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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 0.0003391 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for epi-coprostanol usage levels up to: | | | not for fragrance use.
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| Recommendation for epi-coprostanol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 516-95-0 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 66066 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | (3R,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol |
| Chemidplus: | 0000516950 |
References:
| | (3R,5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 66066 |
| Pubchem (cas): | 516-95-0 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | cholestan-3-ol, (3-alpha,5-alpha)- (9CI) | | epi- | cholestanol | | epi | dihydrocholesterin | | (3R,5S,8R,9S,10S,13R,14S,17R)-10,13- | dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol | | 3alpha- | hydroxy-5alpha-cholestane |
Articles:
| PubMed: | Quantification of total cholesterol in human milk by gas chromatography. |
| PubMed: | Steroid Biomarkers Revisited - Improved Source Identification of Faecal Remains in Archaeological Soil Material. |
| PubMed: | Sterols indicate water quality and wastewater treatment efficiency. |
| PubMed: | Sterols and Stanols Preserved in Pond Sediments Track Seabird Biovectors in a High Arctic Environment. |
| PubMed: | Sterol ratios as a tool for sewage pollution assessment of river sediments in Serbia. |
| PubMed: | Identifying avian sources of faecal contamination using sterol analysis. |
| PubMed: | Microbial water quality and sedimentary faecal sterols as markers of sewage contamination in Kuwait. |
| PubMed: | Determination of Geochemically Important Sterols and Triterpenols in Sediments Using Ultrahigh-Performance Liquid Chromatography Tandem Mass Spectrometry (UHPLC-MS/MS). |
| PubMed: | Trace analysis of selected hormones and sterols in river sediments by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. |
| PubMed: | Assessment of historical fecal contamination in Curitiba, Brazil, in the last 400 years using fecal sterols. |
| PubMed: | An integrated evaluation of molecular marker indices and linear alkylbenzenes (LABs) to measure sewage input in a subtropical estuary (Babitonga Bay, Brazil). |
| PubMed: | Baseline concentrations of faecal sterols and assessment of sewage input into different inlets of Admiralty Bay, King George Island, Antarctica. |
| PubMed: | Evaluation of potential sewage contamination by fecal sterol biomarkers adsorbed in natural biofilms. |
| PubMed: | Macrobenthos and multi-molecular markers as indicators of environmental contamination in a South American port (Mar del Plata, Southwest Atlantic). |
| PubMed: | Climate impacts on human settlement and agricultural activities in northern Norway revealed through sediment biogeochemistry. |
| PubMed: | Predicting the concentration range of unmonitored chemicals in wastewater-dominated streams and in run-off from biosolids-amended soils. |
| PubMed: | Origin of fecal contamination in waters from contrasted areas: stanols as Microbial Source Tracking markers. |
| PubMed: | Multi-molecular markers and metals as tracers of organic matter inputs and contamination status from an Environmental Protection Area in the SW Atlantic (Laranjeiras Bay, Brazil). |
| PubMed: | Extreme variability of steroid profiles in cow feces and pig slurries at the regional scale: implications for the use of steroids to specify fecal pollution sources in waters. |
| PubMed: | Ecosystem evolution of seal colony and the influencing factors in the 20th century on Fildes Peninsula, West Antarctica. |
| PubMed: | Specificity of cholesterol and analogs to modulate BK channels points to direct sterol-channel protein interactions. |
| PubMed: | Sedimentary records of sewage pollution using faecal markers in contrasting peri-urban shallow lakes. |
| PubMed: | Distribution of sewage input in marine sediments around a maritime Antarctic research station indicated by molecular geochemical indicators. |
| PubMed: | [NMR-spectroscopy-based metabonomic approach to analysis of Siwutang, a novel prescription, treated blood deficiency in mice]. |
| PubMed: | Sediments as a potential tool for assessment of sewage pollution in Barigüi River, Brazil. |
| PubMed: | The role of cell cholesterol and the cytoskeleton in the interaction between IK1 and maxi-K channels. |
| PubMed: | Determination of fecal sterols by gas chromatography-mass spectrometry with solid-phase extraction and injection-port derivatization. |
| PubMed: | Assessment of fecal sterols in Barigui River sediments in Curitiba, Brazil. |
| PubMed: | Identification and significance of sterols in MSW landfill leachate. |
| PubMed: | Sterols: a tracer of organic matter in combined sewers. |
| PubMed: | Evaluating potential applications of faecal sterols in distinguishing sources of faecal contamination from mixed faecal samples. |
| PubMed: | Use of selected chemical markers in combination with a multiple regression model to assess the contribution of domesticated animal sources of fecal pollution in the environment. |
| PubMed: | Multivariate logistic regression for predicting total culturable virus presence at the intake of a potable-water treatment plant: novel application of the atypical coliform/total coliform ratio. |
| PubMed: | Bacterial source tracking from diverse land use catchments by sterol ratios. |
