confidence
      We have industry leading processes and procedures to ensure nothing but the most reliable product.
      Sunaux International was founded in 2012 by the owner Mr.John Felton after spending 18 years involved in developing global business in the aromatic chemicals, fragrance and flavour compounds business.
      Email: John Felton
      Email: Stephen Zhou (Sales)
      Voice: 0512-57995626
      Fax: 0512-57570299
      Sales0512-57995626
      Sales0512-57570299
      News
      Product(s):
      H0002 2-Methyl Pyrazine
       
  • Synerzine
    • Synerzine, Inc.
      Innovation. Customization. Aroma Ingredients.
      Synerzine is a leading supplier of flavor and fragrance ingredients.
      Synerzine expresses what we have grown to embody as an organization - the synergy and connection between raw ingredients, science, technology, and the final product. Our experienced team is passionate about bringing our customers high-quality innovative ingredients that they can trust.
      Building upon our 44 year history, the Synerzine team provides customers around the globe with convenient access to over 1200 high-quality aroma ingredients. We actively engage with customers to add a wide array of new products and services on a regular basis. Our aim is to delight every customer with our exceptional services, large product selection, customization and the highest quality and safety standards. We provide our customers with true value designed to help them bring their products to market faster.
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      Product(s):
      512 2-Methylpyrazine
       
  • Taytonn
    • TAYTONN PTE LTD
      Supplying Asia Pacific
      We fully understand the demands of the F&F industry and we endeavour to supply quality products, with ready availability and a personalised service.
      Since 2001 TAYTONN has been distributing key ingredients to the Fragrance and Flavor industry in Asia. We work closely with customers, principals and vendors. Together we forecast demand and match it with supply of aroma chemicals, essential oils and natural isolates & extracts. Sourced from around the world, our F&F ingredient inventory in Singapore is ready to ship to any location in Asia and beyond. Time and again, we help our principals introduce new discoveries to the F&F market - stimulating creativity and bringing value added proposition to our customers.
      Email: Info
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      Voice: + 65 - 6861 8113
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      Product(s):
      2-Methylpyrazine
       
  • TCI AMERICA
    • TCI AMERICA
      Moving Your Chemistry Forward
      We continuously strive to advance our technology.
      With East & West Coast distribution centers, count on TCI to deliver products quickly and reliably. Over 30,000 Reagents available today in benchtop to bulk quantities. We also offer custom synthesis solutions. Sign up for a TCI account today for fast and free shipping!
      Tokyo Chemical Industry Co., Ltd. (TCI) is a leading worldwide manufacturer of specialty organic chemicals founded in 1946. TCI provides organic laboratory chemicals as well as pharmaceutical, cosmetic and functional materials. More than 70 years of synthesis experience and multi-purpose plants enable TCI to offer more than 30,000 products as well as custom synthesis.
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      Voice: 1-800-423-8616
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      Product(s):
      M0736 2-Methylpyrazine >98.0%(GC)
       
  • R C Treatt & Co Ltd
    • R C Treatt and Co Ltd
      Innovative ingredient solutions
      World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.
      We offer innovative and trend-setting product concepts for our customers, collaborating with them to create true value for their products.
      Email: Enquiries
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      Voice: +44 (0) 1284 702500
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      Product(s):
      2-Methylpyrazine Halal, Kosher

      Used in flavours up to 10ppm, in applications such as baked goods, meat and cereal products, confectionery, beverages, and sauces.
       
