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Category: information only not used for fragrances or flavors
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 30.33 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Norathyriol 98.5%
Odor: characteristic Use: Norathyriol isolated from the herbs of Mangifera indica L. It is a potent PTP1B inhibitor with good cell permeability and oral availability.
anti-inflammatory; |
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | information only not used for fragrances or flavors |
| Recommendation for norathyriol usage levels up to: | | | not for fragrance use.
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| Recommendation for norathyriol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 1,3,6,7- | tetrahydroxyxanthen-9-one | | 1,3,6,7- | tetrahydroxyxantone | | 9H- | xanthen-9-one, 1,3,6,7-tetrahydroxy- |
Articles:
| PubMed: | In Vitro Comparative Study of the Inhibitory Effects of Mangiferin and Its Aglycone Norathyriol towards UDP-Glucuronosyl Transferase (UGT) Isoforms. |
| PubMed: | Naturally occurring xanthone and benzophenone derivatives exert significant anti-proliferative and proapoptotic effects in vitro on synovial fibroblasts and macrophages from rheumatoid arthritis patients. |
| PubMed: | In Vitro and In Vivo Effects of Norathyriol and Mangiferin onα-Glucosidase. |
| PubMed: | Pharmacokinetics of mangiferin and its metabolite-norathyriol, Part 2: Influence of UGT, CYP450, P-gp, and enterobacteria and the potential interaction in Rhizoma Anemarrhenae decoction with timosaponin B2 as the major contributor. |
| PubMed: | Pharmacokinetics of mangiferin and its metabolite-Norathyriol, Part 1: Systemic evaluation of hepatic first-pass effect in vitro and in vivo. |
| PubMed: | Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity. |
| PubMed: | Estrogen modulation properties of mangiferin and quercetin and the mangiferin metabolite norathyriol. |
| PubMed: | Norathyriol reverses obesity- and high-fat-diet-induced insulin resistance in mice through inhibition of PTP1B. |
| PubMed: | Host-guest inclusion system of norathyriol with β-cyclodextrin and its derivatives: preparation, characterization, and anticancer activity. |
| PubMed: | Biflavonoids, main constituents from Garcinia bakeriana leaves. |
| PubMed: | Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase. |
| PubMed: | Norathyriol suppresses transformation in JB6 P+ cells by the inhibition of Akt. |
| PubMed: | Yeast-mediated xanthone synthesis through oxidative intramolecular cyclization. |
| PubMed: | Mangiferin aglycone attenuates radiation-induced damage on human intestinal epithelial cells. |
| PubMed: | Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases. |
| PubMed: | Structure elucidation of in vivo and in vitro metabolites of mangiferin. |
| PubMed: | Deglycosylation of puerarin and other aromatic C-glucosides by a newly isolated human intestinal bacterium. |
| PubMed: | The phenolic acids from bacterial degradation of the mangiferin aglycone are quantified in the feces of pigs after oral ingestion of an extract of Cyclopia genistoides (honeybush tea). |
| PubMed: | In vitro modulation of ABCB1/P-glycoprotein expression by polyphenols from Mangifera indica. |
| PubMed: | Benzophenone O-glycosides from Hypericum elegans. |
| PubMed: | In vitro effects of Mangifera indica and polyphenols derived on ABCB1/P-glycoprotein activity. |
| PubMed: | Mangiferin and hesperidin metabolites are absorbed from the gastrointestinal tract of pigs after oral ingestion of a Cyclopia genistoides (honeybush tea) extract. |
| PubMed: | Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. |
| PubMed: | Two proteins, Mn2+, and low molecular cofactor are required for C-glucosyl-cleavage of mangiferin. |
| PubMed: | Xanthone derivatives: new insights in biological activities. |
| PubMed: | Isolation of a human intestinal bacterium that transforms mangiferin to norathyriol and inducibility of the enzyme that cleaves a C-glucosyl bond. |
| PubMed: | Inhibition of the arachidonic acid cascade by norathyriol via blockade of cyclooxygenase and lipoxygenase activity in neutrophils. |
| PubMed: | Decreased protein kinase C activation mediates inhibitory effect of norathyriol on serotonin-mediated endothelial permeability. |
| PubMed: | Evidence for the involvement of protein kinase C inhibition by norathyriol in the reduction of phorbol ester-induced neutrophil superoxide anion generation and aggregation. |
| PubMed: | Examination of the inhibitory effect of norathyriol in formylmethionyl-leucyl-phenylalanine-induced respiratory burst in rat neutrophils. |
| PubMed: | Induction of calcium release from sarcoplasmic reticulum of skeletal muscle by xanthone and norathyriol. |
| PubMed: | Synthesis and antiplatelet effects of omega-aminoalkoxylxanthones. |
| PubMed: | Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A23187-induced pleurisy and analgesia in mice. |
| PubMed: | gamma-Pyrone compounds. 5. Synthesis and antiplatelet effects of xanthonoxypropanolamines and related compounds. |
| PubMed: | Inhibitory effect of norathyriol, a xanthone from Tripterospermum lanceolatum, on cutaneous plasma extravasation. |
| PubMed: | Gamma-pyrone compounds. II: Synthesis and antiplatelet effects of tetraoxygenated xanthones. |
| PubMed: | Antihaemostatic and antithrombotic effect of some antiplatelet agents isolated from Chinese herbs. |
| PubMed: | Vasorelaxation of rat thoracic aorta caused by norathyriol isolated from Gentianaceae. |
| PubMed: | Novel inhibitory actions on platelet thromboxane and inositolphosphate formation by xanthones and their glycosides. |
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