|
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 4.11 mg/L @ 25 °C (est) |
Organoleptic Properties:
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| |
Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Glycycoumarin >98%
Odor: characteristic Use: Glycycoumarin is a natural coumarin compound found in several plants. |
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for glycycoumarin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for glycycoumarin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
| | 3-(2,4-dihydroxyphenyl)-7-hydroxy-5-methoxy-6-(3-methylbut-2-enyl)chromen-2-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5317756 |
| Pubchem (cas): | 94805-82-0 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 3-(2,4- | dihydroxy-phenyl)-7-hydroxy-5-methoxy-6-(3-methyl-but-2-enyl)-1-benzopyran-2-one | | 3-(2,4- | dihydroxyphenyl)-7-hydroxy-5-methoxy-6-(3-methylbut-2-enyl)chromen-2-one |
Articles:
| PubMed: | Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis. |
| PubMed: | Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents. |
| PubMed: | Glycycoumarin inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress/GSK-3-mediated mitochondrial pathway. |
| PubMed: | Identification and Chemical Standardization of Licorice Raw Materials and Dietary Supplements Using UHPLC-MS/MS. |
| PubMed: | Glycycoumarin exerts anti-liver cancer activity by directly targeting T-LAK cell-originated protein kinase. |
| PubMed: | Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities. |
| PubMed: | Pharmacokinetic Profiles of Active Components After Oral Administration of a Kampo Medicine, Shakuyakukanzoto, to Healthy Adult Japanese Volunteers. |
| PubMed: | Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy. |
| PubMed: | [Screening of active compounds with myocardial protective effects from Tongmai Yangxin pill]. |
| PubMed: | Prenylated polyphenolic compounds from Glycyrrhiza iconica and their antimicrobial and antioxidant activities. |
| PubMed: | Protective effects of glycycoumarin and procyanidin B1, active components of traditional Japanese medicine yokukansan, on amyloid β oligomer-induced neuronal death. |
| PubMed: | Metabolites identification of glycycoumarin, a major bioactive coumarin from licorice in rats. |
| PubMed: | Structures of two new flavonoids and effects of licorice phenolics on vancomycin-resistant Enterococcus species. |
| PubMed: | Simultaneous determination of five minor coumarins and flavonoids in Glycyrrhiza uralensis by solid-phase extraction and high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. |
| PubMed: | Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species. |
| PubMed: | Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice. |
| PubMed: | Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix. |
| PubMed: | Isoliquiritigenin is a novel NMDA receptor antagonist in kampo medicine yokukansan. |
| PubMed: | Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities. |
| PubMed: | Separation, characterization and dose-effect relationship of the PPARgamma-activating bio-active constituents in the Chinese herb formulation 'San-Ao decoction'. |
| PubMed: | Survey of Glycyrrhizae Radix resources in Mongolia: chemical assessment of the underground part of Glycyrrhiza uralensis and comparison with Chinese Glycyrrhizea Radix. |
| PubMed: | Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication. |
| PubMed: | Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information. |
| PubMed: | [Inhibitory effects of 11 coumarin compounds against growth of human bladder carcinoma cell line E-J in vitro]. |
| PubMed: | Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. |
| PubMed: | Pharmaceutical evaluation of cultivated Glycyrrhiza uralensis roots in comparison of their antispasmodic activity and glycycoumarin contents with those of licorice. |
| PubMed: | Glycycoumarin from Glycyrrhizae Radix acts as a potent antispasmodic through inhibition of phosphodiesterase 3. |
| PubMed: | Comparative analysis of ten strains of Glycyrrhiza uralensis cultivated in Japan. |
| PubMed: | A licorice ethanolic extract with peroxisome proliferator-activated receptor-gamma ligand-binding activity affects diabetes in KK-Ay mice, abdominal obesity in diet-induced obese C57BL mice and hypertension in spontaneously hypertensive rats. |
| PubMed: | Field survey of Glycyrrhiza plants in Central Asia (1). Characterization of G. uralensis, G. glabra and the putative intermediate collected in Kazakhstan. |
| PubMed: | Antibacterial compounds of licorice against upper airway respiratory tract pathogens. |
| PubMed: | Phenolic constituents of licorice. VIII. Structures of glicophenone and glicoisoflavanone, and effects of licorice phenolics on methicillin-resistant Staphylococcus aureus. |
| PubMed: | [Phenolic constituents of licorice. IV. Correlation of phenolic constituents and licorice specimens from various sources, and inhibitory effects of licorice extracts on xanthine oxidase and monoamine oxidase]. |
| PubMed: | [Quality evaluation of Chinese licorice]. |
|