       
  • United International
    • Qingdao Free Trade Zone United International Co Ltd
      Quality Products
      A partner in your supply chain solution.
      Qingdao Free Trade Zone United International Trade Co., Ltd.was founded in 1996, specializing in the production and import and export of food additives,flavor raw materials and pharmaceutical and chemical raw materials. The company has experienced R&D and business personnel,product quality, low price, efficient service and fast insight and grasp the latest market information.
      Email: Info
      Email: Sales
      Voice: +86-532-83893699
      Fax: +86-532-83893695
      Product(s):
      1001 2-Methyl Pyrazine
       
  • Ernesto Ventós
  • Vigon International
    • Vigon International
      Passion for Simplicity
      Manufacturer and supplier of high quality flavor and fragrance ingredients.
      The growth and success of Vigon is due in large part to a unique corporate concept that Vigon has developed and established within the industry: Creative Partnerships. This partnership concept has been and continues to be the foundation and guiding principle for all of Vigon's activities.
      US Email: Sales
      US Voice: 570-476-6300
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      Product(s):
      500614 Methyl-2 Pyrazine
       
  • WholeChem
    • WholeChem, LLC
      Connecting Innovators To the Building Blocks Of the Universe
      Custom manufacturer and distributor of specialty ingredients. We make global local.
      SQF-Certified Supplier
      We owe our success to our integrity, our dedication to the industry, and our commitment to our clients. We invite your inquiries regarding our current product list and any other products you may be having trouble sourcing.
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      Product(s):
      2-Methyl pyrazine
       
Synonyms   Articles   Notes   Search
Fragrance Demo Formulas    Flavor Demo Formulas
CAS Number: 109-08-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 203-645-8
FDA UNII: RVC6500U9C
Nikkaji Web: J1.501F
Beilstein Number: 0105778
MDL: MFCD00006142
CoE Number: 2270
XlogP3: 0.20 (est)
Molecular Weight: 94.11682000
Formula: C5 H6 N2
NMR Predictor: Predict (works with chrome or firefox)
Category: flavor and fragrance agents
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Perfumer and Flavorist: Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
JECFA Food Flavoring: 761  2-methylpyrazine
DG SANTE Food Flavourings: 14.027  2-methylpyrazine
FEMA Number: 3309 2-methylpyrazine
FDA:No longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF):109-08-0 ; 2-METHYLPYRAZINE
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Appearance: colorless to pale yellow clear liquid (est)
Assay: 98.00 to 100.00 % 
Food Chemicals Codex Listed: Yes
Specific Gravity: 1.01000 to 1.03000 @  25.00 °C.
Pounds per Gallon - (est).: 8.404 to  8.571
Specific Gravity: 1.00700 to 1.03300 @  25.00 °C.
Pounds per Gallon - est.: 8.379 to 8.596
Refractive Index: 1.50400 to 1.50600 @  20.00 °C.
Refractive Index: 1.50100 to 1.50900 @  20.00 °C.
Melting Point: -29.00 °C. @ 760.00 mm Hg
Boiling Point: 135.00 °C. @ 761.00 mm Hg
Boiling Point: 136.00 to  137.00 °C. @ 760.00 mm Hg
Vapor Pressure: 9.690000 mmHg @ 25.00 °C. (est)
Vapor Density: 3.2 ( Air = 1 )
Flash Point: 122.00 °F. TCC ( 50.00 °C. )
logP (o/w): 0.210
Soluble in:
 alcohol
 fixed oils
 water, 1000000 mg/L @ 20 °C (exp)
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
 
Odor Type: nutty
 
Odor Strength: high ,
recommend smelling in a 1.00 % solution or less
 
 nutty  cocoa  roasted  chocolate  peanut  green  
Odor Description:
at 1.00 % in dipropylene glycol. 
nutty cocoa roasted chocolate peanut green
 
 nutty  brown  nut skin  musty  earthy  roasted  
Odor Description:
Nutty, brown, nut skin, musty, pyrazine and earthy with a slight roasted nuance
Mosciano, Gerard P&F 19, No. 3, 51, (1994)
 
 
Flavor Type: nutty
 
 nutty  brown  roasted  musty  astringent  
Taste Description:
at 75.00 ppm.  
Nutty, brown, roasted, musty and astringent
Mosciano, Gerard P&F 19, No. 3, 51, (1994)
 
Odor and/or flavor descriptions from others (if found).
 
Bedoukian Research
2-METHYL PYRAZINE ≥99.0%, FCC, Kosher
Odor Description: A nutty, cocoa, roasted meat aroma
Taste Description: nutty
Used in coffee, cocoa, roasted meats, fresh bread and peanut butter flavors.
 
