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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 1.213e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for neoglucobrassicin usage levels up to: | | | not for fragrance use.
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| Recommendation for neoglucobrassicin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 9576416 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1Z)-2-(1-methoxyindol-3-yl)-N-sulfooxyethanimidothioate |
| Chemidplus: | 0005187848 |
References:
| | [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1Z)-2-(1-methoxyindol-3-yl)-N-sulfooxyethanimidothioate |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 9576416 |
| Pubchem (cas): | 5187-84-8 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| beta-D- | glucopyranose, 1-thio-, 1-(1-methoxy-N-(sulfooxy)-1H-indole-3-ethanimidate) | | 1- | methoxy-3-indolylmethylglucosinolate | | [(2S,3R,4S,5S,6R)-3,4,5- | trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1Z)-2-(1-methoxyindol-3-yl)-N-sulfooxyethanimidothioate |
Articles:
| PubMed: | Molecular characterization of glucosinolates and carotenoid biosynthetic genes in Chinese cabbage (Brassica rapaL. ssp.pekinensis). |
| PubMed: | Synthesis of aromatic and indole alpha-glucosinolates. |
| PubMed: | Rapid and Efficient Desulfonation Method for the Analysis of Glucosinolates by High-Resolution Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry. |
| PubMed: | UVA, UVB Light, and Methyl Jasmonate, Alone or Combined, Redirect the Biosynthesis of Glucosinolates, Phenolics, Carotenoids, and Chlorophylls in Broccoli Sprouts. |
| PubMed: | The ability to manipulate plant glucosinolates and nutrients explains the better performance ofBemisia tabaciMiddle East-Asia Minor 1 than Mediterranean on cabbage plants. |
| PubMed: | Preferentially enhancing anti-cancer isothiocyanates over glucosinolates in broccoli sprouts: How NaCl and salicylic acid affect their formation. |
| PubMed: | Fermentation-Assisted Extraction of Isothiocyanates from Brassica Vegetable Using Box-Behnken Experimental Design. |
| PubMed: | Exogenous Methyl Jasmonate and Salicylic Acid Induce Subspecies-Specific Patterns of Glucosinolate Accumulation and Gene Expression in Brassica oleracea L. |
| PubMed: | Effects of seed priming, salinity and methyl jasmonate treatment on bioactive composition of Brassica oleracea var. capitata (white and red varieties) sprouts. |
| PubMed: | Transcriptome and Metabolome Analyses of Glucosinolates in Two Broccoli Cultivars Following Jasmonate Treatment for the Induction of Glucosinolate Defense to Trichoplusia ni (Hübner). |
| PubMed: | Expression Profiling of Glucosinolate Biosynthetic Genes in Brassica oleracea L. var. capitata Inbred Lines Reveals Their Association with Glucosinolate Content. |
| PubMed: | Plants as Biofactories: Postharvest Stress-Induced Accumulation of Phenolic Compounds and Glucosinolates in Broccoli Subjected to Wounding Stress and Exogenous Phytohormones. |
| PubMed: | Production of glucosinolates, phenolic compounds and associated gene expression profiles of hairy root cultures in turnip (Brassica rapa ssp. rapa). |
| PubMed: | Glucosinolates Are Mainly Absorbed Intact in Germfree and Human Microbiota-Associated Mice. |
| PubMed: | Leaf and root glucosinolate profiles of Chinese cabbage (Brassica rapa ssp. pekinensis) as a systemic response to methyl jasmonate and salicylic acid elicitation. |
| PubMed: | Development and validation of a liquid chromatography-tandem mass spectrometry method to determine intact glucosinolates in bee pollen. |
| PubMed: | Metabolomic assessment reveals an elevated level of glucosinolate content in CaCl₂ treated broccoli microgreens. |
| PubMed: | Simultaneous detection of multiple DNA adducts in human lung samples by isotope-dilution UPLC-MS/MS. |
| PubMed: | Optimization of pulsed electric field pre-treatments to enhance health-promoting glucosinolates in broccoli flowers and stalk. |
| PubMed: | Exogenous methyl jasmonate treatment increases glucosinolate biosynthesis and quinone reductase activity in kale leaf tissue. |
| PubMed: | Variation in broccoli cultivar phytochemical content under organic and conventional management systems: implications in breeding for nutrition. |
| PubMed: | Enhancement of broccoli indole glucosinolates by methyl jasmonate treatment and effects on prostate carcinogenesis. |
| PubMed: | Variation in bioactive content in broccoli (Brassica oleracea var. italica) grown under conventional and organic production systems. |
| PubMed: | Functional identification of genes responsible for the biosynthesis of 1-methoxy-indol-3-ylmethyl-glucosinolate in Brassica rapa ssp. chinensis. |
| PubMed: | Glucosinolates from pak choi and broccoli induce enzymes and inhibit inflammation and colon cancer differently. |
| PubMed: | High mutagenic activity of juice from pak choi (Brassica rapa ssp. chinensis) sprouts due to its content of 1-methoxy-3-indolylmethyl glucosinolate, and its enhancement by elicitation with methyl jasmonate. |
| PubMed: | Optimized extraction, separation and quantification of twelve intact glucosinolates in broccoli leaves. |