| PubMed: | Comparisons of water quality parameters from diverse catchments during dry periods and following rain events. |
| PubMed: | Evaluation of ambrein and epicoprostanol for their antioxidant properties: protection against adriamycin-induced free radical toxicity. |
| PubMed: | Microwave-assisted solvent extraction of solid matrices and subsequent detection of pharmaceuticals and personal care products (PPCPs) using gas chromatography-mass spectrometry. |
| PubMed: | Interaction of the glycoalkaloid tomatine with DMPC and sterol monolayers studied by surface pressure measurements and Brewster angle microscopy. |
| PubMed: | An efficient diethyl ether-based soxhlet protocol to quantify faecal sterols from catchment waters. |
| PubMed: | Free Fatty acids and sterols in swine manure. |
| PubMed: | Identifying the source, transport path and sinks of sewage derived organic matter. |
| PubMed: | Tracking the origin of faecal pollution in surface water: an ongoing project within the European Union research programme. |
| PubMed: | Use of fecal steroids to infer the sources of fecal indicator bacteria in the Lower Santa Ana River Watershed, California: sewage is unlikely a significant source. |
| PubMed: | Application of comprehensive two-dimensional gas chromatography to the quantification of overlapping faecal sterols. |
| PubMed: | Determination of faecal pollutants in Torrens and Patawalonga catchment waters in South Australia using faecal sterols. |
| PubMed: | Structural features of sterols required to inhibit human sperm capacitation. |
| PubMed: | Tracing sewage in the marine environment: altered signatures in Concepción Bay, Chile. |
| PubMed: | Assay of microsomal oxysterol 7alpha-hydroxylase activity in the hamster liver by a sensitive method: in vitro modulation by oxysterols. |
| PubMed: | Sedimentary 4-desmethyl sterols and n-alkanols in an eutrophic urban estuary, Capibaribe River, Brazil. |
| PubMed: | Modulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase activities by steroids and physiological conditions in hamster. |
| PubMed: | Method for simultaneous measurements of traces of heptadeuterated cholesterol and cholesterol by gas chromatography-mass spectrometry: application in humans. |
| PubMed: | New method for determination of fecal sterols in urine using non-chlorinated solvents. |
| PubMed: | Gas chromatographic analysis of resveratrol in plasma, lipoproteins and cells after in vitro incubations. |
| PubMed: | Epicoprostanol found in adipocere from five human autopsies. |
| PubMed: | Protection by epicoprostanol against hyperglycemia and insulitis in normal and diabetic rats. |
| PubMed: | Features of cholesterol structure that regulate the clearance of chylomicron-like lipid emulsions. |
| PubMed: | In vitro modulation of rat adipocyte ghost membrane fluidity by cholesterol oxysterols. |
| PubMed: | Chromatographic separation of cholesterol in foods. |
| PubMed: | Metabolic variables of cholesterol during squalene feeding in humans: comparison with cholestyramine treatment. |
| PubMed: | Electron-capture gas chromatography as a sensitive method for measuring subnanogram amounts of cholesterol in saliva and urine. |
| PubMed: | Intestinal cholesterol metabolism. |
| PubMed: | Calcium-induced phase separation phenomena in multicomponent unsaturated lipid mixtures. |
| PubMed: | Lipid acyl chain-dependent effects of sterols in Acholeplasma laidlawii membranes. |
| PubMed: | Effect of sterol incorporation on head group separation in liposomes. |
| PubMed: | Effect of cholesterol on phospholipid, RNA, and protein synthesis in Mycoplasma capricolum. |
| PubMed: | Molecular packing in steroid-lecithin monolayers. IV. Mixed films of epicoprostanol with dipalmitoyl phosphatidylcholine. |
| PubMed: | Coordinate regulation of unsaturated phospholipid, RNA, and protein synthesis in Mycoplasma capricolum by cholesterol. |
| PubMed: | Reversed-phase thin layer chromatography of some common sterols. |
| PubMed: | Comparative methods of quantifying fecal neutral sterols in rats and humans after intravenous [14C]-, [3H] or [2H]cholesterol labeling. |
| PubMed: | Capillary gas-liquid chromatography of faecal free and esterified neutral sterols. |
| PubMed: | Fecal steroids in diarrhea: IV. Cholera. |
| PubMed: | The structure of mixed cholesterol-phospholipid monolayers spread at the air-water interface as probed by interactions with band 3 protein from erythrocyte membranes. |
| PubMed: | Thin-layer and gas--liquid chromatographic identification of neutral steroids in human and rat feces. |
| PubMed: | Identification and origins of neutral fecal sterols in adult Large White sows: occurrence of externally-secreted intestinal cholesterol. |
| PubMed: | Gas chromatographic detection of the mycotoxin zearalenone in blood serum. |
| PubMed: | Assessment of serum cholesterol by two methods: gas-liquid chromatography on a capillary column and chemical ionization-mass fragmentography with isotopic dilution of [3,4-13C] cholesterol as internal standard. |
| PubMed: | Diet and sterol biohydrogenation in the rat: occurrence of epicoprostanol. |
| PubMed: | Daily elimination of fecal neutral sterols by humans. |
| PubMed: | Fecal steroids in diarrhea. I. Acute shigellosis. |
| PubMed: | Sterol requirements of T-strain mycoplasmas. |
| PubMed: | Esterification of injected epicoprostanol in a human subject. |
| PubMed: | Stero-bile acids and bile alcohols. XCVII. Metabolism of epicoprostanol in the Japanese eel. |
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