R C Treatt & Co Ltd
2-Methylpyrazine Halal, Kosher
Odor Description: nutty/roasted, peanut/chocolate, roast chicken
Taste Description: nutty
Used in flavours up to 10ppm, in applications such as baked goods, meat and cereal products, confectionery, beverages, and sauces.
 
Kingchem Laboratories
2 METHYL PYRAZINE
Odor Description: Roast, Coffee, Stir-fry eathnut
 
Pell Wall Perfumes
Methyl Pyrazine
Odor Description: Nutty, cocoa, roasted, green. Powerful
As with all pyrazines this is used in traces – Methyl Pyrazine at 0.1% in Ethanol has a nutty-chocolate odour (reminiscent of hazelnut chocolate spread) but also has a distinctive green-vegetable aspect. Very useful as part of an authentic chocolate or coffee accord, and can also contribute a nutty note to any gourmand fragrance or form part of a natural-smelling green complex.
 
 
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
None found
Synonyms   Articles   Notes   Search   Top
Suppliers:
Advanced Biotech
2 METHYL PYRAZINE
Ambles Nature et Chimie
2-METHYL PYRAZINE
Anhui Haibei
2-Methyl Pyrazine
Odor: Green nutty cocoa roasted chocolate meaty peanut
Anhui Suzhou Jinli Aromatic Chemicals
2-Methyl Pyrazine
Odor: roast, coffee, Fried Peanuts
Augustus Oils
2 Methyl Pyrazine
Services
Beijing Lys Chemicals
2-Methyl pyrazine
Berjé
2-Methyl Pyrazine
Media
BOC Sciences
For experimental / research use only.
2-Methylpyrazine 95%
Charkit Chemical
METHYL PYRAZINE, 2- FEMA 3309
Citrus and Allied Essences
2-Methyl Pyrazine FCC
Market Report
EMD Millipore
For experimental / research use only.
2-Methylpyrazine
Endeavour Specialty Chemicals
2-Methylpyrazine 99% F&F
Speciality Chemical Product Groups
Ernesto Ventós
2-METHYLPYRAZINE
Odor: COFFEE, NUT
FCI SAS
2-METHYL PYRAZINE
Odor: Roast, coffee, earthy
Fleurchem
2-methyl pyrazine
Frutarom
2-METHYL PYRAZINE
KOSHER
Flavor: Nutty, Roasted, Musty, Earthy
IFF
2-METHYL PYRAZINE
KOSHER
Flavor: Nutty, Roasted, Musty, Earthy
Indukern F&F
2-METHYL PYRAZINE
Odor: NUTTY, CACAO, TOASTED, CHOCOLATE
Jiangyin Healthway
2-Methyl Pyrazine
New functional food ingredients
Jinan Enlighten Chemical Technology(Wutong Aroma )
2-Methyl pyrazine, Kosherk
Kingchem Laboratories
2 METHYL PYRAZINE
Odor: Roast, Coffee, Stir-fry eathnut
Lluch Essence
PYRAZINE 2-METHYL
M&U International
2-METHYL PYRAZINE, Kosher
M&U International
Nat. 2-Methyl Pyrazine
Moellhausen
2-METHYL PYRAZINE
Odor: cocoa, noce, peanuts, chocolate
Pearlchem Corporation
2-Methyl Pyrazine
Pell Wall Perfumes
Methyl Pyrazine
Odor: Nutty, cocoa, roasted, green. Powerful
Use: As with all pyrazines this is used in traces – Methyl Pyrazine at 0.1% in Ethanol has a nutty-chocolate odour (reminiscent of hazelnut chocolate spread) but also has a distinctive green-vegetable aspect. Very useful as part of an authentic chocolate or coffee accord, and can also contribute a nutty note to any gourmand fragrance or form part of a natural-smelling green complex.
Penta International
2-METHYL PYRAZINE FCC
Penta International
2-METHYL PYRAZINE
Penta International
2-METHYLPYRAZINE NATURAL 5% IN ETHYL ALCOHOL
Phoenix Aromas & Essential Oils
Pyrazine, 2- Methyl
R C Treatt & Co Ltd
2-Methylpyrazine
Halal, Kosher
Odor: nutty/roasted, peanut/chocolate, roast chicken
Flavor: nutty
Used in flavours up to 10ppm, in applications such as baked goods, meat and cereal products, confectionery, beverages, and sauces.
Reincke & Fichtner
2-Methylpyrazine
Robinson Brothers
2-Methylpyrazine F&F
https://www.robinsonbrothers.uk/chemistry-competences
Santa Cruz Biotechnology
For experimental / research use only.
2-Methylpyrazine
Sigma-Aldrich
2-Methylpyrazine, ≥99%, FCC, FG
Odor: chocolate; meaty; nutty; green
Certified Food Grade Products
Sunaux International
2-Methyl Pyrazine
Synerzine
2-Methylpyrazine
Taytonn
2-Methylpyrazine
Odor: Cocoa, Green, Nutty, Roast
TCI AMERICA
For experimental / research use only.
2-Methylpyrazine >98.0%(GC)
Tengzhou Jitian Aroma Chemiclal
2-Methyl Pyrazine
Tengzhou Xiang Yuan Aroma Chemicals
2-Methyl Pyrazine
United International
2-Methyl Pyrazine
Vigon International
Methyl-2 Pyrazine
WholeChem
2-Methyl pyrazine
Synonyms   Articles   Notes   Search   Top
Safety Information:
Preferred SDS: View
European information :
Most important hazard(s):
Xn - Harmful.
R 10 - Flammable.
R 22 - Harmful if swallowed.
R 36/37/38 - Irritating to eyes, respiratory system, and skin.
S 02 - Keep out of the reach of children.
S 16 - Keep away from sources of ignition - No Smoking.
S 20/21 - When using do not eat, drink or smoke.
S 24/25 - Avoid contact with skin and eyes.
S 26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 - Wear suitable clothing, gloves and eye/face protection.
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
gavage-rat LD50  1800 mg/kg
(Moran et al., 1980)