| PubMed: | Identification and quantification of protein adducts formed by metabolites of 1-methoxy-3-indolylmethyl glucosinolate in vitro and in mouse models. |
| PubMed: | Optimization of methyl jasmonate application to broccoli florets to enhance health-promoting phytochemical content. |
| PubMed: | A secondary metabolite of Brassicales, 1-methoxy-3-indolylmethyl glucosinolate, as well as its degradation product, 1-methoxy-3-indolylmethyl alcohol, forms DNA adducts in the mouse, but in varying tissues and cells. |
| PubMed: | Methyl jasmonate and 1-methylcyclopropene treatment effects on quinone reductase inducing activity and post-harvest quality of broccoli. |
| PubMed: | Influence of seasonal variation and methyl jasmonate mediated induction of glucosinolate biosynthesis on quinone reductase activity in broccoli florets. |
| PubMed: | MYB transcription factors regulate glucosinolate biosynthesis in different organs of Chinese cabbage (Brassica rapa ssp. pekinensis). |
| PubMed: | Pre-harvest methyl jasmonate treatment enhances cauliflower chemoprotective attributes without a loss in postharvest quality. |
| PubMed: | Virtual screening for oseltamivir-resistant a (H5N1) influenza neuraminidase from traditional Chinese medicine database: a combined molecular docking with molecular dynamics approach. |
| PubMed: | BZR1 and BES1 participate in regulation of glucosinolate biosynthesis by brassinosteroids in Arabidopsis. |
| PubMed: | Glucosinolate biosynthesis in hairy root cultures of broccoli (Brassica oleracea var. italica). |
| PubMed: | Arabidopsis wat1 (walls are thin1)-mediated resistance to the bacterial vascular pathogen, Ralstonia solanacearum, is accompanied by cross-regulation of salicylic acid and tryptophan metabolism. |
| PubMed: | Detection of DNA adducts originating from 1-methoxy-3-indolylmethyl glucosinolate using isotope-dilution UPLC-ESI-MS/MS. |
| PubMed: | Feasibility study on the use of visible-near-infrared spectroscopy for the screening of individual and total glucosinolate contents in broccoli. |
| PubMed: | Effects of various heating methods on glucosinolate, carotenoid and tocopherol concentrations in broccoli. |
| PubMed: | Health benefits and possible risks of broccoli - an overview. |
| PubMed: | Identification of glucosinolate congeners able to form DNA adducts and to induce mutations upon activation by myrosinase. |
| PubMed: | Tri-trophic effects of inter- and intra-population variation in defence chemistry of wild cabbage (Brassica oleracea). |
| PubMed: | Breakdown products of neoglucobrassicin inhibit activation of Nrf2 target genes mediated by myrosinase-derived glucoraphanin hydrolysis products. |
| PubMed: | 1-Methoxy-3-indolylmethyl glucosinolate; a potent genotoxicant in bacterial and mammalian cells: Mechanisms of bioactivation. |
| PubMed: | Glucosinolates profile of "mugnolo", a variety of Brassica oleracea L. native to southern Italy (Salento). |
| PubMed: | Metabolic changes of Brassica rapa transformed with a bacterial isochorismate synthase gene. |
| PubMed: | Genetic variation in defense chemistry in wild cabbages affects herbivores and their endoparasitoids. |
| PubMed: | Metabolic engineering of indole glucosinolates in Chinese cabbage plants by expression of Arabidopsis CYP79B2, CYP79B3, and CYP83B1. |
| PubMed: | Changes of glucosinolates in mixed fresh-cut broccoli and cauliflower florets in modified atmosphere packaging. |
| PubMed: | Glucosinolates in Diplotaxis and Eruca leaves: diversity, taxonomic relations and applied aspects. |
| PubMed: | Development of an insect herbivore and its pupal parasitoid reflect differences in direct plant defense. |
| PubMed: | Correlation of glucosinolate content to myrosinase activity in horseradish (Armoracia rusticana). |
| PubMed: | Desulfoglucosinolate sulfotransferases from Arabidopsis thaliana catalyze the final step in the biosynthesis of the glucosinolate core structure. |
| PubMed: | Health-promoting compounds in broccoli as influenced by refrigerated transport and retail sale period. |
| PubMed: | Flavor-active compounds potentially implicated in cooked cauliflower acceptance. |
| PubMed: | Biochemical effects of dietary intake of different broccoli samples. II. Multivariate analysis of contributions of specific glucosinolates in modulating cytochrome P-450 and antioxidant defense enzyme activities. |
| PubMed: | Biochemical effects of dietary intakes of different broccoli samples. I. Differential modulation of cytochrome P-450 activities in rat liver, kidney, and colon. |
| PubMed: | The myrosinase-glucosinolate system in the interaction between Leptosphaeria maculans and Brassica napus. |
| PubMed: | The role of spatial scale and intraspecific variation in secondary chemistry in host-plant location by Ceutorhynchus assimilis (Coleoptera: Curculionidae). |
| PubMed: | Modulation of cytochrome P-450 and glutathione S-transferase isoform expression in vivo by intact and degraded indolyl glucosinolates. |
| PubMed: | An indole derivative and glucosinolates from Moricandia arvensis. |
| PubMed: | Distribution and Variation of Indole Glucosinolates in Woad (Isatis tinctoria L.). |
| PubMed: | Indole Compounds Related to Auxins and Goitrogens of Woad (Isatis tinctoria L.). |
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