bullatacin, 123123-32-0

Articles:

PubMed:	The fruit of Annona squamosa L. as a source of environmental neurotoxins: From quantification of squamocin to annotation of Annonaceous acetogenins by LC-MS/MS analysis.
PubMed:	[Structure activity relationship of annonaceous acetogenins against multidrug resistant human lung cancer cell line A549/Taxol in vitro].
PubMed:	Reduction of Synthetic Ubiquinone QT Catalyzed by Bovine Mitochondrial Complex I Is Decoupled from Proton Translocation.
PubMed:	Acetogenins as Potential Anticancer Agents.
PubMed:	Amilorides bind to the quinone binding pocket of bovine mitochondrial complex I.
PubMed:	Pinpoint chemical modification of Asp160 in the 49 kDa subunit of bovine mitochondrial complex I via a combination of ligand-directed tosyl chemistry and click chemistry.
PubMed:	Site-specific chemical labeling of mitochondrial respiratory complex I through ligand-directed tosylate chemistry.
PubMed:	Synthesis and tumor cell growth inhibitory activity of biotinylated annonaceous acetogenins.
PubMed:	Antitumor activity and toxicity relationship of annonaceous acetogenins.
PubMed:	Anti-tumor activity of Annona squamosa seeds extract containing annonaceous acetogenin compounds.
PubMed:	Determination of bullatacin in rat plasma by liquid chromatography-mass spectrometry.
PubMed:	Forskolin and derivatives as tools for studying the role of cAMP.
PubMed:	Cytotoxic bistetrahydrofuran annonaceous acetogenins from the seeds of Annona squamosa.
PubMed:	Bis-THF motif of acetogenin binds to the third matrix-side loop of ND1 subunit in mitochondrial NADH-ubiquinone oxidoreductase.
PubMed:	In vitro trematocidal effects of crude alcoholic extracts of Artemisia annua, A. absinthium, Asimina triloba, and Fumaria officinalis: trematocidal plant alcoholic extracts.
PubMed:	The membrane subunit NuoL(ND5) is involved in the indirect proton pumping mechanism of Escherichia coli complex I.
PubMed:	Susceptibility of complete bacteria and spheroplasts of Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi to rolliniastatin-2.
PubMed:	Exploring the binding site of delta(lac)-acetogenin in bovine heart mitochondrial NADH-ubiquinone oxidoreductase.
PubMed:	The ND2 subunit is labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor.
PubMed:	Identification of annonaceous acetogenins in the ripe fruit of the North American pawpaw ( Asimina triloba ).
PubMed:	Bullatacin triggered ABCB1-overexpressing cell apoptosis via the mitochondrial-dependent pathway.
PubMed:	Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species.
PubMed:	Two new adjacent bis-tetrahydrofuran annonaceous acetogenins from seeds of Annona cornifolia.
PubMed:	Alteration of the bis-tetrahydrofuran core stereochemistries in asimicin can affect the cytotoxicity.
PubMed:	Synthesis, determination of the absolute configuration of tonkinelin, and inhibitory action with bovine heart mitochondrial complex I.
PubMed:	Advances in Lewis acid controlled carbon-carbon bond-forming reactions enable a concise and convergent total synthesis of bullatacin.
PubMed:	An outside-in approach to adjacent bistetrahydrofuran annonaceous acetogenins with C2 core symmetry. Total synthesis of asimicin and a C32 analogue.
PubMed:	Synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin, squamostolide, and their inhibitory action with bovine heart mitochondrial complex I.
PubMed:	Synthesis of (+)-bullatacin via the highly diastereoselective [3+2] annulation reaction of a racemic aldehyde and a nonracemic allylsilane.
PubMed:	Total synthesis of asimicin via highly stereoselective [3 + 2] annulation reactions of substituted allylsilanes.
PubMed:	Stereoselective syntheses of rolliniastatin 1, rollimembrin, and membranacin.
PubMed:	Synthesis and inhibition mechanism of Delta lac-acetogenins, a novel type of inhibitor of bovine heart mitochondrial complex I.
PubMed:	Synthesis and inhibitory action of novel acetogenin mimics with bovine heart mitochondrial complex I.
PubMed:	In vitro antitumor SAR of threo/cis/threo/cis/erythro bis-THF acetogenins: correlations with their inhibition of mitochondrial Complex I.
PubMed:	New adjacent Bis-tetrahydrofuran Annonaceous acetogenins from Annona muricata.
PubMed:	A modular synthesis of annonaceous acetogenins.
PubMed:	[Inhibition of oxygen consumption by annonaceous acetogenins in liver cell respiration and their structure-activity relationship].