intraperitoneal-mouse LD50  1820 mg/kg
Toxicology and Applied Pharmacology. Vol. 17, Pg. 244, 1970.

oral-rat LD50  1800 mg/kg
Drug and Chemical Toxicology. Vol. 3, Pg. 249, 1980.

Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: flavor and fragrance agents
IFRA Code of Practice Notification of the 49th Amendment to the IFRA Code of Practice
Recommendation for 2-methyl pyrazine usage levels up to:
  0.1000 % in the fragrance concentrate.
 
Maximised Survey-derived Daily Intakes (MSDI-EU): 17.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA): 7.00 (μg/capita/day)
Structure Class: II
Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances are generally recognized as safe (GRAS).
The Expert Panel also publishes separate extensive reviews of scientific information on all FEMA GRAS flavoring substances and can be found at FEMA Flavor Ingredient Library
publication number: 5
Click here to view publication 5
 average usual ppmaverage maximum ppm
baked goods: -10.00000
beverages(nonalcoholic): -10.00000
beverages(alcoholic): --
breakfast cereal: -10.00000
cheese: --
chewing gum: --
condiments / relishes: --
confectionery froastings: --
egg products: --
fats / oils: --
fish products: --
frozen dairy: -10.00000
fruit ices: -10.00000
gelatins / puddings: -10.00000
granulated sugar: --
gravies: -10.00000
hard candy: -10.00000
imitation dairy: --
instant coffee / tea: --
jams / jellies: --
meat products: -10.00000
milk products: -10.00000
nut products: --
other grains: --
poultry: --
processed fruits: --
processed vegetables: --
reconstituted vegetables: --
seasonings / flavors: --
snack foods: --
soft candy: --
soups: -10.00000
sugar substitutes: --
sweet sauces: --
Synonyms   Articles   Notes   Search   Top
Safety References:
Flavor & Extract Manufacturers Association (FEMA) reference(s):
The FEMA GRAS assessment of pyrazine derivatives used as flavor ingredients. View pdf
European Food Safety Athority(EFSA): Flavor usage levels; Subacute, Subchronic, Chronic and Carcinogenicity Studies; Developmental / Reproductive Toxicity Studies; Genotoxicity Studies...
European Food Safety Authority (EFSA) reference(s):
Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the Commission related to Flavouring Group Evaluation 17 (FGE.17): Pyrazine derivatives from chemical group 24 (Commission Regulation (EC) No 1565/2000 of 18 July 2000)
View page or View pdf
Flavouring Group Evaluation 50 (FGE.50): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17 (2005) (Commission Regulation (EC) No 1565/2000 of 18 July 2000) - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC)
View page or View pdf
Flavouring Group Evaluation 17, Revision 1 (FGE.17Rev1): Pyrazine derivatives from chemical group 24 - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) [1]
