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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 1143 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Trachelogenin >95%
Odor: characteristic Use: Trachelogenin is found in the herbs of Trachelospermum jasminoides (Lindl.) Lem. |
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for trachelogenin usage levels up to: | | | not for fragrance use.
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| Recommendation for trachelogenin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 452855 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | (3S,4S)-4-[(3,4-dimethoxyphenyl)methyl]-3-hydroxy-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one |
| Chemidplus: | 0034209693 |
References:
| | (3S,4S)-4-[(3,4-dimethoxyphenyl)methyl]-3-hydroxy-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 452855 |
| Pubchem (cas): | 34209-69-3 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (3S,4S)-4-[(3,4- | dimethoxyphenyl)methyl]-3-hydroxy-3-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one | | 2(3H)- | furanone, 4-((3,4-dimethoxyphenyl)methyl)dihydro-3-hydroxy-3-((4-hydroxy-3-methoxyphenyl)methyl)-, (3S,4S)- | | 2(3h)- | furanone, dihydro-3-hydroxy-3-vanillyl-4-veratryl- |
Articles:
| PubMed: | In vitro antitumor effect of a lignan isolated from Combretum fruticosum, trachelogenin, in HCT-116 human colon cancer cells. |
| PubMed: | Trachelogenin, a novel inhibitor of hepatitis C virus entry through CD81. |
| PubMed: | Enhancing Effect of Trachelogenin from Trachelospermi caulis Extract on Intestinal Barrier Function. |
| PubMed: | Discovery of a potent anti-yeast triterpenoid saponin, clematoside-S from Urena lobata L. |
| PubMed: | Endogenous enzyme-hydrolyzed fruit of Cirsium brachycephalum: optimal source of the antiproliferative lignan trachelogenin regulating the Wnt/β-catenin signaling pathway in the SW480 colon adenocarcinoma cell line. |
| PubMed: | Active components with inhibitory activities on IFN-γ/STAT1 and IL-6/STAT3 signaling pathways from Caulis Trachelospermi. |
| PubMed: | Antiausterity activity of arctigenin enantiomers: importance of (2R,3R)-absolute configuration. |
| PubMed: | New guaian-type sesquiterpene from Wikstroemia indica. |
| PubMed: | Specific hydrolysis and accumulation of antiproliferative lignans in the fruit of Leuzea carthamoides (Willd.) DC. |
| PubMed: | Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase. |
| PubMed: | Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase. |
| PubMed: | The role of harmonized, gas and liquid chromatography mass spectrometry in the discovery of the neolignan balanophonin in the fruit wall of Cirsium vulgare. |
| PubMed: | [Trace chemical constituents contained in Trachelospermum jasminoides and structure identification]. |
| PubMed: | Bioactivity-guided isolation of antiproliferative compounds from Centaurea jacea L. |
| PubMed: | Optimum yields of dibenzylbutyrolactone-type lignans from Cynareae fruits, during their ripening, germination and enzymatic hydrolysis processes, determined by on-line chromatographic methods. |
| PubMed: | Simultaneous quantification of tracheloside and trachelogenin in rat plasma using liquid chromatography/tandem mass spectrometry. |
| PubMed: | Docking study of HIV-1 reverse transcriptase with phytochemicals. |
| PubMed: | Complementary fragmentation pattern analysis by gas chromatography-mass spectrometry and liquid chromatography tandem mass spectrometry confirmed the precious lignan content of Cirsium weeds. |
| PubMed: | The chemopreventive effects of Saussurea salicifolia through induction of apoptosis and phase II detoxification enzyme. |
| PubMed: | Lignans from Trachelospermum jasminoides. |
| PubMed: | Stereoselective Syntheses of Cis- and Trans-Isomers of alpha-Hydroxy-alpha,beta-dibenzyl-gamma-butyrolactone Lignans: New Syntheses of (+/-)-Trachelogenin and (+/-)-Guayadequiol. |
| PubMed: | Structural transformation of lignan compounds in rat gastrointestinal tract. |
| PubMed: | Differential in vitro anti-HIV activity of natural lignans. |
| PubMed: | [Lignans of Trachelospermum asiaticum var. intermedium. VII. Chemical proof of the position of D-glucose linkage in trachedloside and discussion of trachelogenin derivatives]. |
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