PubMed:	Selective action of acetogenin mitochondrial complex I inhibitors.
PubMed:	Bullatacin, a potent antitumor Annonaceous acetogenin, induces apoptosis through a reduction of intracellular cAMP and cGMP levels in human hepatoma 2.2.15 cells.
PubMed:	[Antitumor effect of anuoning].
PubMed:	[Classification and NMR characteristics of the gamma-lactone and THF rings of antitumor bioactive Annonaceous acetogenins].
PubMed:	Mimicry of annonaceous acetogenins: enantioselective synthesis of a (4R)-hydroxy analogue having potent antitumor activity.
PubMed:	Bullatacin, a potent antitumor annonaceous acetogenin, inhibits proliferation of human hepatocarcinoma cell line 2.2.15 by apoptosis induction.
PubMed:	Gamma-lactone-Functionalized antitumoral acetogenins are the most potent inhibitors of mitochondrial complex I.
PubMed:	Definition of crucial structural factors of acetogenins, potent inhibitors of mitochondrial complex I.
PubMed:	Total synthesis of asimicin and bullatacin.
PubMed:	Circumvention of tumor multidrug resistance by a new annonaceous acetogenin: atemoyacin-B.
PubMed:	Design syntheses and mitochondrial complex I inhibitory activity of novel acetogenin mimics.
PubMed:	New annonaceous acetogenins from Rollinia mucosa.
PubMed:	Tryptamine derived amides and acetogenins from the seeds of Rollinia mucosa.
PubMed:	Kinetic characterization of mitochondrial complex I inhibitors using annonaceous acetogenins.
PubMed:	Inhibition of mitochondrial oxidative phosphorylation induces hyper-expression of glutamic acid decarboxylase in pancreatic islet cells.
PubMed:	NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone.
PubMed:	Biochemical features of mtDNA 14484 (ND6/M64V) point mutation associated with Leber's hereditary optic neuropathy.
PubMed:	Three classes of inhibitors share a common binding domain in mitochondrial complex I (NADH:ubiquinone oxidoreductase).
PubMed:	Annonaceous acetogenins as natural pesticides: potent toxicity against insecticide-susceptible and -resistant German cockroaches (Dictyoptera: Blattellidae).
PubMed:	Purpurediolin and purpurenin, two new cytotoxic adjacent bis-tetrahydrofuran annonaceous acetogenins from the seeds of Annona purpurea.
PubMed:	Acetogenins from seeds of Annona reticulata.
PubMed:	Membrane conformations and their relation to cytotoxicity of asimicin and its analogues.
PubMed:	Cherimolin-1, new selective inhibitor of the first energy-coupling site of the NADH: ubiquinone oxidoreductase (complex I).
PubMed:	Regulation of ornithine decarboxylase induction by deguelin, a natural product cancer chemopreventive agent.
PubMed:	Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells.
PubMed:	Leber's hereditary optic neuropathy: biochemical effect of 11778/ND4 and 3460/ND1 mutations and correlation with the mitochondrial genotype.
PubMed:	The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells.
PubMed:	Measurement of the membrane potential generated by complex I in submitochondrial particles.
PubMed:	Genetic evidence for the existence of two quinone related inhibitor binding sites in NADH-CoQ reductase.
PubMed:	Longimicins A-D: novel bioactive acetogenins from Asimina longifolia (annonaceae) and structure-activity relationships of asimicin type of annonaceous acetogenins.
PubMed:	Squamotacin: an annonaceous acetogenin with cytotoxic selectivity for the human prostate tumor cell line (PC-3).
PubMed:	SARs of annonaceous acetogenins in rat liver mitochondria.
PubMed:	The absolute configuration of adjacent bis-THF acetogenins and asiminocin, a novel highly potent asimicin isomer from Asimina triloba.
PubMed:	Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH oxidase activity of HeLa and HL-60, but not liver, plasma membranes.
PubMed:	Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (Complex I).
PubMed:	Asimin, asiminacin, and asiminecin: novel highly cytotoxic asimicin isomers from Asimina triloba.
PubMed:	Bullatacin--in vivo and in vitro experience in an ovarian cancer model.
PubMed:	Mode of action of bullatacin: a potent antitumor and pesticidal annonaceous acetogenin.
PubMed:	Additional bioactive compounds and trilobacin, a novel highly cytotoxic acetogenin, from the bark of Asimina triloba.
PubMed:	Bullatacin, bullatacinone, and squamone, a new bioactive acetogenin, from the bark of Annona squamosa.
PubMed:	Bullatacin and bullatacinone: two highly potent bioactive acetogenins from Annona bullata.