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 17, Revision 2 (FGE.17Rev2): Pyrazine derivatives from chemical group 24
View page or View pdf
Scientific Opinion on Flavouring Group Evaluation 50, Revision 1 (FGE.50Rev1): Consideration of pyrazine derivatives evaluated by JECFA (57th meeting) structurally related to pyrazine derivatives evaluated by EFSA in FGE.17Rev2 (2010)
View page or View pdf
Safety and efficacy of pyrazine derivatives including saturated ones belonging to chemical group 24 when used as flavourings for all animal species
View page or View pdf
EPI System: View
Chemical Carcinogenesis Research Information System: Search
EPA Substance Registry Services (TSCA): 109-08-0
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 7976
National Institute of Allergy and Infectious Diseases: Data
WISER: UN 1993
WGK Germany: 3
 2-methylpyrazine
Chemidplus: 0000109080
RTECS: UQ3675000 for cas# 109-08-0
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References:
 2-methylpyrazine
NIST Chemistry WebBook: Search Inchi
Canada Domestic Sub. List: 109-08-0
Pubchem (cid): 7976
Pubchem (sid): 134973513
Flavornet: 109-08-0
Synonyms   Articles   Notes   Search   Top
Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS): View
CHEMBL: View
HMDB (The Human Metabolome Database): HMDB33112
FooDB: FDB011112
Export Tariff Code: 2933.99.8090
Typical G.C.
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
For Odor
No odor group found for these
 sulfuryl octanoateFL/FR
 sulfuryl butyrateFL/FR
 sulfuryl decanoateFL/FR
 sulfuryl hexanoateFL/FR
 sulfuryl isobutyrateFL/FR
 sulfuryl propionateFL/FR
bready
 coffee furanoneFL/FR
 furfuralFL/FR
caramellic
 maltolFL/FR
 shoyu furanoneFL/FR
 toffee furanoneFL/FR
 chocolate pyrazine AFL/FR
 cocoa hexenalFL/FR
 cocoa pentenalFL/FR
2,6-dimethyl pyrazineFL/FR
2,5-dimethyl pyrazineFL/FR
2-methoxy-3-methyl pyrazineFL/FR
2-methoxypyrazineFL/FR
cocoa
2-methyl butyraldehydeFL/FR
 theobroma cacao extractFL/FR
earthy
 nutty pyrazineFL/FR
fermented
 valeraldehydeFL/FR
fruity
 cherry oxyacetateFL/FR
green
2-heptyl furanFL/FR
herbal
black camellia sinensis leaf infusionFL/FR
minty
dextro-carvoneFL/FR
musty
2-acetyl pyrroleFL/FR
 cocoa butenalFL/FR
nutty
2-acetyl-3-methyl pyrazineFL/FR
3,5-cocoa pyrazineFL/FR
3,6-cocoa pyrazineFL/FR
2,3-dimethyl pyrazineFL/FR
2-ethyl pyrazineFL/FR
 filbert heptenoneFL/FR
 filbert pyrazineFL/FR
 hazelnut fragranceFR
2,6-lutidineFL/FR
2-methyl thio-3,5 or 6-methyl pyrazineFL/FR
 nutty quinoxalineFL/FR
2,3,5-trimethyl pyrazineFL/FR
popcorn
2-acetyl pyrazineFL/FR
2-acetyl thiazoleFL/FR
roasted
2-acetyl-2-pyrroline 
 trigonella foenum-graecum seed oil CO2 extractFL/FR
spicy
 caraway seed oleoresinFL/FR
 furfuryl thioacetateFL/FR
waxy
 butyl laurateFL/FR
woody
 cedrenyl acetateFR
2-methoxy-4-vinyl phenolFL/FR
yeasty
laevo-glutamic acidCS
 
For Flavor
 
No flavor group found for these
2-acetyl-2-pyrroline 
2(4)-isobutyl-4(2),6-dimethyl dihydro-4H-1,3,5-dithiazineFL
 chocolate pyrazine AFL/FR
6,7-dihydro-2,3-dimethyl-5H-cyclopentapyrazineFL
 dimethyl dihydrocyclopentapyrazineFL
2,5-dimethyl thiazoleFL
4,5-dimethyl-2-ethyl thiazoleFL
 ethyl dimethyl pyrazineFL
2-methoxypyrazineFL/FR
 methyl 2-(methyl thio) acetateFL
 peanut dithiazineFL
 sulfuryl butyrateFL/FR
 sulfuryl decanoateFL/FR
 sulfuryl hexanoateFL/FR
 sulfuryl isobutyrateFL/FR
 sulfuryl formateFL
 sulfuryl octanoateFL/FR
 sulfuryl propionateFL/FR
bready
2-propionyl thiazoleFL
brown
 furfuralFL/FR
 juglans nigra shell extractFL
burnt
 furfuryl alcoholFL
caramellic
 maltolFL/FR
 shoyu furanoneFL/FR
 toffee furanoneFL/FR
cocoa
 butyraldehydeFL
 cacao flavorFL
 cocoa distillatesFL
 cocoa hexenalFL/FR
 theobroma cacao extractFL/FR
coffee
roasted coffee bean concentrateFL
 coffee enhancersFL
 coffee flavorFL
 diisoamyl thiomalateFL
corn chip
2-acetyl thiazoleFL/FR
2-acetyl-2-thiazolineFL
fatty
2-heptyl furanFL/FR
fishy
4,5-dimethyl thiazoleFL
floral
 cocoa pentenalFL/FR
fruity
 cherry oxyacetateFL/FR
fusel
2-methyl butyraldehydeFL/FR
green
 cocoa butenalFL/FR
herbal
black camellia sinensis leaf infusionFL/FR
metallic
2,5-dihydroxy-1,4-dithianeFL
minty
dextro-carvoneFL/FR
musty
2,5-dimethyl pyrazineFL/FR
2-ethoxythiazoleFL
2,3,5-trimethyl pyrazineFL/FR
nutty
2-acetyl pyrroleFL/FR
2-acetyl-3-methyl pyrazineFL/FR
3,6-cocoa pyrazineFL/FR
3,5(6)-cocoa pyrazineFL
3,5-cocoa pyrazineFL/FR
 coffee furanoneFL/FR
2,3-dimethyl pyrazineFL/FR
2,6-dimethyl pyrazineFL/FR
2,4-dimethyl-5-vinyl thiazoleFL
2-ethyl pyrazineFL/FR
 filbert heptenoneFL/FR
 filbert pyrazineFL/FR
2,6-lutidineFL/FR
2-methoxy-3-methyl pyrazineFL/FR
2-methyl thio-3,5 or 6-methyl pyrazineFL/FR
 nutty pyrazineFL/FR
 nutty quinoxalineFL/FR
popcorn
2-propionyl-2-thiazolineFL
roasted
 acer spicatum bark extractFL
2-acetyl pyrazineFL/FR
 furfuryl thioacetateFL/FR
 gluconyl ethanolamineFL
 lactoyl ethanolamine phosphateFL
 trigonella foenum-graecum seed oil CO2 extractFL/FR
smoky
2-methoxy-4-vinyl phenolFL/FR
spicy
 caraway seed oleoresinFL/FR
waxy
 butyl laurateFL/FR
 furfuryl octanoateFL
winey
 valeraldehydeFL/FR
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
 almond toasted almondFL
 breadFL
 butterFR
 chocolateFR
 chocolate cocoaFL
 coffeeFR
 greenFR
 meat roasted meatFL
 peanut butterFL
 potatoFL
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 almond roasted almond
Search Trop  Picture
 almond seed
Search Trop  Picture
 asparagus
Search Trop  Picture
 beef
Search  PMC Picture
 bread white bread
Search  PMC Picture
 chicken
Search  PMC Picture
 coffee
Search  PMC Picture
 fenugreek seed
Search Trop  Picture
 fish
Search  PMC Picture
 guava fruit
Search Trop  Picture
 hazelnut
Search Trop  Picture
 kohlrabi stem
Search Trop  Picture
 lamb
Search  PMC Picture
 lavender oil spike spain @ 0.074%
Data  GC  Search Trop  Picture
 macadamia
Search  PMC Picture
 papaya fruit
Search Trop  Picture
 peanut
Search Trop  Picture
 pork
Search  PMC Picture
 potato chip
Search  PMC Picture
 rice
Search Trop  Picture
 rice cakes
PbMd  Search  PMC Picture
 seafood
Search  PMC Picture
 shrimp
Search  PMC Picture
 tea black tea
Search Trop  Picture
 tea green tea
Search Trop  Picture
 tea leaf
Search Trop  Picture
 tomato
Search Trop  Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
 methyl pyrazine
2 methyl pyrazine
2-methyl pyrazine FCC
2-methyl-1,4-diazine
(±)-2-methylpiperazine
2-methylpyrazine
 pyrazine, 2- methyl
 pyrazine, 2-methyl-
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Headspace-solid phase microextraction-gas chromatography-tandem mass spectrometry (HS-SPME-GC-MS2) method for the determination of pyrazines in perilla seed oils: impact of roasting on the pyrazines in perilla seed oils.
PubMed: Synthesis, structures and magnetic properties of Fe(II) and Co(II) thiocyanato coordination compounds: on the importance of the diamagnetic counterparts for structure determination.
PubMed: Determination of the alkylpyrazine composition of coffee using stable isotope dilution-gas chromatography-mass spectrometry (SIDA-GC-MS).
PubMed: Convenient synthesis of stable deuterium-labeled alkylpyrazines for use in stable isotope dilution assays.
PubMed: Volatile profiling of high quality hazelnuts (Corylus avellana L.): chemical indices of roasting.
PubMed: Characterization of cocoa liquors by GC-MS and LC-MS/MS: focus on alkylpyrazines and flavanols.
PubMed: Short communication: Evidence for methylglyoxal-mediated browning of Parmesan cheese during low temperature storage.
PubMed: Synthesis, crystal structure, spectroscopic investigations, thermal behavior and DFT calculations of pentacarbonyl(2-methylpyrazine)chromium(0).
PubMed: Analysis of volatile organic compounds released from human lung cancer cells and from the urine of tumor-bearing mice.
PubMed: Changes in volatile compound composition of Antrodia camphorata during solid state fermentation.
PubMed: Tuning the surface composition of novel metal vanadates and its effect on the catalytic performance.
PubMed: Similar odorants elicit different behavioral and physiological responses, some supersustained.
PubMed: Dynamics of odorant binding to thin aqueous films of rat-OBP3.
PubMed: Crystal transformation and host molecular motions in CO2 adsorption process of a metal benzoate pyrazine (M(II) = Rh, Cu).
PubMed: Coffee aroma--statistical analysis of compositional data.
PubMed: Syntheses, structures, and photoluminescence of a series of silver(I) sulfonates with pyrazine derivatives.
PubMed: A binuclear Cu(II) metallacycle capable of discerning between pyrazine and its different methyl-substituted derivatives based on reversible intracage metal-ligand binding.
PubMed: Scaled quantum chemical calculations and FTIR, FT-Raman spectral analysis of 2-Methylpyrazine.
PubMed: 2-Methyl-pyrazine 1,4-dioxide.
PubMed: Structural and magnetic study of O2 molecules arranged along a channel in a flexible single-crystal host family.
PubMed: An unusual 3D-topology and dominant ferromagnetic couplings in two Cu(II)-azide coordination polymers.
PubMed: Structural study of silver(I) sulfonate complexes with pyrazine derivatives.
PubMed: Influence of epicatechin reactions on the mechanisms of Maillard product formation in low moisture model systems.
PubMed: Poly[[(μ(2)-2-amino-4,5-dimethybenzene-sulfonato-κN:O)(μ(2)-2-methyl-pyrazine-κN:N')silver(I)] monohydrate].
PubMed: Construction of polyoxometalates-based coordination polymers through direct incorporation between polyoxometalates and the voids in a 2D network.
PubMed: Degradation of 2,5-dimethylpyrazine by Rhodococcus erythropolis strain DP-45 isolated from a waste gas treatment plant of a fishmeal processing company.
PubMed: Role of the solvent glycerol in the Maillard reaction of d-fructose and l-alanine.
PubMed: Tuning the electronic communication and rates of intramolecular electron transfer of dimers of trinuclear ruthenium clusters: bridging and ancillary ligand effects.
PubMed: Determination of the 2H/1H and 15N/14N ratios of Alkylpyrazines from coffee beans (Coffea arabica L. and Coffea canephoravar. robusta) by isotope ratio mass spectrometry.
PubMed: Mixed valence isomers.
PubMed: Pyrazine derivatives in cigarette smoke inhibit hamster oviductal functioning.
PubMed: Long-range ferromagnetic ordering in two-dimensional coordination polymers Co[N(CN)2]2(L) [L = pyrazine dioxide (pzdo) and 2-methyl pyrazine dioxide (mpdo)] with dual mu- and mu3-[N(CN)2] bridges.
PubMed: Mechanisms responsible for the in vitro relaxation of ligustrazine on porcine left anterior descending coronary artery.
PubMed: A study by ultraviolet spectroscopy on the self-association of diazines in aqueous solution.
PubMed: Interaction-induced enhancement in the activity and selectivity of a titania-supported ammonium salt of a 12-molybdophosphoric acid catalyst during ammoxidation of 2-methylpyrazine.
PubMed: Use of gas chromatography-olfactometry to identify key odorant compounds in dark chocolate. Comparison of samples before and after conching.
PubMed: A Proton-Induced N-1 to eta(2) Migration of the Fluxional Pyrazine in the [Ru(II)(hedta)(pz)](-) Complex.
PubMed: Metal-containing ligands for mixed-metal polymers: novel Cu(II)-Ag(I) mixed-metal coordination polymers generated from [Cu(2-methylpyrazine-5-carboxylate)2(H2O)].3H2O and silver(I) salts.
PubMed: Aroma extract dilution analysis of a beeflike process flavor from extruded enzyme-hydrolyzed soybean protein.
PubMed: Effects of olive, canola, and sunflower oils on the formation of volatiles from the Maillard reaction of lysine with xylose and glucose.
PubMed: Determining the crystal structure of twinned 2-methylpyrazine.
PubMed: Solubilization of Hydrophilic Compounds in Copolymer Aggregates.
PubMed: Study of interactions between food phenolics and aromatic flavors using one- and two-dimensional (1)H NMR spectroscopy.
PubMed: Volatile flavor components of rice cakes.
PubMed: Effects of roasting on pyrazine contents and oxidative stability of red pepper seed oil prior to its extraction.
PubMed: Environmental signals modulate olfactory acuity, discrimination, and memory in Caenorhabditis elegans.
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